Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Foods, Journal Year: 2022, Volume and Issue: 11(9), P. 1283 - 1283
Published: April 28, 2022
Fermentation of various food stuffs by lactic acid bacteria is one the oldest forms biopreservation. Bacterial antagonism has been recognized for over a century, but in recent years, this phenomenon received more scientific attention, particularly use strains (LAB). Certain LAB demonstrated antimicrobial activity against foodborne pathogens, including bacteria, yeast and filamentous fungi. Furthermore, many authors proved that have ability to neutralize mycotoxin produced last group. Antimicrobial mainly based on production metabolites such as acid, organic acids, hydroperoxide bacteriocins. In addition, some research suggests other mechanisms pathogens well their toxic metabolites. These properties are very important because future possibility exchange chemical physical methods preservation with biological method Biopreservation defined extension shelf life increase safety controlled microorganisms or This may determine alternative usage preservatives. study, possibilities provided. Our aim yield knowledge about fermentation pathogenic microorganisms. we would like introduce actual information health aspects associated consumption fermented products, probiotics.
Language: Английский
Citations
176
Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)
Published: Feb. 14, 2023
Abstract Vitamin K is a vital micronutrient implicated in variety of human diseases. Warfarin, vitamin antagonist, the most commonly prescribed oral anticoagulant. Patients overdosed on warfarin can be rescued by administering high doses because existence warfarin-resistant reductase. Despite functional discovery reductase over eight decades ago, its identity remained elusive. Here, we report identification using genome-wide CRISPR-Cas9 knockout screen with K-dependent apoptotic reporter cell line. We find that ferroptosis suppressor protein 1 (FSP1), ubiquinone oxidoreductase, enzyme responsible for reduction manner, consistent recent Mishima et al. FSP1 inhibitor inhibited and thus triggered cancer ferroptosis, displays strong inhibition carboxylation. Intriguingly, dihydroorotate dehydrogenase, another ubiquinone-associated parallel to function FSP1, does not support These findings provide new insights into selectively controlling physiological pathological processes involving electron transfers mediated ubiquinone.
Language: Английский
Citations
48
Food Research International, Journal Year: 2024, Volume and Issue: 186, P. 114324 - 114324
Published: April 17, 2024
The growth of the elderly population worldwide is posing significant challenges to human society. progressive physical and physiological changes occur with aging, including decreased appetite, incomplete digestion, reduced absorption nutrients. A common feature many people's diets a deficiency in proteins (especially easily digestible ones) micronutrients (e.g., vitamins, zinc, iron, calcium). One solutions this problem incorporation these components into suitably texture-modified foods. There dearth products that meet needs special medical/health conditions such as dysphagia, osteoporosis, diabetes, cardiovascular disease, well those who are hospital palliative care. Future research development foods for must address specific dietary different subgroups people underlying health conditions. existence stages means their requirements be considered. This review summarizes current knowledge on nutritional problems outlines innovation pathways developing new considering nutrition, texture, flavor, other sensory aspects.
Language: Английский
Citations
17
Plants, Journal Year: 2021, Volume and Issue: 11(1), P. 18 - 18
Published: Dec. 22, 2021
Epidemiological and clinical studies have indicated positive outcomes related to tree nut consumption. Here, we review the production, nutrient, phytochemical composition emerging research trends on health benefits of pistachio nuts (
Language: Английский
Citations
97
Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1412 - 1412
Published: July 21, 2022
Biomarkers of metabolic syndrome and inflammation are pathophysiological predictors factors senescence age-related diseases. Recent evidence showed that particular diet components, such as walnuts rich in antioxidant bioactive compounds with a balanced lipid profile, could have positive outcomes on human health. A systematic search PubMed, EMBASE, Cochrane Library, Scopus, ClinicalTrials.gov databases was performed to retrieve randomized controlled trials published from the beginning each database through November 2021, reporting walnut consumption over 22 inflammatory markers middle-aged older adults. The strategy rendered 17 studies final selection, including 11 crossover 6 parallel trials. study revealed walnut-enriched diets had statistically significant decreasing effects for triglyceride, total cholesterol, LDL cholesterol concentrations some presented no consequences anthropometric glycemic parameters. Although further better-designed ones needed strengthen these findings, results emphasize benefits dietary plans this age group.
Language: Английский
Citations
54
Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 113, P. 374 - 388
Published: Aug. 8, 2023
Language: Английский
Citations
34
Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 415 - 415
Published: Feb. 8, 2023
Alzheimer’s disease (AD) is the most common type of dementia that affects millions individuals worldwide. It an irreversible neurodegenerative disorder characterized by memory loss, impaired learning and thinking, difficulty in performing regular daily activities. Despite nearly two decades collective efforts to develop novel medications can prevent or halt progression, we remain faced with only a few options limited effectiveness. There has been recent growth interest role nutrition brain health as begin gain better understanding what how nutrients affect hormonal neural actions not lead typical cardiovascular metabolic diseases but also array neurological psychiatric disorders. Vitamins minerals, known micronutrients, are elements indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, antioxidant anti-inflammatory properties. In this review, provide overview on some vitamins minerals discuss current studies have revealed link between these essential micronutrients cognitive performance AD.
Language: Английский
Citations
27
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 1147 - 1160
Published: Feb. 1, 2024
Vitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature the form VK1 VK2.As its initial recognition originated from ability to promote blood coagulation, it is known as coagulation vitamin.However, based on extensive research, VK has shown potential for prevention treatment various diseases.Studies demonstrating beneficial effects immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, bone protection have drawn growing interest recent years.This review article focuses mechanism action preventive therapeutic infections (eg, asthma, COVID-19), inflammation type 2 diabetes mellitus, Alzheimer's disease, Parkinson's cancer, aging, atherosclerosis) autoimmune disorders inflammatory bowel 1 multiple sclerosis, rheumatoid arthritis).In addition, VK-dependent proteins (VKDPs) are another crucial by which exerts anti-inflammatory immunomodulatory effects.This explores role preventing combating neurological abnormalities, treating diseases such cancer diabetes.Although current research appoints tool practical clinical applications infections, inflammation, diseases, future necessary elucidate more detail overcome limitations.
Language: Английский
Citations
15
Pharmacological Reviews, Journal Year: 2025, Volume and Issue: 77(2), P. 100037 - 100037
Published: Jan. 8, 2025
Taking a historical perspective, we review the discovery, pharmacology, and clinical evaluation of old new anticoagulants that have been approved for use. The drugs are discussed chronologically, starting in 1880s, progressing through to 2024. innovations technology used develop novel came fits starts reflected advances science over these decades, whereas shift from anecdote evidence-based use was delayed until principles epidemiology biostatistics were introduced into trial design approval process. Hirudin, heparin, vitamin K antagonists discovered by chance, clinically before their mechanism action elucidated net benefits evaluated randomized trials. Subsequent designed based on better understanding structure function coagulation proteins, including antithrombin, thrombin, factor Xa, underwent more rigorous preclinical regulatory approval. By simplifying oral anticoagulation, direct revolutionized anticoagulation care enhanced uptake but bleeding has not eliminated there is need effective convenient thrombosis triggered contact pathway coagulation. newly developed XIa XIIa inhibitors potential address unmet needs undergoing several indications. SIGNIFICANCE STATEMENT: Anticoagulant therapy cornerstone treatment prevention thrombosis, which remains leading cause morbidity mortality worldwide. Elucidation enzymes, cofactors, inhibitors, coupled with structure-based led discovery convenient, safer, management thrombotic disorders.
Language: Английский
Citations
1
Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(10), P. 864 - 881
Published: Aug. 23, 2022
Language: Английский
Citations
38