The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Interleukin-10 (IL-10) is a pleiotropic cytokine that has fundamental role in modulating inflammation and maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from uncontrolled immune response, mostly through Jak1/Tyk2 STAT3 signaling pathway. On other hand, IL-10 can also have immunostimulating functions under certain conditions. Given pivotal of modulation, this could relevant implications pathologies characterized by hyperinflammatory state, such cancer, or infectious diseases case COVID-19 Post-COVID-19 syndrome. Recent evidence proposed predictor severity mortality for patients with acute post-acute SARS-CoV-2 infection. In context, act endogenous danger signal, released tissues undergoing damage attempt to protect organism harmful hyperinflammation. Pharmacological strategies aimed potentiate restore immunomodulatory action may represent novel promising avenues counteract storm arising hyperinflammation effectively mitigate severe complications. Natural bioactive compounds, derived terrestrial marine photosynthetic organisms able increase expression, useful prevention strategy curb elevation will be discussed here. However, multifaceted nature taken into account attempts modulate its levels.

Language: Английский

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Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches

GeroScience, Journal Year: 2024, Volume and Issue: 46(5), P. 5267 - 5286

Published: April 26, 2024

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced medical community to phenomenon of long COVID, a condition characterized persistent symptoms following resolution acute phase infection. Among myriad reported COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond initial viral pathology. Emerging evidence pointed mitochondrial dysfunction as potential underpinning mechanism contributing persistence diversity symptoms. This review aims synthesize current findings related in exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic endothelial dysfunction. Through comprehensive analysis literature, we highlight significance health pathophysiology drawing parallels with similar clinical syndromes linked post-infectious states other diseases where impairment been implicated. We discuss therapeutic strategies targeting function, including pharmacological interventions, lifestyle modifications, exercise, dietary approaches, emphasize need further research collaborative efforts advance our understanding management COVID. underscores critical role calls multidisciplinary approach address gaps knowledge treatment options those affected this condition.

Language: Английский

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Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3113 - 3113

Published: Dec. 2, 2022

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as "brain fog", fatigue and clotting problems. Explanations for "long COVID" include immune imbalance, incomplete viral clearance potentially, mitochondrial dysfunction. As conditions sub-optimal function are associated initial severity of disease, their prior health could be key in resistance to long COVID recovery. The SARs virus redirects host metabolism towards replication; response, can metabolically react control virus. Resolution is normally achieved after stress activates a hormetic negative feedback mechanism. It therefore possible that, some individuals function, "tip" into chronic inflammatory cycle. This might explain main including platelet Long thus described virally induced self-perpetuating imbalanced non-resolving state characterised by dysfunction, where reactive oxygen species continually drive inflammation shift glycolysis. would suggest that sufferer's needs "tipped" back using stimulus, physical activity, calorie restriction, or chemical compounds mimic these enhancing perhaps combination inhibitors quell response.

Language: Английский

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The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications

Biochemical Journal, Journal Year: 2022, Volume and Issue: 479(16), P. 1653 - 1708

Published: Aug. 31, 2022

Ischaemia-reperfusion (I-R) injury, initiated via bursts of reactive oxygen species produced during the reoxygenation phase following hypoxia, is well known in a variety acute circumstances. We argue here that I-R injury also underpins elements pathology chronic, inflammatory diseases, including rheumatoid arthritis, ME/CFS and, our chief focus and most proximally, Long COVID. Ischaemia may be fibrin amyloid microclot blockage capillaries, for instance as exercise started; reperfusion necessary corollary when it finishes. rehearse mechanistic evidence these occurrences here, terms their manifestation oxidative stress, hyperinflammation, mast cell activation, production marker metabolites related activities. Such microclot-based phenomena can explain both breathlessness/fatigue post-exertional malaise observed conditions, many other observables. The recognition processes implies, mechanistically, therapeutic benefit potentially to had from antioxidants, anti-inflammatories, iron chelators, suitable, safe fibrinolytics, and/or anti-clotting agents. review considerable existing consistent with this, biochemical mechanisms involved.

Language: Английский

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The SARS-CoV-2 spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

Molecular Metabolism, Journal Year: 2023, Volume and Issue: 74, P. 101756 - 101756

Published: June 20, 2023

As the pandemic evolves, post-acute sequelae of CoV-2 (PASC) including cardiovascular manifestations have emerged as a new health threat. This study aims to whether Spike protein plus obesity can exacerbate PASC-related cardiomyopathy.A protein-pseudotyped (Spp) virus with proper surface tropism SARS-CoV-2 was developed for viral entry assay in vitro and administration into high fat diet (HFD)-fed mice. The systemic loads cardiac transcriptomes were analyzed at 2 24 h, 3, 6, weeks post introducing (wpi) Spp using RNA-seq or real time RT-PCR. Echocardiography used monitor functions.Low-density lipoprotein cholesterol enhanced uptake endothelial cells, macrophages, cardiomyocyte-like H9C2 cells. Selective adipose depositions observed HFD mice but not normal-chow-fed transcriptional signatures wpi showed suppression mitochondria respiratory chain genes ATP synthases nicotinamide adenine dinucleotide:ubiquinone oxidoreductase gene members, upregulation stress pathway-related crucial factors such nuclear factor-erythroid 2-related factor 1 signal transducer activator transcription 5A, increases expression glucose metabolism-associated genes. compared age-matched control mice, ejection fraction fractional shortening significantly decreased, while left ventricular end-systolic diameter volume elevated, fibrosis increased wpi.Our data demonstrated that could induce long-term metabolic cause myocardial contractile impairment obese providing mechanistic insights cardiomyopathy.

Language: Английский

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COVID-19 induced liver injury from a new perspective: Mitochondria

Mitochondrion, Journal Year: 2023, Volume and Issue: 70, P. 103 - 110

Published: April 11, 2023

Language: Английский

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Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 207, P. 194 - 199

Published: July 15, 2023

Language: Английский

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Effectiveness of a combined lifestyle intervention for older people in long-term care: A randomized controlled trial

Archives of Gerontology and Geriatrics, Journal Year: 2024, Volume and Issue: 120, P. 105340 - 105340

Published: Jan. 23, 2024

Lifestyle medicine interventions combining physical, nutritional, and psychological components have been found effective in general older population. However, evidence from the long-term care (LTC) is scarce.

Language: Английский

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Plasma Redox Balance in Advanced Maternal Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Published: March 20, 2024

Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development maternal-fetal complications with possible repercussions even in long-term. Here, we analyzed changes plasma redox balance and effects on human umbilical cord mesenchymal cells (hUMSCs) AMA pregnant women (patients) various timing pregnancy. One hundred patients twenty younger than 40 years (controls) were recruited, evaluated timings during pregnancy until after delivery. Plasma samples used to measure thiobarbituric acid reactive substances (TBARS), glutathione nitric oxide (NO). In addition, was stimulate hUMSCs, which tested cell viability, oxygen species (ROS) NO release. The obtained results showed that throughout delivery levels lower those controls, while TBARS higher. Moreover, reduced viability release, increased ROS release hUMSCs. Our highlighted alterations presence potentially harmful circulating factors They could have clinical relevance prevention related

Language: Английский

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Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4869 - 4869

Published: April 29, 2024

Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development maternal–fetal complications with possible repercussions even in long term. Here, we analyzed changes plasma redox balance and effects on human umbilical cord mesenchymal cells (hUMSCs) AMA pregnant women (patients) various timings pregnancy. One hundred patients twenty younger than 40 years (controls) were recruited evaluated during pregnancy until after delivery. Plasma samples used to measure thiobarbituric acid reactive substances (TBARS), glutathione nitric oxide (NO). In addition, was stimulate hUMSCs, which tested cell viability, oxygen species (ROS) NO release. The obtained results showed that, throughout delivery patients, levels lower those controls, while TBARS higher. Moreover, reduced viability release, increased ROS release hUMSCs. Our highlighted alterations presence potentially harmful circulating factors patients. They could have clinical relevance prevention related

Language: Английский

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