Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 30, 2023
EDITORIAL article Front. Psychol., 30 January 2023Sec. Psychology for Clinical Settings Volume 14 - 2023 | https://doi.org/10.3389/fpsyg.2023.1088086
Language: Английский
European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2023, Volume and Issue: 273(7), P. 1513 - 1525
Published: Feb. 14, 2023
Cognitive impairment has been observed in patients with various psychiatric disorders, including schizophrenia, major depressive disorder (MDD), and bipolar (BD). Although modern therapeutic drugs can improve certain symptoms (i.e., psychosis, depression) these patients, have not found to cognitive impairment. The N-methyl-D-aspartate receptor antagonist (R,S)-ketamine attracted attention as a rapidly acting antidepressant. In addition its robust antidepressant effects, suggested MDD BD, despite causing healthy control subjects. is racemic mixture of equal amounts (R)-ketamine (or arketamine) (S)-ketamine esketamine). Arketamine more potent antidepressant-like actions than esketamine rodents. Interestingly, arketamine, but esketamine, phencyclidine-induced deficits mice. Furthermore, arketamine ameliorate rodent offspring after maternal immune activation. the current article, it proposed that potential for treating disorders. Additionally, role gut-microbiome-brain axis disorders discussed.
Language: Английский
Citations
33
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Jan. 2, 2024
Evidence on the association between multimorbidity and cognitive impairment in Chinese older population is limited. In addition, whether a healthy lifestyle can protect function multimorbid remains unknown.
Language: Английский
Citations
14
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 20, 2024
Various microbial communities reside in the gastrointestinal tract of humans and play an important role immunity, digestion, drug metabolism, intestinal integrity, protection from pathogens. Recent studies have revealed that gut microbiota (GM) is involved communication with brain, through a bidirectional network known as gut-brain axis. This involves humoral, immunological, endocrine, neural pathways. Gut dysbiosis negatively impacts these pathways, leading to neurological complications cognitive deficits. Both pre-clinical clinical demonstrated probiotics can restore healthy GM, reduce pH, inflammation pathogenic microbes gut. Additionally, improve cell-to-cell signaling increase blood-brain-derived neurotrophic factors. Probiotics emerge potential approach for preventing managing Despite promising findings, safety concerns possible risks probiotic usage must be closely monitored addressed. review article provides brief overview significance health.
Language: Английский
Citations
13
Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22
Published: Feb. 5, 2025
Alcohol abuse-triggered alcohol-related liver disease (ALD) has become as a global public health concern that substantially affects the well-being and clinical status of patients. Although modern medicine provides various treatments for ALD, their effectiveness is limited can lead to adverse side effects. Probiotics have been employed prevent, alleviate, even treat with promising results. However, few comprehensive reviews are available on how they mitigate ALD by targeting gut-liver axis. This review systematically clarifies specific mediators axis in healthy states. It also describes alterations observed ALD. Furthermore, this thoroughly summarizes underlying mechanisms through which probiotics act relieve discusses current challenges faced research applications. Finally, we discuss future prospects using improves our understanding supports development application target therapeutic use.
Language: Английский
Citations
1
European Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 79, P. 49 - 58
Published: Dec. 20, 2023
Language: Английский
Citations
17
Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105722 - 105722
Published: May 15, 2024
Language: Английский
Citations
6
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: Sept. 9, 2024
Language: Английский
Citations
6
Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30426 - e30426
Published: April 26, 2024
The brain is sensitive to oxidative stress, which can trigger microglial activation and neuroinflammation. Antioxidant therapies may provide neuroprotection against stress. In recent years antioxidant effects of probiotics their possible mechanisms in stress-related models have been determined. the current study, for first time, we assessed
Language: Английский
Citations
5
OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12
Published: Feb. 28, 2025
Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: April 9, 2025
Vitamin D is known to have a potential impact on cognitive function and mental health. This study aims assess the association between dietary vitamin intake performance, as well depression, in an elderly U.S. population. Data from National Health Nutrition Examination Survey (NHANES) 2013-2014 were analyzed. A total of 1,344 participants categorized into three tertiles based their (D2 + D3). Cognitive was measured using Consortium Establish Registry for Alzheimer's Disease (CERAD) test, Digit Symbol Substitution Test (DSST), Animal Fluency Test, while depression assessed through Patient Questionnaire-9 (PHQ-9). Adjustments made confounding variables, including age, sex, race, education, physical activity level, other factors. After adjustment confounders, individuals 3rd tertile (≥4.9 mcg/day) had significantly reduced odds low performance CERAD test (OR: 0.77, 95% CI: 0.57-0.98; p = 0.031) 0.63, 0.49-0.85; 0.013) compared 1st (≤2.4 mcg/day). Similarly, lower (PHQ-9 score > 4) after 0.68, 0.48-0.99; 0.046). Our findings suggest that associated with improved depressive symptoms individuals. However, further longitudinal studies are needed establish causality explore underlying mechanisms.
Language: Английский
Citations
0