Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1546 - 1546
Published: May 21, 2024
Background: The ketogenic diet (KD) has been highly developed in the past for treatment of epileptic pathological states children and adults. Recently, current re-emergence its popularity mainly focuses on therapy cardiometabolic diseases. KD can also have anti-inflammatory neuroprotective activities which may be applied to prevention and/or co-treatment a diverse range psychiatric disorders. Purpose: This is comprehensive literature review that intends critically collect scrutinize pre-existing research basis clinical data potential advantageous impacts stress, anxiety, depression, schizophrenia bipolar disorder. Methods: was performed thoroughly represent existing this topic, as well find gaps international scientific community. In aspect, we carefully investigated ultimate web databases, e.g., PubMed, Scopus, Web Science, derive currently available animal human surveys by using efficient representative keywords. Results: Just recent years, an increasing amount focused investigating possible schizophrenia, Pre-existing basic with studies consistently demonstrated promising results KD, showing propensity ameliorate symptoms However, translation these findings settings presents more complex issue. majority seem moderate, usually not controlled, assessed short-term effects KD. addition, some appear characterized enormous dropout rates significant absence compliance measurement, elevated heterogeneity their methodological design. Conclusions: Although evidence seems promising, it recommended accomplish larger, long-term, randomized, double-blind, controlled trials prospective design, order conclusive whether could act preventative factor or even agent against Basic examine molecular mechanisms above
Language: Английский
Citations
4Therapeutic effects of ketogenic diets on physiological and mental health
Published: March 25, 2025
Ketogenic diets are emerging dietary patterns that have demonstrated potential as therapeutic tools in a variety of symptoms and conditions, such epileptic seizures, diabetes, obesity, cancer, migraines, metabolic syndrome. This narrative review examines the effects ketogenic on physiological mental health, including their role modulating gut microbiome. promote weight loss, enhance insulin sensitivity, may lower dyslipidemia, which crucial factors preventing cardio-metabolic diseases. They also play significant composition function microbiome, serving approach to control autoimmune diseases, given effectiveness reducing pro-inflammatory cells. Conversely, downside these is decrease beneficial bacteria been positively associated with human health. Regarding capability stabilize neural networks, improve neuroplasticity, exert direct benefits brain bioenergetics, thereby potentially alleviating related several epilepsy, anxiety, depression, schizophrenia, bipolar disorder, autism spectrum certain neurodegenerative However, more randomized, long-term studies required assess efficacy, sustainability, safety, methodological rigor strengthen findings impacts.
Language: Английский
Citations
0Retrospective case study: ketogenic metabolic therapy in the effective management of treatment-resistant depressive symptoms in bipolar disorder
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Aug. 12, 2024
This retrospective case study assessed Ketogenic Metabolic Therapy’s (KMT) efficacy in a bipolar disorder patient with treatment-resistant depressive symptoms insufficiently controlled by weekly ketamine treatments. Monitoring included relevant biomarkers of ketone production and macronutrient levels, alongside mood evaluations through the Generalized Anxiety Disorder-7 (GAD-7), Depression Stress Scales (DASS), PTSD Checklist for DSM-5 (PCL-5), showing stabilization improved functionality. Qualitative analysis revealed sub-stantial enhancements functioning, life quality, mental well-being. enriches metabolic psychiatry literature, emphasizing KMT’s potential benefits integrating quantitative data from recognized psychiatric assessment tools qualitative insights.
Language: Английский
Citations
3Exploring diet-induced ketosis with exogenous ketone supplementation as a potential intervention in post-traumatic stress disorder: a feasibility study
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 31, 2024
Post-Traumatic Stress Disorder (PTSD) is a severe and pervasive mental disorder, patients experience numerous distressing symptoms impairments that significantly impact their lives. In addition to being PTSD strongly associated with wide range of metabolic abnormalities affect the entire body. Existing treatment options psychotherapy medications are often ineffective. Exploring other potential treatments necessitated. The ketogenic diet has shown as therapy in certain neurological disorders promising intervention PTSD.
Language: Английский
Citations
1Mitochondria at the crossroad of dysregulated inflammatory and metabolic processes in bipolar disorders
Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 123, P. 456 - 465
Published: Oct. 6, 2024
Language: Английский
Citations
0A physical perspective on lithium therapy
Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: 194, P. 55 - 74
Published: Nov. 14, 2024
Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They recently gathered attention due to their potential preventive effect viral infections. Though the therapeutic of lithium was documented by Cade late 1940s, its underlying mechanism action is still disputed. Acute exposure has an activating on excitable organic tissue organisms, highly toxic. associated with a metabolic response organism, large changes phospholipid cholesterol expression. Opposite acute exposure, this alleviates excessive cellular activity. The presence ions strongly affects lipid conformation membrane phase unlike other alkali ions, consequences for permeability, buffer property excitability. This review investigates how affect composition function, might fact be body's attempt counteract physical at cell level. Ideas further research microbiology drug development are discussed.
Language: Английский
Citations
0Does keto make the difference? A comprehensive review of its impact on physical activity, cognitive function and hormonal balance.
Quality in Sport, Journal Year: 2024, Volume and Issue: 34, P. 56223 - 56223
Published: Nov. 23, 2024
Introduction: The ketogenic diet, characterized by high fat and low carbohydrate intake, has become increasingly popular among athletes fitness enthusiasts due to its potential for supporting weight loss enhancing metabolic health. This study aims analyze the impact of keto diet on physical cognitive performance, as well understand mechanisms challenges associated with use. Materials methods: A systematic review available studies was conducted through extensive searches in databases such PubMed, NCBI, Google Scholar. State knowledge: can be beneficial endurance sports improving utilization an energy source increasing stability, but aerobic capacity time exhaustion varies. In strength that require intense effort, restriction negatively affect muscle mass development, glycogen is a key activities. does not provide full benefits high-intensity sports, sprints or team limited availability. improve body composition efficiency athletes, performance depends individual responses, adaptation process may involve "keto flu." Ketogenic positively mental health reducing symptoms anxiety depression. Additionally, it enhance sleep quality, particularly deep sleep, potentially increase testosterone production. Conclusions: benefit oxidation sustaining levels, though effectiveness high-intensity, glycogen-dependent activities less certain. Strategies like TKD CKD, along monitoring, help optimize results.
Language: Английский
Citations
0Bipolar Disorder, Diet, and Nutrition
Published: Jan. 1, 2024
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