Mechanisms of Cancer Cell Radioresistance: Modern Trends and Research Prospects DOI
М. Г. Шарапов, E. E. Karmanova, Sergey V. Gudkov

et al.

BIOPHYSICS, Journal Year: 2024, Volume and Issue: 69(6), P. 1064 - 1088

Published: Dec. 1, 2024

Language: Английский

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine DOI Creative Commons
Jing Li,

Qingyin Long,

Huang Ding

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 28, 2024

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range

Language: Английский

Citations

12
Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer DOI Creative Commons
Bassant Samir,

Amal H. El‐Kamel,

Noha Zahran

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(12), P. 3354 - 3370

Published: Feb. 15, 2024

Skin cancer is a widespread type of representing 30% all types worldwide. Resveratrol (RSV) an anticancer drug used for skin treatment. Several limitations RSV such as poor aqueous solubility, first-pass metabolism, and instability limit their topical use. The study aimed to develop optimize RSV-loaded invasomes administration well assess efficacy in vivo. optimized showed small particle size (208.7 ± 74 nm), PDI (0.3 0.03), high % entrapment efficiency (77.7 6%), negative zeta potential (-70.4 10.9 mV). They initial burst effect followed by controlled release 24 h. invasomal gel revealed the highest deposition percentage (65%) ex vivo rat skin, potency (low IC

Language: Английский

Citations

11
The Emerging Role of Natural Products in Cancer Treatment DOI
Sumit Ghosh, Sanjib Das, Krishnendu Sinha

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2353 - 2391

Published: May 25, 2024

Language: Английский

Citations

11
Unraveling the complexities of colorectal cancer and its promising therapies – An updated review DOI

Sayan Saha,

Shreya Ghosh, Suman Ghosh

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113325 - 113325

Published: Oct. 14, 2024

Language: Английский

Citations

7
Serving up health: How phytochemicals transform food into medicine in the battle against cancer DOI Creative Commons
Eshita Sharma, Manju Tewari,

Priyanka Sati

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(5), P. 1866 - 1908

Published: July 7, 2024

Abstract The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention their potential chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms influence cell signaling pathways offers a promising avenue management. This review aims synthesize current knowledge on phytochemicals’ chemopreventive chemotherapeutic potential, focusing of action impacts involved cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web Science, Scopus, Google Scholar. strategy uses Medical Subject Headings (MeSH) free‐text terms using Boolean operators capture relevant studies. Inclusion criteria targeted original research reviews effects phytochemicals cancer, with specific focus mechanisms. flavonoids, polyphenols, terpenoids, demonstrated significant anticancer properties by inducing cycle arrest, apoptosis, autophagy. They critical pathways, such as cyclooxygenase‐2, nuclear factor kappa B, various growth factor‐related rectify epigenetic alterations, contributing effects. Phytochemicals represent valuable resource developing novel prevention treatment strategies; actions underscore combat. Further is warranted translate these findings into clinical applications, optimizing phytochemical‐based interventions

Language: Английский

Citations

4
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases DOI
Sajad Abolfazli, Sercan Karav,

Thomas P. Johnston

et al.

Pharmacological Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

0
HMGB1 secretion by resveratrol in NSCLC: A pathway to ferroptosis-mediated platelet activation suppression DOI
Yifan Zhang,

Shihao Bao,

Jingtong Zeng

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111607 - 111607

Published: Jan. 1, 2025

Language: Английский

Citations

0
Unveiling the future of cancer stem cell therapy: a narrative exploration of emerging innovations DOI Creative Commons

Joseph Nhyira Obisi,

Abike Ndidiamaka Josephine Abimbola,

Oluwasegun Adesina Babaleye

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Cancer stem cells (CSCs), are a critical subpopulation within tumours, and defined by their capacity for self-renewal, differentiation, tumour initiation. These unique traits contribute to progression, metastasis, resistance conventional treatments like chemotherapy radiotherapy, often resulting in cancer recurrence poor patient outcomes. As such, CSCs have become focal points developing advanced therapies. This review highlights progress CSC-targeted treatments, including chimeric antigen receptor T-cell (CAR-T) therapy, immunotherapy, molecular targeting, nanoparticle-based drug delivery systems. Plant-derived compounds gene-editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), explored potential enhance precision minimize side effects. Metabolic pathways integral CSC survival, mitochondrial dynamics, mitophagy (regulated dynamin-related protein 1 [DRP1] the PINK1/Parkin pathway), one-carbon metabolism, amino acid metabolism (involving enzymes glutaminase (GLS) glutamate dehydrogenase (GDH]), lipid hypoxia-induced metabolic reprogramming mediated hypoxia-inducible factors (HIF-1α HIF-2α), examined therapeutic targets. The adaptability of through autophagy, flexibility, epigenetic regulation metabolites α-ketoglutarate, succinate, fumarate is discussed. Additionally, extracellular vesicles nicotinamide adenine dinucleotide (NAD⁺) identified pivotal redox balance, DNA repair, modifications. Addressing challenges heterogeneity, immune evasion, treatment durability requires interdisciplinary collaboration. Advancing therapies essential overcoming preventing relapse, paving way transformative treatments. underscores importance leveraging innovative technologies fostering collaboration revolutionize treatment.

Language: Английский

Citations

0
Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone) DOI
Samia Manawy, Eman Mohamed Faruk, Rabab Fawzy Hindawy

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 87, P. 102330 - 102330

Published: Feb. 20, 2024

Language: Английский

Citations

3
Resveratrol: A Natural Compound Targeting the PI3K/Akt/mTOR Pathway in Neurological Diseases DOI

Biswajit Kumar Utpal,

Fatima Zohra Mokhfi,

Mehrukh Zehravi

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Language: Английский

Citations

3