Paper title: Therapeutic effect of Momordica charantia on cardiomyopathy in a diabetic maternal rat model DOI

Shaimaa Elnahas,

Hend Abd El‐Halim Mansour, Mamdouh Rashad El-Sawi

et al.

Journal of Experimental Zoology Part A Ecological and Integrative Physiology, Journal Year: 2024, Volume and Issue: 341(9), P. 977 - 990

Published: July 8, 2024

Abstract Myocardial structural and functional abnormalities are hallmarks of diabetic cardiomyopathy (DCM), a chronic consequence diabetes mellitus (DM). Maternal DM affects increases the risk heart defects in mothers compared with nondiabetic mothers. Momordica charantia exhibits antidiabetic effects due to various bioactive compounds that phytochemicals, broad group includes phenolic compounds, alkaloids, proteins, steroids, inorganic lipids. Pregnant maternal rats were split into four groups: control (C), M. ‐treated (MC), type 2 (T2DM) (DM), (MC + DM) groups. Diabetes had increased serum glucose, insulin, total cholesterol, triglyceride, low‐density lipoprotein cholesterol levels reduced high‐density levels. Cardiac biomarkers such as cardiac troponin T (cTnT), creatine kinase‐myocardial band (CK‐MB), lactate dehydrogenase increased. Hormone follicle‐stimulating hormone, luteinizing progesterone, estrogen decreased significantly. Inflammatory markers interleukin 6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), vascular adhesion molecule‐1 (VCAM‐1) elevated Oxidative stress indicated malondialdehyde nitric oxide levels, while antioxidants glutathione, superoxide dismutase, catalase tissue. The apoptotic suppressor 53 (P ) cysteine aspartic protease‐3 (caspase‐3) significantly greater Histopathological analysis revealed tissue rats. extract improved diabetes‐induced changes inflammation, antioxidant structure.

Language: Английский

Moringa oleifera: a valuable insight into recent advances in medicinal uses and pharmacological activities DOI Open Access
Agatha Ngukuran Jikah, Great Iruoghene Edo

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 103(15), P. 7343 - 7361

Published: Aug. 3, 2023

Moringa oleifera is an important medicinal plant in several countries; for example, Nigeria, the USA, Turkey, Germany, Greece, and Ukraine. The abundant bioactive nutritional properties of this make it useful many diverse areas life, including health, cosmetic, agricultural, food industries to mention but a few. Research has found that presence proteins, carbohydrates, lipids, vitamins, minerals, flavonoids, phenols, alkaloids, fatty acids, saponins, essential oils, folate, aromatic hydrocarbons, sterols, glucosinolates, glycosides, among others, characterize moringa nutrient profile and, as result, give rise its remedial effects on ailments such wounds, stomach duodenal ulcers, allergies, obesity, diabetes, inflammation, asthma, so on. It aim review provide insight into pharmacological remedies attributed moringa, stating both past recent discoveries. This article also takes look botanical features, compounds, antinutrients, applications, bacterial fermentation products, biosafety, industrial other uses moringa. Finally, with belief knowledge progressive, we acknowledge there are things yet undiscovered about wonder will be value medicine general life; therefore recommend research work continues plant. © 2023 Society Chemical Industry.

Language: Английский

Citations

48

Biopolymer-based hydrogels for biomedical applications: Bioactivity and wound healing properties DOI
Fariba Mehvari, Vahid Ramezanzade, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093

Published: July 25, 2024

Language: Английский

Citations

12

Overview of anti-inflammatory diets and their promising effects on non-communicable diseases DOI Creative Commons
Xiaoping Yu, Hongquan Pu, Margaret A. Voss

et al.

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: 132(7), P. 898 - 918

Published: Oct. 14, 2024

Abstract An anti-inflammatory diet is characterised by incorporating foods with potential properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red processed meat, refined carbohydrates saturated fats are limited. This article explores the effects of an on non-communicable diseases (NCD), concentrating underlying mechanisms that connect systemic chronic inflammation, dietary choices disease outcomes. Chronic inflammation a pivotal contributor to initiation progression NCD. review provides overview intricate pathways through which influences pathogenesis conditions obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer cognitive disorders. Through comprehensive synthesis existing research, we aim identify some bioactive compounds present in deemed anti-inflammatory, explore their capacity modulate inflammatory and, consequently, prevent or manage The findings demonstrated herein contribute understanding interplay between nutrition, paving way for future recommendations research regarding preventive therapeutic strategies.

Language: Английский

Citations

11

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications DOI Creative Commons
Aaser M. Abdelazim, Mohamed Afifi, Mohammed H. Abu-Alghayth

et al.

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: Jan. 5, 2024

Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant this purpose. The present review aimed to spot light on recent medicinal, biochemical, and nutritional applications of MO. contains a huge number nutrients such as fatty acids, amino proteins, polysaccharides, minerals, vitamins. It has been control glucose, lipids, vitamins, hormones, antioxidants in many animals human models. Its are also varied wide; it manage lots disorders. Extracts isolated ingredients from open way researchers all over world study its biochemical impact experimental clinical spots significance MO opening discussion demonstrating strengths weaknesses research area. Regardless contrary concept, we promising that studied both molecular levels. We recommended further effects healthy diseased

Language: Английский

Citations

9

Ultrasound-assisted hydrogen peroxide–ascorbic acid method to degrade sweet corncob polysaccharides can help treat type 2 diabetes via multiple pathways in vivo DOI Creative Commons

Weiye Xiu,

Xin Wang,

Zhiguo Na

et al.

Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 101, P. 106683 - 106683

Published: Nov. 7, 2023

In this study, we aimed to investigate the impact of various ultrasound durations on structure and bioactivity sweet corncob polysaccharides treated with ultrasound-assisted degradation using hydrogen peroxide ascorbic acid (H2O2-Vc). We subjected treatment for 0, 30, 60, 90 min alongside H2O2-Vc method. then analyzed their chemical composition structure. Additionally, administered these mice type 2 diabetes (T2DM) through gavage at a dosage 200 mg/kg/day. The results indicated significant reduction in molecular weight degraded polysaccharides, while remained relatively stable. However, basic was retained. vivo experiments demonstrated that had positive T2DM, particularly 60-minute (UH-DSCBP-60 min), which effectively controlled blood glucose levels by regulating glycolipid metabolism livers T2DM. This approach also reduced inflammation oxidative stress inhibited disaccharide activity small intestine. can positively affect hypoglycemic activity. findings our study provide theoretical foundation valuable utilization polysaccharides.

Language: Английский

Citations

21

The development of nanocarriers for natural products DOI
Liying Huang, Shicui Luo, Sen Tong

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)

Published: May 1, 2024

Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems

Language: Английский

Citations

6

Optimized Extraction of Polyphenols from Unconventional Edible Plants: LC-MS/MS Profiling of Polyphenols, Biological Functions, Molecular Docking, and Pharmacokinetics Study DOI Creative Commons
Hafiza Sehrish Kiani, Waheed Ahmad,

Sana Nawaz

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6703 - 6703

Published: Sept. 19, 2023

Plant bioactive phenolic metabolites have recently attracted the attention of researchers due to their numerous health advantages. Therefore, this study aimed investigate with advanced techniques and antioxidant antidiabetic capacity four unconventional edible plant leaves: lemongrass (Cymbopogon citratus (DC.) Stapf), chicory (Cichorium intybus L.), moringa (Moringa oleifera Lam.), ryegrass (Lolium perenne L.). The extraction process was optimized using different solvents. These plants' composition, identification, characterization been determined herein LCESI-QTOF-MS/MS. This research identified 85 compounds, including 24 acids, 31 flavonoids, 7 stilbenes lignans, 17 other metabolites. Moreover, that has highest total content (TPC; 18.5 ± 1.01 mg GAE/g), whereas lowest (3.54 0.08 GAE/g) among selected plants. It seems that, compared plants, found potential potential. In addition, twenty-two compounds were quantified in these chosen Rosmarinic acid, chlorogenic chicoric ferulic protocatechuic caffeic acid most abundant acids. silico molecular docking also conducted structure-function relationship inhibit alpha-glucosidase. Finally, simulated pharmacokinetic characteristics common substances predicted. short, investigation opens way for further into pharmaceutical dietary

Language: Английский

Citations

14

Fortification of Cow Milk with Moringa oleifera Extract: Influence on Physicochemical Characteristics, Antioxidant Capacity and Mineral Content of Yoghurt DOI Creative Commons
Katarina Lisak Jakopović, Maja Repajić, Ivana Rumora Samarin

et al.

Fermentation, Journal Year: 2022, Volume and Issue: 8(10), P. 545 - 545

Published: Oct. 16, 2022

Background: Fermented dairy products are known for their many positive effects on human health and consumed worldwide. The supplementation of food with plant extracts as sources valuable nutritional compounds has recently gained a lot attention. Milk fermented deficient in bioactive components such phenolic iron. Moringa oleifera leaf extract is rich vitamins, minerals (iron), polyphenols, flavonoids, tannins proteins. Its addition to milk before fermentation might represent an excellent way enrich products. Methods: Yoghurts enriched moringa (ME) (1, 3 4-%, v/v) were produced compared control yoghurt without ME. In all samples, acidity, microbiological parameters, syneresis water holding capacity, rheology total colour difference, mineral content, phenols antioxidant capacity (FRAP method) sensory properties determined. Results: ME resulted shorter time, lower pH, increased growth bacteria, better rheological content well yoghurts. Moreover, yoghurts had higher score when the sample.

Language: Английский

Citations

22

Efficacy of nanoencapsulated Moringa oleifera L. seeds and Ocimum tenuiflorum L. leaves extracts incorporated in functional soft cheese on streptozotocin-induced diabetic rats DOI Creative Commons
Tarek N. Soliman, Alshymaa Karam-Allah,

Eman Abo-Zaid

et al.

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(3), P. 100598 - 100598

Published: June 8, 2024

In recent years, there has been significant interest in using various plant-based phytochemicals with exceptional biological activities as nutraceuticals to prevent the development and advancement of diabetes mellitus its severe consequences. The extracts Moringa oleifera L. seeds Ocimum tenuiflorum leaves are used herbal therapy due their beneficial effects combating disorders, notably paper aimed investigate incorporation both free seed extract nanoencapsulated whey protein isolate cold gelation ultra-filtration cheese natural functional foods explore nano-encapsulated impacts a novel application on diabetic rats through nutritional parameters, biochemical physicochemical sensory evaluation. Thirty-six male Sprague-Dawley were given only one dose streptozotocin (35 mg/kg body weight) intraperitoneally. parameters assessed. successfully encapsulated, best ratio added was 75 mg both, which gave results regarding particle size distribution, surface charge encapsulation efficiency. charge, Their forms had increased total solids, protein, ash cheese. extract, cheese, antioxidant activity stability significantly captured radicals. samples' qualities evaluations received high marks suitable for incorporating nanoparticles food systems. confirmed that nanoencapsulation plant sources soft containing demonstrated potential anti-hyperglycemic effect without any problems.

Language: Английский

Citations

4

Evaluating the anti-yeast, anti-diabetic, wound healing activities of Moringa oleifera extracted at different conditions of pressure via supercritical fluid extraction DOI Creative Commons

Mutasem Saad Almehayawi,

Mohammed S. Almuhayawi,

Shams R. Abo El-Fadl

et al.

BioResources, Journal Year: 2024, Volume and Issue: 19(3), P. 5961 - 5977

Published: July 16, 2024

Plants represent a great source of medicines, and for their components to be discovered, extraction processes must developed, especially methods based on green technology. Supercritical fluid (SFE) was employed as method Moringa oleifera in the present investigation. The maximum yield obtained at 25 MPa. Moreover, MPa induced release various phenols flavonoids, analyzed via high-performance liquid chromatography. investigation revealed concentrations chlorogenic, gallic, rosmarinic, coumaric acids 150.59, 89.90, 44.75, 29.41 µg/mL, respectively However, were 0.73, 1.53, 0.24, 0.04 15 MPa; vs. 4.73, 2.62, 1.06, 0.50 35 MPa, respectively. Totals saponin, flavonoid, phenolic, tannins, alkaloid recorded extracted reflected highest inhibition zones 27 ± 0.1, 30 0.2, 0.1 mm against C. glabrata, tropicalis, albicans, correspondingly. α-Amylase α-glucosidase activities greatly suppressed by M. extract with less IC50 (12.97 µg/mL 6.0 µg/mL), than (53.46 22.02 µg/mL) compared acarbose (5.52 2.64

Language: Английский

Citations

4