The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects DOI Open Access

Linan Ren,

Haiying Cui, Yao Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114465 - 114465

Published: March 3, 2023

Lipotoxicity is the dysregulation of lipid environment and/or intracellular composition that leads to accumulation harmful lipids and ultimately organelle dysfunction, abnormal activation signaling pathways, chronic inflammation cell death. It plays an important role in development acute kidney injury disease, including diabetic nephropathy, obesity-related glomerulopathy, age-related polycystic like. However, mechanisms overload remain poorly understood. Herein, we discuss two pivotal aspects lipotoxic injury. First, analyzed mechanism kidney. Accumulating data indicate different diseases are inconsistent. Second, summarize multiple by which species affect behavior, oxidative stress, endoplasmic reticulum mitochondrial dysregulated autophagy, inflammation, highlighting central stress. Blocking molecular pathways damage may be potential therapeutic targets for antioxidant drugs play a treatment disease future.

Language: Английский

Apolipoprotein D in Oxidative Stress and Inflammation DOI Creative Commons

Guillaume Fyfe-Desmarais,

Frédérik Desmarais, Éric Rassart

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1027 - 1027

Published: April 28, 2023

Apolipoprotein D (ApoD) is lipocalin able to bind hydrophobic ligands. The APOD gene upregulated in a number of pathologies, including Alzheimer’s disease, Parkinson’s cancer, and hypothyroidism. Upregulation ApoD linked decreased oxidative stress inflammation several models, humans, mice, Drosophila melanogaster plants. Studies suggest that the mechanism through which modulates regulate via its capacity arachidonic acid (ARA). This polyunsaturated omega-6 fatty can be metabolised generate large variety pro-inflammatory mediators. serves as sequester, blocking and/or altering metabolism. In recent studies diet-induced obesity, has been shown modulate lipid mediators derived from ARA, but also eicosapentaenoic docosahexaenoic an anti-inflammatory way. High levels have better metabolic health inflammatory state round ligament morbidly obese women. Since expression numerous diseases, it might serve therapeutic agent against pathologies aggravated by OS such many obesity comorbidities. review will present most findings underlying central role modulation both inflammation.

Language: Английский

Citations

31
Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism DOI Creative Commons
Maocai Luo,

Yuhong Zheng,

Shiyun Tang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: May 12, 2023

Background: The incidence of glycolipid metabolic diseases is extremely high worldwide, which greatly hinders people’s life expectancy and patients’ quality life. Oxidative stress (OS) aggravates the development in metabolism. Radical oxygen species (ROS) a key factor signal transduction OS, can regulate cell apoptosis contribute to inflammation. Currently, chemotherapies are main method treat disorders metabolism, but this lead drug resistance damage normal organs. Botanical drugs an important source new drugs. They widely found nature with availability, practicality, low cost. There increasing evidence that herbal medicine has definite therapeutic effects on diseases. Objective: This study aims provide valuable for treatment botanical from perspective ROS regulation by further promote effective clinical Methods: Using herb*, plant medicine, Chinese phytochemicals, natural phytomedicine, extract, drug, ROS, free radicals, radical, oxidizing agent, glucose lipid saccharometabolism, glycometabolism, blood glucose, lipoprotein, triglyceride, fatty liver, atherosclerosis, obesity, diabetes, dysglycemia, NAFLD, DM as keywords or subject terms, relevant literature was retrieved Web Science PubMed databases 2013 2022 summarized. Results: regulating mitochondrial function, endoplasmic reticulum, phosphatidylinositol 3 kinase (PI3K)/protein B (AKT), erythroid 2-related 2 (Nrf-2), nuclear κB (NF-κB), other signaling pathways improve OS glucolipid Conclusion: multi-mechanism multifaceted. Both studies animal experiments have demonstrated effectiveness ROS. However, safety need be improved, more needed support application

Language: Английский

Citations

30
Advances and perspectives in fluorescent probes for imaging hepatopathy-related biomarkers DOI

Quan Wei,

Wenhui Song, Qian Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215407 - 215407

Published: Sept. 12, 2023

Language: Английский

Citations

29
Sestrin2: multifaceted functions, molecular basis, and its implications in liver diseases DOI Creative Commons
Chunfeng Lu, Yiming Jiang, Wenxuan Xu

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(2)

Published: Feb. 25, 2023

Abstract Sestrin2 (SESN2), a highly conserved stress-responsive protein, can be triggered by various noxious stimuli, such as hypoxia, DNA damage, oxidative stress, endoplasmic reticulum (ER) and inflammation. Multiple transcription factors regulate SESN2 expression, including hypoxia-inducible factor 1 (HIF-1), p53, nuclear E2-related 2 (Nrf2), activating 4 (ATF4), ATF6, etc. Upon induction, generally leads to activation of adenosine monophosphate-activated protein kinase (AMPK) inhibition mechanistic target rapamycin complex (mTORC1). To maintain cellular homeostasis, its downstream molecules directly scavenge reactive oxygen species or indirectly influence the expression patterns key genes associated with redox, macroautophagy, mitophagy, ER apoptosis, synthesis, In liver diseases acute injury, fatty diseases, hepatic fibrosis, hepatocellular carcinoma (HCC), is abnormally expressed correlated disease progression. NAFLD, helps postponing progression through balancing glycolipid metabolism macroautophagy (lipophagy), rectifying damage stress. During represses HSCs intrahepatic inflammation, hindering occurrence progress fibrogenesis. However, role in HCC controversial due paradoxical pro-autophagic anti-apoptotic effects. conclusion, this review summarizes biological functions genotoxic specifically emphasizes pathophysiological significance aiming providing comprehensive understanding for potential therapeutic diseases.

Language: Английский

Citations

27
The role of lipotoxicity in kidney disease: From molecular mechanisms to therapeutic prospects DOI Open Access

Linan Ren,

Haiying Cui, Yao Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114465 - 114465

Published: March 3, 2023

Lipotoxicity is the dysregulation of lipid environment and/or intracellular composition that leads to accumulation harmful lipids and ultimately organelle dysfunction, abnormal activation signaling pathways, chronic inflammation cell death. It plays an important role in development acute kidney injury disease, including diabetic nephropathy, obesity-related glomerulopathy, age-related polycystic like. However, mechanisms overload remain poorly understood. Herein, we discuss two pivotal aspects lipotoxic injury. First, analyzed mechanism kidney. Accumulating data indicate different diseases are inconsistent. Second, summarize multiple by which species affect behavior, oxidative stress, endoplasmic reticulum mitochondrial dysregulated autophagy, inflammation, highlighting central stress. Blocking molecular pathways damage may be potential therapeutic targets for antioxidant drugs play a treatment disease future.

Language: Английский

Citations

26