Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155523 - 155523

Published: March 9, 2024

Language: Английский

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Total Saponins from Panax japonicus Reduced Lipid Deposition and Inflammation in Hepatocyte via PHD2 and Hepatic Macrophage-derived Exosomal miR-463-5p

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119376 - 119376

Published: Jan. 1, 2025

Language: Английский

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Improving quality of poultry and its meat products with probiotics, prebiotics, and phytoextracts

Poultry Science, Journal Year: 2023, Volume and Issue: 103(2), P. 103287 - 103287

Published: Nov. 22, 2023

Remarkable changes have occurred in poultry farming and meat processing recent years, driven by advancements breeding technology, feed conditions, management practices. The incorporation of probiotics, prebiotics, phytoextracts has made significant contributions to the development products that promote both health functionality throughout growth phase during processing. Poultry fed with these substances improve quality, while incorporating processing, as additives or supplements, inhibits pathogens offers benefits consumers. However, it is vital assess safety functional fermented containing compounds their potential effects on consumer health. Currently, there's still uncertainty aspects. Additionally, research utilizing next-generation probiotic strains synergistic combinations probiotics prebiotics its early stages. Therefore, further investigation required gain a comprehensive understanding beneficial considerations future. This review offered overview applications farming, focusing nutrient utilization, efficiency, gut Furthermore, enhancing production was explored for improved functionality, possible issues associated use were discussed. Moreover, conclusions drawn from this future perspectives field are presented.

Language: Английский

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Coated sodium butyrate and vitamin D₃ supplementation improve gut health through influencing intestinal immunity, barrier, and microflora in early‐stage broilers

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(7), P. 4058 - 4069

Published: Jan. 25, 2024

Abstract BACKGROUND Intestinal development and function are critical to maintaining sustained broiler growth. The present study aimed evaluate the effects of coated sodium butyrate (CSB) vitamin D 3 (VD ) on intestinal immunity, barrier, oxidative stress microflora in early‐stage broilers. In total, 192 one‐day‐old broilers were assigned a 2 × factorial design including two dietary supplements at different levels, which main VD (3000 or 5000 IU kg −1 CSB (0 1 g ). RESULTS results showed that supplementation increased ileal goblet cells (GCs) numbers, villus height decreased crypt depth proliferating cell nuclear antigen expression high‐level cluster differentiation expression. reduced serum d ‐lactate, endotoxin (ET), adrenocorticotropic hormone, corticosterone malondialdehyde (MDA) concentrations total antioxidant capacity (T‐AOC) level. Meanwhile, ET concentration. Furthermore, T‐AOC, lysozyme (LYZ) transforming growth factor (TGF)‐β MDA, whereas MDA secretory immunoglobulin A. up‐regulated claudin1, superoxide dismutase 1, TGF‐β LYZ mRNA down‐regulated interleukin‐1β combined with Faecalibaculum abundance. Spearman correlation analysis was related immune barrier function. CONCLUSION Dietary improved early gut health by promoting development, enhancing capacity, strengthening favorable composition bacterial flora. © 2024 Society Chemical Industry.

Language: Английский

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The Effects of Optimal Dietary Vitamin D3 on Growth and Carcass Performance, Tibia Traits, Meat Quality, and Intestinal Morphology of Chinese Yellow-Feathered Broiler Chickens

Animals, Journal Year: 2024, Volume and Issue: 14(6), P. 920 - 920

Published: March 16, 2024

This study aimed to assess the effects of different dietary vitamin D3 (VD3) levels on growth and carcass performance, tibia traits, meat quality, intestinal morphology yellow-feathered broilers. One-day-old broilers (n = 1440) were assigned into four treatment groups with six replicates per group, each replicate contained 60 chicks. Dietary VD3 significantly improved performance traits broilers, only low-dose supplementation decreased abdominal fat percentage. High-dose in finisher stage, while b* value breast muscle color markedly under (p < 0.05). Serum Ca P composition correlated positively at early stage. The weight, length, ash contents increased linearly increasing VD3, maximum values achieved high-dose group all three stages. Intestinal 16S rRNA sequencing liver transcriptome analysis showed that might represent an effective poultry production by regulating lipid immune-related metabolism gut–liver axis, which promotes through absorption calcium phosphorus intestine improves their protective humoral immunity reduces infection mortality. affected growth—immunity bone development during suggesting strategies optimize feeding.

Language: Английский

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Dietary curcumin supplementation alleviates diquat-induced oxidative stress in the liver of broilers

Poultry Science, Journal Year: 2023, Volume and Issue: 102(12), P. 103132 - 103132

Published: Sept. 20, 2023

This study purposed to investigate the alleviating effect of dietary curcumin supplementation on oxidative stress in liver broilers induced by diquat. One-day-old Cobb (400) were selected and randomly divided into 5 groups, with 8 replicates 10 per replicate. The control group diquat fed basal diet, while groups diet supplemented different amounts (50, 100, 150 mg/kg). On d 21 test, 1 broiler was from each replicate intraperitoneally injected 20 mg/mL solution at a dose mL/kg BW or equivalent physiological saline (for group). After 48 h feeding, slaughtered for analysis. results show that treatment reduced antioxidant capacity liver, caused stress, affected its lipid metabolism. However, using completely partially reversed broilers. blood alanine aminotransferase activity, total bilirubin protein levels, Caspase-3 mRNA abundance lower significantly than (P < 0.05). had higher activity but malondialdehyde triglyceride level activities cetyl coenzyme A carboxylase mg/kg DQ In conclusion, could ameliorate effects diquat-induced capacity, tissue morphology, metabolism broilers, thus protecting liver. recommended dosage diets is 100 curcumin.

Language: Английский

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Effects of supplementation with vitamin D3 on growth performance, lipid metabolism and cecal microbiota in broiler chickens

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 6, 2025

Lower intramuscular fat (IMF) and excessive abdominal reduce carcass quality in broilers. The study aimed to investigate the effects of dietary VD3 on growth performance, lipid metabolism cecal microbiota broilers over an 84-d feeding experiment. One-day-old male Luhua (210) were randomly assigned control (basal diet) VD group diet supplemented with 3,750 IU/kg VD3). Samples collected after a 12-h fasted days 28, 56, 84. Supplementary significantly enhanced average daily gain (ADG) aged 57-84 d 1-84 d, increased leg muscle rate content breast muscles reduced at 84 d. TG glycogen liver 28- 84-d-old broilers, serum VLDL-C 56 TC, HDL-C LDL-C mRNA expressions genes related de novo lipogenesis (DNL) (mTOR, SREBP-1c, FAS ACC), oxidation (AMPK, PPARα, CPT-1α ACO) transport (ApoB MTTP), FAS, ACC CPT1 enzyme activities liver. However, levels involved DNL cellular uptake (LPL FATP1) LPL activity decreased adipose tissue, that lipolysis (HSL ATGL) was by VD3. FATP1 expression Moreover, abundance cecum Bacteroides 28 Rikenellaceae_RC9_gut_group Faecalibacterium Lachnoclostridium These bacteria correlated DNL, liver, muscle, as well uptake, tissue. Altogether, supplementary basal improved IMF, rate, which is significant for enhancing feed utilization improving regulation could associated variation composition.

Language: Английский

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Automatic Analysis of High, Medium, and Low Activities of Broilers with Heat Stress Operations via Image Processing and Machine Learning

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104954 - 104954

Published: Feb. 28, 2025

Heat stress is a major welfare problem in the poultry industry, altering broilers' activity levels. Advancements image processing and machine learning provide opportunities to automatically quantify analyze broiler activity. This study aimed evaluate effects of moderate heat exposure on behavioral via learning. 132 Cobb 500 broilers were raised 2 nutritional treatment groups, each with 3 replicates. The control groups fed basal diet, while variation diet 0.05 % 25-hydroxyvitamin D3. All birds under standard environmental conditions for 27 days before cyclic 29.56 ± 1.34 °C humidity 76.97 5.98 from 8:00-18:00 thermoneutral 26.67 1.76 80.23 3.05 18:00-8:00. Birds continuously video recorded, bird index (BAI) was analyzed by subtracting consecutive frames summing up pixel differences. effect using two-way ANOVA P-value < 0.05. K-means clustering used determine BAI as high, medium, low result showed significantly higher (P 0.01) group contrast control. Absolute values high medium lower cyclical heating operations than those without operations. also at onset end moderately correlated flock age (|r| = 0.35-0.45). performed differently different treatments, temperature ranges, relative ranges. It concluded that useful tool predicting stress, but prediction effectiveness could be influenced age, diets, temperature, humidity, behavior metrics.

Language: Английский

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Effects of 1,25-Dihydroxycholecalciferol Glycoside Supplementation on the Growth, Intestinal Health, and Immunity of Broilers from Breeders Supplemented or Not with the Same Additive

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(5), P. 434 - 434

Published: May 1, 2025

This study aimed to investigate the effects of 1,25-Dihydroxycholecalciferol glycoside (1,25(OH)2D3-G) supplementation on performance, biochemical blood, bone health, intestinal histomorphometry, and gene expressions in broilers from breeders supplemented or not with 1,25(OH)2D3-G. A total 1152 one-day-old, male Ross 308 AP chicks were distributed a completely randomized design 2 × 3 factorial arrangement. One factor was inclusion 1,25(OH)2D3-G breeders’ diets 21 62 weeks age. The other involved three levels (0, 50, 100 mg/kg) broilers’ 1 days totaled six treatments, eight replicates 24 birds per experimental unit. Breeders resulted heavier broiler at hatch, better feed conversion, higher concentrations calbindin D28K, interleukin 10, 1β Villus height absorption area jejunum showed interactions between breeder diets. this additive both sufficient increase villus It is concluded that improves growth immunity broilers.

Language: Английский

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Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Diquat is a widely used bipyridyl herbicide that extensively applied in agricultural production and water management due to its high efficacy weed control. However, environmental persistence the toxic effects it induces have raised widespread concern. Studies show primarily enters body through digestive tract, leading poisoning. The core mechanism of toxicity involves reactive oxygen species (ROS)-induced oxidative stress, which not only directly damages intestinal barrier function but also exacerbates inflammation systemic by disrupting balance gut microbiota normal metabolic products. This review systematically summarizes physicochemical properties Diquat, with focus on analyzing mechanisms tissue structure, function, after tract exposure. aim provide theoretical support for deeper understanding Diquat’s tract-centered characteristics, laying scientific foundation development effective interventions protective strategies against toxicity.

Language: Английский

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