The impact of the mRNA COVID-19 vaccine on the Th-like cytokine profile in individuals with no history of COVID-19: insights into autoimmunity targeting heat shock proteins
Stefan Tukaj,
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Magdalena Sitna,
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Krzysztof Sitko
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et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 14, 2025
Although
some
reports
suggest
that
COVID-19
vaccination
may
exacerbate
existing
autoimmune
diseases
or
trigger
new-onset
cases,
a
definitive
causal
relationship
between
the
vaccines
and
these
conditions
has
not
been
established.
Several
potential
mechanisms
have
proposed
to
explain
this
association,
including:
(i)
molecular
mimicry,
which
refers
structural
similarity
SARS-CoV-2
human
antigens;
(ii)
bystander
activation,
involving
both
B
T
lymphocytes;
(iii)
effects
of
adjuvants.
In
study,
we
investigated
whether
two
doses
mRNA
vaccine
influenced
blood
cytokine
levels
associated
with
major
helper
cell
populations,
are
known
play
significant
role
in
autoimmunity
revisited
humoral
response
directed
against
heat
shock
proteins
(Hsps)
individuals
no
history
COVID-19.
While
differences
were
found
IFN-γ,
IL-6,
IL-22,
IL-4,
IL-8,
IL-10,
IL-17A,
vaccinated
unvaccinated
people,
several
positive
correlations
observed
serum
circulating
autoantibodies
self-Hsps
exclusively
individuals.
These
findings
does
impact
cytokines
involved
pathogenesis
diseases.
Further
research
is
required
evaluate
safety
patients
conditions,
particularly
those
whom
anti-Hsps
suspected
contribute
disease
development.
Language: Английский
Ocular Manifestations of COVID-19
Progress in Retinal and Eye Research,
Journal Year:
2024,
Volume and Issue:
102, P. 101285 - 101285
Published: June 24, 2024
There
is
an
increasing
body
of
knowledge
regarding
how
COVID-19
may
be
associated
with
ocular
disease
varying
severity
and
duration.
This
article
discusses
the
literature
on
manifestations
COVID-19,
including
appraisal
current
evidence,
suggested
mechanisms
action,
comorbidities
risk
factors,
timing
from
initial
infection
to
diagnosis
clinical
red
flags.
The
primarily
comprises
case
reports
series
which
inevitably
lack
control
groups
evidence
support
causality.
However,
these
early
data
have
prompted
development
larger
population-based
laboratory
studies
that
are
emerging.
As
new
become
available,
a
better
true
effects
eye
will
possible.
While
pandemic
was
officially
declared
no
longer
"global
health
emergency"
by
World
Health
Organization
(WHO)
in
May
2023,
numbers
continue
rise.
Reinfection
different
variants
predicted
lead
growing
cumulative
burden
disease,
particularly
as
more
chronic,
multi-organ
sequelae
apparent
potentially
significant
implications.
postulated
due
three
main
mechanisms:
firstly,
there
dysregulated
immune
response
linked
inflammatory
disease;
secondly,
patients
greater
tendency
towards
hypercoagulable
state,
leading
prothrombotic
events;
thirdly,
severe
requiring
hospitalisation
immunosuppressed
administered
corticosteroids
or
such
diabetes
mellitus
at
increased
secondary
infections,
endophthalmitis
rhino-orbital-mucormycosis.
Reported
ophthalmic
associations
therefore,
include
range
conditions
conjunctivitis,
scleritis,
uveitis,
endogenous
endophthalmitis,
corneal
graft
rejection,
retinal
artery
vein
occlusion,
non-arteritic
ischaemic
optic
neuropathy,
glaucoma,
neurological
orbital
sequelae.
With
need
consider
telemedicine
consultation
view
COVID-19's
infectivity,
understanding
present
during
following
essential
ensure
appropriately
triaged,
prompt
in-person
examination
for
management
sight-threatening
life-threatening
diseases.
Language: Английский
Soluble form of immune checkpoints in autoimmune diseases
利正 浅原,
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Yuxia Wang,
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Xuxia Shen
No information about this author
et al.
Journal of Autoimmunity,
Journal Year:
2024,
Volume and Issue:
147, P. 103278 - 103278
Published: June 28, 2024
Language: Английский
A Novel Association Between Human Papillomavirus and Thyroid Eye Disease
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 30, 2024
ABSTRACT
Context
Thyroid
eye
disease
(TED)
is
an
autoimmune
characterized
by
orbital
inflammation
and
tissue
remodeling.
TED
pathogenesis
poorly
understood
but
linked
to
autoantibodies
thyroid-stimulating
hormone
receptor
(TSHR)
insulin-like
growth
factor
1
(IGF-1R).
Objective
To
explore
the
potential
involvement
of
viral
infections
in
pathogenesis.
Methods
Using
NCBI
BLAST,
we
compared
human
TSHR
IGF-1R
proteins
various
proteomes,
including
Papillomaviridae
,
Paramyxoviridae
Herpesviridae
Enterovirus
Polyomaviridae
Rhabdoviridae
.
Enzyme-linked
immunoassays
(ELISAs)
were
performed
on
adipose
samples
from
22
patients
controls
quantify
antiviral
antibody
titers.
Demographics
clinical
data
reviewed.
Results
Homology
analysis
revealed
conserved
motifs
between
with
several
proteins,
particularly
papillomavirus
18
(HPV18)
L1
capsid
protein.
Basic
demographic
information
cohorts
comparable.
ELISAs
showed
statistically
significant
differences
average
HPV18
IgG
normalized
optical
density
levels
among
tissues
control
(
M
=
0.9387,
SD
0.3548),
chronic
2.305,
1.064),
active
acute
4.087,
2.034)
patients.
These
elevated
titers
did
not
correlate
TSH,
T4,
or
TSI
levels,
irrespective
treatment
teprotumumab,
indicating
a
direct
immunological
response
HPV.
Conclusions
This
study
presents
first
molecular
evidence
linking
HPV
TED,
highlighting
mimicry
protein
key
autoimmunity
targets
TED.
suggests
link
contributing
TED’s
pathogenesis,
opening
new
avenues
for
understanding
managing
disease.
Language: Английский
Causal association between COVID-19 vaccination and thrombosis-related biomarkers/thrombosis/ischemic stroke: Mendelian randomization study
Xiaoqi Peng,
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Lang Zhuo,
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Yong Ma
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et al.
Journal of Stroke and Cerebrovascular Diseases,
Journal Year:
2024,
Volume and Issue:
34(1), P. 108113 - 108113
Published: Nov. 7, 2024
Language: Английский
The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study
Xiaoju Wan,
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Xiaobao Lai,
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Meizhen Huang
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et al.
Gynecological Endocrinology,
Journal Year:
2024,
Volume and Issue:
40(1)
Published: Dec. 23, 2024
Background
Previous
studies
on
the
impact
of
mitochondrial
DNA
(mtDNA)
copy
number
female
infertility
were
limited
and
inconsistent.
Language: Английский