Majör Depresif Bozukluk ve Omega 3 Yağ Asitleri

Balkan Sağlık Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 3(3), P. 164 - 186

Published: April 8, 2025

Bu derlemenin amacı, omega 3 yağ asitleri ile majör depresif bozukluk arasındaki ilişkiye genel bir bakış sunmaktır. Majör bozukluk, dünya çapında 280 milyon insanı etkileyen yaygın mental bozukluktur ve etiyolojisi tam olarak belli değildir. bozukluğu olan bireylerde, eritrosit membranlarında veya plazma fosfolipitlerinde düşük eikosapentaenoik asit + dokosaheksaenoik seviyeleri görülmektedir. nedenle, diyette asitleri, özellikle eksikliği bozukluğun patofizyolojisi arasında olası ilişki olduğu kabul edilmektedir. Son yıllarda omega-3 merkezi sinir sistemi üzerindeki potansiyel antidepresan etkileri nedeniyle depresyon tedavisinde dikkat çekmektedir. Bazı çalışmalar, takviyesi sonrasında semptomlarda anlamlı azalmalar bildirirken, diğer çalışmalar bu doğrulamamıştır. tutarsız bulgular, çalışma tasarımlarındaki farklılıklardan bireysel faktörlerden kaynaklanabilir. Ancak takviyeleri güvenli edilmekte standart tedavisine ek kullanılabilecekleri düşünülmektedir. alanda, daha geniş örneklem gruplarıyla tutarlı tasarımlarıyla yapılacak ileri araştırmalara ihtiyaç vardır.

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Which has a more protective effect against neuronal changes in the cingulate cortex of newborn rats of diabetic mothers: omega 3 or glutathione?

Ultrastructural Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: April 11, 2025

Different researches suggests that unchecked maternal hyperglycemia during pregnancy may negatively impact the offspring's neurodevelopment. Omega 3 polyunsaturated fatty acids are vital antioxidant micronutrients for neurological health. Glutathione (GSH) is an essential non-enzymatic in mammalian cells. The study aimed to assess possible ameliorative effect of omega3 versus GSH against neuronal changes cingulate cortex new born rats diabetic mothers. Fifty female were divided randomly into 5 equal groups: Group I given saline, group II where induction diabetes by single intraperitoneal injection 150 mg/kg alloxan monohydrate, III oral omega at a dose 300 mg/kg, IV injections (200 mg/kg) and V both with same routes regimens as throughout whole pregnancy. newborn each was collected anaesthetized then brain specimens extracted processed light, immunohistochemical electron microscopic studies. showed marked degenerative all layers light microscopy. most degree improvement comparison IV. There strong caspase3 immunoreaction while weak reaction appeared III, V. We concluded combined administration mitigate adverse effects on newborn's cortex.

Language: Английский

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From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4271 - 4271

Published: April 30, 2025

The brain-derived neurotrophic factor (BDNF) has become one of the cornerstones neuropathology, influencing synaptic plasticity, cognitive resilience, and neuronal survival. Apart from its molecular biology, BDNF is a powerful target for transformative benefit in precision medicine, leading to innovative therapeutic approaches neurodegenerative psychiatric diseases like Alzheimer's disease (AD), Parkinson's (PD), major depressive disorder (MDD), post-traumatic stress (PTSD). Nevertheless, clinical applicability obstructed by hurdles delivery, patient-specific diversity, pleiotropic signaling. Here, we summarize findings research, including regulatory pathways diagnostic/prognostic biomarkers integrative approaches. We describe delivery systems, such as lipid nanoparticle-based mRNA therapies CRISPR-dCas9-based epigenetic editing that bypass obstacles BBB (blood-brain barrier) enzymatic degradation. recent implementation multiplex panels combining biodynamic indicators with tau amyloid-β signaling markers showcases novel levels specificity both early detection potential monitoring. Humanized preclinical models iPSC-derived neurons organoids point key role neurodeveloping processes, paralleling advances bridging observation environments. Moreover, tools delivering TrkB activators or AI-based dynamic care platforms enable tailored scalable treatments. This review also aims extend framework used understanding BDNF's relevance traditional situating more work detailing actions ischemic tissues gut-brain axis context systemic health. Finally, outline roadmap incorporation BDNF-centered into worldwide healthcare, highlighting ethical issues, equity, interdisciplinary decomposition. heralds new era neuroscience revolutionizing brain health paving way advancement medicine.

Language: Английский

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Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1259 - 1259

Published: July 26, 2024

This review discusses the potential of targeting kynurenine pathway (KP) in treatment inflammatory diseases. The KP, responsible for catabolism amino acid tryptophan (TRP), produces metabolites that regulate various physiological processes, including inflammation, cell cycle, and neurotransmission. These metabolites, although necessary to maintain immune balance, may accumulate excessively during leading systemic disorders. Key KP enzymes such as indoleamine 2,3-dioxygenase 1 (IDO1), 2 (IDO2), (TDO), 3-monooxygenase (KMO) have been considered promising therapeutic targets. It was highlighted both inhibition activation these be beneficial, depending on specific disorder. Several conditions, autoimmune diseases, which modulation activity holds promise, described detail. Preclinical studies suggest this an effective strategy diseases options are currently limited. Taken together, highlights importance further research clinical application enzyme development new strategies

Language: Английский

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Associations of the intake of individual and multiple fatty acids with depressive symptoms among adults in NHANES 2007–2018

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 365, P. 364 - 374

Published: Aug. 22, 2024

Language: Английский

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