Walnut Intake Interventions Targeting Biomarkers of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1412 - 1412

Published: July 21, 2022

Biomarkers of metabolic syndrome and inflammation are pathophysiological predictors factors senescence age-related diseases. Recent evidence showed that particular diet components, such as walnuts rich in antioxidant bioactive compounds with a balanced lipid profile, could have positive outcomes on human health. A systematic search PubMed, EMBASE, Cochrane Library, Scopus, ClinicalTrials.gov databases was performed to retrieve randomized controlled trials published from the beginning each database through November 2021, reporting walnut consumption over 22 inflammatory markers middle-aged older adults. The strategy rendered 17 studies final selection, including 11 crossover 6 parallel trials. study revealed walnut-enriched diets had statistically significant decreasing effects for triglyceride, total cholesterol, LDL cholesterol concentrations some presented no consequences anthropometric glycemic parameters. Although further better-designed ones needed strengthen these findings, results emphasize benefits dietary plans this age group.

Language: Английский

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A Review on Medicinal Uses, Nutritional Value, and Antimicrobial, Antioxidant, Anti-Inflammatory, Antidiabetic, and Anticancer Potential Related to Bioactive Compounds of J. regia

Food Reviews International, Journal Year: 2022, Volume and Issue: 39(9), P. 6199 - 6249

Published: July 11, 2022

Juglans regia is a medicinal plant widely used in traditional medicine and it. It applied for healing numerous ailment such us diabetes, digestive problems, hypertension, gout diseases. This review aims to highlight the importance of as source nutritional bioactive compounds. Mechanisms antimicrobial, antioxidant, anti-inflammatory, antidiabetic, anticancer activities leaves, fruit, septum kernels, flowers, bark, husk have been discussed. fruits an important nutritive value allowed by their richness lipids proteins. Medicinal properties are certainly due its Indeed, husks, roots contain several secondary metabolites including polyphenols, flavonoids, glycosides. Pharmacological investigations reported literature demonstrated that exhibit different biological anti-diabetic, antitumoral, antifungal, antibacterial effects, vitro, vivo clinical trials. compound action include ROS neutralization, proinflammatory mediators enzyme inhibition, insulin levels increase, regulation apoptosis, cell cycle disruption. Biological were remarkably correlated with compounds containing regia. Therefore, values compounds, could be considered relevant functional food.

Language: Английский

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Optimization of ultrasonic-assisted extraction of phenolic compounds from pomegranate and orange peels and their antioxidant activity in a functional drink

Food Bioscience, Journal Year: 2022, Volume and Issue: 49, P. 101918 - 101918

Published: July 21, 2022

Language: Английский

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Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7752 - 7752

Published: Nov. 24, 2023

Plant-based materials are an important source of bioactive compounds (BC) with interesting industrial applications. Therefore, adequate experimental strategies for maximizing their recovery yield required. Among all procedures extracting BC (maceration, Soxhlet, hydro-distillation, pulsed-electric field, enzyme, microwave, high hydrostatic pressure, and supercritical fluids), the ultrasound-assisted extraction (UAE) highlighted as advanced, cost-efficient, eco-friendly, sustainable alternative recovering (polyphenols, flavonoids, anthocyanins, carotenoids) from plant sources higher yields. However, UAE efficiency is influenced by several factors, including operational variables process (frequency, amplitude, ultrasonic power, pulse cycle, type solvent, time, solvent-to-solid ratio, pH, particle size, temperature) that exert impact on molecular structures targeted molecules, leading to variations in biological properties. In this context, a diverse design experiments (DOEs), full or fractional factorial, Plackett-Burman, Box-Behnken, Central composite, Taguchi, Mixture, D-optimal, Doehlert have been investigated alone combination optimize plant-based materials, using response surface methodology mathematical models simple multi-factorial/multi-response approach. The present review summarizes advantages limitations most common DOEs materials.

Language: Английский

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Cultivated St. John’s Wort Flower Heads Accumulate Tocotrienols over Tocopherols, Regardless of the Year of the Plant

Plants, Journal Year: 2025, Volume and Issue: 14(6), P. 852 - 852

Published: March 9, 2025

St. John’s wort (Hypericum perforatum L.) has been extensively utilized across various traditional medicinal systems, including ancient Greek medicine, Chinese and Islamic medicine. H. is a well-known plant due to the presence of hypericin hyperforin, which are natural antidepressants. Recent studies indicate that inflorescences wild source rare tocotrienols, primarily δ-T3. Similar lacking for cultivated species. was grown three years. At full bloom each year, cut separated into its parts: stems, leaves, flower buds, flowers. Tocotrienols (T3s) were present in part perforatum. The lowest concentration tocotrienols recorded stems highest buds (1.7–4.2 88.2–104.7 mg/100 g dry weight, respectively). Flower flowers main α-T3 δ-T3 tocotrienols. significant impact on tocochromanol profile concentration, while year harvest/plant aging does not. study demonstrates heads first known with relatively high concentrations accumulate over tocopherols, regardless plant.

Language: Английский

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Phenolic Profile and Antioxidant, Antibacterial, and Antiproliferative Activity of Juglans regia L. Male Flowers

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2762 - 2762

Published: April 26, 2022

Juglans regia L., walnut, is a large, long-living tree, cultivated in temperate climates around the world. It highly appreciated for its nutritional kernels and high-quality timber. Its barks, leaves, husk are used as dyes folk medicine herbal remedies several diseases. From biological chemical standpoint, relatively little known about male flowers of tree. Therefore, aim study was to evaluate phenolic profile well vitro antioxidant, antimicrobial, antiproliferative activity L. flowers. Phenolic content determined by UPLC/PDA/MS/MS analyses; antioxidant assessed five different methods; antimicrobial evaluated against six most common pathogenic strains Gram-positive Gram-negative bacteria, properties were cell lines. Most analyses carried out this performed first time raw material. J. flower extract characterized strong ability scavenge DPPH˙ free radicals, hydroxyl chelating metal ions. Among examined bacterial neoplastic lines, strongest shown S. aureus, monocytogenes, B. cereus, cytotoxic breast cancer, glioblastoma, astrocytoma cells. Male have also been found be rich source compounds. The polyphenols 4369.73 mg/100 g d.w., 24 compounds from group flavonoids, acids, juglunosides identified. Additionally, correlation between capacity observed. This why tested an excellent effective natural antibacterial, chemopreventive that potential pharmaceutical or food industries.

Language: Английский

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Phytochemicals and Antioxidant Properties of Edible Flowers

Applied Sciences, Journal Year: 2022, Volume and Issue: 12(19), P. 9937 - 9937

Published: Oct. 2, 2022

Nowadays there is a growing interest among consumers for functional food products, and edible flowers could be solution to fulfill this demand. Edible have been used throughout the centuries their pharmaceutical properties, but also in some areas culinary purposes. There great variety of flowers, numerous studies are available regarding chemical composition potential antioxidant characteristics. Therefore, present work focuses on gathering vast amount data flowers. Phytochemical content, total phenolic flavonoid content activity (DPPH, FRAP, ABTS, etc.) more than 200 presented. The main phytochemicals belong groups acids, flavonoids, carotenoids tocols, while variability reported content. study useful tool select that can served as sources specific with increased evaluate them safety application industry, during processing storage.

Language: Английский

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Valorization of Corn Silk as an Agricultural By-Product through the Optimization of Ultrasound-Assisted Extraction

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 1516 - 1516

Published: Feb. 13, 2024

Corn silk, derived from the stigmas of corn (Zea mays, Poaceae) flowers, possesses valuable bioactive compounds that can be harnessed for therapeutical, nutritional, and industrial purposes. This research aimed to optimize extraction specifically flavonoids total antioxidant capacity, by comparing it with classical (infusion maceration). The study identified significant factors influencing flavonoid content (TFC) activity (assessed through an ABTS assay), including ethanol concentration, ultrasonic amplitude, their quadratic interactions. optimized combination independent variables (37.89% ethanolic 48.58% ultrasound time 38.72 min) yielded a balanced extraction, maximizing both TFC activity. Further analyses revealed phenolic content, (50.69 ± 0.36 mg GAE, 23.54 0.01 QE, 78.33 0.94 TE/g extract, respectively), potent in vitro activity, affirming efficacy extraction. also explored inhibitory effects on α-glucosidase (IC50 = 411.67 25.39 µg/mL), acetylcholinesterase 1166.4 399.38 pancreatic lipase 1519.67 209.04 showcasing potential antidiabetic neuroprotective properties. While tyrosinase inhibition was not observed, emphasizes nutraceutical offering insights its utilization further exploration pharmaceutical functional food industries.

Language: Английский

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Antioxidants in Age-Related Diseases and Anti-Aging Strategies

Antioxidants, Journal Year: 2022, Volume and Issue: 11(10), P. 1868 - 1868

Published: Sept. 21, 2022

Aging is an intricate process and important risk factor in the development advancement of many disorders [...].

Language: Английский

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Epilobium Species: From Optimization of the Extraction Process to Evaluation of Biological Properties

Antioxidants, Journal Year: 2022, Volume and Issue: 12(1), P. 91 - 91

Published: Dec. 30, 2022

Epilobium species are used in Romanian folk medicine as tinctures, tea, or tablets for ameliorating the symptoms of benign prostate hyperplasia (BPH), but scientific-based evidence is scarce this other endemic plants same genus. Therefore, aims research were to evaluate phytochemical profile five (E. hirsutum L., E. parviflorum Schreb., palustre L. dodonaei Vill., and angustifolium L.) assess their vitro biological activity. For enhanced recovery polyphenols, a D-optimal experimental plan was developed using Modde software optimal working conditions ultra-turrax-assisted extraction, 8 min, with 30% ethanol water. The optimized extracts obtained from various plant parts further characterized by LC-MS analysis, major compound being oenothein B. All demonstrated good antioxidant activity, evaluated DPPH TEAC assays. most prominent antimicrobial potency displayed against Bacillus cereus, while Gram-(+) bacteria, moderate efficacy observed. Furthermore, anti-cancer, anti-inflammatory, potential assessed on normal fibroblasts carcinoma cell lines. From extracts, aerial had highest selectivity toward killing cancerous cells, followed extract. effect, leaves hirstum potency, decreasing ROS at level observed positive control. anti-inflammatory potential, based IL-6 IL-8 levels, extracts. In conclusion, all harvested flora possess diverse composition, which supports complex activities.

Language: Английский

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