Manual segmentation of the paraventricular nucleus of the hypothalamus and the dorsal and ventral bed nucleus of stria terminalis using multimodal 7 Tesla structural MRI: probabilistic atlases for a stress-control triad DOI Creative Commons

Brandon M. Sibbach,

Helmet T. Karim,

Daniel Lo

et al.

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 229(2), P. 273 - 283

Published: Oct. 9, 2023

Abstract The paraventricular nucleus of the hypothalamus (PVN) is uniquely capable proximal control over autonomic and neuroendocrine stress responses, bed stria terminalis (BNST) directly modulates PVN function, as well playing an important role in itself. dorsal BNST (dBNST) predominantly preautonomic, while ventral (vBNST) viscerosensory, receiving dense noradrenergic signaling. Distinguishing dBNST vBNST, along with PVN, may facilitate our understanding dynamic interactions among these regions. T1-weighted MPRAGE high resolution gradient echo (GRE) modalities were acquired at 7T. GRE was coregistered to segmentations performed MRIcroGL based on their Atlas Human Brain depictions. dBNST, vBNST manually segmented 25 participants; 10 images rated by 2 raters. These normalized probabilistic atlases for each region generated MNI space, now available resources future research. We found moderate–high inter-rater reliability [ n = 10; Mean Dice (SD); 0.69 (0.04); 0.77 0.62 (0.04)]. Probabilistic reverse into native space six additional participants that but not included original 25. also moderate between manual 6; 0.55 (0.12); 0.60 (0.10); 0.47 (0.12 SD)]. By isolating hypothalamic subregions using ultra-high field MRI modalities, more specific delineations regions can greater mechanisms underlying stress-related function psychopathology.

Language: Английский

Neural circuits regulating visceral pain DOI Creative Commons
Xiaoli Chang, Haiyan Zhang, S.R. Wayne Chen

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: April 13, 2024

Abstract Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development chronic visceral pain, which is major challenge for both patients and health providers. Neural circuits in brain encode, store, transfer pain information across regions. In this review, we focus on anterior cingulate cortex paraventricular nucleus hypothalamus highlight progress identifying neural involved pain. We also discuss several circuit mechanisms emphasize importance cross-species, multiangle approaches identification specific neurons determining that control

Language: Английский

Citations

9
Allostasis, health, and development in Latin America DOI
Joaquín Migeot, Carolina Panesso, Claudia Durán-Aniotz

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105697 - 105697

Published: May 4, 2024

Language: Английский

Citations

9
Glutamatergic and GABAergic anteroventral BNST projections to PVN CRH neurons regulate maternal separation-induced visceral pain DOI

Siting Huang,

Ke Wu, Miaomiao Guo

et al.

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 48(12), P. 1778 - 1788

Published: July 29, 2023

Language: Английский

Citations

16
Adverse childhood and adulthood experiences and risk of new-onset cardiovascular disease with consideration of social support: a prospective cohort study DOI Creative Commons
Wanxin Wang,

Yifeng Liu,

Yuwei Yang

et al.

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 8, 2023

The relationship between adverse childhood experiences (ACEs) and adulthood (AAEs) their association with incident cardiovascular disease (CVD) have not been extensively studied. Considering social support, we evaluated the complex relations of ACEs AAEs CVD.This prospective cohort study used data from 2014 life course survey 2015 2018 surveys China Health Retirement Longitudinal Study, a national Chinese adults aged ≥ 45 years 28 provinces across China. population included 5836 individuals (mean [SD] age, 59.59 [8.22] years, 49.7% were males). Information on ACEs, AAEs, young health behavior factors, status demographics was measured. Cox regression models, difference method to estimate mediation proportion, additive multiplicative interactions performed. Subgroup sensitivity analyses also conducted.During follow-up, 789 cases CVD occurred. fully adjusted model, including demographics, behaviors, factors (e.g., depressive symptoms), support as control variables, demonstrated that overall number (Hazard ratio [HR]: 1.11, 95% CI: 1.08 1.14) (HR: 1.19, 1.16 1.22) associated an increased risk CVD. A dose-response existed or risk. found mediate 17.7% (95% 8.2 34.2%) Moreover, significant interaction detected (RERI [95% CI]: 0.32 [0.09 0.56]). Compared without exposure both ACE AAE, those at least one AAE indicator had highest 1.96, 1.72 2.23).Exposure independently among middle-aged older in manner, partially mediated Preventive measures aimed addressing either alone may significantly reduce later life. necessity comprehensive life-course strategy targeting prevention adversity merits attention.

Language: Английский

Citations

11
Brain and cardiovascular responses to acute stress in remitted and recurrent late-life depression DOI
Thomas E. Kraynak, Helmet T. Karim, Layla Banihashemi

et al.

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Frequency of post-traumatic stress disorder among orthopedic trauma patients and its association with personal parameters DOI

Fareeha Qamar,

Amna Mehboob,

Amna Rehman

et al.

Irish Journal of Medical Science (1971 -), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma DOI Creative Commons
Farah Harb, Michael T. Liuzzi, Ashley A. Huggins

et al.

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 4(4), P. 100312 - 100312

Published: April 5, 2024

Childhood abuse (physical, emotional, and sexual) is associated with aberrant connectivity of the amygdala, a key threat processing region. Heightened amygdala activity also predicts adult anxiety posttraumatic stress disorder (PTSD) symptoms, as do experiences childhood abuse. The current study explored whether resting-state functional (rsFC) may explain relationship between PTSD symptoms following trauma exposure in adults. Two-weeks post-trauma, survivors (N=152, M age=32.61; SD=10.35; female=57.2%) completed Trauma Questionnaire underwent magnetic resonance imaging. were assessed six-months post-trauma. Seed-to-voxel analyses evaluated association rsFC. A mediation model potential mediating role on post-traumaanxiety PTSD. was increased precuneus, covarying for age, gender, neglect, baseline symptoms. Amygdala-precuneus rsFC significant mediator effect six months post-trauma (B=0.065, CI [0.013, 0.130], SE=0.030), but not secondary analysis investigating depression an outcome significant. be underlying neural mechanism by which increases risk trauma. Specifically, this heightened reflect attentional vigilance or tendency toward negative self-referential thoughts. Findings suggest that contribute to longstanding upregulation circuits, makes one vulnerable anxiety-related adulthood.

Language: Английский

Citations

3
The contribution of childhood trauma to irritability symptoms DOI Creative Commons
Lana Ruvolo Grasser, Ruiyu Yang, Melissa A. Brotman

et al.

JCPP Advances, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Irritability is a transdiagnostic psychiatric phenotype defined as an increased proneness to anger relative peers. Trauma actual or threatened death, serious injury, sexual violence while adversity more broadly describes difficult challenging situations including abuse, neglect, and household dysfunction. [or aggression] symptom of posttraumatic stress disorder (PTSD) may arise in response trauma traumatic events. Responses negative early life experiences differ based on the type exposure, for example, threat (abuse) versus deprivation (neglect), with implications development psychopathology. Therefore, objective this study was investigate relation between exposure deprivation, irritability predominantly Hispanic/Latin sample. We hypothesized unique effects irritability. investigated relations aspects childhood (within each dimension) later sample n = 48 (26F) youth ages 9-19 (M age 14.89, SD 2.04) recruited exposure. Multivariate regression tested (measurement: Childhood Questionnaire) Affective Reactivity Index). Greater associated severe self-reported irritability, F(1,46) 8.64, B 0.40, R 2 0.14, p 0.005. Findings remained significant after controlling values excessive influence non-significant effect gender (B 0.25, t 1.88, 0.067). When looking at adjusted significant, 0.35, 2.45, 0.019. There no association 3.35, 0.26, 0.05, 0.074. Exposure threat, but not increase risk youth. Early should be considered assessment treatment clinically impairing Transdiagnostic treatments targeting who do meet criteria post-traumatic disorder.

Language: Английский

Citations

3
Do trait‐level emotion regulation strategies moderate associations between retrospective reports of childhood trauma and prospective changes in systemic inflammation? DOI
Emily J. Jones, Anna L. Marsland, Peter J. Gianaros

et al.

Stress and Health, Journal Year: 2022, Volume and Issue: 39(3), P. 525 - 538

Published: Oct. 20, 2022

Childhood trauma may confer risk for poorer adult health through changes in systemic inflammation. Emotion regulation plausibly moderate associations between childhood and psychological well-being, but it remains unclear whether moderation effects extend to differences To examine emotion separately interactively predict prospective C-reactive protein (CRP) interleukin-6 (IL-6) biopsychosocial factors account observed associations. Healthy midlife adults (N = 331) retrospectively reported on trauma, current trait-level cognitive reappraisal expressive suppression, had their blood drawn. At baseline then a median of 2.85 years later, 279 the 331 participants drawn, body mass index calculated, behaviours (smoking, sleep), distress (perceived stress, depressive symptoms), education. predicted increases CRP (B 0.004, p 0.049), which were partially accounted by adiposity, distress, behaviours. In contrast, decreases IL-6 -0.007, 0.006), independent influences. Cognitive further moderated association -0.001, 0.012) such that greater only among lower 0.006, 0.007). There no main or suppression (ps > 0.05). attenuate over time inflammation midlife.

Language: Английский

Citations

14
Alterations in BNST Intrinsic Functional Connectivity in Early Abstinence from Alcohol Use Disorder DOI
Elizabeth A. Flook, Brandee Feola, Margaret M. Benningfield

et al.

Alcohol and Alcoholism, Journal Year: 2023, Volume and Issue: 58(3), P. 298 - 307

Published: Feb. 27, 2023

Maintaining abstinence from alcohol use disorder (AUD) is extremely challenging, partially due to increased symptoms of anxiety and stress that trigger relapse. Rodent models AUD have identified the bed nucleus stria terminalis (BNST) contributes anxiety-like behavior drug-seeking during abstinence. In humans, however, BNST's role in remains poorly understood. The aims this study were assess BNST network intrinsic functional connectivity individuals compared healthy controls examine associations between connectivity, severity

Language: Английский

Citations

7