Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications DOI Creative Commons
Miguel Á. Ortega,

Diego De León-Oliva,

Diego Liviu Boaru

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(8), P. 617 - 617

Published: July 29, 2023

The growing impact of infections and the rapid emergence antibiotic resistance represent a public health concern worldwide. exponential development in field biomaterials its multiple applications can offer solution to problems that derive from these situations. In this sense, antimicrobial hydrogels promising opportunity with translational expectations medical management infectious diseases due their unique physicochemical biological properties as well for drug delivery specific areas. Hydrogels are three-dimensional cross-linked networks hydrophilic polymers absorb retain large amounts water or fluids. Moreover, (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, properties. review, we collect discuss most strategies AMH, which divided into inherent activity agent-loaded based on composition. Then, an overview main applications: wound healing, tissue engineering regeneration, systems, contact lenses, 3D printing, biosensing, purification.

Language: Английский

Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends DOI Creative Commons
Naveed Ahmad, Syed Nasir Abbas Bukhari, Muhammad Ajaz Hussain

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564

Published: Jan. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Language: Английский

Citations

42
Hydrogel-based materials as antibacterial agents and super adsorbents for the remediation of emerging pollutants: A comprehensive review DOI Creative Commons
Shahin Ahmadi, Sina Pourebrahimi, Alhadji Malloum

et al.

Emerging contaminants, Journal Year: 2024, Volume and Issue: 10(3), P. 100336 - 100336

Published: March 29, 2024

Hydrogels have various potential applications due to their unique characteristics and recently, hydrogels been utilized as adsorbents in wastewater treatment because of ability remove contaminants from water. Constructing strong with high adsorption capabilities is crucial for effective treatment. Scientists researchers are working improve the properties by incorporating inorganic elements into polymer networks, which further reduces costs well simplifies preparation. Natural polymers like starch alginate widespread economic biological advantages, such biodegradability, biocompatibility, reduced toxicity, environmental friendliness, low cost. The pollutants onto use antimicrobial agents has garnered significant attention. This review paper summarizes latest studies on using endocrine-disrupting chemicals (EDCs), persistent organic (POPs), other emerging water environments along agents. In first step, different classes characterization techniques discussed. Next elaborated understand how these can be a candidate activities. While discussing application hydrogels, isothermal, kinetics thermodynamics models discussed highlight mechanism nature forces involved pollutants. Further simulations DFT MD get more holistic understanding hydrogels. A limited number Monte Carlo computational fluid dynamics (CFD) so it important explore variety methods gain comprehensive process

Language: Английский

Citations

29
New Perspectives of Hydrogels in Chronic Wound Management DOI Creative Commons

A. S. Alberts,

Ana‐Maria Bratu, Adelina-Gabriela Niculescu

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

Citations

5
Nanoparticle-Enhanced Collagen Hydrogels for Chronic Wound Management DOI Creative Commons
Alexandra Cătălina Bîrcă,

Mihai Alexandru Minculescu,

Adelina-Gabriela Niculescu

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 91 - 91

Published: March 5, 2025

Chronic wound infections present a persistent medical challenge; however, advancements in dressings and antimicrobial nanomaterials offer promising solutions for improving healing outcomes. This study introduces hydrothermal synthesis approach producing zinc oxide (ZnO) copper (CuO) nanoparticles, subsequently incorporated into PLGA microspheres embedded within collagen hydrogels. The nanoparticles’ physicochemical properties were characterized using X-ray diffraction (XRD) to confirm crystalline structure, scanning electron microscopy (SEM) surface morphology, Fourier-transform infrared spectroscopy (FT-IR) verify functional groups successful hydrogel integration. hydrogels tested activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, which are key pathogens chronic wounds. Biocompatibility was assessed the human HaCat keratinocyte cell line. Both ZnO- CuO-loaded exhibited broad-spectrum efficacy. Cytocompatibility tests demonstrated that both sustain viability proliferation, highlighting their biocompatibility suitability applications, with superior biological performance of ZnO-loaded Furthermore, distinct profiles ZnO CuO suggest tailored use based on microbial composition, excelling antibacterial applications showing potential antifungal treatments. These results underscore nanoparticle-based as innovative therapeutic tools managing

Language: Английский

Citations

5
NIR photo-responsive injectable chitosan/hyaluronic acid hydrogels with controlled NO release for the treatment of MRSA infections DOI
Chuanshan Xu, Yiqing Chen, Chenxiang Lin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140304 - 140304

Published: Jan. 1, 2025

Language: Английский

Citations

2
Advanced polymer hydrogels that promote diabetic ulcer healing: mechanisms, classifications, and medical applications DOI Creative Commons

Yamei Xu,

Qiyuan Hu,

Zongyun Wei

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

Diabetic ulcers (DUs) are one of the most serious complications diabetes mellitus. The application a functional dressing is crucial step in DU treatment and associated with patient's recovery prognosis. However, traditional dressings simple structure single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer hydrogels solve therapeutic bottleneck treatment. Hydrogels class gels three-dimensional network that good moisturizing properties permeability promote autolytic debridement material exchange. Moreover, mimic natural environment extracellular matrix, providing suitable surroundings for cell proliferation. Thus, different mechanical strengths biological been extensively explored as platforms. In this review, we define types elaborate mechanisms by which they repair DUs. summarize pathological process DUs review various additives used Finally, examine limitations obstacles exist development clinically relevant applications these appealing technologies. This defines carefully diabetic (DUs), summarizes DUs, reviews bioactivators

Language: Английский

Citations

34
3D-Printed Hydrogel for Diverse Applications: A Review DOI Creative Commons
Arpana Agrawal, Chaudhery Mustansar Hussain

Gels, Journal Year: 2023, Volume and Issue: 9(12), P. 960 - 960

Published: Dec. 7, 2023

Hydrogels have emerged as a versatile and promising class of materials in the field 3D printing, offering unique properties suitable for various applications. This review delves into intersection hydrogels exploring current research, technological advancements, future directions. It starts with an overview hydrogel basics, including composition properties, details used printing. The explores diverse printing methods hydrogels, discussing their advantages limitations. emphasizes integration 3D-printed biomedical engineering, showcasing its role tissue regenerative medicine, drug delivery. Beyond healthcare, it also examines applications food, cosmetics, electronics industries. Challenges like resolution limitations scalability are addressed. predicts trends material development, techniques, novel

Language: Английский

Citations

31
Unleashing the power of polymeric nanoparticles — Creative triumph against antibiotic resistance: A review DOI Creative Commons
Gaurisha Alias Resha Ramnath Naik,

Amrita Arup Roy,

Srinivas Mutalik

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134977 - 134977

Published: Aug. 24, 2024

Antibiotic resistance (ABR) poses a universal concern owing to the widespread use of antibiotics in various sectors. Nanotechnology emerges as promising solution combat ABR, offering targeted drug delivery, enhanced bioavailability, reduced toxicity, and stability. This comprehensive review explores concepts antibiotic resistance, its mechanisms, multifaceted approaches ABR. The provides an in-depth exploration polymeric nanoparticles advanced delivery systems, focusing on strategies for targeting microbial infections contributing fight against Nanoparticles revolutionize antimicrobial approaches, emphasizing passive active targeting. role molecules, including small peptides, proteins, carbohydrates, stimuli-responsive is being explored recent research works. complex comprehension mechanisms ABR strategic nanotechnology present avenue advancing tactics, ensuring treatment efficacy, minimizing toxic effects, mitigating development Polymeric nanoparticles, derived from natural or synthetic polymers, are crucial overcoming Natural polymers like chitosan alginate exhibit inherent antibacterial properties, while such polylactic acid (PLA), polyethylene glycol (PEG), polycaprolactone (PCL) can be engineered specific effects. study valuable source information researchers, healthcare professionals, policymakers engaged urgent quest overcome

Language: Английский

Citations

14
Hydrogels based on lignin extracted from cashew apple bagasse and its application in antimicrobial wound dressings DOI
Tiago Lima de Albuquerque,

Victor Gabriel Cunha Cavalcante,

Weslley S. Rocha

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 130169 - 130169

Published: Feb. 14, 2024

Language: Английский

Citations

13
Polymer hydrogels: Classification and recent advances DOI

Mahua Dhara

Journal of Macromolecular Science Part A, Journal Year: 2024, Volume and Issue: 61(5), P. 265 - 288

Published: March 19, 2024

Hydrogels comprise of a group crosslinked hydrophilic polymeric materials which are capable absorbing and holding large quantities water in their three-dimensional network structure without undergoing dissolution. More importantly, the ability 'smart' hydrogels to respond certain environmental changes e.g. pH, heat, light, magnetic field, biomolecules have set them apart as unique class materials. A combination several such useful properties resulted tremendous progress toward development advanced hydrogel-based materials, is evident from an explosive amount research publications available this area over last few decades. Owing particularly biocompatibility biodegradability, become material prime importance context wide range applications starting simple contact lenses more complex ones tissue repair, drug delivery, sensors, 3D bioprinting, soft robotics agriculture. This review includes i) overview its classifications based on source, structure, crosslinking mechanism stimuli responsiveness, ii) detailed discussion some most works being carried out field years smart that need hour, domain biomedical applications.

Language: Английский

Citations

12