Antibiotic Resistance: One Health One World Outlook

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Nov. 25, 2021

Antibiotic resistance (ABR) is a growing public health concern worldwide, and it now regarded as critical One Health issue. Health's interconnected domains contribute to the emergence, evolution, spread of antibiotic-resistant microorganisms on local global scale, which significant risk factor for health. The persistence resistant microbial species, association determinants at human-animal-environment interface can alter genomes, resulting in superbugs various niches. ABR motivated by well-established link between three domains: human, animal, environmental As result, addressing through approach makes sense. Several countries have implemented national action plans based combat microbes, following Tripartite's Commitment Food Agriculture Organization (FAO)-World Animal (OIE)-World (WHO) guidelines. has been identified concern, efforts are being made mitigate this threat. To summarize, interdisciplinary unified approaches principles required limit dissemination cycle, raise awareness education about antibiotic use, promote policy, advocacy, antimicrobial stewardship.

Language: Английский

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Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements, and Usefulness for the Synthesis of Nanoparticles

Materials, Journal Year: 2021, Volume and Issue: 14(15), P. 4135 - 4135

Published: July 25, 2021

Natural extracts are the source of many antioxidant substances. They have proven useful not only as supplements preventing diseases caused by oxidative stress and food additives oxidation but also system components for production metallic nanoparticles so-called green synthesis. This is important given drastically increased demand nanomaterials in biomedical fields. The ecological technology producing can be plants or microorganisms (yeast, algae, cyanobacteria, fungi, bacteria). review presents recently published research on synthesis nanoparticles. conditions biosynthesis possible mechanisms nanoparticle formation with participation bacteria presented. potential natural biogenic depends content reducing assessment activity multicomponent mixtures still a challenge analytical chemistry. There no universal test measuring total capacity (TAC). vitro chemical tests that quantify scavenging free radicals their ability to chelate metals reduce radical damage. paper classification antioxidants non-enzymatic methods testing vitro, particular emphasis based Examples recent studies obtained from different species such plants, bacteria, lichens, actinomycetes were collected, giving evaluation methods, reference antioxidants, details preparation extracts.

Language: Английский

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Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1149 - 1149

Published: Feb. 9, 2022

According to the latest report released by World Health Organization, bacterial resistance well-known and widely available antibacterial drugs has become a significant severe global health concern grim challenge tackle in order cure infections associated with multidrug-resistant pathogenic microorganisms efficiently. Consequently, various strategies have been orchestrated complications related bacteria effectively. Some approaches involved retardation of biofilm formation multidrug-resistance pumps as well discovery new antimicrobial agents demonstrating different mechanisms action. In this regard, natural products namely alkaloids, terpenoids, steroids, anthraquinone, flavonoids, saponins, tannins, etc., suggested strains owing their versatile pharmacological effects. Amongst these, also known polyphenolic compounds, evaluated for property due tendency retard growth wide range microorganisms, including bacteria. The hydroxylation C5, C7, C3′, C4′; geranylation or prenylation at C6 extensively studied increase inhibition flavonoids. On other hand, methoxylation C3′ C5 reported decrease flavonoids’ Hence, information on activity flavonoids is summarized review, particular attention structure–activity relationship broad class compounds discover safe potent products.

Language: Английский

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Antibiotic resistance in aquaculture and aquatic organisms: a review of current nanotechnology applications for sustainable management

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(46), P. 69241 - 69274

Published: Aug. 15, 2022

Language: Английский

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Antimicrobial Natural Hydrogels in Biomedicine: Properties, Applications, and Challenges—A Concise Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2191 - 2191

Published: Jan. 22, 2023

Natural hydrogels are widely used as biomedical materials in many areas, including drug delivery, tissue scaffolds, and particularly wound dressings, where they can act an antimicrobial factor lowering the risk of microbial infections, which serious health problems, especially with respect to healing. In this review article, a number promising strategies development biocidal properties, those originating from natural polymers, briefly summarized concisely discussed. Common design fabricate intrinsic or stimuli-triggered antibacterial activity exemplified, mechanisms lying behind these properties also Finally, practical applications considered while discussing current challenges perspectives.

Language: Английский

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Emerging challenges in antimicrobial resistance: implications for pathogenic microorganisms, novel antibiotics, and their impact on sustainability

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 29, 2024

Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic microbes which a growing public health challenge at global level. Higher causes severe infections, high complications, longer stays hospitals and even increased mortality rates. Antimicrobial (AMR) has significant impact on national economies their systems, as it affects productivity patients or caregivers due to prolonged hospital with economic costs. The main factor AMR includes improper excessive use antimicrobials; lack access clean water, sanitation, hygiene for humans animals; poor infection prevention control measures in hospitals; medicines vaccines; awareness knowledge; irregularities legislation. represents problem, epidemiological surveillance systems have been established, aiming promote collaborations directed well-being human animal balance ecosystem. MDR bacteria such E. coli , Staphylococcus aureus Pseudomonas aeruginosa Enterococcus spp., Acinetobacter Klebsiella pneumonia can cause death. These microorganisms variety antibiotic mechanisms, development drug-deactivating targets, alterations decrease intracellular concentration, render themselves resistant numerous antibiotics. In context, United Nations issued Sustainable Development Goals (SDGs) 2015 serve worldwide blueprint better, more equal, sustainable existence our planet. SDGs place context socioeconomic issues; also, continued growth may hinder achievement SDGs. this review, we discuss role environmental pollution rise AMR, different mechanisms underlying resistance, threats posed by microbes, novel antibiotics, strategies One Health combat sustainability goals.

Language: Английский

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Prevalence of Infections and Antimicrobial Resistance of ESKAPE Group Bacteria Isolated from Patients Admitted to the Intensive Care Unit of a County Emergency Hospital in Romania

Antibiotics, Journal Year: 2024, Volume and Issue: 13(5), P. 400 - 400

Published: April 27, 2024

The ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella Pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) is a of bacteria very difficult to treat due their high ability acquire resistance antibiotics and are the main cause nosocomial infections worldwide, posing threat global public health. Nosocomial with MDR found mainly in Intensive Care Units, multitude maneuvers invasive medical devices used, prolonged antibiotic treatments, serious general condition these critical patients, duration hospitalization. Materials Methods: During period one year, from January 2023 December 2023, this cross-sectional study was conducted on patients diagnosed sepsis admitted Unit Sibiu County Emergency Clinical Hospital. Samples taken were tracheal aspirate, catheter tip, pharyngeal exudate, wound secretion, urine culture, blood peritoneal fluid. Results: most common isolated our pneumoniae, followed by baumanii aeruginosa. Gram-positive cocci faecium Staphilococcus aureus) rarely isolated. Most bacteria. Conclusions: rise antimicrobial among strains environment especially Units raises concerns about limited treatment options.

Language: Английский

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Unseen Enemy: Mechanisms of Multidrug Antimicrobial Resistance in Gram-Negative ESKAPE Pathogens

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 63 - 63

Published: Jan. 9, 2025

Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by particularly concerning gram-negative Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens. Designated as "priority" 2017, these bacteria continue to pose significant threat 2024, during worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed worsened patient outcomes. The declining effectiveness current treatments against pathogens has led an increased disease burden increase mortality rates globally. This review explores sophisticated mechanisms driving AMR bacteria, focusing on Key bacterial contributing include limitations drug uptake, production antibiotic-degrading enzymes, alterations target sites, enhanced efflux systems. Comprehending pathways is vital for formulating innovative therapeutic strategies tackling ongoing posed resistant

Language: Английский

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Emerging Treatment Options for Multi-Drug-Resistant Bacterial Infections

Life, Journal Year: 2021, Volume and Issue: 11(6), P. 519 - 519

Published: June 3, 2021

Antimicrobial resistance (AMR) remains one of the top public health issues global concern. Among most important strategies for AMR control there is correct and appropriate use antibiotics, including those available treatment pathogens. In this article, after briefly reviewing clinically relevant multi-drug-resistant bacteria their main mechanisms, we describe emerging antimicrobial options both MDR Gram-positive cocci Gram-negative bacilli, recently marketed agents, molecules just approved or under evaluation rediscovered older antibiotics that have regained importance due to spectrum. Specifically, reviewed include ceftaroline, ceftobiprole, tedizolid, dalbavancin, fosfomycin. Emerging bacilli considered comprise ceftolozane-tazobactam, ceftazidime-avibactam, meropenem-vaborbactam, imipenem-relebactam, aztreonam-avibactam, minocycline, fosfomycin, eravacycline, plazomicin, cefiderocol. An exciting scenario opening today with long awaited growing availability novel bacteria. Knowledge mechanisms action patterns allows physicians increasingly drive towards a precision medicine approach. Strict adherence stewardship practices will allow us preserve antimicrobials our future.

Language: Английский

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The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic

European Respiratory Review, Journal Year: 2022, Volume and Issue: 31(166), P. 220068 - 220068

Published: Oct. 19, 2022

Antibiotic resistance is recognised as a global threat to human health by national healthcare agencies, governments and medical societies, well the World Health Organization. Increasing available antimicrobial agents of concern for bacterial, fungal, viral parasitic pathogens. One greatest concerns continuing escalation among Gram-negative bacteria resulting in endemic presence multidrug-resistant (MDR) extremely drug-resistant (XDR) This heightened identification such MDR/XDR water food sources, colonisers intestine other locations both hospitalised patients individuals community, all types infections. Pneumonia respiratory infections are most common caused associated with high rates mortality. Future already due emergence existing developed past decade treat scarcity novel developmental pipeline. clinical scenario increases likelihood future pandemic bacteria.

Language: Английский

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