Risk and Severity of COVID-19 Infection in Monoclonal Gammopathy of Undetermined Significance: A 3-Year Propensity Matched Cohort Study DOI Creative Commons
Omer S. Ashruf, Zara Orozco, David C. Kaelber

et al.

Clinical Lymphoma Myeloma & Leukemia, Journal Year: 2023, Volume and Issue: 23(8), P. 626 - 632

Published: April 28, 2023

IntroductionMonoclonal gammopathy of undetermined significance (MGUS) is a premalignant disorder causing monoclonal plasma cell proliferation in bone marrow. This population at risk developing multiple myeloma (MM) and severe viral infections; factors COVID-19 infection. Using TriNetX, global platform providing data 120 million patients, we aimed to quantify the severity MGUS patients.Patients MethodsA retrospective cohort analysis was performed using TriNetX Global Collaborative Network. From January 20, 2020, 2023, identified 58,859 patients compared non-MGUS determined by relevant diagnosis/LOINC test codes. After 1:1 propensity score-matching, cases identify who had been hospitalized, ventilated/intubated, deceased severity. Measures association Kaplan-Meier were conducted.ResultsAfter propensity-score matching, there 58,668 both cohorts. found be reduced contracting (RR 0.88, 95% CI 0.85-0.91). with showed higher mortality decreased survival time general (HR 1.14, 1.01-1.27). hospitalized exhibited significantly (log-rank test, P = 0.04).ConclusionAs remains looming health concern, especially amongst vulnerable populations, our emphasizes need for adequate vaccination treatment regimens as well an understanding infection justification precautionary measures.

Language: Английский

Periodic Characteristics of Hepatitis Virus Infections From 2013 to 2020 and Their Association With Meteorological Factors in Guangdong, China: Surveillance Study DOI Creative Commons
Xixi Zhao, Meijia Li, Naem Haihambo

et al.

JMIR Public Health and Surveillance, Journal Year: 2023, Volume and Issue: 9, P. e45199 - e45199

Published: June 15, 2023

In the past few decades, liver disease has gradually become one of major causes death and illness worldwide. Hepatitis is most common diseases in China. There have been intermittent epidemic outbreaks hepatitis worldwide, with a tendency toward cyclical recurrences. This periodicity poses challenges to prevention control.In this study, we aimed investigate relationship between periodic characteristics local meteorological elements Guangdong, China, which representative province largest population gross domestic product China.Time series data sets from January 2013 December 2020 for 4 notifiable infectious caused by viruses (ie, A, B, C, E viruses) monthly temperature, precipitation, humidity) were used study. Power spectrum analysis was conducted on time data, correlation regression analyses performed assess epidemics elements.The showed clear phenomena 8-year set connection elements. Based analysis, temperature demonstrated strongest C epidemics, while humidity significantly associated epidemic. Regression revealed positive significant coefficient had strong association epidemic, its relatively weak.These findings provide better understanding mechanisms underlying different their factors. can help guide governments predicting preparing future based weather patterns potentially aid development effective measures policies.

Language: Английский

Citations

13
Analysing monkeypox epidemic drivers: Policy simulation and multi-index modelling across 39 nations DOI Creative Commons
Mengxuan Lin,

Yingrong Xin,

Jiaojiao Wang

et al.

Journal of Global Health, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 9, 2024

Abstract Background This study aimed to analyse the drivers of monkeypox (Mpox) epidemic and policy simulation support health care policies against Mpox epidemic. Methods We established a three-round selection mechanism for 164 factors using Lasso negative binomial regression investigate correlation between significant cumulative confirmed cases Mpox. Policy each driver was evaluated, varying effects implementation at different times were examined. Results HIV/AIDS prevalence air transport passengers carried determinants risk across various countries, with coefficients 1.417 0.766, respectively. A decrease in by 10, 20, 30, 40% corresponded reductions number 6.28, 6.55, 6.87, 7.26%, Similarly, 40, 60, 80% travel restrictions led 7.16, 15.63, 26.28%, 41.46%, Controlling first month could postpone outbreak onset 0.5–2.0 months. Conclusions prevention control should primarily focus on during high disease-risk periods flight suspensions from high-risk nations combination regular treatment strategies.

Language: Английский

Citations

4
Anticipating the transmissibility of the 2022 mpox outbreak DOI Open Access

Tuoyu Liu,

Shan Yang,

Boyu Luo

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(3)

Published: March 1, 2023

Abstract An ongoing outbreak of monkeypox virus (MPXV) was first reported in the United Kingdom on 6 May 2022. As 17 November, there had been a total 80 221 confirmed MPXV cases over 110 countries. Based data between and 30 June 2022 Kingdom, Spain, Germany, we applied deep learning approach using convolutional neural networks to evaluate parameters outbreak. The basic reproduction number ( R 0 ) estimated be 2.32 which indicates active diffusion since beginning from Spain Germany produced higher median values 2.42 2.88, respectively. Importantly, three countries tends previously calculated smallpox (3.50 6.00). Furthermore, incubation (1/ε) infectious (1/γ) period predicted 9 10 days 4−5 days, value derived is consistent with significantly increasing cases, indicating risk rapid spread worldwide, would provide important insights for prevention control epidemic.

Language: Английский

Citations

9
Temporal dynamic effects of meteorological factors and air quality on the physical health of the older adults in Shenzhen, China DOI Creative Commons
Shuai Jiang, Chuanliang Han,

Yue Ma

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 6, 2024

Introduction Meteorological and environmental factors can affect people’s lives health, which is crucial among the older adults. However, it currently unclear how they specifically physical condition of adults people. Methods We collected analyzed basic examination indicators 41 people for two consecutive years (2021 2022), correlated them with meteorological factors. Partial correlation was also conducted to exclude unrelated as well. Results found that years, five (HB, WBC, HbAlc, CB, LDL-C) showed significant differences across population, had significantly different dynamic patterns six (air pressure, temperature, humidity, precipitation, wind speed, sunshine duration) seven air quality (NO2, SO2, PM10, O3-1h, O3-8h, CO, PM2.5). Discussion Our study has discovered first time between in normal examinations indicators, will provide guidance future development policies care healthy life

Language: Английский

Citations

1
Risk and Severity of COVID-19 Infection in Monoclonal Gammopathy of Undetermined Significance: A 3-Year Propensity Matched Cohort Study DOI Creative Commons
Omer S. Ashruf, Zara Orozco, David C. Kaelber

et al.

Clinical Lymphoma Myeloma & Leukemia, Journal Year: 2023, Volume and Issue: 23(8), P. 626 - 632

Published: April 28, 2023

IntroductionMonoclonal gammopathy of undetermined significance (MGUS) is a premalignant disorder causing monoclonal plasma cell proliferation in bone marrow. This population at risk developing multiple myeloma (MM) and severe viral infections; factors COVID-19 infection. Using TriNetX, global platform providing data 120 million patients, we aimed to quantify the severity MGUS patients.Patients MethodsA retrospective cohort analysis was performed using TriNetX Global Collaborative Network. From January 20, 2020, 2023, identified 58,859 patients compared non-MGUS determined by relevant diagnosis/LOINC test codes. After 1:1 propensity score-matching, cases identify who had been hospitalized, ventilated/intubated, deceased severity. Measures association Kaplan-Meier were conducted.ResultsAfter propensity-score matching, there 58,668 both cohorts. found be reduced contracting (RR 0.88, 95% CI 0.85-0.91). with showed higher mortality decreased survival time general (HR 1.14, 1.01-1.27). hospitalized exhibited significantly (log-rank test, P = 0.04).ConclusionAs remains looming health concern, especially amongst vulnerable populations, our emphasizes need for adequate vaccination treatment regimens as well an understanding infection justification precautionary measures.

Language: Английский

Citations

2