Dietary Nutrient Deficiencies and Risk of Depression (Review Article 2018–2023)

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2433 - 2433

Published: May 23, 2023

Depression is classified as one of the most common mental disorders. Its prevalence has recently increased, becoming a growing public health threat. This review focuses on clarifying role and importance individual nutrients in diet impact nutrient deficiencies risk depression. Deficiencies such protein, B vitamins, vitamin D, magnesium, zinc, selenium, iron, calcium, omega-3 fatty acids have significant brain nervous system function, which can affect appearance depressive symptoms. However, it important to remember that itself not only factor influencing or helping treat There are many other aspects, physical activity, sleep, stress management, social support, also play an maintaining health. The data observed available analyses based cross-sectional studies. Further studies, including prospective cohort, case-control recommended draw more reliable conclusions.

Language: Английский

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A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 459 - 467

Published: March 16, 2024

Omega-3 polyunsaturated fatty acids (PUFAs) may benefit migraine improvement, though prior studies are inconclusive. This study evaluated the effect of eicosapentaenoic acid (EPA) on episodic (EM) prevention. Seventy individuals with EM participated in a 12-week randomized, double-blind, placebo-controlled trial from March 2020 and May 2022. They were randomly assigned to either EPA (N = 35, 2 g fish oil 1.8 mg as stand-alone treatment daily), or placebo group soybean daily). Migraine frequency headache severity assessed using monthly days, visual analog scale (VAS), Disability Assessment (MIDAS), Hospital Anxiety Depression Scale (HADS), Migraine-Specific Quality-of-Life Questionnaire (MSQ), Pittsburgh Sleep Quality Index (PSQI) comparison baseline measurements. The significantly outperformed reducing days (−4.4 ± 5.1 vs. − 0.6 3.5 p 0.001), acute medication (−1.3 3.0 0.1 2.3 0.035), improving scores for (ΔVAS score: −1.3 2.4 0.0 2.2, 0.030), disability (ΔMIDAS −13.1 16.2 2.6 20.2, anxiety depression (ΔHADS −3.9 9.4 1.1 9.1, 0.025), quality life (ΔMSQ −11.4 19.0 3.1 24.6, 0.007). Notably, female particularly benefited EPA, underscoring its potential management. In conclusion, high-dose has reduced severity, improved psychological symptoms patients, shown no major adverse events, suggesting prophylactic EM.

Language: Английский

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The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 19, 2025

Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.

Language: Английский

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Omega-3 Polyunsaturated Fatty Acids in Depression

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8675 - 8675

Published: Aug. 8, 2024

Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, particular regarding treatment depression. This review presents an overview current research on role omega-3 prevention and depressive disorders. The existing body evidence demonstrates that acids, eicosapentaenoic acid (EPA) docosahexaenoic (DHA), antidepressant effects can be attributed to their modulation neuroinflammation, neurotransmitter function, neuroplasticity. Nevertheless, clinical trials supplementation yielded inconsistent results. Some studies demonstrated significant reductions symptoms following treatment, whereas others shown minimal no beneficial impact. A range factors, encompassing dosage, ratio EPA DHA, baseline nutritional status, been identified as having a potential impact noted Furthermore, it has suggested may act adjunctive for those undergoing treatment. Notwithstanding these encouraging findings, discrepancies study designs variability individual responses underscore necessity further order establish uniform, standardized guidelines use management

Language: Английский

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The Role of Nutrition, Oxidative Stress, and Trace Elements in the Pathophysiology of Autism Spectrum Disorders

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 808 - 808

Published: Jan. 18, 2025

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and interaction, alongside repetitive behaviors, atypical sensory-motor patterns. The growing prevalence of ASD has driven substantial advancements research aimed at understanding its etiology, preventing onset, mitigating impact. This ongoing effort necessitates continuous updates to the body knowledge identification previously unexplored factors. present study addresses this need examining roles nutrition, oxidative stress, trace elements pathophysiology ASD. In review, an overview provided key dietary recommendations for individuals with ASD, including gluten-free casein-free (GFCF) diets, ketogenic diets (KDs), other nutritional interventions. Furthermore, it explores involvement stress highlights significance maintaining neuropsychiatric health. impact these factors on molecular cellular mechanisms was discussed, therapeutic strategies their efficacy managing

Language: Английский

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Personalized Eicosapentaenoic Acid Therapy for Clinical Depression

Psychiatric Annals, Journal Year: 2025, Volume and Issue: 55(2)

Published: Feb. 1, 2025

Major depressive disorder (MDD) is a leading global cause of disability, and current antidepressant treatments remain inadequate for many patients. Emerging evidence highlights the role inflammation in pathophysiology depression, offering novel therapeutic target. Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty (n-3 PUFA) with potent anti-inflammatory pro-resolving effects, shows promise as adjunctive treatment depression. This article examines rationale behind EPA's effects explores potential personalized EPA therapy to enhance outcomes. A daily dose at least 1 g pure or EPA/docosahexaenoic formulation ratio greater than 2:1 favor recommended alongside standard therapy. Factors such inflammatory status, psychiatric medical comorbidities, endogenous n-3 PUFA genetic polymorphisms, should be considered optimize response. anti-inflammatory, pro-resolving, neuroprotective properties make it compelling option strategies MDD. [ Psychiatr Ann . 2025;55(2):e28–e33.]

Language: Английский

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Omega-3 Fatty Acids Supplementation in the Treatment of Depression: An Observational Study

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(2), P. 224 - 224

Published: Jan. 27, 2023

Depression is a common mood disorder characterized by persistent sadness and loss of interest. Research suggests an association between the inclusion omega-3 fatty acids in diet reduced risk for depression. The present study evaluated effectiveness acid supplements alleviating depressive symptoms patients with mild to moderate A total 165 suffering from moderated depression were randomized receive supplementation, antidepressant (single agent), or combination supplementation. clinical features assessed using Hamilton Rating Scale (HDRS) during follow-up period. statistically significant improvement was observed baseline first, second third follow-ups within each treatment arm as measured HRDS scores (p = 0.00001). Further, HDRS at significantly lower on therapy supplement antidepressants (arm-3) than alone (arm-1) [Q 5.89; p 0.0001] taking (arm 2) 4.36; 0.0068]. elicited higher alone.

Language: Английский

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The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 13, 2024

Depressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine serotonin pathways may play role. The exact mechanisms, especially depressed children adolescents, are not fully understood. Our primary hypothesis was whether the metabolites of tryptophan degradation adolescents with depressive might be influenced by omega-3 FAs compared omega-6 during 12-week supplementation. A secondary investigate associated markers inflammatory response, cortisol, serum omega-6/omega-3 FA ratio. Metabolites pteridines, neopterin, biopterin urine were analyzed an HPLC system. Surprisingly, stimulated both (kynurenine/tryptophan ratio) (5-hydroxytryptophan) pathways, whereas only increased kynurenine/tryptophan Neopterin different from healthy controls. Biopterin after Serotonin positively correlated lipoperoxidation marker protein damage. Of monitored metabolites, 5-hydroxyindolacetic acid severity depression, total cholesterol, negatively brain-derived neurotrophic factor glutathione peroxidase. conclusion, supplemented pathway formation. However, FA. Tryptophan metabolism inflammation, cortisol. We first point out association between (KYN/TRP metabolite 5-HIAA could role pathophysiology adolescents. Clinical Trial Registration https://www.isrctn.com/ISRCTN81655012 , identifier ISRCTN81655012.

Language: Английский

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Omega-3 fatty acids for inflamed depression – A match/mismatch study

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 118, P. 192 - 201

Published: March 1, 2024

Despite decades of research on the pathophysiology depression, development new therapeutic interventions has been slow, and no biomarkers treatment response have clinically implemented. Several lines evidence suggest that clinical biological heterogeneity among patients with major depressive disorder (MDD) hampered progress in field. MDD low-grade inflammation – "inflamed depression" is a subtype depression may be associated superior antidepressant to anti-inflammatory compounds. Omega-3 fatty acid eicosapentaenoic (EPA) properties, preliminary data it particularly efficacious inflamed depression. In this study we tested hypothesis add-on EPA greater efficacy high baseline high-sensitivity C-reactive protein (hs-CRP) compared low hs-CRP. All subjects received 2.2 g EPA, 400 mg docosahexaenoic 800 other acids/day for 8 weeks, added stable ongoing treatment. The primary outcome was change 17-item Hamilton Depression Rating Scale (HAMD-17). Patients raters were blind hs-CRP status. an intention-to-treat analysis including all at least one post visit (n = 101), cut-off ≥1 mg/L, but not ≥3 improvement HAMD-17 total score. addition general effect ≥ 1 adjuvant improved symptoms putatively related such as fatigue sleep difficulties. This adds mounting delineation MDD-subgroups based relevant predict interventions.

Language: Английский

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The Role of Dietary Antioxidants, Food Supplements and Functional Foods for Energy Enhancement in Healthcare Professionals

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1508 - 1508

Published: Dec. 10, 2024

Healthcare professionals frequently experience significant work overload, which often leads to substantial physical and psychological stress. This stress is closely linked increased oxidative a corresponding decline in energy levels. scoping review investigates the potential impact of dietary antioxidants food supplements conjunction with diet controlling these negative effects. Through an analysis biochemical pathways involved metabolism, paper emphasizes effectiveness targeted interventions. Key antioxidants, such as vitamins C E, polyphenols, carotenoids, are evaluated for their ability counteract enhance Additionally, assesses various supplements, including omega-3 fatty acids, coenzyme Q10, ginseng, mechanisms action enhancement. Practical guidelines incorporating energy-boost strategies into routine healthcare provided, emphasizing importance modifications reducing improving overall well-being performance high-stress environments. The concludes by suggesting directions future research validate findings explore new interventions that may further support under overload.

Language: Английский

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