BMJ Nutrition Prevention & Health, Journal Year: 2023, Volume and Issue: 6(2), P. 119 - 121
Published: Oct. 19, 2023
Language: Английский
Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee pollen is characterized by an exceptional diversity and abundance of micronutrients bioactive phytochemicals. This richness remains very sparsely investigated, but accumulating evidence strongly supports a promising future for bee in human nutrition medicine. Epigenetic regulation among the most compelling biomedical topics that remain completely untapped derivative research. In our current research, we identified numerous ubiquitous compounds are consistently present this matrix, regardless its botanical geographical origins, have been well studied documented as epigenetic regulators recent years. Given relative newness both research studies within nutritional, pharmaceutical, medical sciences, review aims to bridge these valuable fields advance related experimental investigations. To best knowledge, first work has aimed comprehensively investigate modulatory potential compounds. Our findings also unveiled several intriguing phenomena, such dual effect same compound depending on cellular context or some cross-generational heritability traits. Although whole extract still lacking, study clearly indicates avenue worth further We hope constitutes foundational cornerstone investigations
Language: Английский
Citations
2
Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5116 - 5116
Published: Dec. 15, 2023
Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of global population. These conditions not only affect quality life individuals their families, but also pose significant economic burdens on healthcare systems. In this context, our comprehensive narrative review critically examines role nutritional supplements in mitigating cognitive decline. Amidst growing interest non-pharmacological interventions for enhancement, delves into efficacy vitamins, minerals, antioxidants, other dietary supplements. Through a systematic evaluation randomized controlled trials, observational studies, meta-analysis, focuses outcomes such as memory attention improvement, executive function support, neuroprotection. The findings suggest complex interplay between supplementation health, with some showing promising results others displaying limited or context-dependent effectiveness. highlights importance dosage, bioavailability, individual differences response to supplementation. Additionally, it addresses safety concerns potential interactions conventional treatments. By providing clear overview current scientific knowledge, aims guide professionals researchers making informed decisions about use health.
Language: Английский
Citations
27
Science Advances, Journal Year: 2023, Volume and Issue: 9(32)
Published: Aug. 11, 2023
Obesity is associated with cognitive decline. Recent observations in mice propose an adipose tissue (AT)-brain axis. We identified 188 genes from RNA sequencing of AT three cohorts that were performance different domains. These mostly involved synaptic function, phosphatidylinositol metabolism, the complement cascade, anti-inflammatory signaling, and vitamin metabolism. findings translated into plasma metabolome. The circulating blood expression levels most these also several domains a cohort 816 participants. Targeted misexpression candidate gene ortholog Drosophila fat body significantly altered flies memory learning. Among them, down-regulation neurotransmitter release cycle-associated SLC18A2 improved abilities mice. Up-regulation RIMS1 enhanced abilities. Current results show previously unidentified connections between transcriptome brain function humans, providing unprecedented diagnostic/therapeutic targets AT.
Language: Английский
Citations
19
Annals of Neurology, Journal Year: 2024, Volume and Issue: 95(6), P. 1069 - 1079
Published: Feb. 26, 2024
People who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested hypothesis that healthy diet protects against dementia because it slows pace aging.
Language: Английский
Citations
6
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102599 - 102599
Published: Nov. 1, 2024
Language: Английский
Citations
5
Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5467 - 5467
Published: July 17, 2023
Metal ions are fundamental to guarantee the regular physiological activity of human organism. Similarly, vitamins play a key role in many biological functions metabolism, among which coenzymes, redox mediators, and antioxidants. Due their importance organism, both metals have been extensively studied for involvement neurodegenerative diseases (NDs). However, full potential interaction between metal has not fully explored by researchers yet, further investigation on this topic is needed. The aim review provide an overview scientific literature implications selected two most common diseases, Alzheimer’s Parkinson’s disease. Furthermore, vitamin–metal ion interactions discussed detail focusing bioinorganic chemistry, with perspective arousing more interest fascinating field.
Language: Английский
Citations
11
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15481 - 15481
Published: Oct. 23, 2023
In the rapidly evolving field of Alzheimer's Disease (AD) research, intricate role Hydrogen Sulfide (H
Language: Английский
Citations
11
Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1099 - 1115
Published: Jan. 1, 2024
This is a review of several vitamins (A, B, C, D, E, and K) that have been closely linked to the development autism, exploring their mechanisms action significance in prevention, mitigation, treatment autism.
Language: Английский
Citations
4
Aging and Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 100226 - 100226
Published: March 1, 2025
Language: Английский
Citations
0
Neuroscience Insights, Journal Year: 2024, Volume and Issue: 19
Published: Jan. 1, 2024
Historically known as neuronal support cells, astrocytes are now widely studied for their close structural and functional interactions with multiple neural cell types cerebral vessels where they maintain an ideal environment optimized brain function. Under pathological conditions, become reactive lose key protective functions. In this commentary, we discuss our recent work in The Journal of Neuroscience (Sompol et al., 2023) that showed Ca2+ dysregulation astrocytes, well hyperactivation the Ca2+-dependent protein phosphatase calcineurin (CN) Nuclear Factor Activated T Cells (NFATs), a diet-induced hyperhomocystienemia (HHcy) mouse model Vascular Contributions to Cognitive Impairment Dementia (VCID). Intravital multiphoton imaging coupled whisker stimulation was used explore astrocyte signaling neurovascular function under active phase, fully awake conditions. Interestingly, evoked transients individual were greater, even though intercorrelated across networks impaired HHcy mice. Blockade astrocytic CN/NFAT reduced signs reactivity, normalized cerebrovascular function, improved hippocampal synaptic strength dependent cognition mice, revealing previously unrecognized deficit regarding neuron-astrocyte-vascular interactions. These findings strongly use targeting strategies mitigate pathophysiological changes associated VCID other Alzheimer's-related dementias.
Language: Английский
Citations
2