Prevalence and Impact of Post-Exertional Malaise on Recovery in Adults with Post COVID-19 Condition. A Systematic Review with Meta-Analysis

Archives of Physical Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

ObjectiveTo assess the prevalence of PEM in people with PCC; and change following rehabilitation interventions PCC.Data sourcesWe searched MEDLINE, Embase, Central, CINAHL, PsychINFO Clinical Trial Registries from inception until January 12th, 2024.Study SelectionWe included observational studies that measured adults PCC interventional PCC. Two independent researchers screened titles abstracts. Any discrepancies underwent full text review. articles at level. were resolved by consensus.Data ExtractionTwo extracted data eligible studies. We point-prevalence cross-sectional studies; period-prevalence longitudinal reviewers assessed risk bias (ROB). Discrepancies a senior research team member. For we used Cochrane Risk Of Bias In Non-randomized Studies - Exposure (ROBINS-E) tool. randomised controlled trials tool II – (RoB2). non-randomised Non-Randomized Interventions (ROBINS-I)1 to applied Grades Recommendation, Assessment, Development, Evaluation (GRADE) approach grade quality evidenceData SynthesisWe performed single-arm proportional meta-analysis synthesize estimates using logit transformation. conducted sensitivity analysis multilevel-mixed-effects logistic regression. This study is registered PROSPERO (CRD42024516682).The community-dwelling living was 36% (95% CI: 0.19 0.57; 2,263 participants). (61 patients) found decrease frequency intensity episodes tailored program centered on integrating pacing approaches. None reported an increase symptoms' individually therapeutic exercise component (5 892 patients).ConclusionsOur confirms there large burden PCC, highlighting critical challenge for healthcare systems urgent need more inclusive rigorous research, offer safe effective solutions meet variable needs experience PEM.There subgroup patients do not PEM; limited evidence supervised, tailored, symptom-titrated active components may trigger this Our results are insufficient reporting percentage baseline before enrolling programs, number non-validated, unstandardized tools measure hence strengthen methods future

Language: Английский

---

Cognitive-behavioral therapy for patients with post-COVID-19 condition (CBT-PCC): a feasibility trial

Psychological Medicine, Journal Year: 2023, Volume and Issue: 54(6), P. 1122 - 1132

Published: Oct. 16, 2023

Abstract Background The post-COVID-19 condition describes the persistence or onset of somatic symptoms (e.g. fatigue) after acute COVID-19. Based on an existing cognitive-behavioral treatment protocol, we developed a specialized group intervention for individuals with condition. present study examines feasibility, acceptance, and effectiveness program inpatients in neurological rehabilitation setting. Methods comprises eight sessions includes psychoeducational experience-based interventions common psychophysiological mechanisms persistent symptoms. A feasibility trial was conducted using one-group design naturalistic N = 64 history mild COVID-19 that fulfilled WHO criteria were enrolled. After each session, evaluation forms completed psychometric questionnaires psychopathological symptom burden collected pre- post-intervention. Results well received by participants therapists. Each session rated as comprehensible overall satisfaction high. Pre-post effect sizes (of standard incl. new program; intention-to-treat) showed significantly reduced subjective fatigue ( p < 0.05, d av 0.33) improved disease coping ps 0.33–0.49). Conclusions Our results support acceptance newly Yet, findings have to be interpreted cautiously due lack control follow-up measurement, small sample size, relatively high drop-out rate.

Language: Английский

---

Psychotherapy in patients with long/post-COVID – A systematic review on the feasibility, acceptability, safety, and efficacy of available and emerging interventions

Journal of Psychosomatic Research, Journal Year: 2025, Volume and Issue: 190, P. 112048 - 112048

Published: Feb. 8, 2025

Language: Английский

---

Rehabilitation beim Long-/Post-COVID-Syndrom: ein bewegungstherapeutisches Handlungskonzept

B&G Bewegungstherapie und Gesundheitssport, Journal Year: 2025, Volume and Issue: 41(01), P. 14 - 29

Published: Feb. 1, 2025

Zusammenfassung Dank flächendeckender Impfungen konnten die COVID-19-bedingte Letalität und Hospitalisierungsrate substanziell reduziert werden. Dennoch sind Langzeitfolgen der COVID-19-Infektionen damit nicht beseitigt. Etwa Hälfte Betroffenen berichtet auch nach Ende Infektion von persistierenden Symptomen, dem Long-COVID- bzw. Post-COVID-Syndrom (LCS/PCS). Zwar können einige Kardinalsymptome des LCS/PCS ausgemacht werden, aber keineswegs alle leiden unter diesen. Auch ansonsten bleibt das Krankheitsbild sehr heterogen kann in Extremfällen einer schweren, Myalgischen Enzephalomyelitis (Chronisches Fatigue-Syndrom) vergleichbaren Symptomatik münden. ihrer vielseitigen Wirkungen Wirkmechanismen stellt Bewegungstherapie eine sinnvolle Maßnahme dar, dieses heterogene zu adressieren. Hier ist jedoch kein Vorgehen „Schema F“, sondern ein differenzierter, hoch individualisierter Ansatz verfolgen.

---

Work ability and return-to-work of patients with post-COVID-19: a systematic review and meta-analysis

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 7, 2024

Abstract Background In addition to several sequelae of post-COVID-19, individuals also experience significant limitations in work ability, resulting negative consequences for the return-to-work (RTW) process. This systematic review and meta-analysis were conducted assess impact post-COVID-19 on ability RTW previously infected with SARS-CoV-2. Methods Studies patients (more than 12 weeks after an acute SARS-CoV-2 infection) regarded eligible inclusion. Systematic search literature was performed up March 2023 using five databases (MEDLINE, EMBASE, CINAHL, CENTRAL WHO COVID 19). Study selection followed Preferred Reporting Items Review Meta-analysis (PRISMA) Statement. A estimated overall success rate RTW. The risk bias included studies evaluated Newcastle Ottawa Scale (NOS). Results 19 relevant studies, published between 2021 2023, review, involving 21.155 from 14 different countries. findings indicate that a proportion persistent symptoms functional impairments, fatigue being most prominent symptom. These can have considerable (negative) individuals’ physical psychological capacity participate work-related activities, leading lower increased absenteeism. is complex, approximately 60.9% successfully returning or more following infection. Among those who work, number need modifications their duties hours cope residual impairments. Factors such as workplace accommodations, supportive policies, occupational rehabilitation programs play crucial role facilitating successful Conclusions underscores substantial outcomes. implications this research highlight healthcare providers, employers, policymakers collaborate creating inclusive environments implementing tailored support recovering post-COVID-19. Further should focus long-term follow-up mixed methods gain comprehensive understanding PROSPERO registration CRD42023385436.

Language: Английский

---

Changes in fatigue symptoms following an exercise-based rehabilitation programme for patients with long COVID

ERJ Open Research, Journal Year: 2024, Volume and Issue: 10(4), P. 00089 - 2024

Published: May 9, 2024

Background There is evidence to support COVID-19 rehabilitation programmes improving persistent symptoms; however, there concern that therapies include an exercise component may increase fatigue and post-exertional symptom exacerbation (PESE). The objectives of the present study were determine effect a 6-week programme on PESE in individuals with ongoing symptoms. Methods After routine medical assessment, symptoms enrolled specific programme. included symptom-titrated exercise, education self-management advice. Fatigue was assessed pre- post-programme using Functional Assessment Chronic Illness Therapy questionnaire (FACIT). Exercise capacity (Incremental Endurance Shuttle Walking Test (ISWT ESWT)) (DePaul Symptom Questionnaire (DSQ)) also post-programme. Composite scores calculated for frequency severity domains DSQ. Results 148 patients (median (IQR) age 59 (49–72) years, 82 (55%) female, 81 (54%) hospitalised) completed FACIT score reduced by mean (CI) change −5 (−7– −4); p<0.01. increased (65–99) m ISWT 398 (333–462) s ESWT (n=148). 44 patients. DSQ composite improved 20 (13–28) 19 (13–26) points, respectively (p<0.01, n=44). Conclusion These data demonstrate potential benefits fatigue, those

Language: Английский

---

Attention deficits and depressive symptoms improve differentially after rehabilitation of post-COVID condition – A prospective cohort study

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 175, P. 111540 - 111540

Published: Oct. 27, 2023

Language: Английский

---

S1 Leitlinie Long/Post-COVID-Syndrom

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: June 17, 2024

---

Chronic pain, fibromyalgia, and long COVID

Exploration of Musculoskeletal Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Chronic pain is a common problem in rheumatology. A distinction made between nociceptive and nociplastic pain. Nociceptive is, for example, mechanistically explained by persistent inflammation. Neuropathic caused nerve damage of various possible causes. In contrast, not due to tissue or lesion the somatosensory nervous system—at least with currently available techniques. Nociplastic based on an altered perception through modulation stimulus processing. The concept central sensitization, together other neurobiological psychosocial mechanisms, considered be best explanation such conditions. syndrome fibromyalgia (FM), plays major role rheumatology—both terms differential diagnosis because management inflammatory rheumatic diseases can more difficult simultaneous presence FM. During coronavirus pandemic, syndromes similarities FM were described following COVID-19 infection. There growing scientific controversy as whether so-called long COVID (LCS) separate entity just variant

Language: Английский

---

Chronische Schmerzsyndrome bei muskuloskelettalen Erkrankungen – wie verschieden sind Fibromyalgie und Long COVID? – Teil 2

Zeitschrift für Rheumatologie, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

---