Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e25548 - e25548

Published: Jan. 30, 2024

Recent human clinical studies indicate that cannabidiol (CBD), the primary non-addictive component of cannabis, possesses considerable therapeutic potentials. The purpose present study was to explore possibility effects CBD administration on behaviors healthy domestic dogs. It is well-known when temporarily separated from their caregivers, they may show an increase in vocalization. Here upon such vocal activity were assessed. Ten 4- 7-year-old dogs experienced temporary separation caregivers twice, once following at 2.0 mg/kg/day over a 2-week-period, and same amount olive oil as placebo length period. When behavioral assessment conducted by computing total duration any exhibited before after separation, it found all 10 participant vocalized more often being left alone (after separation) than with (before separation), whether had received or placebo. Following administration, however, degree significantly less robust (p < 0.01). As one possible explanations for results. author hypothesizes anxiolytic dogs, has been reported humans.

Language: Английский

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Full spectrum cannabidiol-rich extract reduced propofol dosage required for anesthetic induction in dogs—a pilot study

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: April 5, 2024

Introduction Cannabinoids show great therapeutic potential, but their effect on anesthesia still remains unclear. Use of chronic recreational Cannabis in humans undergoing anesthetic procedures tends to require a higher dose when compared non-users. On the other hand, studies rodents and dogs have shown that cannabinoid agonists may potentiate certain anesthetics. This contrast effects possibly occurs due different time lengths administration phytocannabinoids at doses, distinct Endocannabinoid System, which is also affected by anesthetics such as propofol isoflurane. Methods Twenty-seven healthy male dogs, client-owned, ranging from 1 7 years, 5 35 kg were selected, mean weight 15.03±7.39 kg, with owners volunteering animals participate research performed Federal University Santa Catarina (UFSC). Dogs randomized into 3 groups. The Control Group (CON, n = 9), receiving only Extra Virgin Olive Oil, same oil-base used treatment 2 (G2, 9) received mg/kg total phytocannabinoids, (G3, 6 phytocannabinoids. All groups treatments transmucosally, 75 min before induction propofol. Heart respiratory rate, blood pressure, temperature sedation evaluated prior to, 30, 60, after fsCBD-rich extract or Placebo extract. Preanesthetic medication protocol was included across all groups, 15 induction. Parametric data analyzed one-way ANOVA, followed Student–Newman–Keuls (SNK) if significant statistical differences found. Non-parametric using Friedman’s test, Dunn test for comparisons between timepoints group. Kruskal-Wallis utilized comparisons. Propofol necessary through One-way ANOVA Tukey’s Multiple Comparisons Test, Instat Graphpad, considered statistically p &lt; 0.05. Our analysis assessed significance present points group, points. Results In our study, able reduce 23% control did not produce within although heart rate systolic pressure Discussion findings indicate could be an adjunct option anesthesia, further better confirm this data. Additionally, needed determine best dosage, delivery method, administration, ideal molecular profile desired effects, safety, drug–drug interactions, transurgical effects.

Language: Английский

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Exploring sleep heart rate variability: linear, nonlinear, and circadian rhythm perspectives

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: April 11, 2024

Background Heart rate variability (HRV) is believed to possess the potential for disease detection. However, early identification of heart remains challenging, as HRV analysis in dogs primarily reflects advanced stages disease. Hypothesis/objective The aim this study compare 24-h with sleep assess utility analysis. Animals Thirty healthy no echocardiographic abnormalities were included study, comprising 23 females and 7 males ranging age from 2 months 8 years (mean [standard deviation], 1.4 [1.6]). Methods This employed a cross-sectional study. measured 48-h Holter recordings. Both linear analysis, traditional method nonlinear novel approach, conducted. Additionally, circadian rhythm parameters assessed. Results In frequency parasympathetic index nHF was significantly higher during compared mean period deviation] vs. 24 h 95% confidence interval, p value, r-family: 0.24 [0.057] 0.23 [0.045], 0.006–0.031, = 0.005, r 0.49). Regarding time domain indices SDNN RMSSD also (SDNN: 179.7 [66.9] 156.6 [53.2], 14.5–31.7, &lt; 0.001, 0.71 RMSSD: 187.0 [74.0] 165.4 [62.2], 13.2–30.0, 0.70). geometric SD1 SD2 showed values (SD1: 132.4 [52.4] 117.1 [44.0], 9.3–21.1, 0.70 SD2: 215.0 [80.5] 185.9 [62.0], 17.6–40.6, 0.69). Furthermore, items SDNN, RMSSD, SD1, exhibited positive peaks sleep. Conclusion findings suggest that focusing on can provide more accurate representation activity, it captures peak items.

Language: Английский

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Tolerability of 2 and 4 mg/kg Dosing Every 12 Hour of a Cannabidiol- and Cannabidiolic Acid-Rich Hemp Extract on Mixed-Breed Dogs Utilized for Teaching in a Closed Colony

Animals, Journal Year: 2024, Volume and Issue: 14(13), P. 1863 - 1863

Published: June 24, 2024

With the increase in popularity of utilizing cannabidiol (CBD) for human ailments, owners are actively interested possible utilization cannabinoid products their pets. The evaluation CBD-rich hemp as an anti-anxiolytic, anti-inflammatory, immunomodulator, and anti-epileptic supplement has been assessed previous studies dogs, with adverse events such ataxia or lethargy noted. In this study, was at two concentrations to ascertain impact on behavior well tolerability medication given a typically recommended dose then twice that dose. Eighteen dogs were utilized randomized, double-blinded, placebo-controlled, 3 × designed study. Each group six provided placebo, 2 mg/kg, 4 mg/kg cannabidiol/cannabidiolic acid (CBD/CBDA)-rich two-week intervals one-week washout periods between each treatment period. Throughout 10-week period, student evaluations performed, simulating clients’ subjective assessments. Improvements anxiety-related related not observed may indicate behavioral changes require higher dosing mitigate unwanted behaviors normal, healthy dogs. Furthermore, serum chemistry cortisol evaluated after period showing only mildly significant alkaline phosphatase when every 12 h, which is consistent previously reported CBD these concentrations. Adverse associated CBD/CBDA-rich extract h weeks reported, suggesting using young, safe during treatment.

Language: Английский

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Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(5), P. 2915 - 2941

Published: Aug. 20, 2024

Since the discovery of endocannabinoid system and due to empirical evidence therapeutic effects on several illnesses both in humans animals that follow administration exogenous cannabinoids (i.e., phytocannabinoids), numerous studies have been conducted. These investigations aimed identify expression distribution cannabinoid receptors healthy pathologic organs tissues different animal species define interactions phytocannabinoids with these receptors. In last decade, pharmacokinetics, efficacy tolerability many Cannabis derivatives formulations, mainly containing cannabidiol, main veterinary interest, also investigated. This manuscript summarizes findings reported by scientific published so far molecular mode action phytocannabinoids, localization tissues, as well dogs, cats, horses other interest. A deep knowledge issues is crucial for use purposes species.

Language: Английский

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Investigating the effect a single dose of cannabidiol has on measures of stress in cats when being transported in a carrier and meeting a novel person in an unfamiliar environment

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 4, 2024

Domestic cats ( Felis Catus ) are often exposed to stimuli that have the potential negatively impact their welfare. These can include situations such as veterinary visits, travel, changes home environment, and interactions with unfamiliar people or pets. Cannabidiol (CBD)-infused pet products grown in popularity recent years, owners search for ways calm relax However, research into pharmacokinetic properties of CBD is limited investigations its efficacy infancy. The present study aimed explore effect a single 4 mg/kg bodyweight dose THC-free distillate on measures stress when experiencing composite stress-paradigm, consisting cat carrier travel exposure novel person within an environment. Physiological behavioural indicators were collected pre-, during, post-testing. No significant was observed serum cortisol, IgA, glucose, either before immediately after stress-paradigm (all p &gt; 0.05). This true despite cortisol being shown significantly increase post-test both treatments (both &lt; 0.001), suggesting meeting successfully induced response this population cats. differences any behaviour, including latency approach person, between Overall, no influence cats, further appropriate dosage, delivery matrices, other conditional factors, individual coping styles, should be considered.

Language: Английский

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Pharmacokinetics of cannabidiol-/cannabidiolic acid-rich hemp oil in juvenile cynomolgus macaques (Macaca fascicularis)

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 29, 2023

Cannabinoids are increasingly popular in human and veterinary medicine have been studied as an alternative treatment for a wide range of disorders. The goal this study was to perform pharmacokinetic analysis oral cannabidiol (CBD)-/cannabidiolic acid (CBDA)-rich hemp oil (CBD/ArHO) juvenile cynomolgus macaques (Macaca fascicularis).After 2 mg/kg CBD/ArHO pilot study, 4 8 direct-to-mouth were administered (n = per dose) once daily 14 days blood collected at 0-, 0.5-, 1-, 2-, 4-, 8-, 12-, 24-h, on Days 7 14, quantify serum cannabinoid concentrations by high-performance liquid chromatography-tandem mass spectrometry. Serum biochemistries complete counts performed 0, 1, 14.The maximum mean concentration (Cmax) CBDA 28.6-36.2 times that CBD mg/kg. At mg/kg, the Cmax 1.4 higher (p 0.0721), significantly 1.8 0.0361), than ∆9-tetrahydrocannabinol (THC) 4.80 ng/mL Changes over time not clinically significant.Given low concentrations, doses frequency used may be insufficient therapeutic effect particular; therefore, clinical studies needed determine dose macaques, which differ based disorder targeted.

Language: Английский

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Behavioral observations, heart rate and heart rate variability in horses following oral administration of a cannabidiol containing paste in three escalating doses (part 1/2)

Frontiers in Veterinary Science, Journal Year: 2023, Volume and Issue: 10

Published: Dec. 11, 2023

Cannabidiol (CBD) products have been proposed to exert stress- and anxiety-relieving effects in animals. Despite the increasing popularity of CBD for veterinary use, available research detailing horses is limited. The aim this study (part 1 2) was analyze stress parameters via behavioral observations heart rate monitoring healthy following single oral administration a containing paste different doses. Study were two pastes administration, one no active ingredient. Pastes applied as administrations consecutive trials with escalating dosages (doses: 0.2, 1.0, 3.0 mg CBD/kg) treatment (trial 1: n = 3, trial 2: 3: 5 horses) control group 6 minimum wash-out periods seven days between. Behavioral evaluated using video recordings score levels sedation including horses' reactions acoustic visual stimuli. Facial expression assessed photographs. Evaluation based on previously described facial scale (FaceSed) Horse Grimace Scale. For baseline values, identical recorded day before each administration. Both evaluation performed double blinded. Cardiac beat-to-beat (R-R) intervals continuously throughout variability parameters. Statistical analysis included comparison between over doses time points linear mixed models. well tolerated, side observed. Analysis scores expressions did not indicate significant differences neither reduced, nor changes observed compared group. Main limitation small sample size. Further required determine adequate indications use horses.

Language: Английский

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Effect of casozepine administration on stress in dogs during a veterinary examination – A randomized placebo-controlled trial

The Veterinary Journal, Journal Year: 2024, Volume and Issue: 306, P. 106148 - 106148

Published: June 4, 2024

The aim of the study was to investigate stress-reducing effect a casozepine before veterinary examination in dogs. It should be examined whether dogs are less stressed during standardized after an oral application over 2 days and administration has influence on salivary concentrations stress hormones vasopressin cortisol. Across group (n=36), significantly lower score (P=0.0026) mean (P=0.01) maximum (P=0.024) pulse rates were seen at follow-up administration, contrast placebo (n=26). Salivary increased (P=0.04), whereas they remained same group. Cortisol casozepin (P=0.01). results indicate that although both groups excited follow-up, short-term visit had weak based subjective scoring rate.

Language: Английский

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Impact of acute stress on the canine gut microbiota

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 14, 2024

Abstract There is growing evidence that a relationship exists between mental and emotional wellbeing the gut microbiota. Little known regarding how microbiota reacts to repeated acute stress events in dogs, whether it predictor of response. In this study, we explored impact on digestive health with two common many pet dogs find stressful. Twenty healthy adult living within colony, were exposed either car travel or separation three times across eight-week intervals. Faecal samples collected 24 h before, h, 24–48 after. quality pH, diversity composition analysed context wider published work physiological measures. No significant changes observed faecal pH event at any timepoint, indicating all pets remained good health. Microbiota analysis demonstrated no alpha beta stressor. Microbial signatures previously linked not identified these functional composition. Irrespective was considered “stressed” (i.e., exhibited an increase serum cortisol), there effect taxa predictive Collectively, demonstrates, for population, certain have meaningful canine microbiota, has associated

Language: Английский

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