Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4149 - 4149
Published: Nov. 29, 2024
The
aim
of
this
study
was
to
outline
the
relationships
between
selected
parameters
connected
with
lifestyle
and
serum
anti-Müllerian
hormone
(AMH)
levels,
i.e.,
a
marker
ovarian
reserve.
By
examining
AMH
levels
in
connection
nutrient
intake
body
composition
parameters,
aimed
provide
preliminary
background
for
further
studies
focused
on
establishing
dietary
recommendations
that
could
lead
improvements
fertility
outcomes.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 20, 2025
Integrating
machine
learning
(ML)
models
into
healthcare
systems
is
a
rapidly
evolving
field
with
the
potential
to
revolutionize
care
delivery.
This
study
aimed
classify
fertility
rates
and
identify
significant
predictors
using
ML
among
reproductive
women
in
Ethiopia.
utilized
eight
5864
reproductive-age
Ethiopian
Demographic
Health
Survey
(EDHS),
2019
data.
Phyton
programming
language
was
used
develop
these
models.
Predictors
of
rate
were
determined
feature
important
techniques.
The
performance
evaluated
accuracy,
area
under
curve
(AUC),
precision,
recall,
F1-score,
specificity,
sensitivity.
mean
age
participants
32.7
(±
5.6)
years.
random
forest
classifier
(accuracy
=
0.901
AUC
0.961)
followed
by
one-dimensional
convolutional
neural
network
0.899
0.958),
logistic
regression
0.874
0.937),
gradient
boost
0.851
0.927)
top
performing
Family
size,
age,
occupation,
education
an
average
importance
score
0.198,
0.151,
0.118,
0.081,
respectively
rate.
best
predict
forest,
network,
regression,
classifier.
findings
on
factors
can
inform
targeted
public
health,
programs
that
address
disparities
related
family
education,
other
socioeconomic
factors.
DNA and Cell Biology,
Journal Year:
2025,
Volume and Issue:
44(4), P. 174 - 185
Published: April 1, 2025
Bisphenol
A
(BPA)
is
the
most
common
endocrine
disruptor
that
has
toxicity
to
reproductive
system
and
male
infertility.
However,
underlying
mechanisms
of
BPA's
Sertoli
cells
remain
poorly
understood.
Cellular
communication
network
factor
5
(CCN5)
reported
regulate
cell
proliferation,
apoptosis,
differentiation.
Our
study
demonstrated
a
significant
elevation
CCN5
expression
in
testis
nonobstructive
azoospermia
patients
TM4
exposed
BPA.
Knockdown
reduced
apoptotic
after
BPA
treatment,
as
determined
by
flow
cytometry
terminal
deoxynucleotidyl
transferase
dUTP
nick
end
labeling
assays.
Cells
showed
increased
expressions
Bax
cleaved
poly(ADP-ribose)
polymerase,
decreased
Bcl-2,
well
elevated
activities
caspase-3
caspase-9
BPA-induced
cells,
which
were
reversed
inhibition.
Loss
declined
phosphorylation
protein
kinase
R-like
endoplasmic
reticulum
eukaryotic
translation
initiation
2A
activating
transcription
4
C/EBP-homologous
BPA-treated
cells.
Furthermore,
silencing
blocked
p38
c-Jun
N-terminal
(JNK).
Administration
anisomycin,
mitogen-activated
(MAPK)
activator,
effects
knockdown
on
(ER)
stress
apoptosis.
Taken
together,
promotes
apoptosis
ER
p38/JNK
MAPK
signaling
pathway.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 570 - 570
Published: May 9, 2025
Male-factor
infertility
accounts
for
nearly
half
of
all
cases,
and
mounting
evidence
points
to
oxidative
stress
as
a
pivotal
driver
sperm
dysfunction,
genetic
instability,
epigenetic
dysregulation.
In
particular,
the
DNA
lesion
8-hydroxy-2′-deoxyguanosine
(8-OHdG)
has
emerged
central
mediator
at
interface
damage
regulation.
We
discuss
how
this
can
disrupt
key
mechanisms
such
methylation,
histone
modifications,
small
non-coding
RNAs,
thereby
influencing
fertilization
outcomes,
embryo
development,
offspring
health.
propose
that
interplay
between
reprogramming
is
further
exacerbated
by
aging
in
both
paternal
maternal
germlines,
creating
“perfect
storm”
increases
risk
heritable
(epi)mutations.
The
consequences
unresolved
lesions
thus
persist
beyond
fertilization,
contributing
transgenerational
health
risks.
Finally,
we
explore
promise
potential
pitfalls
antioxidant
therapy
strategy
mitigate
damage.
While
supplementation
may
hold
significant
therapeutic
value
men
with
subfertility
experiencing
elevated
stress,
careful,
personalized
approach
essential
avoid
reductive
unintended
disruptions.
Recognizing
dual
role
shaping
genome
epigenome
underscores
need
integrating
redox
biology
into
reproductive
medicine,
aim
improving
fertility
treatments
safeguarding
future
generations.
Human Reproduction,
Journal Year:
2024,
Volume and Issue:
39(12), P. 2645 - 2654
Published: Oct. 3, 2024
This
Directions
article
examines
the
mechanisms
by
which
a
father's
age
impacts
health
and
wellbeing
of
his
children.
Such
are
significant
include
adverse
birth
outcomes,
dominant
genetic
conditions,
neuropsychiatric
disorders,
variety
congenital
developmental
defects.
As
well
as
age,
wide
environmental
lifestyle
factors
also
known
to
impact
offspring
via
changes
mediated
male
germ
line.
picture
dynamic
line
responsive
range
intrinsic
extrinsic
contrasts
with
results
trio
studies
indicating
that
incidence
mutations
in
is
low
exhibits
linear,
monotonic
increase
paternal
(∼two
new
per
year).
While
traditional
explanation
for
this
pattern
mutation
has
been
metronomic
plod
replication
errors,
an
alternative
model
pivots
around
'faulty
male'
hypothesis.
According
concept,
integrity
can
be
dynamically
impacted
other
factors,
it
aberrant
repair
such
damage
drives
mutagenesis.
Fortunately,
DNA
proofreading
during
spermatogenesis
extremely
effective
these
mutant
cells
either
repaired
or
deleted
apoptosis/ferroptosis.
There
appear
only
two
escape
apoptotic
fate:
(i)
if
acquire
enhancing
proliferation
suppressing
apoptosis,
permits
their
clonal
expansion
(selfish
selection
hypothesis)
(ii)
genetically
damaged
spermatozoon
manages
fertilize
oocyte,
then
fixes
(or
epimutation)
result
defective
(oocyte
collusion
hypothesis).
Exploration
proposed
should
not
help
us
better
understand
aetiology
effects
but
inform
potential
avenues
remediation.
Epidemiologia,
Journal Year:
2024,
Volume and Issue:
5(4), P. 627 - 642
Published: Sept. 26, 2024
Background/Objectives:
To
support
women’s
informed
decisions
and
reproductive
self-care,
confident
health-related
knowledge
is
needed,
supported
by
adequate
health
literacy
(HL).
No
corresponding
survey
has
been
carried
out
in
Hungary
on
inequalities
to
provide
information
addressing
education.
Materials
Methods:
In
the
current
cross-sectional
online
survey,
301
women
of
age
(27.16
±
0.36
years)
were
asked
with
Hungarian
versions
validated
standardised
questionnaires
about
hormones,
ovulation,
menstrual
cycle,
pregnancy
signs
birth
control
(Knowledge
Female
Body
Scale—KFB),
HL
(Brief
Health
Literacy
Screening
Tool—BRIEF).
Spearman
correlation
multivariable
linear
regression
analyses
utilised,
a
significance
level
set
at
p
<
0.05.
IBM
SPSS
version
28.0
(IBM
SPSS,
Armonk,
NY,
USA:
Corp.)
G*Power
(version
3.1.9.7;
Heinrich-Heine-Universität
Düsseldorf,
Germany)
software.
The
STROBE
checklist
was
followed.
Clinical
Trial
Registry
Nr.
NCT06146673.
Results:
KFB
composite
score
high
(20.01
2.33);
86.374%
had
“high
knowledge”.
Still,
lacking
identified
for
mechanisms
certain
contraceptive
methods
early
physical
pregnancy.
A
significant
difference
also
found
scores
case
higher
(p
=
0.019),
education
0.018)
previous
live
0.028).
positive
between
0.001),
0.005),
0.021).
multiple
analysis
(R2
0.087,
0.001)
indicated
that
both
0.003)
are
potential
predictors
knowledge,
whereas
induced
abortion
0.013)
might
serve
as
an
inverse
predictor.
Conclusions:
Inequalities
their
system
found,
it
significantly
lowest
highest
conception
probability
age.
Therefore,
addition
targeted
education,
needs
improvement.
Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 11, 2024
Reproductive
toxicology
testing
is
essential
to
safeguard
public
health
of
current
and
future
generations.
Traditional
toxicological
male
reproduction
has
focused
on
evaluating
substances
for
acute
toxicity
the
reproductive
system,
with
fertility
assessment
as
a
main
endpoint
infertility
adverse
outcome.
Newer
studies
in
last
few
decades
have
significantly
widened
our
understanding
what
represents
an
event
toxicology,
thus
changed
perspective
constitutes
toxicant,
such
endocrine
disrupting
chemicals
that
affect
offspring
intergenerational
manner.
Besides
or
congenital
abnormalities,
outcomes
can
present
increased
likelihood
various
problems
offspring,
including
metabolic
syndrome,
neurodevelopmental
like
autism
cancer
predisposition,
among
others.
To
enable
toxicologic
accurately
represent
population,
designs
need
model
changing
population
characteristics
exposure
circumstances.
Current
trends
increasing
importance
human
include
paternal
age,
associated
decline
nicotinamide
adenine
dinucleotide
(NAD),
higher
prevalence
obesity,
both
which
are
factors
study
design
should
account
for.
In
this
article,
we
highlighted
some
limitations
standard
protocols,
expanding
assessed
by
genetic
epigenetic
sperm
parameters,
potential
recent
developments,
mixture
testing,
novel
animal
models,
vitro
systems
organoids,
multigenerational
well
silico
modelling,
machine
learning
artificial
intelligence.