Differential Accumulation of Bioactive Compounds in Different Populations of Mesona chinensis Benth: An Integrated Transcriptomic and Metabolomic Analysis DOI
Yan Qin, Rui Xie, Shaozhong Peng

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105722 - 105722

Published: Dec. 1, 2024

Language: Английский

Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway DOI
Shuhan Wang, Yaqi Yang,

Jiahong Lin

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Insights on the Phytochemistry and Bioactive Properties of Ailanthus altissima (Mill.) Swingle for Nutritional and Curative Potential DOI

Mufida Fayaz,

Paulami Dam, Tanay Barman

et al.

Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Language: Английский

Citations

0
Profiling the Phytochemicals of Orostachys margaritifolia: Biological Activities, LC-ESI/MS, and HPLC Analyses DOI Creative Commons

Nari Yoon,

Hyeonjun Yu,

Gia Han Tran

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 290 - 290

Published: Feb. 23, 2024

Orostachys margaritifolia Y. N. Lee (OMY) is an endemic Korean plant in the family Crassulaceae that known to contain a variety of bioactive compounds. To assess physiological activities OMY ethanol extract, ABTS+ and DPPH radical scavenging assays nitric oxide (NO) inhibition assay were conducted. The phytochemical makeup extract was profiled via liquid chromatography-mass spectrometry (LC-ESI/MS) high-performance chromatography with photodiode array detector (HPLC/PDA). found have weaker than control group (green tea). In NO assay, induced significant increase macrophage cell viability but showed lower inhibitory activity l-NAME, producing IC50 value 202.6 μg/mL. LC-ESI/MS HPLC/PDA analyses identified isoquercitrin astragalin quantifying their contents at 3.74 mg/g 3.19 mg/g, respectively. study revealed possibilities for utilization as future source drugs alleviating inflammation diseases related reactive oxygen species.

Language: Английский

Citations

2
Ethyl acetate fraction of Thesium chinense Turcz. alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis mediated by activating Nrf2/SLC7A11/GPX4 axis DOI
Mingjie Liu,

Zhen‐Peng Xu,

Yue-Qin Guan

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118776 - 118776

Published: Aug. 31, 2024

Language: Английский

Citations

2
Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin DOI
Yao Zhao, Xueying Zhang,

Zhuoliang Lang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(11), P. 6053 - 6063

Published: March 7, 2024

Legumes possess several bioactive nutrients, including flavonoids, and the study of flavonoid profile legumes is great significance to human health. Using widely targeted metabolomics, we revealed profiles five popular fresh legumes: cowpea, soybean, pea, fava bean, kidney bean. A total 259 flavonoids were identified, accumulation patterns remarkably different. In addition analyzing common species-specific in legumes, also generalized representative various subclasses. We related these health-promoting effects legumes. Furthermore, legumes' content antioxidant system activity detected. Intriguingly, sakuranetin, sole phytoalexin that can be induced by UV radiation, was detected only peas metabolomics. Meanwhile, found treatment could significantly increase sakuranetin postharvest Botrytis cinerea resistance pea pods. This provides clues for target diet, industrial development a new idea preservation peas.

Language: Английский

Citations

2
Dietary astragalin confers protection against lipopolysaccharide-induced intestinal mucosal barrier damage through mitigating inflammation and modulating intestinal microbiota DOI Creative Commons

Enhui Tang,

Huan Lin, Yihao Yang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 2, 2024

The intestinal mucosal barrier (IMB) damage is intricately linked with the onset of numerous diseases. Astragalin (AS), a flavonoid present in edible plants, exhibits notable antioxidant and anti-inflammatory properties, demonstrating promising impact on certain ailments. In this study, our objective was to investigate protective effects AS elucidate underlying mechanisms by which it mitigates lipopolysaccharide (LPS)-induced IMB mice.

Language: Английский

Citations

2
Astragalin protects against lipopolysaccharide-triggered acute liver injury through suppression of necroptosis and inflammation and improvement of energy metabolism DOI Creative Commons

Minmin Cao,

Zhe Guo,

Yitong Lu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 118, P. 106298 - 106298

Published: June 12, 2024

Language: Английский

Citations

1
Comparative Metabolome and Transcriptome Analysis Reveals the Defense Mechanism of Chinese Cabbage (Brassica rapa L. ssp. pekinensis) against Plasmodiophora brassicae Infection DOI Open Access
Xiaochun Wei,

Yingyi Du,

Wenjing Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10440 - 10440

Published: Sept. 27, 2024

Chinese cabbage (

Language: Английский

Citations

1
Family Malvaceae: a potential source of secondary metabolites with chemopreventive and anticancer activities supported with in silico pharmacokinetic and pharmacodynamic profiles DOI Creative Commons

Salma Sameh,

Ahmed M. Elissawy, Eman Al‐Sayed

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 16, 2024

Introduction Cancer is the second most widespread cause of mortality following cardiovascular disorders, and it imposes a heavy global burden. Nowadays, herbal nutraceutical products with plethora bioactive metabolites represent foundation stone for development promising chemopreventive anticancer agents. Certain members family Malvaceae have traditionally been employed to relieve tumors. The literature concerning effects plant species along isolated cytotoxic phytometabolites was reviewed. Based on findings, comprehensive computational modelling studies were performed explore pharmacokinetic pharmacodynamic profiles reported present basis future plant-based drug discovery. Methods All available information about research in its retrieved from official sources. Extensive search carried out using keywords Malvaceae, cancer, cytotoxicity, mechanism signalling pathway. Pharmacokinetic study SWISS ADME model. Acute oral toxicity expressed as median lethal dose (LD 50 ) predicted Pro Tox 3.0 web tool. compounds docked AutoDock Vina platform against epidermal growth factor receptor (EGFR kinase enzyme) obtained Protein Data Bank. Molecular dynamic simulations MMGBSA calculations GROMACS 2024.2 gmx_MMPBSA tool v1.5.2. Results One hundred forty-five articles eligible study. Several tested showed safe properties. Also, molecular docking that possessed agreeable binding affinities EGFR enzyme. Tiliroside (25), boehmenan (30), H (31), isoquercetin (22) elicited highest affinity toward enzyme score −10.4, −10.2 −10.1 Kcal/mol compared reference erlotinib having equal −9 Kcal/mol. Additionally, 25 31 free energies −42.17 −42.68 Kcal/mol, respectively, comparable erlotinib. Discussion Overall, current presents helpful insights into properties belonging members. results intensify roles secondary medicinal plants fighting cancer.

Language: Английский

Citations

1
Analysis of Different Strains Fermented Douchi by GC×GC-TOFMS and UPLC–Q-TOFMS Omics Analysis DOI Creative Commons
Liqiang Sui,

Sugui Wang,

Xin Wang

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(21), P. 3521 - 3521

Published: Nov. 4, 2024

Douchi is a kind of soybean-fermented food in China. To explore the common and differential compounds different Douchi, was fermented by

Language: Английский

Citations

0