Neurocritical Care, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 23, 2024
Language: Английский
Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 282 - 282
Published: Jan. 14, 2025
Sarcopenia, an age-related decline in skeletal muscle mass, strength, and function, is increasingly recognized as a significant condition the aging population, particularly among those with cardiovascular diseases (CVD). This review provides comprehensive synthesis of interplay between sarcopenia cardiogeriatrics, emphasizing shared mechanisms such chronic low-grade inflammation (inflammaging), hormonal dysregulation, oxidative stress, physical inactivity. Despite advancements diagnostic frameworks, EWGSOP2 AWGS definitions, variability criteria assessment methods continues to challenge standardization. Key tools include dual-energy X-ray absorptiometry (DXA) bioimpedance analysis (BIA) for alongside functional measures grip strength gait speed. The highlights bidirectional relationship conditions heart failure, aortic stenosis, atherosclerotic disease, which exacerbate each other through complex pathophysiological mechanisms. Emerging therapeutic strategies targeting mTOR pathway, NAD+ metabolism, senescence-related processes offer promise mitigating sarcopenia’s progression. Additionally, integrated interventions combining resistance training, nutritional optimization, novel anti-aging therapies hold potential improving outcomes. paper underscores critical gaps evidence, including need longitudinal studies establish causality validation advanced approaches clinical settings. Future research should leverage multi-omics technologies machine learning identify biomarkers personalize interventions. Addressing these challenges essential reducing burden enhancing quality life elderly individuals comorbid conditions. aims guide future promote effective, individualized management strategies.
Language: Английский
Citations
2
Knee Surgery and Related Research, Journal Year: 2025, Volume and Issue: 37(1)
Published: March 17, 2025
Abstract Background Understanding sarcopenia is becoming increasingly important as society ages. This comprehensive review covers the definition, epidemiology, causes, pathogenesis, diagnosis, prevention, management, and future directions for management of sarcopenia, major issues related to in knee joint. Main text Sarcopenia, a condition aging, characterized by decreased muscle mass strength, which significantly affects physical function. Its prevalence may vary region age, with reports up 50% elderly population. The potential causes include neurodegeneration, poor nutrition, changes hormonal effects, elevated levels proinflammatory cytokines, reduced activation satellite cells. Various pathogeneses, such apoptosis, proteolysis, inhibition signaling increasing mass, contribute development sarcopenia. Generally, diagnostic criteria are based on performance, can be assessed using various equipment clinical tests. A healthy lifestyle consisting balanced diet, sufficient protein intake, regular exercise recommended prevent involves resistance exercise, proper deprescribing from polypharmacy. In future, pharmacological treatment personalized nutrition become alternative options Finally, since associated osteoarthritis outcomes after total arthroplasty, appropriate physicians treating knee-related conditions. Conclusions Sarcopenia significant pathological that needs recognized, especially older Although common aging occurs, it prevented lifestyle. Currently, there no approved drugs sarcopenia; however, nutritional supplementation essential methods managing sarcopenic Given its diverse approach necessary effectively manage prevention effective osteoarthritis.
Language: Английский
Citations
1
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: June 28, 2024
Sarcopenia, an age-related disease, has become a major public health concern, threatening muscle and daily functioning in older adults around the world. Changes gut microbiota can affect skeletal metabolism, but exact association is unclear. The richness of refers to number different species sample, while diversity not only considers also evenness their abundances. Alpha comprehensive metric that measures both (richness) abundances, thereby providing thorough understanding composition structure community.
Language: Английский
Citations
4
Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123357 - 123357
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 3, 2025
Sarcopenia is an age-related condition characterized by the progressive loss of skeletal muscle mass and strength. With global aging population, its incidence rapidly increasing. Lipid peroxidation a critical biochemical process that generates reactive oxygen species (ROS), leading to destruction cell structure function. It plays pivotal role in onset progression sarcopenia. This review summarizes mechanisms which lipid contributes sarcopenia, with focus on regulatory effects membrane damage, mitochondrial dysfunction, death. In addition, we discuss protective antioxidant factors such as GPX4 (glutathione peroxidase 4) peptides like SS mitigating delaying Finally, potential various strategies, including natural compounds, supplements, extracts, lifestyle interventions, inhibiting promoting health explored.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2016 - 2016
Published: Feb. 26, 2025
Hemojuvelin (HJV) is a membrane-bound protein prominently expressed in the skeletal muscle, heart, and liver. Despite its established function iron regulation, specific role of HJV muscle physiology pathophysiology not well understood. In this study, we explored involvement disuse-induced atrophy uncovered potential mechanisms. Hindlimb unloading (HU) resulted soleus wild type (WT) mice, accompanied by significant decrease expression. The muscle-specific deletion Hjv (MKO) exacerbated myofiber atrophy, which was associated with an increase expression ubiquitin ligases following HU. Furthermore, transforming growth factor-β II receptor (TβRII) level phosphorylated Smad3 (p-Smad3) were elevated after HU, these effects MKO mice. knockdown TβRII mice mitigated reversed hyperactivation TβRII/Smad3 pathway induced Our findings demonstrate that absence contributes to activation signaling and, consequently, onset response Given abundant emerges as therapeutic target for atrophy.
Language: Английский
Citations
0
Journal of Biosciences and Medicines, Journal Year: 2025, Volume and Issue: 13(02), P. 450 - 464
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2626 - 2626
Published: March 14, 2025
Aucubin (AU) is one of the main components traditional Chinese medicine Eucommia ulmoides Oliv (EU). This study investigated effects AU on aging-related skeletal muscle atrophy in vitro and vivo. The results network pharmacology revealed potential therapeutic atrophy. In vitro, effectively attenuated D-gal-induced cellular damage, reduced number senescence-associated β-galactosidase (SA-β-Gal)-positive cells, down-regulated expression levels atrophy-related proteins Atrogin-1 MuRF1, improved myotube differentiation, thereby mitigating Notably, was found to attenuate oxidative stress apoptosis cells by reducing ROS production, regulating Cleaved caspase3 BAX/Bcl-2 apoptotic pathways, enhancing Sirt1 PGC-1α signaling pathways. vivo studies demonstrated that treatment extended average lifespan Caenorhabditis elegans (C. elegans), increased locomotor activity, body wall mitochondrial content, alleviated damage C. elegans. These findings suggested can ameliorate show significant preventing treating
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116303 - 116303
Published: March 22, 2025
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1217 - 1217
Published: March 30, 2025
Background/Objectives: Muscle atrophy, defined by diminished muscle mass and function, is a notable concern associated with aging, disease, glucocorticoid treatment. Pueraria montana var. lobata extract (PMLE) demonstrates multiple bioactive properties, such as antioxidant, anti-inflammatory, metabolic regulatory activities; however, its role in atrophy has not been extensively investigated to date. This study examined how PMLE influences both cell differentiation dexamethasone (DEX)-induced degeneration focusing on the underlying molecular mechanisms. Methods: effects of myogenic DEX-induced atrophy. C2C12 myoblasts were treated (10-100 ng/mL) assessed for changes expression myogenesis-related genes activation Akt/mTOR AMPK/SIRT1/PGC-1α signaling cascades. In vivo, model was used assess mass, fiber morphology, changes. Results: promoted development increasing MyHC, MyoD, myogenin while activating protein synthesis mitochondrial biogenesis pathways. counteracted myotube restoring diameter promoting cellular fusion vitro. mitigated degradation fast-twitch groups reversed suppression key anabolic Conclusions: These findings suggest that promotes protects against regulating critical pathways, indicating promise treatment candidate conditions involving wasting. Further studies are required clinical application long-term safety efficacy.
Language: Английский
Citations
0