Cell Metabolism,
Journal Year:
2023,
Volume and Issue:
35(7), P. 1195 - 1208.e6
Published: July 1, 2023
Maternal-offspring
interactions
in
mammals
involve
both
cooperation
and
conflict.
The
fetus
has
evolved
ways
to
manipulate
maternal
physiology
enhance
placental
nutrient
transfer,
but
the
mechanisms
involved
remain
unclear.
imprinted
Igf2
gene
is
highly
expressed
murine
endocrine
cells.
Here,
we
show
that
deletion
these
cells
impairs
signaling
mother,
without
affecting
morphology.
controls
hormone
production,
including
prolactins,
crucial
establish
pregnancy-related
insulin
resistance
partition
nutrients
fetus.
Consequently,
fetuses
lacking
are
growth
restricted
hypoglycemic.
Mechanistically,
protein
synthesis
cellular
energy
homeostasis,
actions
dependent
on
cell
type.
loss
also
additional
long-lasting
effects
offspring
metabolism
adulthood.
Our
study
provides
compelling
evidence
for
an
intrinsic
fetal
manipulation
system
operating
placenta
modifies
resource
allocation,
with
long-term
consequences
metabolic
health.
Cellular and Molecular Life Sciences,
Journal Year:
2019,
Volume and Issue:
76(18), P. 3479 - 3496
Published: May 3, 2019
Abnormal
placentation
is
considered
as
an
underlying
cause
of
various
pregnancy
complications
such
miscarriage,
preeclampsia
and
intrauterine
growth
restriction,
the
latter
increasing
risk
for
development
severe
disorders
in
later
life
cardiovascular
disease
type
2
diabetes.
Despite
their
importance,
molecular
mechanisms
governing
human
placental
formation
trophoblast
cell
lineage
specification
differentiation
have
been
poorly
unravelled,
mostly
due
to
lack
appropriate
cellular
model
systems.
However,
over
past
few
years
major
progress
has
made
by
establishing
self-renewing
stem
cells
3-dimensional
organoids
from
blastocysts
early
tissues
opening
path
detailed
investigations.
Herein,
we
summarize
present
knowledge
about
development,
its
cells,
progenitors
differentiated
types
epithelium
villous
core.
Anatomy
placenta,
current
systems,
critical
key
regulatory
factors
signalling
cascades
will
be
elucidated.
In
this
context,
discuss
role
developmental
pathways
Wingless
Notch,
controlling
stemness/differentiation
invasive
progenitors,
respectively.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
101(3), P. 739 - 795
Published: Dec. 3, 2020
Almost
2
billion
adults
in
the
world
are
overweight,
and
more
than
half
of
them
classified
as
obese,
while
nearly
one-third
children
globally
experience
poor
growth
development.
Given
vast
amount
knowledge
that
has
been
gleaned
from
decades
research
on
development,
a
number
questions
remain
to
why
is
now
midst
global
epidemic
obesity
accompanied
by
"double
burden
malnutrition,"
where
overweight
coexists
with
underweight
micronutrient
deficiencies.
This
challenge
human
condition
can
be
attributed
nutritional
environmental
exposures
during
pregnancy
may
program
fetus
have
higher
risk
chronic
diseases
adulthood.
To
explore
this
concept,
frequently
called
developmental
origins
health
disease
(DOHaD),
review
considers
host
factors
physiological
mechanisms
drive
or
child
toward
obesity,
fatty
liver
disease,
hypertension,
and/or
type
diabetes
(T2D).
end,
explores
epidemiology
DOHaD
discussions
focused
adaptations
energetics,
placental
dysmetabolism,
key
act
promote
These
areas
complementary
additive
understanding
how
providing
best
conditions
for
optimal
create
possible
lifelong
health.
Moreover,
both
well
epigenetic
molecular
vital
most
fully
address
issues
other
diseases.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(1), P. 122 - 122
Published: Jan. 19, 2021
Since
the
2013
Nobel
Prize
was
awarded
for
discovery
of
vesicle
trafficking,
a
subgroup
nanovesicles
called
exosomes
has
been
driving
research
field
to
new
regime
understanding
cellular
communication.
This
exosome-dominated
traffic
control
system
increased
many
diseases,
including
cancer
metastasis,
diabetes,
and
HIV.
In
addition
important
diagnostic
role,
are
particularly
attractive
drug
delivery,
due
their
distinctive
properties
in
information
transfer
uptake.
Compared
viral
non-viral
synthetic
systems,
natural,
cell-derived
exhibit
intrinsic
payload
bioavailability.
Most
importantly,
easily
cross
biological
barriers,
obstacles
that
continue
challenge
other
delivery
nanoparticle
systems.
Recent
emerging
studies
have
shown
numerous
critical
roles
blood–brain
barrier
(BBB),
blood–cerebrospinal
fluid
(BCSFB),
blood–lymph
(BlyB),
blood–air
(BAB),
stromal
(SB),
blood–labyrinth
(BLaB),
blood–retinal
(BRB),
placental
(PB),
which
opens
exciting
possibilities
using
as
platform.
However,
systematic
reviews
summarizing
such
discoveries
still
limited.
review
covers
state-of-the-art
exosome
on
crossing
several
barriers
with
focus
current,
accepted
models
used
explain
mechanisms
crossing,
tight
junctions.
The
potential
design
engineer
enhance
efficacy,
leading
future
applications
precision
medicine
immunotherapy,
is
discussed.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 15, 2024
An
interdisciplinary
fetal-neonatal
neurology
(FNN)
program
over
the
first
1,000
days
teaches
perspectives
of
neural
exposome
that
are
applicable
across
life
span.
This
curriculum
strengthens
neonatal
neurocritical
care,
pediatric,
and
adult
training
objectives.
Teaching
at
maternal-pediatric
hospital
centers
optimally
merges
reproductive,
pregnancy,
pediatric
approaches
to
healthcare.
Phenotype–genotype
expressions
health
or
disease
pathways
represent
a
dynamic
developmental
time.
The
science
uncertainty
applied
FNN
re-enforces
importance
shared
clinical
decisions
minimize
bias
reduce
cognitive
errors.
Trainees
select
mentoring
committee
participants
will
maximize
their
learning
experiences.
Standardized
questions
oral
presentations
monitor
educational
progress.
Master
doctoral
defense
preparation
competitive
research
funding
can
be
goals
for
specific
individuals.
principles
practice
offer
an
understanding
gene–environment
interactions
recognizes
effects
reproductive
on
maternal-placental-fetal
triad,
neonate,
child,
adult.
Pre-conception
prenatal
adversities
potentially
diminish
life-course
brain
health.
Endogenous
exogenous
toxic
stressor
interplay
(TSI)
alters
through
maladaptive
neuroplasticity.
Developmental
disorders
epilepsy
primarily
expressed
during
days.
Communicable
noncommunicable
illnesses
continue
interact
with
express
diverse
neurologic
lifespan,
particularly
critical/sensitive
time
periods
adolescence
senescence.
Anomalous
destructive
fetal
neuropathologic
lesions
change
this
developmental-aging
continuum.
integrated
placental,
neonatal,
childhood,
offers
perspective
exposome.
Exosome
promises
improved
monitoring
drug
delivery
starting
pregnancy.
origins
anticipate
diagnoses
interventions
benefit
successive
generations.
Addressing
care
disparities
in
Global
South
high-income
country
medical
deserts
require
constructive
dialogue
among
stakeholders
achieve
equity.
Population
policies
capital
strategy
reduces
global
burden
diseases
by
applying
practice.
integrative
approach
prolong
survival
quality
persons
lifespan
confronted
neurological
disorders.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 19, 2024
The
transition
from
oviparity
to
viviparity
and
the
establishment
of
feto-maternal
communications
introduced
placenta
as
major
anatomical
site
provide
nutrients,
gases,
hormones
developing
fetus.
has
endocrine
functions,
orchestrates
maternal
adaptations
pregnancy
at
different
periods
pregnancy,
acts
a
selective
barrier
minimize
exposure
fetus
xenobiotics,
pathogens,
parasites.
Despite
fact
that
this
ancient
organ
is
central
for
normal
in
eutherians,
remains
one
least
studied
organs.
first
step
embryo
implantation,
finely
regulated
by
trophoectoderm,
precursor
all
trophoblast
cells.
There
bidirectional
communication
between
endometrium
leading
decidualization,
critical
maintenance
pregnancy.
are
three-direction
interactions
placenta,
immune
cells,
adaptation
endometrial
system
allogeneic
While
65%
systemically
expressed
human
proteins
have
been
found
tissues,
it
expresses
numerous
placenta-specific
proteins,
whose
expression
dramatically
changed
gestational
diseases
could
serve
biomarkers
early
detection
diseases.
Surprisingly,
placentation
carcinogenesis
exhibit
shared
features
metabolism
cell
behavior,
molecular
signatures,
signaling
pathways,
tissue
microenvironment,
which
proposes
concept
"cancer
ectopic
trophoblastic
cells".
By
extensive
researches
novel
field,
handful
cancer
discovered.
This
review
paper,
inspired
part
our
experiences
during
past
couple
years,
highlights
new
aspects
placental
functions
with
emphasis
on
its
immunomodulatory
role
successful
potential
link
carcinogenesis.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 16, 2025
Growing
evidence
places
the
gestational
period
as
a
unique
moment
of
heightened
neuroplasticity
in
adult
life.
In
this
longitudinal
study
spanning
pre,
during,
and
post
pregnancy,
we
unveil
U-shaped
trajectory
gray
matter
(GM)
volume,
which
dips
late
pregnancy
partially
recovers
during
postpartum.
These
changes
are
most
prominent
brain
regions
associated
with
Default
Mode
Frontoparietal
Network.
The
is
predominantly
linked
to
factors,
it
only
presents
mothers
correlates
fluctuations
estrogens
over
time.
Finally,
mother's
mental
health
status
mediates
relationship
between
postpartum
GM
volume
recovery
maternal
attachment
at
6
months
This
research
sheds
light
on
complex
interplay
hormones,
development,
behavior
transition
motherhood.
It
addresses
significant
knowledge
gap
neuroscience
human
opens
new
possibilities
for
interventions
aimed
enhancing
well-being.
Proceedings of the National Academy of Sciences,
Journal Year:
2020,
Volume and Issue:
117(24), P. 13562 - 13570
Published: June 1, 2020
Various
pregnancy
complications,
such
as
severe
forms
of
preeclampsia
or
intrauterine
growth
restriction,
are
thought
to
arise
from
failures
in
the
differentiation
human
placental
trophoblasts.
Progenitors
latter
either
develop
into
invasive
extravillous
trophoblasts,
remodeling
uterine
vasculature,
fuse
multinuclear
syncytiotrophoblasts
transporting
oxygen
and
nutrients
growing
fetus.
However,
key
regulatory
factors
controlling
trophoblast
self-renewal
have
been
poorly
elucidated.
Using
primary
cells,
three-dimensional
organoids,
CRISPR-Cas9
genome-edited
JEG-3
clones,
we
herein
show
that
YAP,
transcriptional
coactivator
Hippo
signaling
pathway,
promotes
maintenance
cytotrophoblast
progenitors
by
different
genomic
mechanisms.
Genetic
chemical
manipulation
YAP
these
cellular
models
revealed
it
stimulates
proliferation
expression
cell
cycle
regulators
stemness-associated
genes,
but
inhibits
fusion
production
syncytiotrophoblast
(STB)-specific
proteins,
hCG
GDF15.
Genome-wide
comparisons
villous
cytotrophoblasts
overexpressing
constitutively
active
YAP-5SA
with
KO
cells
syncytializing
trophoblasts
common
target
genes
involved
stemness
differentiation.
ChIP-qPCR
unraveled
overexpression
increased
binding
YAP–TEAD4
complexes
promoters
proliferation-associated
CCNA
CDK6
.
Moreover,
repressive
containing
histone
methyltransferase
EZH2
were
detected
regions
STB-specific
CGB5
CGB7
genes.
In
summary,
plays
a
pivotal
role
epithelium.
Besides
activating
factors,
also
directly
represses
promoting
fusion.
Nutrients,
Journal Year:
2019,
Volume and Issue:
11(8), P. 1812 - 1812
Published: Aug. 6, 2019
Energy
intake
requirements
in
pregnancy
match
the
demands
of
resting
metabolism,
physical
activity,
and
tissue
growth.
balance
is,
therefore,
defined
as
energy
equal
to
expenditure
plus
storage.
A
detailed
understanding
these
components
their
changes
throughout
gestation
can
inform
recommendations
for
minimizing
risk
poor
outcomes.
is
sum
activity-related
expenditure.
Resting
metabolic
rate
increases
during
a
result
increased
body
mass,
pregnancy-associated
physiological
changes,
i.e.,
cardiac
output,
growing
fetus.
Physical
activity
extremely
variable
between
women
may
change
over
course
pregnancy.
The
requirement
storage
depends
on
maternal
pregravid
size.
For
optimal
outcomes,
with
low
weight
require
more
fat
mass
accumulation
than
obesity,
who
do
not
accumulate
at
all.
Given
high
density
differences
affect
healthy
greatly.
In
contrast,
stored
fetal
placental
tissues
comparable
all
have
small
impact
requirements.
Different
prediction
equations
been
developed
quantify
we
provide
brief
review
strengths
weaknesses
discuss
application
management
gain
pregnant
women.