Dissecting the rising tide of inflammatory bowel disease among youth in a changing world: insights from GBD 2021 DOI Creative Commons
He Zhang, Yang Xu,

Feiyan Ai

и другие.

International Journal of Colorectal Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Фев. 18, 2025

This study investigates the alarming epidemiological trends of inflammatory bowel disease (IBD) among children and young adults, highlighting associated burden on global health. Utilizing data from Global Burden Disease (GBD) 2021, we conducted a comprehensive analysis age-standardized incidence rates (ASIR), mortality (ASMR), disability-adjusted life years (DALYs), estimated annual percentage changes (EAPC). Future were forecasted using Bayesian age-period-cohort model. From 1990 to IBD DALY remained persistently high, with concerning upward trend noted adults. While men experienced decline in rates, women faced increasing burdens. In high-income regions, particularly North America, reported highest contrasting sharply Central Latin which exhibited lowest ASIR. Southeast Asia presented most favorable rates. A notable negative correlation was identified between socio-demographic index (SDI) at national level, high high-middle SDI countries continuing bear substantial burden, while low middle nations rising challenges. The persistent adults signifies critical public health concern. marked geographical gender disparities underscore urgent need for tailored regional population-based strategies aimed primary prevention effective management. illuminates pressing necessity policy interventions address growing epidemic vulnerable populations.

Язык: Английский

Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study DOI Creative Commons
Xuejie Chen,

Xin Xiang,

Weitong Xia

и другие.

Journal of Epidemiology and Global Health, Год журнала: 2023, Номер 13(4), С. 725 - 739

Опубликована: Сен. 1, 2023

Asia's inflammatory bowel disease (IBD) burden has rapidly increased recently, but the epidemiological trends in Asia remain unclear. We report IBD's incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) 52 Asian countries from 1990 to 2019.Data Global Burden of Disease 2019 were analyzed for IBD across countries, using metrics like mortality rates, DALY. The trend was assessed with Joinpoint APC methods. Decomposition frontier analyses examined factors behind case death changes. NORPRED forecasted morbidity 2044.From 2019, incidence prevalence Asia, while DALY decreased. East had highest increase burden. among 30-34 age group, peaking 45-49 group. In high-income regions, peak shifted younger groups. Decompose analysis showed population growth as primary factor increasing cases Asia. NORDPRED model predicted a continued over next 25 years.Between ASIR ASPR increased, ASMR ASDR Due aging, is expected rise years, particularly

Язык: Английский

Процитировано

29
Global epidemiology of alcohol‐associated liver disease in adolescents and young adults DOI
Pojsakorn Danpanichkul, Vincent Chen,

Primrose Tothanarungroj

и другие.

Alimentary Pharmacology & Therapeutics, Год журнала: 2024, Номер 60(3), С. 378 - 388

Опубликована: Июнь 3, 2024

Summary Background and Aims The objective of the study was to analyse prevalence, incidence, death alcohol‐associated liver disease (ALD) among adolescents young adults globally, continentally, nationally, focusing on trends over time. Methods analysed data from Global Burden Disease (GBD) between 2000 2019. It examined ALD's in aged 15–29, segmented by region, nation, sociodemographic index. analysis utilised Joinpoint regression modelling calculate annual per cent change (APC) rate these parameters Results In 2019, there were 281,450 ALD prevalences, 18,930 incidences, 3190 deaths globally. From age‐adjusted prevalence 100,000 increased 25–29 age group (APC: +0.6%, p = 0.003), remained stable ages 20–24 ( 0.302) 15–19 0.160). Prevalence significantly (19‐fold increase) (2.5‐fold increase). rates all groups Africa Eastern Mediterranean region. Around three‐quarters countries territories experienced an increase incidence adults. Conclusion Over two decades, burden has emphasises importance public health policies aimed at reducing alcohol consumption preventing younger populations.

Язык: Английский

Процитировано

16
Global, regional, and national burden of inflammatory bowel disease, 1990–2021: Insights from the global burden of disease 2021 DOI Creative Commons

Dao-po Lin,

Jin Yang, Xiaoxiao Shao

и другие.

International Journal of Colorectal Disease, Год журнала: 2024, Номер 39(1)

Опубликована: Сен. 7, 2024

Язык: Английский

Процитировано

15
The global burden of otitis media in 204 countries and territories from 1992 to 2021: a systematic analysis for the Global Burden of Disease study 2021 DOI Creative Commons
Guan‐Jiang Huang, Bao-Rui Lin, Pei-Shan Li

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 12

Опубликована: Янв. 21, 2025

Objectives This study aims to analyze the global burden of otitis media and predict future trends using data from Global Burden Disease 2021 (GBD 2021). Study design A cross-sectional analysis GBD results was conducted. Methods Age-standardized incidence rates (ASIR), age-standardized prevalence (ASPR), disability-adjusted life years (DALYs) (ASDR) were calculated. Trend conducted estimated annual percentage change (EAPC), Joinpoint regression, age-period-cohort, decomposition analyses. Future projections generated Bayesian age-period-cohort (BAPC) auto-regressive integrated moving average (ARIMA) models. Results The rose 322.1 million cases in 1992 391.3 2021, with ASIR increasing slightly 5345.09 5529.1 per 100,000 (EAPC: 0.11%). Despite this increase, ASPR decreased 1786.56 1593.74 -0.43%). DALYs increased 2.16 2.48 million; however, ASDR declined 37.68 32.54 −0.51%). Notably, low low-middle SDI regions showed significant disparities, higher ASIRs (up 5315.08 for males) but declining ASPR. Regionally, East Asia exhibited most substantial decline (−1.14%) (−1.22%), while Central Sub-Saharan Africa demonstrated stable ASDR. indicate a rising through 2036. Conclusion shows regional rate. Public health interventions have been effective regions, targeted efforts are needed further reduce media.

Язык: Английский

Процитировано

1
Landscape and predictions of inflammatory bowel disease in China: China will enter the Compounding Prevalence stage around 2030 DOI Creative Commons
Bule Shao, Wenjing Yang, Qian Cao

и другие.

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Окт. 25, 2022

This study aims to explore the epidemiological trends of inflammatory bowel disease (IBD) over past three decades in China and further predict IBD next 25 years.The prevalence, incidence, mortality, years life lived with disability (YLDs), lost (YLLs), disability-adjusted (DALYs), annual percentage changes above metrics from 1990 2019 were extracted Global Burden Disease Study 2019. The corresponding predicted.From 2019, cases raised 484 thousand [95% uncertainty interval (UI) 411-571] 427 (366-498) among males females, respectively. age-standardized incidence rate increased 1.72 per 100,000 population (1.44-2.05) 3.35 (2.88-3.88) 1.20 (1.02-1.42) 2.65 (2.29-3.08) females. highest occurred people aged 35-39 years. total YLDs attributed significantly increased, but YLLs showed a decreasing trend, resulting minor alterations DALYs. In years, would continue increase until plateau by 2030, IBD-related deaths also about 7.57 2044 despite mortality rate. Similar observed for both sexes, slight male predominance.Although is still low-endemic area IBD, prevalence dramatically decades. burden expected grow continuously due large base severe aging problem. estimated enter Compounding Prevalence stage around 2030.

Язык: Английский

Процитировано

25
Grape Processing Waste: Effects on Inflammatory Bowel Disease and Colorectal Cancer DOI Creative Commons
Lucas Fornari Laurindo, Rosa Direito,

Alda Maria Machado Bueno Otoboni

и другие.

Food Reviews International, Год журнала: 2023, Номер 40(1), С. 336 - 369

Опубликована: Фев. 8, 2023

Inflammatory Bowel Diseases (IBD) are inflammatory conditions characterized by bowel disruption and the involvement of immune system can be associated with development colorectal cancer. Conventional therapeutic approaches based on administering drugs capable modulating response; however, many patients irresponsive to conventional therapies. Grapes largely used in producing wine, juice, jam, other products. However, waste from production process represents an environmental problem. On hand, grape by-products rich bioactive compounds such as proanthocyanidins, anthocyanins, phenolic acids, stilbenes, flavonols. These help prevention or treatment several IBD Grape promote remarkable effects reducing pro-inflammatory, pro-oxidative, proliferative actions CRC both vivo vitro. related improvement epithelial integrity, reduction Disease Activity Index, mucosal barrier reinforcement, induction strong chemopreventive actions, tumor incidence, cell proliferation.

Язык: Английский

Процитировано

12
Potent Intestinal Mucosal Barrier Enhancement of Nostoc commune Vaucher Polysaccharide Supplementation Ameliorates Acute Ulcerative Colitis in Mice Mediated by Gut Microbiota DOI Open Access
Min Guo,

Dehai Xing,

Jin Wang

и другие.

Nutrients, Год журнала: 2023, Номер 15(13), С. 3054 - 3054

Опубликована: Июль 6, 2023

Ulcerative colitis (UC) is evolving into a global burden with substantially increasing incidence in developing countries. It characterized by inflammation confined to mucosa and recognized as an intestinal barrier disease. The microbiota plays crucial role UC pathogenesis. N. commune has long been appreciated healthy food supplement worldwide polysaccharides account for 60%. Here, we examined the amelioration of against acute mice induced DSS assessed mediating gut microbiota. An integrated analysis microbiome, metabolomics, transcriptomics fully elaborated it markedly enhanced mucosal function, including: relative abundance Akkermansia muciniphila, uncultured_bacterium_g__norank_f__Muribaculaceae, unclassified_g__norank_f__norank_o__Clostridia_UCG-014; decreasing microbiota-derived phosphatidylcholines thromboxane 2 levels mapped arachidonic acid metabolism; improving mucin2 biosynthesis secretion; enhancing ZO-1 occludin expression; reducing neutrophil infiltration; regulating level colitis-related inflammatory cytokines; involving immune function-associated signaling pathways. Further, mediation effect was evaluated administering cocktail antibiotics. In conclusion, our results demonstrated that predominantly reinforced microbiota-mediated confer protection exhibited dramatic prebiotic-like functions, providing alternative or complementary treatment UC.

Язык: Английский

Процитировано

12
Time trends in the burden of autoimmune diseases across the BRICS: an age–period–cohort analysis for the GBD 2019 DOI Creative Commons
Fenghao Zhang, yiran cui,

Xiao Gao

и другие.

RMD Open, Год журнала: 2023, Номер 9(4), С. e003650 - e003650

Опубликована: Дек. 1, 2023

This study aims to evaluate the long-term trend of prevalence and DALY (disability-adjusted life-year) rate on age, period cohort (APC) BRICS (Brazil, Russia, India, China South Africa) country for autoimmune diseases (rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) psoriasis).The data are sourced from Global Burden Disease Study 2019, it uses Joinpoint regression model estimate time trends 1990 2019. Additionally, employs Age-Period-Cohort period, effects 2019.For ASPR (age-standardised rate) IBD increased significantly Africa, decreased Brazil, Russian. The Russian MS demonstrated a decreasing (average annual percent change=-0.5%, 95% CI -0.6 -0.5), with most occurring in Brazil at 2009-2014. effect rates Psoriasis displayed an ongoing 1929-1933 birth 1999-2003 cohort. Specifically, five countries relative risk values (RRs) DALYs due RA by 7.98, 16.07, 5.98, 3.19, 9.13 times, 20 24 age group 65 69 group.The population accounts more than 40% global population. And we found that various is heavily influenced ageing.

Язык: Английский

Процитировано

10
Therapeutic Implications of Phenolic Acids for Ameliorating Inflammatory Bowel Disease DOI Open Access

Yanan Lu,

Xue Han

Nutrients, Год журнала: 2024, Номер 16(9), С. 1347 - 1347

Опубликована: Апрель 29, 2024

Inflammatory bowel disease (IBD) is a chronic inflammatory intestinal disorder, and its complex etiology makes prevention treatment challenging. Research on new drugs strategies currently focal point. Phenolic acids are widely present in plant-based diets have demonstrated the potential to alleviate colitis due their powerful antioxidant anti-inflammatory properties. In this review, we provide an overview of structures main dietary sources phenolic acids, encompassing benzoic acid cinnamic acid. Additionally, explore as nutritional therapy for preventing treating IBD. animal cell experiments, effectively IBD induced by drug exposure or genetic defects. The mechanisms include improving mucosal barrier function, reducing oxidative stress, inhibiting excessive activation immune response, regulating balance microbiota. Our observation points towards need additional basic clinical investigations derivatives novel therapeutic agents

Язык: Английский

Процитировано

4
The Effect of Protein Nutritional Support on Inflammatory Bowel Disease and Its Potential Mechanisms DOI Open Access
Qingye Li, Jing Wang

Nutrients, Год журнала: 2024, Номер 16(14), С. 2302 - 2302

Опубликована: Июль 17, 2024

Inflammatory bowel disease (IBD), a complex chronic inflammatory disorder that includes Crohn’s (CD) and Ulcerative Colitis (UC), has become globally increasing health concern. Nutrition, as an important factor influencing the occurrence development of IBD, attracted more attention. As most nutrient, protein can not only provide energy nutrition required by patients, but also help repair damaged intestinal tissue, enhance immunity, thus alleviate inflammation. Numerous studies have shown nutritional support plays significant role in treatment remission IBD. This article presents comprehensive review pathogenesis IBD analyzes summarizes potential mechanisms Additionally, it provides overview clinical effects its impact on complications. Research findings reveal demonstrates benefits improving symptoms, reducing risk complications, quality life patients. Therefore, is expected to new approach for

Язык: Английский

Процитировано

4