Journal of Oral Biosciences,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100587 - 100587
Published: Nov. 1, 2024
Fibrotic
responses
in
the
gingiva
are
characterized
by
their
hyperproliferative
nature
instead
of
scar
tissue
formation.
Clinically,
these
conditions
appear
as
"gingival
overgrowth"
(GO),
which
can
be
drug-induced
or
genetic
origin.
Despite
surgical
removal,
GO
recur.
Therefore,
non-invasive
methods
treating
required.
In
other
fibrotic
systems,
matricellular
protein
CCN2
represents
a
potential
therapeutic
target.
However,
has
been
relatively
understudied
context
GO.
Journal of Hematology & Oncology,
Journal Year:
2025,
Volume and Issue:
18(1)
Published: Jan. 13, 2025
The
tumor
microenvironment
(TME)
is
integral
to
cancer
progression,
impacting
metastasis
and
treatment
response.
It
consists
of
diverse
cell
types,
extracellular
matrix
components,
signaling
molecules
that
interact
promote
growth
therapeutic
resistance.
Elucidating
the
intricate
interactions
between
cells
TME
crucial
in
understanding
progression
challenges.
A
critical
process
induced
by
epithelial-mesenchymal
transition
(EMT),
wherein
epithelial
acquire
mesenchymal
traits,
which
enhance
their
motility
invasiveness
progression.
By
targeting
various
components
TME,
novel
investigational
strategies
aim
disrupt
TME's
contribution
EMT,
thereby
improving
efficacy,
addressing
resistance,
offering
a
nuanced
approach
therapy.
This
review
scrutinizes
key
players
emphasizing
avenues
therapeutically
components.
Moreover,
article
discusses
implications
for
resistance
mechanisms
highlights
current
toward
modulation
along
with
potential
caveats.
Biomarker Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: March 5, 2025
The
tumour
microenvironment
is
the
"hotbed"
of
cells,
providing
abundant
extracellular
support
for
growth
and
metastasis.
However,
not
static
constantly
remodelled
by
a
variety
cellular
components,
including
through
mechanical,
biological
chemical
means
to
promote
Focal
adhesion
plays
an
important
role
in
cell-extracellular
matrix
adhesion.
An
in-depth
exploration
focal
metastasis,
especially
their
contribution
at
biomechanical
level,
direction
current
research.
In
this
review,
we
first
summarize
assembly
adhesions
explore
kinetics
cells.
Then,
describe
detail
various
stages
its
key
functions
cell
migration,
invasion,
remodelling.
Finally,
anti-tumour
strategies
targeting
progress
development
some
inhibitors
against
proteins.
paper,
time
that
play
positive
feedback
pro-tumour
metastatic
remodelling
summarizing
five
processes
multidimensional
way.
It
beneficial
researchers
have
deeper
understanding
behaviour
metastasis
potential
as
therapeutic
target,
new
ideas
prevention
treatment
metastases.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: Feb. 21, 2025
Glioblastoma
(GBM)
is
the
most
malignant
of
astrocytomas,
primarily
involving
cerebral
hemispheres
and
cortex.
It
one
fatal
refractory
solid
tumors
with
a
5-year
survival
rate
only
5%
in
adults.
Cells
biological
tissues
are
subjected
to
mechanical
forces,
including
hydrostatic
pressure,
shear
stress,
compression
tension.
can
convert
mechanomechanical
signals
into
or
electrical
signals,
process
known
as
signaling.
Piezo1
channels,
members
Piezo
family
mechanosensitive
ion
be
directly
activated
by
stimuli
alone,
mediating
cation
currents
that
activate
subsequent
signaling
pathways.
Studies
have
shown
largely
unexpressed
normal
brain
but
expressed
at
high
levels
glioblastoma
significantly
contribute
development
progression,
its
role
pathogenesis
remains
unclear.
We
reviewed
relevant
literature
data
six
major
databases
PubMed,
EMBASE,
CINAHL,
Scopus,
Web
Science
TCGA.
Finally,
total
126
papers
were
selected
for
review
analysis
(Search
terms
include:
glioblastoma,
piezo1,
biomechanical,
targeted
therapy,
mechanomechanical,
extracellular
matrix,
radiation
therapy
more).
The
piezo1
was
summarized.
affects
several
fundamental
pathophysiological
processes
such
tissue
sclerosis,
angiogenesis,
energy
supply,
immune
cell
infiltration,
used
an
indicator
malignancy
prognosis
patients
well
therapeutic
target
control
tumor
progression.
pathological
mechanism
very
complex,
aberrant
expression
plays
important
glioblastoma.
Specific
mechanistic
studies
focusing
on
will
help
us
understand
mechanobiology
develop
new
approaches
patients.
