Production of Bioactive Phytochemicals from Ethnomedicinal Plant Endophytic Microorganisms DOI Creative Commons

Jacqueline Makatiani,

Elijah Kipkorir Lelmen

Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Ethnomedicinal plants are extensively explored for the discovery of new bioactive phytochemicals with applications in agrochemical, food and pharmaceutical industries. This could lead to extinction some endangered plant species, hence need phytochemical production strategies. Medicinal plant-associated microbial endophytes act as a promising eco-friendly source high-valued phytochemicals. Numerous reports have focused on bioprospecting novel or existing biomolecules. However, investigations techniques high-value-low volume secondary metabolites extremely limited. Moreover, exploration bacterial actinomycete sources has not been fully elucidated. chapter highlights diversity, distribution, bioactivity ethnomedicinal isolated between 2014 2024. Additionally, recent advances biotechnological strain improvement such genome editing enhanced vitro discussed.

Language: Английский

Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential DOI Creative Commons

Dana-Mihaela Asiminicesei,

Daniela Ionela Ferţu, Maria Gavrilescu

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(6), P. 913 - 913

Published: March 21, 2024

The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing its impact antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between metals physiological biochemical responses highlighting how disrupts pathways, altering concentrations secondary metabolites. This disruption may compromise overall quality efficacy requiring holistic understanding cumulative impacts. Furthermore, study discusses potential targeted genetic editing enhance plant resilience against by manipulating genes associated with defenses. approach represents promising frontier in safeguarding plants metal-contaminated environments. Additionally, research investigates role phytohormone signaling adaptive mechanisms stress, revealing influence responses, thereby adding complexity adaptation. underscores importance innovative technologies global cooperation protecting plants’ highlights need for mitigation strategies address contamination effectively.

Language: Английский

Citations

31

Environmental factors on secondary metabolism in medicinal plants: exploring accelerating factors DOI Creative Commons
Mohammad Murtaza Alami,

S. Guo,

Zhinan Mei

et al.

Medicinal Plant Biology, Journal Year: 2024, Volume and Issue: 3(1), P. 0 - 0

Published: Jan. 1, 2024

Medicinal plants are vital in synthesizing crucial substrates, fortifying stress resilience, and serving clinical industrial domains. The optimization of pharmacological potential necessitates a nuanced understanding the factors governing synthesis secondary metabolites sourced from plants. Cultivation success hinges upon many dictating production these compounds. Biotic factors, encompassing pathogens herbivores, alongside abiotic such as light exposure, altitude, temperature variations, irrigation patterns, soil fertility, drought susceptibility, salinity levels, collectively orchestrate medicinal plants' growth, development, metabolic pathways. This comprehensive review delves into intricate interplay influencing formation metabolites, exploring roles endophytes, pathogens, availability, fluctuations, stress, pollution impacts, plant growth regulators. Grasping dynamics is imperative for devising strategic interventions to enhance metabolite production, thereby ensuring sustainable efficient cultivation

Language: Английский

Citations

10

Phyllanthus Lignans: A Review of Biological Activity and Elicitation DOI Creative Commons
Winda Nawfetrias,

Lukita Devy,

Rizkita Rachmi Esyanti

et al.

Horticulturae, Journal Year: 2024, Volume and Issue: 10(2), P. 195 - 195

Published: Feb. 19, 2024

The Phyllanthus genus exhibits a broad distribution spanning across the majority of tropical and subtropical regions. Due to their ability synthesize medicinal bioactive compounds such as lignans, they have been utilized historically in traditional medicine treat wide range ailments. This review discusses current knowledge on potency lignans for purposes, benefit plants, various produced by Phyllanthus, how lignan synthesis could be increased through biotic abiotic elicitation. Finally, we present set connected hypotheses explain signaling crosstalk between endophytic microbes drought stress responses regulates production. Although mechanisms are not fully explored, this strongly supports view that fungi can increase production plants belonging Phyllanthus. plant–endophyte–drought relationship helps improve yield which is crucial human health optimized under vitro vivo conditions.

Language: Английский

Citations

5

Deciphering the endomicrobiome of Podophyllum hexandrum to reveal the endophytic bacterial-association of in-planta podophyllotoxin biosynthesis DOI
Meena Kumari, Anish Tamang, Mohit Kumar Swarnkar

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 16, 2025

Language: Английский

Citations

0

Seed bacterization with siderophore-producing bacteria: a strategy to enhance growth and alkaloid content in Catharanthus roseus DOI Creative Commons
Vyoma Mistry,

Sapna Chandwani,

Natarajan Amaresan

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 20, 2025

Language: Английский

Citations

0

Marine fungi as a goldmine for novel antibiotics: a 2024 perspective DOI Creative Commons
Chengqian Pan,

Syed Shams ul Hassan,

Ishaq Muhammad

et al.

Frontiers in Marine Science, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 21, 2025

The microbial diversity in oceans is considerable, widely distributed seawater, marine sediments, and organisms. Compared with terrestrial resources traditional natural product research, the living environments of microorganisms are starkly different. drastic differences survival conditions, such as high salinity, oligotrophic lack light, limited oxygen, determine that exhibit distinctive characteristics metabolism, modes, adaptive mechanisms. These factors contribute to significant distinctions secondary metabolic pathways enzymatic reaction mechanisms between microorganisms. In this review, we summarized a total 72 novel products antibacterial activity, published 2024, which derived from marine-derived fungi. (polyketides, alkaloids, terpenoids, peptides) emphasized terms their structures biological activities. This article aims provide useful information for research development antibiotics.

Language: Английский

Citations

0

Phytohormone Production by Endophytic Fungi DOI

Hajira Younas,

Fatima Younas

Published: Jan. 1, 2025

Language: Английский

Citations

0

Mass spectrometric profile, antioxidant and oral pathogen biofilm control capacity of small molecules from an endophyte Cladospoium species: in vitro and in silico models DOI Creative Commons

A. P. Manasa,

Deena Mendez,

P Kiranmayee

et al.

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100267 - 100267

Published: Feb. 1, 2025

Language: Английский

Citations

0

Occurrence and characterization of fungal species in medicinal plants from South Africa DOI Creative Commons

Oluwaseun Mary Oladeji,

Judith Zanele Phoku,

Oluwasola Abayomi Adelusi

et al.

Discover Life, Journal Year: 2025, Volume and Issue: 55(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0

Endophytic fungi and age-related diseases: Potential for geriatric therapeutics DOI
Rachan Karmakar,

Sunil Kumar,

Vijay Tripathi

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 295 - 313

Published: Jan. 1, 2025

Language: Английский

Citations

0