Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2542 - 2542

Published: Feb. 25, 2022

Diet might affect male reproductive potential, but the biochemical mechanisms involved in modulation of sperm quality remain poorly understood. While a Western diet is considered risk factor for infertility, Mediterranean seems to protect against infertility; moreover, role vegetarian habitus preservation controversial. The aim this review analyze molecular effects single nutrients on quality, focusing their involvement related bioenergetics. It appears that diets rich saturated fatty acids (SFA) and low polyunsaturated (PUFA) negatively whereas unsaturated supplementation ameliorates quality. In fact, administration PUFA, especially omega-3 determined an increase mitochondrial energetic metabolism reduction oxidative damage. Carbohydrates proteins are also nutritional modulators stress testosterone levels, which strictly linked function, key element Moreover, many dietary natural polyphenols differentially (positively or negatively) depending concentration. We believe understanding responsible will lead more targeted effective therapeutics infertility.

Language: Английский

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Plant Extracts as Alternative Additives for Sperm Preservation

Antioxidants, Journal Year: 2021, Volume and Issue: 10(5), P. 772 - 772

Published: May 13, 2021

Sperm preservation is a crucial factor for the success of assisted reproductive technology (ART) in humans, livestock, and wildlife. Irrespective extender storage conditions used, semen handling negatively affect sperm quality. Moreover, oxidative stress, which often arises during storage, significantly reduces function compromises fertilizing ability by inducing damage to proteins, lipids, nucleic acids. Plant extracts have recently emerged as cheap natural source additives preserve enhance storage. The present work provides an update on use these compounds alternative 13 animal species, including humans. A detailed description effects 45 plant belonging 28 families, presented. material extraction method employed, dosage, possible toxic effects, antimicrobial properties are provided.

Language: Английский

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Apigenin supplementation substantially improves rooster sperm freezability and post-thaw function

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 24, 2024

Abstract This pioneering research investigated apigenin potential to augment rooster sperm cryosurvival in an extender model. Apigenin is a natural antioxidant flavonoid showing promise for improved post-thaw function. However, its effects on avian semen cryopreservation remain unexplored. first study supplemented Lake with 0, 50, 100, 200, 400 μmol/L determine the optimal concentrations quality. Supplementation 100 resulted significant enhancements total motility (from 41.5% up 71.5%), progressive (18.1% 29.1%) (p < 0.05), membrane integrity (40% 68%), mitochondrial function 0.001), viability (37% 62%) and capacity 0.001) compared control. It also substantially reduced percentages of abnormal morphology, reactive oxygen species apoptosis 0.001). Although 200 significantly enhanced some attributes, were markedly lower than μmol/L. Higher doses did not improve cryoprotective parameters. indicates as concentration. represents report protecting from cryodamage. The quality, likely by suppressing oxidative stress apoptosis. shows enhancing cryosurvival.

Language: Английский

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Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(1), P. 17 - 33

Published: Sept. 11, 2023

Abstract Purpose The purpose of this review is to examine the current evidence on potential role Mediterranean diet (MD) in prevention and management endocrine disorders highlight importance interdisciplinary collaboration between endocrinologists nutritionists. Methods A literature search was conducted using PubMed Google Scholar databases identify relevant studies published English. Studies were selected based their relevance MD disorders. terms included "Mediterranean diet," "endocrine disorders," "thyroid "gonadal "neuroendocrine tumors". Results reviewed suggest that may have a beneficial effect various disorders, including thyroid gonadal neuroendocrine tumors. has been associated with decreased risk nodular disease cancer, improved male female reproductive health, MD's anti-inflammatory antioxidant properties, as well its high levels phytochemicals, play effects. Conclusion Interdisciplinary nutritionists essential for optimal management. While further research needed, suggests protective against incorporation into dietary recommendations be beneficial.

Language: Английский

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The Role of Dietary Nutrients in Male Infertility: A Review

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 519 - 519

Published: Feb. 14, 2023

Male infertility is the main health issue with economic, psychological, and medical attributions. Moreover, it characterized by an inability to produce a sufficient amount of sperm for fertilization oocyte. Dietary nutrients (DN) have great effect on male reproductive potential. Observations indicated that adding DN may protect or treat infertility. The scope this criticism scrutinize DN, such as omega-3 fatty acids, vitamins, minerals other phytochemicals, in enhancing semen attributes, bioenergetics functionality It seems diets rich acids affect quality maintain membrane mitochondria stability. An administration phytochemicals caused escalation mitochondrial function decrease oxidative damage. Furthermore, sundry dietary natural differentially (negatively positively) motility, quality, function, dependent their levels. Vitamins trace elements are also nutritional modulators reducing stress, thereby which accurately connected function. Also, we described different types enhancer health. We believe understanding supports epigenetic be responsible health, will lead more embattled efficient therapeutics

Language: Английский

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The Role of Selected Natural Biomolecules in Sperm Production and Functionality

Molecules, Journal Year: 2021, Volume and Issue: 26(17), P. 5196 - 5196

Published: Aug. 27, 2021

Emerging evidence from in vivo as well vitro studies indicates that natural biomolecules may play important roles the prevention or management of a wide array chronic diseases. Furthermore, use compounds treatment male sub- infertility has been proposed potential alternative to conventional therapeutic options. As such, we aimed evaluate effects selected on sperm production, structural integrity, and functional activity. At same time, reviewed their possible beneficial adverse reproductive health. Using relevant keywords, literature search was performed collect currently available information regarding molecular mechanisms by which exhibit biological context dysfunction. Evidence gathered clinical trials, experiments suggest affect key targets related mitochondrial metabolism motion behavior, oxidative stress, inflammation, DNA integrity cell death. The majority reports emphasize ameliorative, stimulating protective function. Nevertheless, toxic behavior indicated well, pointing out dose-dependent impact survival functionality. further research leading deeper understanding is necessary before these can be employed for

Language: Английский

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Genistein and chlorin E6-loaded versatile nanoformulation for remodeling the hypoxia-related tumor microenvironment and boosting photodynamic therapy in nasopharyngeal carcinoma treatment

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 21, 2025

Language: Английский

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Effect of Biotin Supplementation and Swimming Training on Oxidative Stress and Testicular Function in Male Rats

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42468 - e42468

Published: Feb. 1, 2025

Oxidative stress (OS) affects testicular function and is a significant cause of sperm cell dysfunction in males. The development male infertility closely linked to sedentary lifestyle diet. This study aimed characterize the protective effects biotin supplementation (BS) swimming training (ST) on OS markers reproductive system rats. Forty rats (200-250 g) were randomly assigned four groups (n = 10 per group) treated for 28 days as follows: control, BS (this group received through oral gavage), ST, + ST groups. Our results showed that glutathione (GSH) levels significantly increased BS, (p < 0.05), 0.01) groups, whereas malondialdehyde (MDA) decreased these experimental 0.05 all). Additionally, compared controls, there was increase 0.05) blood follicle-stimulating hormone (FSH), luteinizing (LH), testosterone (T), high-density lipoprotein (HDL) evidenced by decrease other biochemical parameters (cholesterol (CHO), triglyceride (TG), low-density (LDL), alanine transaminase (ALT), aspartate (AST), alkaline phosphatase (ALP)). According histological examination, an improvement control group. In conclusion, had positive antioxidant activity, along with improved

Language: Английский

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Pre-clinical evidence for mitochondria as a therapeutic target for luteolin: a mechanistic view

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111492 - 111492

Published: March 1, 2025

Language: Английский

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Exploration of the genetic and environmental determinants of male infertility: a comprehensive review

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 16, 2025

Abstract Infertility is a significant reproductive health issue in which couple unable to conceive child after having unprotected intercourse for one year. Various conditions contribute male infertility, with over half of cases being idiopathic, potentially inherited, or acquired. Poor spermatogenesis often linked infertility. Spermatogenesis, the transformation immature stem cells into mature gametes, can be disrupted by harmful substances. Azoospermia, absence spermatozoa two centrifuged semen samples, key cause Nonobstructive azoospermia (NOA) occurs when issues sperm production lead complete semen, due genetic abnormalities. Male infertility complex and depends on gene interactions, epigenetic regulation, environmental lifestyle factors. Genetic factors like chromosomal abnormality 20% population, diagnosed 5% 7% oligozoospermic males 15% azoospermic males. This review discusses influencing identifies knowledge gaps, suggests areas further research. The results showcase critical influence mutations, endocrine disruptors, toxins spermatogenesis, explicitly affecting association between external stressors predispositions. Furthermore, this study provides an overview improving diagnostic therapeutic options studying region-specific risk factors, specifically Pakistani population. Graphical

Language: Английский

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