The beneficial role of simple inflammatory blood indices in pediatric cardiology

Advances in Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 32(9), P. 1041 - 1048

Published: March 15, 2023

Simple whole blood analysis can effectively demonstrate complex changes in inflammatory responses to cardiovascular disorders adults and enable the prediction of adverse outcomes or diminished survival.Such activation has also been detected pediatric population.Blood results are repeatable readily available, which gives method an advantage over others.Inflammatory phenomena such as a high leukocyte count increased neutrophil-to-lymphocyte ratio (NLR) related poor prognosis advanced heart defects worse after cardiac surgery stages disease.Surgery-associated inflammation exacerbates these diseases, response may further complicate postoperative period.Simple cell counts indices be beneficial for evaluating disorder infants children.This review summarizes current knowledge on markers diseases surgery.

Language: Английский

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Current Insights and Future Directions in the Treatment of Heart Failure with Preserved Ejection Fraction

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 440 - 440

Published: Dec. 28, 2023

Heart failure is a clinical syndrome associated with poor quality of life, substantial healthcare resource utilization, and premature mortality, in large part related to high rates hospitalizations. The manifestations heart are similar regardless the ejection fraction. Unlike reduced fraction, there few therapeutic options for treating preserved Molecular therapies that have shown mortality morbidity not been proven be effective patients study pathophysiological processes involved production fraction basis identifying new means. In this narrative review, we intend synthesize existing means, but also those under research (metabolic microRNA therapy) treatment

Language: Английский

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Establishment of a HFpEF model using female Dahl salt-sensitive rats: a valuable tool for elucidating the pathophysiology of HFpEF in women

Hypertension Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

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Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 27, 2023

Heart failure (HF) is a chronic and progressive syndrome affecting worldwide billions of patients. Exercise intolerance early fatigue are hallmarks HF patients either with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Alterations the skeletal muscle contribute to exercise in HF. This review will provide contemporary summary clinical molecular alterations currently known occur muscles both HFrEF HFpEF, thereby differentiate effects on locomotor respiratory muscles, particular diaphragm. Moreover, current future therapeutic options address weakness be discussed focusing mainly training.

Language: Английский

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Vascular compliance and left ventricular compliance cross talk: Implications for using long-term heat acclimation in cardiac care

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: March 7, 2023

1) The first evidence of the beneficial impact Long-Term-Heat-Acclimation (LTHA) on cardio-vascular compliance was positive inotropic response and improved left ventricular (LV) noted when isolated hearts from LTHA rats were studied. Human echo study demonstrates that passive HA affects right ventricle atria as well. 2) There is a cross-talk between vascular cardiac compliance. Vascular per se defined by central venous pressure—Blood volume relationship—Global Compliance (GVC). It determined sum vessels in every organ any physiological state, varies with thus influences performance. improves endothelial function, increases NO (nitric oxide) production, in-turn stimulating alterations ECM (extracellular matrix) via TGF β1-SMAD pathway. 3) associated transformation fast to slow myosin, heat acclimation ischemic/hypoxic cross-tolerance extracellular matrix. 4) A human translational demonstrated LV following bypass surgery subjects compared controls. 5) Diastolic dysfunction comorbidities non- origins are major contributors syndrome heart failure preserved ejection function (HFPEF). Unfortunately, there paucity treatment modalities improve diastolic dysfunction. 6) In current mini-review we suggest may be HFPEF patients remodeling response.

Language: Английский

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Diastolic heart failure: boundaries of term application

Bulletin of Siberian Medicine, Journal Year: 2023, Volume and Issue: 22(1), P. 113 - 120

Published: April 21, 2023

Important changes regarding the understanding of pathogenesis chronic heart failure (CHF) marked beginning millennium, and its first decade was called diastology. Even though numerous studies convincingly proved that deterioration left ventricular (LV) filling pressure often precedes impairment systolic function a number factors affect (especially at onset) mainly diastolic without changing conditions blood ejection, modern classifications approaches to CHF treatment are primarily based on results LV ejection fraction (EF) assessment. In recent years, (DHF) has been overlooked replaced by ambiguous term “CHF with preserved EF”. However, sometimes authors use DHF extensively, since myocardial insufficiency develops only via two mechanisms (systolic / or dysfunction), excluding one allows identify underlying one. The can be used in clinical practice cannot diagnosis EF. EF is broader concept which includes full spectrum cardiovascular diseases, complicated development depression global contractility requiring differentiated therapy. addition, repeated LVEF many patients may require reclassification this phenotype, established following analysis baseline value contractility. We join M.R. Zile appeal stop discriminating against “DHF” present boundaries correct application.

Language: Английский

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The role of endosarcomeric cytoskeleton proteins in the mechanisms of left ventricular diastolic dysfunction: focus on titin

Bulletin of Siberian Medicine, Journal Year: 2023, Volume and Issue: 22(3), P. 98 - 109

Published: Oct. 18, 2023

Recognizing the fact that isolated left ventricular (LV) diastolic dysfunction (DD) underlies approximately 50% of all heart failure cases requires a deep understanding its principal mechanisms so effective diagnostic and treatment strategies can be developed. Despite abundance knowledge about underlying DD, many important questions regarding pathophysiology diastole remain unresolved. In particular, role endosarcomeric cytoskeleton pathology in deterioration so-called active (relaxation LV myocardium atrioventricular pressure gradient at beginning diastole, closely related to it healthy heart) passive (myocardial stiffness) characteristics needs clarified. The lecture briefly discusses complex hierarchy DD (from sarcomere whole covers giant protein titin latter, which is main determinant intracellular stiffness. Impairment myocardial relaxation wall compliance under wide range pathological conditions (pressure overload, ischemia, inflammation, cardiotoxic effects, oxidative stress, etc.) explained by shift expression toward more rigid N2B isoform, hypophosphorylation kinases A G or dephosphorylation serine / threonine phosphatase 5 molecule extensible segment containing unique sequence, hyperphosphorylation PEVK regions kinase C, as well inhibition Ca 2 +-dependent – actin interaction. results deciphering these become tool for developing new approaches targeted therapy currently does not have treatment, on one hand, key therapeutic effects drugs already used treat chronic with preserved ejection fraction, other hand.

Language: Английский

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Research Progress on the Correlation between Nonalcoholic Fatty Liver and Ejection Fraction Preservation Heart Failure

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(01), P. 1104 - 1110

Published: Jan. 1, 2024

Language: Английский

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Dissecting the heart failure phenotype through phenomics

European Journal of Heart Failure, Journal Year: 2024, Volume and Issue: 26(4), P. 851 - 853

Published: March 19, 2024

Language: Английский

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Digital health in cardiovascular medicine: An overview of key applications and clinical impact by the Portuguese Society of Cardiology Study Group on Digital Health

Revista Portuguesa de Cardiologia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Digital health interventions including telehealth, mobile health, artificial intelligence, big data, robotics, extended reality, computational and high-fidelity bench simulations are an integral part of the path toward precision medicine. Current applications encompass risk factor modification, chronic disease management, clinical decision support, diagnostics interpretation, preprocedural planning, evidence generation, education, training. Despite acknowledged potential, their development implementation have faced several challenges constraints, meaning few digital tools reached daily practice. As a result, Portuguese Society Cardiology Study Group on Health set out to outline main applications, address some roadblocks hampering large-scale deployment, discuss future directions in support cardiovascular at large.

Language: Английский

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