The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms

GeroScience, Journal Year: 2023, Volume and Issue: 45(6), P. 3211 - 3239

Published: July 26, 2023

Abstract Physical activity, including walking, has numerous health benefits in older adults, supported by a plethora of observational and interventional studies. Walking decreases the risk or severity various outcomes such as cardiovascular cerebrovascular diseases, type 2 diabetes mellitus, cognitive impairment dementia, while also improving mental well-being, sleep, longevity. Dose-response relationships for walking duration intensity are established adverse outcomes. Walking’s favorable effects on factors attributed to its impact circulatory, cardiopulmonary, immune function. Meeting current physical activity guidelines briskly 30 min per day 5 days can reduce several age-associated diseases. Additionally, low-intensity exercise, exerts anti-aging helps prevent age-related making it powerful tool promoting healthy aging. This is exemplified lifestyles individuals Blue Zones, regions world with highest concentration centenarians. other activities contribute significantly longevity these regions, being an integral part their daily lives. Thus, incorporating into routines encouraging walking-based interventions be effective strategy aging all populations. The goal this review provide overview vast consistent evidence supporting specific focus discuss outcomes, prevention Furthermore, will delve molecular cellular mechanisms aging, providing insights underlying biological through which beneficial effects.

Language: Английский

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A review on the influence of nutraceuticals and functional foods on health

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 5, P. 100749 - 100749

Published: June 10, 2024

In recent years, functional foods have gained attention for their potential health benefits beyond basic nutrition, serving as rich sources of proteins, carbohydrates, vitamins, and dietary fiber. Enriched with bioactive compounds such polyphenols, tannins, flavonoids, alkaloids, these shown promise in inhibiting cell signaling pathways related to proliferation, communication, apoptosis. Key components offer benefits. Omega-3 fatty acids scavenge free radicals, reducing the risk chronic diseases like heart disease cancer. Antioxidants sesame seed oil promote cardiovascular anti-inflammatory effects. Curcumin inhibits cancer by suppressing inflammatory cytokines. Understanding mechanisms action is crucial realizing therapeutic However, identifying suitable substances comprehending role prevention are challenging. As we enter food era, this review aims present current state nutraceuticals, exploring applications human wellness. Recognizing nutrition's individualized nature nutrition a central theme, emphasizing importance tailored recommendations based on diverse responses elements, ensuring that personalized approaches aligned individual goals.

Language: Английский

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Nutritional immunological effects and mechanisms of chemical constituents from the homology of medicine and food

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

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A Comprehensive Review of Cancer Drug–Induced Cardiotoxicity in Blood Cancer Patients: Current Perspectives and Therapeutic Strategies

Current Treatment Options in Oncology, Journal Year: 2024, Volume and Issue: 25(4), P. 465 - 495

Published: Feb. 19, 2024

Language: Английский

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How the COVID-19 pandemic and related school closures reduce physical activity among children and adolescents in the WHO European Region: a systematic review and meta-analysis

International Journal of Behavioral Nutrition and Physical Activity, Journal Year: 2023, Volume and Issue: 20(1)

Published: Dec. 19, 2023

Emerging research suggests that physical activity among children and adolescents decreased during the COVID-19 pandemic. However, a differentiated overview of European youth is lacking. In particular, no systematic analysis has been conducted to date on impact heterogeneous pandemic restrictions school closures within countries, with regard potentially vulnerable groups.We searched seven databases included studies for (≤ 19 years) WHO Region compared pre-pandemic baseline using validated measurement instruments. We used Oxford Stringency Index School Closure as indicators restriction stringency. Screening eligibility, data extraction, assessment study risk bias (using 'Risk Bias in Non-randomized Studies - Exposure' [ROBINS-E]) certainty grading evidence GRADE approach), were all done duplicate. Unpublished was requested from authors. Data pooled random effects models. An priori protocol published, reporting carried out accordance 'Preferred Reporting Items Systematic Review Meta-Analyses' (PRISMA) statement.Of 14,897 non-duplicate records, 26 publications (n = 15,038 pre-pandemic, n 13,041 pandemic) met full inclusion criteria. Comparison before revealed significant reduction total (standardized mean difference [SMD], -0.57 [95%CI, -0.95; -0.20]) moderate-to-vigorous (SMD, -0.43 [95% CI, -0.75; -0.10]), corresponding decrease 12 min per day (a 20% recommendation). A sporting also recorded. Subgroup analyses suggested middle childhood (aged 8-12) particularly affected by decline. associated activity. The outcomes low.A sharp decline forms recorded This higher periods closure mainly younger schoolchildren adolescents. Immediate action policy-makers practitioners, well evidence-based public health strategies, are imperative reversing this trend.PROSPERO: CRD42023395871.

Language: Английский

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Exploring the prevalence of depression, anxiety, and stress among university students in Bangladesh and their determinants

Clinical Epidemiology and Global Health, Journal Year: 2024, Volume and Issue: 28, P. 101677 - 101677

Published: June 13, 2024

BackgroundDepression, anxiety and stress among university students present a growing global challenge. This study aims to explore the prevalence of depression, anxiety, identifying their associated factors in Bangladesh.MethodsWe analyzed data 738 collected through cross-sectional survey. Outcome variables considered were levels. Explanatory several socio-demographic characteristics. Multinomial logistic regression analysis was employed association outcome with explanatory variables.ResultsWe found notable moderate severe levels Bangladesh, ranging from 25 % 71 %. Among extended families, there 32 lower likelihood experiencing depression (relative risk ratio [RRR], 0.68; 95 confidence interval [CI], 0.47–0.97) 35 (RRR, 0.65; CI, 0.44–0.97) compared counterparts without stress. Furthermore, enrolled business faculty reported significantly higher stress, 2.28 times greater odds (95 1.32–3.93) Science Engineering faculty.ConclusionThis underscores pressing necessity for tailored interventions address elevated Bangladesh. The findings accentuate importance recognizing diverse implementing mental health support programs.

Language: Английский

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A Review: The Effect of Bovine Colostrum on Immunity in People of All Ages

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2007 - 2007

Published: June 25, 2024

Bovine colostrum provides newborn calves with strong passive immunity, which will further affect the immunity of their offspring. Compared other commercial dairy products, bovine emphasizes limit aflatoxin M1, pathogenic bacteria, microorganisms, antibiotics, stimulants, and items, so it is safe to use. There are many reports that use as a breast milk fortifier for preterm infants necessary immune support premature infants, but selection products chosen must be free Bacillus cereus because they very dangerous infants. This also used in more clinical research needed. At same time, should emphasized composition BC different from human colostrum, particular, main protein casein, while whey protein, especially α-lactalbumin, together ovalbumin still reference best biological value, muscles. Therefore, currently not complete substitute milk. In recent years, addition studies have found has immunomodulatory promoting effects adolescents, adults, elderly. suggests potential provide appropriate people all ages. this study aimed evaluate quality nutritional characteristics on three dimensions. The ages narrative review identified several classes immunoactive substances including immunoglobulins, cytokines, enzymes, compared mature milk, full-term demonstrate rich range components. addition, influencing factors affecting (immunoglobulin) were reviewed, was individual differences, environmental factors, processing methods had great impact BC. More importantly, reviewed detail (with an emphasis immunocompromised children neonates) evidence hopes above make understand health role having effect, at when seeing value future, limitations its application deeply re-explored, such lactose intolerance, allergies, etc., effective solutions wide colostrum.

Language: Английский

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An immunologist’s guide to immunosenescence and its treatment

Expert Review of Clinical Immunology, Journal Year: 2022, Volume and Issue: 18(9), P. 961 - 981

Published: July 25, 2022

Introduction Aging causes several changes in the immune system, although aging is strongly influenced by individual immunological history, as well genetic and environmental factors leading to inter-individual variability.Areas covered We focused on biological clinical meaning of immunosenescence. SARS-CoV-2 Yellow Fever vaccine have demonstrated relevance immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at looking for risk phenotypes, revealed that immunosenescence highly context-dependent. Large projects allowed delineation drivers system variance, including factors, sex, smoking, co-habitation. Therefore, it difficult identify interventions can be envisaged maintain or improve function older people. That suggests drug treatment should require personalized intervention. Regarding this, we discussed role lifestyle a potential therapeutic approach.Expert opinion Our review points out age only part problem Everyone ages differently because unique genetics experience life this applies even more (immunobiography). Finally, shows how appreciable results modification biomarkers achieved with modification.

Language: Английский

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Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis

JCO Precision Oncology, Journal Year: 2024, Volume and Issue: 8

Published: Jan. 11, 2024

Lynch syndrome is the most common hereditary cause of colorectal and endometrial cancers. Modifiable risk factors, including obesity, physical activity, alcohol intake, smoking, are well-established in sporadic cancers but less studied syndrome.

Language: Английский

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Thermally Conductive Boron Nitride Nanosheets on Electrospun Thermoplastic Polyurethane for Wearable Janus-Type Fabrics with Simultaneous Thermal and Moisture Management

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 8229 - 8237

Published: March 15, 2024

Fabric comfort is essential for maintaining both physiological and psychological well-being. The inherent low thermal conductivity single-layer porous structure of traditional cotton fabrics compromise the body's cooling pathways moisture management capabilities. Multifunctional fabrics, combining excellent with superior management, are emerging as potential candidates next generation human textiles. In this study, a straightforward strategy preparing dual-function wearable Janus-type fabric proposed involving electrospinning thermoplastic polyurethane elastomer onto surface cellulose fiber concurrently loading thermally conductive boron nitride nanosheets. prepared exhibits characteristics. It achieves 0.307 W/mK, reducing overall resistance to 10.62 K cm2/W. practical indoor outdoor tests in winter demonstrate that temperature contact skin 2.9 3.1 °C higher than common fabric, suggesting its favorable heat dissipation ability. construction dual wetting gradient allows directed transport within water evaporation rate 0.276 g/h. Additionally, robust stability mechanical properties ensure reliability prolonged device applications.

Language: Английский

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