Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 26, 2024
This
study
aimed
to
determine
whether
urinary
creatinine
excretion
rate
(CER),
a
marker
of
muscle
mass,
is
associated
with
diabetic
retinopathy
in
individuals
type
2
diabetes
and
ascertain
this
putative
association
depends
on
body
mass
index
(BMI).
cross
sectional
evaluated
2035
diabetes.
Twenty-four-hour
urine
was
collected.
Individuals
had
lower
CER
BMI
values
than
those
without.
Patients
higher
quartiles
prevalence
retinopathy.
A
significant
relationship
between
persisted,
even
after
adjusting
for
traditional
risk
factors,
including
glycated
hemoglobin,
duration,
hypertension,
multivariable
analysis.
Further
adjustment
did
not
significantly
alter
the
suggests
that
inversely
diabetes,
independent
BMI.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(16), P. 8520 - 8520
Published: Aug. 7, 2021
In
the
last
decade,
clear
evidence
has
emerged
that
cellular
components
of
skeletal
muscle
are
important
sites
for
release
proteins
and
peptides
called
“myokines”,
suggesting
plays
role
a
secretory
organ.
After
their
secretion
by
muscles,
these
factors
serve
many
biological
functions,
including
exertion
complex
autocrine,
paracrine
and/or
endocrine
effects.
sum,
myokines
affect
multi-organ
processes,
such
as
trophism,
metabolism,
angiogenesis
immunological
response
to
different
physiological
(physical
activity,
aging,
etc.)
or
pathological
states
(cachexia,
dysmetabolic
conditions,
chronic
inflammation,
etc.).
The
aim
this
review
is
describe
in
detail
number
are,
varying
degrees,
involved
aging
processes
belong
group
present
functional
environment
surrounding
cell
known
“Niche”.
particular
described
those
that,
acting
both
from
within
an
autocrine
manner,
have
defined
relationship
with
modulation
oxidative
stress
cells
(mature
stem)
regulatory
(metabolic
regenerative)
aging.
Myostatin,
IGF-1,
NGF,
S100
irisin
examples
specific
peculiar
features
mechanisms
action.
particular,
potential
one
most
recently
characterized
myokines—irisin,
directly
linked
active
lifestyle—in
reducing
if
not
reversing
senescence-induced
damage
discussed
terms
its
possible
application
agent
able
counteract
deleterious
effects
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3113 - 3113
Published: Dec. 2, 2022
Many
people
infected
with
the
SARS-CoV-2
suffer
long-term
symptoms,
such
as
"brain
fog",
fatigue
and
clotting
problems.
Explanations
for
"long
COVID"
include
immune
imbalance,
incomplete
viral
clearance
potentially,
mitochondrial
dysfunction.
As
conditions
sub-optimal
function
are
associated
initial
severity
of
disease,
their
prior
health
could
be
key
in
resistance
to
long
COVID
recovery.
The
SARs
virus
redirects
host
metabolism
towards
replication;
response,
can
metabolically
react
control
virus.
Resolution
is
normally
achieved
after
stress
activates
a
hormetic
negative
feedback
mechanism.
It
therefore
possible
that,
some
individuals
function,
"tip"
into
chronic
inflammatory
cycle.
This
might
explain
main
including
platelet
Long
thus
described
virally
induced
self-perpetuating
imbalanced
non-resolving
state
characterised
by
dysfunction,
where
reactive
oxygen
species
continually
drive
inflammation
shift
glycolysis.
would
suggest
that
sufferer's
needs
"tipped"
back
using
stimulus,
physical
activity,
calorie
restriction,
or
chemical
compounds
mimic
these
enhancing
perhaps
combination
inhibitors
quell
response.
Annals of Medicine,
Journal Year:
2023,
Volume and Issue:
55(2)
Published: Aug. 29, 2023
Aim:
To
discuss
the
progress
of
extracellular
matrix
(ECM)
characteristics,
mitochondrial
homeostasis,
and
their
potential
crosstalk
in
pathogenesis
sarcopenia,
a
geriatric
syndrome
characterized
by
generalized
progressive
reduction
muscle
mass,
strength,
physical
performance.Methods:
This
review
focuses
on
anatomy
physiology
skeletal
muscle,
alterations
ECM
mitochondria
during
ageing,
role
interplay
between
sarcopenia.Results:
Emerging
evidence
points
to
clear
various
tissues
organs.
Under
ageing
process,
undergoes
changes
composition
properties
that
may
mediate
via
systematic
metabolism,
ROS,
SPARC
pathway,
AMPK/PGC-1α
signalling,
which
turn
exacerbate
degeneration.
However,
precise
effects
such
pathobiology
particularly
have
not
yet
been
fully
understood.Conclusion:
The
are
partially
responsible
for
worsened
function
process.
A
deeper
understanding
interactions
sarcopenic
patients
can
help
prevent
sarcopenia
improve
its
prognoses.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
10
Published: Feb. 21, 2022
Skeletal
muscle
fibers
contain
a
large
number
of
mitochondria,
which
produce
ATP
through
oxidative
phosphorylation
(OXPHOS)
and
provide
energy
for
contraction.
In
this
process,
mitochondria
also
several
types
“reactive
species”
as
side
product,
such
reactive
oxygen
species
nitrogen
have
attracted
interest.
Mitochondria
been
proven
to
an
essential
role
in
the
production
skeletal
oxygen/nitrogen
(RONS).
Traditionally,
elevation
RONS
is
related
stress,
leading
impaired
contractility
atrophy.
However,
recent
studies
shown
that
optimal
level
under
action
antioxidants
critical
physiological
signal
muscle.
Here,
we
will
review
origin
functions
RONS,
mitochondrial
structure
function,
dynamics,
coupling
between
stress.
The
crosstalk
mechanism
function
its
regulation
stem
cell
fate
myogenesis
be
discussed.
all,
aims
describe
comprehensive
systematic
network
interaction
RONS.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(1), P. 222 - 222
Published: Jan. 1, 2023
High-intensity
exercise
in
athletes
results
mainly
the
production
of
excess
reactive
oxygen
species
(ROS)
skeletal
muscle,
and
thus
should
maintain
greater
ROS
scavenging
activity
body.
We
investigated
changes
six
different
ROS-scavenging
activities
following
high-intensity
anaerobic
exercise.
A
30-s
Wingate
test
as
a
form
was
completed
by
10
male
university
track
field
team
members.
Blood
samples
were
collected
before
after
exercise,
(OH•,
O2•−,
1O2,
RO•
ROO•,
CH3•)
evaluated
electron
spin
resonance
(ESR)
spin-trapping
method.
The
significantly
increased
ROO•
activities,
total
area
radar
chart
178%
from
that
pre-exercise.
significant
correlation
between
mean
power
1O2
revealed
(r
=
0.72,
p
<
0.05).
increase
ratio
OH•
higher
mean-power
group
compared
to
lower
(n
5,
each).
These
suggest
(i)
some
are
immediately
(ii)
an
individual’s
responsiveness
may
be
related
his
performance.
In
addition,
pre-exercise
might
lead
generation
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 10116 - 10116
Published: Sept. 20, 2024
Irisin,
a
myokine
derived
from
fibronectin
type
III
domain-containing
5
(FNDC5),
is
increasingly
recognized
for
its
protective
role
in
musculoskeletal
health
through
the
modulation
of
mitochondrial
quality
control.
This
review
synthesizes
current
understanding
irisin’s
impact
on
biogenesis,
dynamics,
and
autophagy
skeletal
muscle,
elucidating
capacity
to
bolster
muscle
strength,
endurance,
resilience
against
oxidative-stress-induced
atrophy.
The
multifunctional
nature
irisin
extends
bone
metabolism,
where
it
promotes
osteoblast
proliferation
differentiation,
offering
potential
intervention
osteoporosis
other
disorders.
Mitochondrial
control
vital
cellular
particularly
energy-demanding
tissues.
Irisin’s
influence
this
process
highlighted,
suggesting
integral
maintaining
homeostasis.
also
touches
upon
regulatory
mechanisms
secretion,
predominantly
induced
by
exercise,
systemic
effects
as
an
endocrine
factor.
While
therapeutic
promising,
need
standardized
measurement
techniques
further
elucidation
humans
acknowledged.
collective
findings
underscore
burgeoning
interest
keystone
candidate
future
strategies.
