Mitochondria Quality Control and Male Fertility

Biology, Journal Year: 2023, Volume and Issue: 12(6), P. 827 - 827

Published: June 6, 2023

Mitochondria are pivotal to cellular homeostasis, performing vital functions such as bioenergetics, biosynthesis, and cell signalling. Proper maintenance of these processes is crucial prevent disease development ensure optimal function. Mitochondrial dynamics, including fission, fusion, biogenesis, mitophagy, apoptosis, maintain mitochondrial quality control, which essential for overall health. In male reproduction, mitochondria play a role in germ any defects can have serious consequences on fertility. Reactive oxygen species (ROS) also sperm capacitation, but excessive ROS levels trigger oxidative damage. Any imbalance between caused by non-communicable diseases or environmental factors, lead an increase stress, damage, turn affect concentration, quality, motility. Therefore, assessing functionality control gain valuable insights into infertility. sum, proper health, particularly important The assessment provide information the study management infertility may new strategies its management.

Language: Английский

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Energy metabolism in mammalian sperm motility

WIREs Mechanisms of Disease, Journal Year: 2022, Volume and Issue: 14(5)

Published: June 9, 2022

Abstract Mammalian sperm, the only cells that achieve their purpose outside organism of origin, have to swim vigorously within female reproductive tract reach an oocyte. Flagellar dyneins drive sperm motility, which accounts for consumption high amounts ATP. The two main ATP‐producing metabolic pathways are compartmentalized in sperm: oxidative phosphorylation midpiece and glycolysis principal piece. relative preponderance these has been discussed decades (the so‐called energy debate ). muddled by species‐specific variances technical constraints. But recent findings suggest from most mammalian species employ a versatile strategy maintain motility according physiological environment. Different likely coordinate using exogenous and/or endogenous substrates order produce ATP efficiently. Defects any (glycolysis, mitochondrial phosphorylation, Krebs cycle, fatty acids oxidation, ketone bodies among others) may disturb be at origin male infertility. Understanding bioenergetics is thus crucial building new diagnostic tools, development treatments patients presenting with low motility. Some benefit personalized supplementations dietary interventions. This article categorized under: Reproductive System Diseases > Molecular Cellular Physiology

Language: Английский

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The Influence of Metabolic Factors and Diet on Fertility

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1180 - 1180

Published: Feb. 27, 2023

Infertility is a disease globally affecting 20–30% of the reproductive age female population. However, in up to 50% on recorded cases, problems with infertility are ascribed men; therefore, it important popularize healthy eating also this group. During last decade, has been observed that society’s lifestyle changed drastically: reduced energy expenditure physical activity per day, increased consumption hypercaloric and high-glycemic-index foods high content trans fats, dietary fiber, which negatively affects fertility. Increasing evidence points link between diet It becoming clear well-planned nutrition can contribute effectiveness ART. The low-GI plant-based appears have positive effect, especially when based Mediterranean patterns: rich antioxidants, vegetable protein, MUFA fatty acids, omega-3, vitamins, minerals. Importantly, shown protect against chronic diseases associated oxidative stress, translates into pregnancy success. As seem be factors fertility, worth expanding knowledge regard among couples trying conceive child.

Language: Английский

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Mediterranean diet and mitochondria: New findings

Experimental Gerontology, Journal Year: 2023, Volume and Issue: 176, P. 112165 - 112165

Published: April 5, 2023

Mitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key mitochondria the physiological response to both acute and chronic stress exposure, and, ultimately, biological embedding of adversity health psychological functioning that increases interest these medical conditions typical older people. At same time, Mediterranean diet (MedDiet) seems affect function further justifying this lowering risk negative outcomes. In review, we have elucidated human diseases including fundamental stress, aging, neuropsychiatric metabolic disorders. Overall, MedDiet can limit production free radicals, being rich polyphenols. Moreover, reduced mitochondrial reactive oxygen species (mtROS) ameliorated damage apoptosis. Similarly, whole grains maintain respiration membrane potential, finally improving function. Other components anti-inflammatory effects, again modulating For example, delphinidin (a flavonoid present red wine berries) restored elevated level respiration, mtDNA content, complex IV activity; similarly, resveratrol lycopene, grapefruits tomatoes, exerted an effect enzymes. Altogether, findings support notion positive effects be mediated by modulation indicating necessity studies beings confirming findings.

Language: Английский

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Implications of lifestyle factors on male reproductive health

JBRA, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In recent decades, there has been a substantial decline in sperm quality humans, with lifestyle factors playing major role this trend.There are several which contributing to male infertility.This review, however, discusses such as obesity, diet/nutrition, psychological stress, radiation exposure, cigarette smoking, and alcohol use reference infertility.Sperm count, motility, morphology DNA may be adversely affected by factors, also affect the endocrine regulation of reproductive function.The fertility significant impact on rates, resulting implications for human population make serious public health concern twenty-first century.Thus, interventions through specific framework educational, environmental, nutritional/physical exercise, support coupled nutritional antioxidants supplements can help couples achieve better well-being improve their prospects or increase chances conception.

Language: Английский

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Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 193 - 193

Published: Feb. 3, 2024

Infertility represents a significant global health challenge, affecting more than 12% of couples worldwide, and most cases infertility are caused by male factors. Several pathological pathways implicated in infertility. The main mechanisms involved driven the loss reduction–oxidation (redox) homeostasis resulting oxidative damage as well chronic inflammatory process. Increased or severe stress leads to sperm plasma membrane DNA damage, dysregulated RNA processing, telomere destruction. signaling these molecular events also regulated Nuclear factor-E2-related factor 2 (Nrf2). causes infertility, role Keap1-Nrf2 antioxidant pathway reviewed. This review highlights regulatory Nrf2 balance between oxidants antioxidants relevant fertility. is regulation spermatogenesis quality. Establishing link fertility provides basis for modulation processes, reactive oxygen species generation, network, including Nrf2-regulated response, improve reproductive outcomes.

Language: Английский

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Gut microbiota is involved in male reproductive function: a review

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Globally, ~8%−12% of couples confront infertility issues, male-related issues being accountable for 50%. This review focuses on the influence gut microbiota and their metabolites male reproductive system from five perspectives: sperm quality, testicular structure, sex hormones, sexual behavior, probiotic supplementation. To improve can secrete by themselves or regulate host metabolites. Endotoxemia is a key factor in structure damage that causes orchitis disrupts blood-testis barrier (BTB). In addition, hormone levels participating synthesis hormone-related enzymes directly enterohepatic circulation affect hypothalamic-pituitary-testis (HPT) axis. They also activate areas brain control arousal behavior through Probiotic supplementation function. Therefore, may function behavior; however, further research needed to better understand mechanisms underlying microbiota-mediated infertility.

Language: Английский

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The impact of mitochondrial impairments on sperm function and male fertility: a systematic review

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 17, 2024

Abstract Background Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium homeostasis, generation reactive oxygen species (ROS), apoptosis, in some cases steroid hormone biosynthesis. Normal mitochondrial membrane potential with optimal performance is essential capacitation, acrosome reaction, DNA integrity. Results Defects function can severely harm fertility males. The role its final fate after still controversial. Here, we review current knowledge on human characteristics their physiological pathological conditions, paying special attention to improvements assistant reproductive technology available treatments ameliorate male infertility. Conclusion Although variants associated infertility have clinical use, research limited. Further understanding needed determine how these lead adverse pregnancy outcomes affect potential.

Language: Английский

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The association between consumption of ultra-processed foods and sperm quality parameters: a cross-sectional study

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 1, 2025

While recent studies suggest a correlation between unhealthy dietary patterns, oxidative stress, inflammation, and male infertility, the potential association ultra-processed foods (UPFs) infertility remains underexplored. Therefore, aim of present study was to investigate UPF intake by evaluating sperm quality parameters. The participants (n = 260) current cross-sectional were recruited from an center in Isfahan Province, Iran. Four semen parameters—such as total motility, concentration, volume, normal morphology—were evaluated. Also, participants' food assessed using validated 168-item frequency questionnaire. Moreover, NOVA system employed calculate index. UPFs parameters analyzed logistic regression. In crude model, no significant associations observed second last tertiles with abnormalities morphology (p > 0.05 for all). However, after adjusting age, marriage duration, body mass index, physical activity, depression, anxiety, energy intake, cigarette history, mineral vitamin supplements, significantly higher identified tertile concentration (odds ratio (OR) 3.962, 95% confidence interval (CI): 1.345–11.670, p 0.013). conclusion, although analysis did not find consumption impaired motility morphology, it revealed trends linking lower concentration. If future confirm these results, they could aid designing interventional preventive programs aimed at addressing men reproductive age field public health.

Language: Английский

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Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(1), P. 17 - 33

Published: Sept. 11, 2023

Abstract Purpose The purpose of this review is to examine the current evidence on potential role Mediterranean diet (MD) in prevention and management endocrine disorders highlight importance interdisciplinary collaboration between endocrinologists nutritionists. Methods A literature search was conducted using PubMed Google Scholar databases identify relevant studies published English. Studies were selected based their relevance MD disorders. terms included "Mediterranean diet," "endocrine disorders," "thyroid "gonadal "neuroendocrine tumors". Results reviewed suggest that may have a beneficial effect various disorders, including thyroid gonadal neuroendocrine tumors. has been associated with decreased risk nodular disease cancer, improved male female reproductive health, MD's anti-inflammatory antioxidant properties, as well its high levels phytochemicals, play effects. Conclusion Interdisciplinary nutritionists essential for optimal management. While further research needed, suggests protective against incorporation into dietary recommendations be beneficial.

Language: Английский

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