Ionics, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 27, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: June 17, 2024
Ovarian aging is a complex process characterized by decline in oocyte quantity and quality, directly impacting fertility overall well-being. Recent researches have identified mitochondria as pivotal players the of ovaries, influencing various hallmarks pathways governing this intricate process. In review, we discuss multifaceted role determining ovarian fate, outline mechanisms through which contribute to aging. Specifically, emphasize potential targeting mitochondrial dysfunction innovative therapeutic approaches, including antioxidants, metabolic improvement, biogenesis promotion, mitophagy enhancement, transfer, traditional Chinese medicine. These strategies hold promise effective means mitigate age-related preserve health. Drawing insights from advanced field, review provides deeper understanding interplay between function aging, offering valuable perspectives for development novel interventions aimed at preserving enhancing reproductive
Language: Английский
Citations
6
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6)
Published: May 30, 2024
Polycystic ovary syndrome (PCOS) is a prevalent reproductive, endocrine, and metabolic disease that affects 5–18% of women worldwide, with rising incidence. Hyperandrogenemia insulin resistance are two key pathophysiological factors contribute to PCOS, both which variety health issues such as menstrual irregularities, obesity, dysfunctional glucose lipid homeostasis, infertility, mental disorders, cardiovascular cerebrovascular diseases. Despite ongoing studies, the origin pathogenesis PCOS remain elusive; there also clinical need for simpler, more effective, longer lasting, comprehensive treatments PCOS. The gut–fat axis, critical regulatory route metabolism, endocrine function, immune response, has received considerable interest in recent years research etiology treatment illnesses type 2 diabetes mellitus non-alcoholic fatty liver disease. latest revealed significant alterations homogeneity phylogenetic diversity gut microbiota. Animal using fecal microbiota transplantation confirmed importance regulating sensitivity sex hormone balance Furthermore, studies have shown decrease volume and/or activity brown adipose tissue (BAT) patients, change alters adipokine release, leading hyperandrogenemia, aggravating progression. Given function BAT increasing energy expenditure alleviating parameters, efforts activate or induce browning white emerged possible Recent suggested can influence creation via metabolites short-chain acids bile acids, well gut–brain axis. Cold exposure, healthy dieting, metformin, bariatric surgery, glucagon-like peptide 1 receptor agonists melatonin all been basic modulate by influencing microbiota, demonstrating potential. However, into regulation mechanisms gut–BAT axis required produce comfortable, safe tailored therapeutics
Language: Английский
Citations
4
Veterinary Research, Journal Year: 2025, Volume and Issue: 56(1)
Published: March 22, 2025
Abstract Mycoplasma synoviae ( M. ) is a major bacterial pathogen that causes serious economic losses in the global poultry industry. Systemic changes specific free White Leghorn egg-laying hens after infection were investigated using intra-tracheally inoculated animals. Samples collected 10 days post-infection (dpi) (204-day-old) and 52 dpi (246-day-old). Infection caused air sac lesion, footpad swelling oviduct atrophy. The qPCR situ hybridization showed bacteria colonized trachea oviduct, loads magnum uterus significantly higher than infundibulum isthmus. Histopathological examination revealed increased tracheal mucosal thickening accompanied by inflammatory cell infiltration, tubular glands of edematous or dissolved. also induced decreased egg production eggshell strength, apex abnormalities appeared at 14 dpi. Plasma metabolomics analyzed liquid chromatography-tandem mass spectrometry 168 128 differentially-expressed metabolites (DEM) dpi, respectively. Pathway analysis DEM enriched five distinctive pathways: regulation actin cytoskeleton, neuroactive ligand-receptor interaction, sphingolipid metabolism, gap junctions, necroptosis. In contrast, fifteen pathways involved steroid hormone biosynthesis, ferroptosis, calcium signaling pathway, apelin progesterone-mediated oocyte maturation, meiosis. Combined metabolic demonstrated ethylsalicylate, nicotinamide, (3-Methoxy-4-hydroxyphenyl) ethylene glycol sulfate, sphingosine-1-phosphate (d18:1), carnitine C24:6, 15(R)-prostaglandin E1 correlated best with infection. This study provides new insights into understanding mechanisms signposts novel treatments for poultry.
Language: Английский
Citations
0
Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 336 - 336
Published: April 5, 2025
The aim of this investigation was to measure the natural nocturnal plasma melatonin concentration in gestating and fresh ewes. Studies humans showed that maternal had a significant increase as pregnancy progressed then decreased after birth. Two studies conducted sheep so far, considering entire gestation, have led conflicting results. breed 16 pregnant ewes selected for research Tsigai. Blood samples were taken into EDTA vacutainers predetermined times night at different stages their gestation. RIA method used determine concentrations. For estimation its variations during population genetic statistics applied. It found average 134 pg mL−1 is characteristic investigated period, it rises between autumnal equinox winter solstice. Secondly, revealed adjusted midnight 162.4 mL−1, moderate variation night. there no connection gestational age Tsigai Middle Europe. Our result consistent with results single donkey, contrast human observations. With regard melatonin, reduced same level (30 mL−1) lambs early postpartum period without nightly fluctuation. expelled placenta, constant vigilance mother her lamb, opposition prolactin may provide plausible explanation this.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 682 - 682
Published: May 8, 2025
Melatonin (N-acetyl-5-methoxytryptamine) is a hormone associated with the regulation of biological rhythms. The indoleamine secreted by pineal gland during night, following circadian rhythm. highest plasmatic levels are reached whereas lowest achieved day. In addition to gland, other organs and tissues also produce melatonin, like, for example, retina, Harderian glands, gut, ovaries, testes, skin, leukocytes, or bone marrow. list extensive, including cerebellum, airway epithelium, liver, kidney, adrenals, thymus, thyroid, pancreas, carotid body, placenta, endometrium. At all these locations, availability melatonin intended local use. Interestingly, decline amplitude secretion occurs in old subjects comparison that found younger subjects. Moreover, genetic environmental factors primary causes diseases, oxidative stress key contributor most pathologies. Numerous studies exist show interesting effects different models disease. Impairment its might have deleterious consequences cellular physiology. this regard, natural compound carrier not yet completely known potential deserves consideration. Thus, has emerged as helpful ally could be considered guard powerful tools orchestrate homeostasis majorly based on antioxidant effects. review, we provide an overview widespread actions against diseases preferentially affecting elderly.
Language: Английский
Citations
0
Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16
Published: May 13, 2025
During space exploration missions the organism is subjected to several challenges. Most of studies have been performed on male health in space, leaving focus sex differences behind. With development new biological technologies, attention now being paid more how spaceflight conditions affect human reproductive health. In this review, weightlessness disrupts ovarian function and endocrine signaling by affecting hypothalamic-pituitary-gonadal axis. Emerging evidence suggests that microgravity can impair estrogen production through suppression aromatase expression granulosa cells. This condition leads a hypo-estrogenic harms ovulation menstrual cycle. Likely, due reduced availability, bone density, cardiovascular consequently be severely involved. New space-related deregulation involving steroidogenesis look like picture observed Polycystic Ovary Syndrome. These similarities open perspective counteract pharmacologically abnormalities. However, our knowledge constrained limited data available as well lack proper experimental models investigation. Indeed, much required order acquire full understanding functional changes occurring during exposure, including joint effect radiation deserve thoroughly investigated recognize respective contribution each one eventual synergies.
Language: Английский
Citations
0
Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 8, 2024
Advanced maternal age is associated with decreased oocyte quantity and quality in vitro fertilization (IVF) success rates. This study aimed to investigate whether melatonin supplementation can improve IVF outcomes women of advanced by modulating cuproptosis ferroptosis.
Language: Английский
Citations
2
Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
1
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 1009 - 1009
Published: Sept. 22, 2024
Melatonin and serotonin can influence certain aging processes in the ovaries. The main melatonin receptors are represented by types MT1 MT2. goal of investigation. Here, we evaluated expression genes synthesis MT2 receptors, as well ovaries during ontogenesis.
Language: Английский
Citations
1
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)
Published: Dec. 1, 2024
ABSTRACT We hypothesized that melatonin (Mel) supplementation may offer therapeutic benefits for obesity, particularly in women. Therefore, the study evaluated Mel's effects on white adipose tissue (WAT) diet‐induced obese female mice. Four‐week‐old C57BL/6 females were assigned to either a control diet (C group) or high‐fat (HF 6 weeks ( n = 20/group). Following this, Mel was administered (10 mg/kg/day) 8 10/group), resulting four groups: C, CMel, HF, and HFMel. The HF group developed obesity. HFMel displayed reduced fat pad size, lower plasma insulin, improved glucose tolerance insulin resistance compared HF. In ovarian WAT (oWAT), versus showed pro‐inflammatory markers, less endoplasmic reticulum (ER) stress, smaller adipocyte size. subcutaneous (sWAT), demonstrated increased multiloculation, higher uncoupling protein‐1 expression, elevated thermogenic gene expression. Principal component analysis of expressions oWAT sWAT revealed significant differences: oWAT, ER stress inflammation markers linked group, while CMel clustered together, indicating beneficial effect. sWAT, opposite side which is associated with expressions. conclusion, findings demonstrate mice, even when maintained an diet, effectively modulated weight gain accumulation. positively influenced resistance, inflammation, promoting thermogenesis
Language: Английский
Citations
0