Antioxidants,
Journal Year:
2024,
Volume and Issue:
unknown, P. 257 - 283
Published: Nov. 17, 2024
The
chapter
provides
a
comprehensive
overview
of
the
relationship
between
oxidative
stress
and
aging
process.
Oxidative
arises
from
an
imbalance
production
Reactive
Oxygen
Species
(ROS)
body's
antioxidant
defense
system.
mechanisms
action
antioxidants
are
explored,
including
enzymatic
non-enzymatic
antioxidants,
metal-binding
proteins,
dietary
sources,
nutritional
supplements.
also
delves
into
role
in
cellular
senescence
Furthermore,
effectiveness
supplements
combating
is
examined.
highlights
impact
on
skin
health
aging,
discusses
use
topical
anti-aging
cosmetics.
Lifestyle
factors
such
as
exercise,
stress,
sleep,
smoking,
alcohol
consumption
explored
contributors
to
diminished
defense.
concludes
with
discussion
potential
for
personalized
interventions
development
novel
compounds
plants,
marine,
microorganisms,
synthetic
sources
future
research.
Overall,
this
valuable
insights
promoting
healthy
aging.
Foods,
Journal Year:
2023,
Volume and Issue:
12(2), P. 270 - 270
Published: Jan. 6, 2023
Ellagitannins
(ETs)
are
a
large
group
of
bioactive
compounds
found
in
plant-source
foods,
such
as
pomegranates,
berries,
and
nuts.
The
consumption
ETs
has
often
been
associated
with
positive
effects
on
many
pathologies,
including
cardiovascular
diseases,
neurodegenerative
syndromes,
cancer.
Although
multiple
biological
activities
(antioxidant,
anti-inflammatory,
chemopreventive)
have
discussed
for
ETs,
their
limited
bioavailability
prevents
reaching
significant
concentrations
systemic
circulation.
Instead,
urolithins,
ET
gut
microbiota-derived
metabolites,
better
absorbed
could
be
the
molecules
responsible
antioxidant
anti-inflammatory
or
anti-tumor
cell
progression.
In
this
review,
we
examined
dietary
sources,
metabolism,
analyzed
last
recent
findings
ellagic
acid,
intestinal
brain
activities,
potential
mechanisms
action,
connection
between
microbiota
metabolism
consequences
detected
gut–brain
axis.
current
vitro,
vivo,
clinical
studies
indicate
that
ET-rich
individual
microbiomes,
urolithin
types
modulate
signaling
pathways
promote
beneficial
health
effects.
A
understanding
role
these
metabolites
disease
pathogenesis
may
assist
prevention
treatment
pathologies
targeting
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(4), P. 566 - 566
Published: April 6, 2021
As
human
life
expectancy
is
rising,
the
incidence
of
age-associated
diseases
will
also
increase.
Scientific
evidence
has
revealed
that
healthy
diets,
including
good
fats,
vitamins,
minerals,
or
polyphenolics,
could
have
antioxidant
and
anti-inflammatory
activities,
with
antiaging
effects.
Recent
studies
demonstrated
vitamin
K
a
vital
cofactor
in
activating
several
proteins,
which
act
against
age-related
syndromes.
Thus,
can
carboxylate
osteocalcin
(a
protein
capable
transporting
fixing
calcium
bone),
activate
matrix
Gla
(an
inhibitor
vascular
calcification
cardiovascular
events)
Gas6
(involved
brain
physiology
cognitive
decline
neurodegenerative
disease
inhibitor).
By
improving
insulin
sensitivity,
lowers
diabetes
risk.
It
exerts
antiproliferative,
proapoptotic,
autophagic
effects
been
associated
reduced
risk
cancer.
research
shows
S,
another
K-dependent
protein,
prevent
cytokine
storm
observed
COVID-19
cases.
The
activation
S
due
to
pneumonia-induced
depletion
was
correlated
higher
thrombogenicity
possibly
fatal
outcomes
patients.
Our
review
aimed
present
latest
scientific
about
its
role
preventing
and/or
effectiveness
medical
treatments
mature
adults
˃50
years
old.
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(7), P. 1412 - 1412
Published: July 21, 2022
Biomarkers
of
metabolic
syndrome
and
inflammation
are
pathophysiological
predictors
factors
senescence
age-related
diseases.
Recent
evidence
showed
that
particular
diet
components,
such
as
walnuts
rich
in
antioxidant
bioactive
compounds
with
a
balanced
lipid
profile,
could
have
positive
outcomes
on
human
health.
A
systematic
search
PubMed,
EMBASE,
Cochrane
Library,
Scopus,
ClinicalTrials.gov
databases
was
performed
to
retrieve
randomized
controlled
trials
published
from
the
beginning
each
database
through
November
2021,
reporting
walnut
consumption
over
22
inflammatory
markers
middle-aged
older
adults.
The
strategy
rendered
17
studies
final
selection,
including
11
crossover
6
parallel
trials.
study
revealed
walnut-enriched
diets
had
statistically
significant
decreasing
effects
for
triglyceride,
total
cholesterol,
LDL
cholesterol
concentrations
some
presented
no
consequences
anthropometric
glycemic
parameters.
Although
further
better-designed
ones
needed
strengthen
these
findings,
results
emphasize
benefits
dietary
plans
this
age
group.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 604 - 604
Published: March 1, 2023
In
the
last
few
decades,
scientific
evidence
has
stressed
importance
of
plants
in
prevention
and/or
supportive
treatment
a
plethora
diseases,
many
them
chronic,
age-associated
disorders.
Juglans
regia
L.
is
traditional
plant
that
been
integrated
into
medicine
since
ancient
times.
Due
to
presence
biologically
active
compounds,
walnut
was
used
various
maladies.
Recently,
investigations
have
focused
on
by-products
and
waste
products,
with
research
their
valuable
constituents
properties.
Among
these
secondary
septum
analyzed
several
studies,
its
phytochemical
profile
described,
some
biological
activities
examined.
However,
compared
other
by-products,
no
comprehensive
review
gather
all
pertinent
knowledge
found
literature.
Therefore,
aim
this
study
critically
assess
information
furnished
by
peer-reviewed
articles
regarding
chemical
composition
related
activities,
including
antioxidant
anti-inflammatory
effects,
antimicrobial
properties,
antidiabetic
anti-tumor
anti-aging
potential.
conclusion,
as
preclinical
studies
showed
metabolites
were
responsible
for
wide
range
preventive
therapeutic
uses,
further
should
confirm
beneficial
outcomes
clinical
trials.
Antioxidants,
Journal Year:
2021,
Volume and Issue:
10(4), P. 607 - 607
Published: April 15, 2021
The
extraction
of
bioactive
compounds
present
in
walnut
(Juglans
regia
L.)
male
flowers
(WMFs)
was
performed
based
on
an
experimental
design
using
ultrasonic-assisted
extraction.
Solvent
nature,
time,
and
water
content
were
selected
as
variables,
phenolic,
flavonoidic,
condensed
tannins
contents
antioxidant
properties
evaluated.
Acetone
the
solvent
with
highest
performance,
extracts
obtained
this
displaying
increased
concentration
activities.
For
several
high
content,
individual
polyphenolic
tocopherolic
evaluated
by
means
LC-MS
LC-MS/MS.
best
conditions
for
(2.86
mg
gallic
acid
equivalents/g
WMF)
(29.4
µg/g
acetone
40%
(N20)
20%
(N15),
respectively.
Although
total
tocopherol
concentrations
lower
than
other
Juglans
parts,
most
quantity
provided
highly
biologically
active
δ-tocopherol
(84%).
Significant
quantities
quercetin
(101.9
µg/g),
hyperoside
(2662.9
quercitrin
(405.7
isoquercitrin
(1293.7
µg/g)
determined
WMF
(N20).
Both
inhibited
enzymatic
activity
α-glucosidase
tyrosinase;
however,
inhibition
observed
N20,
extract
higher
content.
Conversely,
N15
had
anticancerous
cell
lines
used,
a
moderate
selectivity
towards
cancerous
phenotype
being
both
extracts.
At
non-cytotoxic
concentrations,
displayed
good
activities
cellular
cultures,
decreasing
basal
H2O2-induced
oxidative
stress.
This
is
first
characterization
hydrophilic
lipophilic
phytochemicals
outcomes
our
study
reveal
that
have
strong
biological
activities,
thus
justifying
further
research
to
demonstrate
their
usefulness
food,
pharmaceutical,
and/or
cosmetic
industries.
Plants,
Journal Year:
2022,
Volume and Issue:
11(4), P. 539 - 539
Published: Feb. 17, 2022
Naturally,
thiophenes
represent
a
small
family
of
natural
metabolites
featured
by
one
to
five
thiophene
rings.
Numerous
plant
species
belonging
the
Asteraceae
commonly
produce
thiophenes.
These
possessed
remarkable
bioactivities,
including
antimicrobial,
antiviral,
anti-inflammatory,
larvicidal,
antioxidant,
insecticidal,
cytotoxic,
and
nematicidal
properties.
The
current
review
provides
an
update
over
past
seven
years
for
reported
derivatives,
their
sources,
biosynthesis,
spectral
data,
bioactivities
since
last
published
in
2015.
Additionally,
with
help
SuperPred
webserver,
AI
(artificial
intelligence)
tool,
potential
drug
target
compounds
was
predicted.
In
silico
studies
were
conducted
Cathepsin
D
ADMET
(drug
absorption/distribution/metabolism/excretion/and
toxicity)
properties
prediction,
molecular
docking
binding
interaction,
dynamics
evaluate
ligand-target
interaction
stability
under
simulated
physiological
conditions.
Life,
Journal Year:
2023,
Volume and Issue:
13(4), P. 874 - 874
Published: March 24, 2023
Inflammation
is
a
natural
protective
response
of
the
human
body
to
variety
hostile
agents
and
noxious
stimuli.
Standard
anti-inflammatory
therapy
includes
drugs
whose
usage
associated
with
number
side
effects.
Since
ancient
times,
compounds
have
been
used
for
treatment
inflammation.
Traditionally,
use
medicinal
plants
considered
safe,
inexpensive,
widely
acceptable.
In
Serbia,
traditional
medicine,
based
on
strong
belief
in
power
herbs,
widespread
form
treatment.
This
supported
by
fact
that
Serbia
classified
as
one
158
world
centers
biodiversity,
which
confirms
this
country
treasure
herbs.
Some
most
herbs
inflammations
various
causes
Serbian
tradition
are
yarrow,
common
agrimony,
couch
grass,
onion,
garlic,
marshmallow,
birch,
calendula,
liquorice,
walnut,
St.
John’s
wort,
chamomile,
peppermint,
white
willow,
sage,
many
others.
The
biological
activity
effect
selected
attributed
different
groups
secondary
biomolecules
such
flavonoids,
phenolic
acids,
sterols,
terpenoids,
sesquiterpenes,
tannins.
paper
provides
an
overview
reference
available
studies
examined
effect.
Plants
medicine
could
be
powerful
source
development
new
remedies.
Therefore
intensive
research
bioactive
potential
each
region
should
focus
scientists
around
world.
