Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits DOI Creative Commons
Lucas Fornari Laurindo,

Otávio Augusto Garcia Simili,

Adriano Cressoni Araújo

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 143 - 143

Published: Jan. 30, 2025

Melatonin is indispensable for the homeostasis of plants and animals. In humans, it can help prevent or be an adjuvant treatment several diseases mainly related to immune system, inflammation, oxidative stress. Moreover, a melatonin-rich diet linked health benefits, such as regulation circadian rhythm, immunological epilepsy control, delaying aging process, diminishing hormones cancer. This review aimed show effects melatonin in beyond its traditional use. The results showed present scavenging free radicals, reducing inflammatory cytokines, modulating system. improve insulin resistance, blood pressure, LDL-c, adipose tissue mass, adhesion molecules, endothelial impairment, plaque formation. These result neuro- cardioprotection, improvement liver diseases, rheumatoid arthritis, dermatitis, COVID-19, polycystic ovaries, sepsis. We conclude that plant benefit patients with many besides sleep problems neurodegeneration. Plant may more cost-effective fewer adverse events than synthetic. However, clinical trials should performed adequate doses, formulation, time.

Language: Английский

Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview DOI Open Access
Giuseppe Mannino, Carlo Pernici, Graziella Serio

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(18), P. 9996 - 9996

Published: Sept. 16, 2021

Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of several physiological processes both animals and plants. In last century, it was reported that this molecule may be produced high concentrations by species belonging to plant kingdom stored specialized tissues. review, main information related chemistry melatonin metabolism has been summarized. Furthermore, biosynthetic pathway characteristics animal cells have compared, differences between two systems highlighted. Additionally, order investigate distribution indolamine kingdom, cluster analysis performed using database composed 47 previously published articles reporting content different families, Finally, potential pharmacological biostimulant benefits derived from administration exogenous on or plants via intake dietary supplements application formulation discussed.

Language: Английский

Citations

122
Melatonin enhanced the heavy metal-stress tolerance of pepper by mitigating the oxidative damage and reducing the heavy metal accumulation DOI
Muhammad Ahsan Altaf,

Yuanyuan Hao,

Huangying Shu

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 454, P. 131468 - 131468

Published: April 23, 2023

Language: Английский

Citations

111
Chlorophylls as Natural Bioactive Compounds Existing in Food By-Products: A Critical Review DOI Creative Commons
Peyman Ebrahimi,

Zahra Shokramraji,

Setareh Tavakkoli

et al.

Plants, Journal Year: 2023, Volume and Issue: 12(7), P. 1533 - 1533

Published: April 2, 2023

Chlorophylls are a group of naturally occurring pigments that responsible for the green color in plants. This pigment could have numerous health benefits due to its high antioxidant activity, including anti-inflammatory, anti-cancer, and anti-obesity properties. Many food by-products contain level chlorophyll content. These discarded considered environmental pollutants if not used as source bioactive compounds. The recovery chlorophylls from is an interesting approach increasing sustainability production. paper provides insight into properties effect different treatments on their stability, then reviews latest research extraction sustainable perspective.

Language: Английский

Citations

81
Melatonin as a key regulator in seed germination under abiotic stress DOI Open Access
Lei Wang, Mohsin Tanveer, Hongling Wang

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(1)

Published: Jan. 1, 2024

Abstract Seed germination (SG) is the first stage in a plant's life and has an immense importance sustaining crop production. Abiotic stresses reduce SG by increasing deterioration of seed quality, reducing potential, vigor. Thus, to achieve sustainable level yield, it important improve under abiotic stress conditions. Melatonin (MEL) biomolecule that interplays developmental processes regulates many adaptive responses plants, especially stresses. this review specifically summarizes discusses mechanistic basis MEL‐mediated MEL regulating some stress‐specific common responses. For instance, induced specific include regulation ionic homeostasis, hydrolysis storage proteins salinity stress, C‐repeat binding factors signaling cold starch metabolism high temperature heavy metal activation aquaporins accumulation osmolytes drought stress. On other hand, mediated gibberellins biosynthesis abscisic acid catabolism, redox Ca 2+ are amongst Nonetheless such as endogenous contents, plant species, growth conditions also influence above‐mentioned In conclusion, interacting with different physiological mechanisms.

Language: Английский

Citations

22
Uncovering the role of melatonin in plant stress tolerance DOI
Ahsan Ayyaz,

Aneela Kanwal Shahzadi,

Saba Fatima

et al.

Theoretical and Experimental Plant Physiology, Journal Year: 2022, Volume and Issue: 34(3), P. 335 - 346

Published: July 19, 2022

Language: Английский

Citations

47
Function, Mechanism, and Application of Plant Melatonin: An Update with a Focus on the Cereal Crop, Barley (Hordeum vulgare L.) DOI Creative Commons

Xin‐xing Yang,

Jie Chen, Yuan Ma

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(4), P. 634 - 634

Published: March 25, 2022

Melatonin is a multiple-function molecule that was first identified in animals and later plants. Plant melatonin regulates versatile processes involved plant growth development, including seed germination, root architecture, flowering time, leaf senescence, fruit ripening, biomass production. Published reviews on have been focused two model plants: (1) Arabidopsis (2) rice, which the natural contents are quite low. Efforts to integrate function mechanism of determine how benefits human health also lacking. Barley unique cereal crop used for food, feed, malt. In this study, bioinformatics analysis identify genes required barley biosynthesis performed, after effects exogenous development were reviewed. Three integrated mechanisms cells found: serving as an antioxidant, modulating hormone crosstalk, (3) signaling through putative receptor. Reliable approaches characterizing biosynthetic modulate grains discussed. The present paper should be helpful improvement production under hostile environments reduction pesticide fungicide usage cultivation. This study beneficial enhancement nutritional values healthcare functions food industry.

Language: Английский

Citations

41
The involvement of hydrogen sulphide in melatonin-induced tolerance to arsenic toxicity in pepper (Capsicum annuum L.) plants by regulating sequestration and subcellular distribution of arsenic, and antioxidant defense system DOI
Cengiz Kaya, Ferhat Uğurlar, Muhammad Ashraf

et al.

Chemosphere, Journal Year: 2022, Volume and Issue: 309, P. 136678 - 136678

Published: Sept. 30, 2022

Language: Английский

Citations

39
Melatonin-mediated endogenous nitric oxide coordinately boosts stability through proline and nitrogen metabolism, antioxidant capacity, and Na+/K+ transporters in tomato under NaCl stress DOI Creative Commons
Abazar Ghorbani, Leila Pishkar,

Kobra Valed Saravi

et al.

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: March 13, 2023

The interactions between nitric oxide (NO) and melatonin in alleviating sodium chloride (NaCl) toxicity plants are poorly comprehended. Here, the associations exogenous application of endogenous NO levels inducing tomato seedlings' defense response during NaCl were investigated. results indicated that (150 μM) increased height (23.7%) biomass (32.2%), improved chlorophyll (a (137%) b (92.8%)), proline metabolisms, reduced contents superoxide anion radicals (49.6%), hydrogen peroxide (31.4%), malondialdehyde (38%), electrolyte leakage (32.6%) 40-day-old seedlings grown under mM) treatment. Melatonin antioxidant system NaCl-stressed by increasing activity enzymes. also N metabolism content upregulating enzymes implicated assimilation. Furthermore, ionic balance Na NaCl-exposed expression genes involved K/Na ratio homeostasis (NHX1-4) accumulation mineral nutrients (P, N, Ca, Mg). However, addition cPTIO (100 μM; an scavenger) reversed beneficial impacts melatonin, indicating effective function melatonin-induced mechanisms seedlings. Therefore, our revealed improves tolerance mediating internal NO.

Language: Английский

Citations

37
Melatonin as a Key Factor for Regulating and Relieving Abiotic Stresses in Harmony with Phytohormones in Horticultural Plants — a Review DOI Creative Commons
Mahmoud A. A. Ali, Mohamed A. Nasser, Ahmed N. Abdelhamid

et al.

Journal of soil science and plant nutrition, Journal Year: 2023, Volume and Issue: 24(1), P. 54 - 73

Published: Dec. 26, 2023

Abstract Melatonin was found in plants the late 1990s, but its function, signaling, and interaction with other phytohormones still unclear. research has increased substantially recent years, including reports on impact of this putative plant hormone under biotic abiotic stress situations. Temperature extremes, salt, drought, hypoxia or anoxia, nutrient deficiency, herbicides, UV radiation stress, heavy metal toxicity are all important obstacles to horticulture crop production worldwide. To deal these environmental challenges, have evolved complex signaling networks. Phytohormones essential for controlling growth, development, responses. Melatonin, a pleiotropic chemical present variety species, recently emerged as powerful regulator tolerance. The purpose review is investigate interplay between melatonin control responses horticultural crops. We explore interactions several various stresses.

Language: Английский

Citations

34
Melatonin enhances drought tolerance by affecting jasmonic acid and lignin biosynthesis in wheat (Triticum aestivum L.) DOI Open Access
Mingzhao Luo, Daoping Wang, Pierre Delaplace

et al.

Plant Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 202, P. 107974 - 107974

Published: Aug. 16, 2023

Language: Английский

Citations

30