Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(24), P. 8845 - 8862

Published: June 8, 2023

The increasing levels and frequencies at which active pharmaceutical ingredients (APIs) are being detected in the environment of significant concern, especially considering potential adverse effects they may have on nontarget species such as fish. With many pharmaceuticals lacking environmental risk assessments, there is a need to better define understand risks that APIs their biotransformation products pose fish, while still minimizing use experimental animals. There both extrinsic (environment- drug-related) intrinsic (fish-related) factors make fish potentially vulnerable human drugs, but not necessarily captured nonfish tests. This critical review explores these factors, particularly focusing distinctive physiological processes underlie drug absorption, distribution, metabolism, excretion toxicity (ADMET). Focal points include impact life stage absorption (A) via multiple routes; implications fish's unique blood pH plasma composition distribution (D) molecules throughout body; how endothermic nature varied expression activity drug-metabolizing enzymes tissues affect metabolism (M); physiologies relative contribution different excretory organs (E) metabolites. These discussions give insight into where existing data properties, pharmacokinetics pharmacodynamics from mammalian clinical studies or help inform

Language: Английский

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Impact of Pesticide Residues on the Gut-Microbiota–Blood–Brain Barrier Axis: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6147 - 6147

Published: March 24, 2023

Accumulating evidence indicates that chronic exposure to a low level of pesticides found in diet affects the human gut-microbiota-blood-brain barrier (BBB) axis. This axis describes physiological and bidirectional connection between microbiota, intestinal (IB), BBB. Preclinical observations reported gut microbial alteration induced by pesticides, also known as dysbiosis, condition associated not only with gastrointestinal disorders but diseases affecting other distal organs, such However, interplay IB, BBB is still fully explored. In this review, we first consider similarities/differences these two barriers different pathways link microbiota better understand dialogue bacteria brain. We then discuss effects oral pesticide on gut-microbiota-BBB raise awareness danger exposure, especially during perinatal period (pregnant women offspring).

Language: Английский

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Turning fishery waste into aquafeed additives: Enhancing shrimp enzymes immobilization in alginate-based particles using electrohydrodynamic atomization

Aquaculture, Journal Year: 2024, Volume and Issue: 587, P. 740846 - 740846

Published: March 20, 2024

Language: Английский

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The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1901)

Published: March 18, 2024

Commensal enteric bacteria have evolved systems that enable growth in the ecologic niche of host gastrointestinal tract. Animals parallel mechanisms to survive constant exposure and their metabolic by-products. We propose drug transporters encompass a crucial system managing gut microbiome. Drug are present apical surface epithelia. They detoxify cells from small molecules toxins (xenobiotics) lumen. Here, we review what is known about commensal structure absence transporter ABCB1/P-glycoprotein mammalian models. Knockout or low-activity alleles ABCB1 lead dysbiosis, Crohn's disease ulcerative colitis mammals. However, exact function these contexts remain unclear. highlight emerging models—the zebrafish Danio rerio sea urchin Lytechinus pictus —that poised help dissect fundamental ATP-binding cassette (ABC) tolerance pathogenic communities gut. others hypothesize plays direct role exporting inflammatory bacterial products Interdisciplinary work this research area will lend novel insight transporter-mediated pathways impact microbiome community accelerate pathogenesis bowel when perturbed. This article part theme issue ‘Sculpting microbiome: how factors determine respond microbial colonization’.

Language: Английский

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Effects of Commercial Probiotics on the Growth Performance, Intestinal Microbiota and Intestinal Histomorphology of Nile Tilapia (Oreochromis niloticus) Reared in Biofloc Technology (BFT)

Biology, Journal Year: 2024, Volume and Issue: 13(5), P. 299 - 299

Published: April 26, 2024

Though different types of commercial probiotics are supplemented in biofloc technology (BFT), very little information is available on their effects the farmed fish. Therefore, this study focused evaluating three most commonly used growth performance, intestinal histomorphology, and microbiota Nile tilapia (

Language: Английский

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Toxic heavy metals in a landfill environment (Vientiane, Laos): Fish species and associated health risk assessment

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104460 - 104460

Published: May 3, 2024

Language: Английский

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Exploration of Response Mechanisms in the Gills of Pacific Oyster (Crassostrea gigas) to Cadmium Exposure through Integrative Metabolomic and Transcriptomic Analyses

Animals, Journal Year: 2024, Volume and Issue: 14(16), P. 2318 - 2318

Published: Aug. 9, 2024

Marine mollusks, including oysters, are highly tolerant to high levels of cadmium (Cd), but the molecular mechanisms underlying their response acute Cd exposure remain unclear. In this study, Pacific oyster Crassostrea gigas was used as a biological model, exposed stress for 96 h. Transcriptomic analyses gills were performed, and metabolomic further validated these results. our total 111 differentially expressed metabolites (DEMs) 2108 genes (DEGs) identified under exposure. Further revealed alterations in key metabolic pathways associated with heavy metal response. triggered physiological responses enhanced oxidative disturbances energy metabolism, changes oysters stress. Moreover, could effectively enhance tolerance detoxification ability through activating ABC transporters, enhancing glutathione metabolism sulfur relay system gill cells, regulating metabolism. This study reveals mechanism explores by using combined metabolomics transcriptome analysis.

Language: Английский

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Tandem mass tag (TMT) proteomic analysis of rohu intestine against Edwardsiella tarda

Aquaculture International, Journal Year: 2025, Volume and Issue: 33(2)

Published: Jan. 13, 2025

Language: Английский

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Sublethal exposure to boscalid induced respiratory abnormalities and gut microbiota dysbiosis in adult zebrafish

Aquatic Toxicology, Journal Year: 2025, Volume and Issue: 283, P. 107370 - 107370

Published: April 17, 2025

Language: Английский

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Acidification affects the early development of Colombian endemic fish Prochilodus magdalenae

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 111875 - 111875

Published: May 1, 2025

Language: Английский

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