The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat DOI Creative Commons
Akpoghene Eyeghre Onoriode,

Ezeokafor E.N Dike C.C,

Oparaji K.C

et al.

Magna Scientia Advanced Research and Reviews, Journal Year: 2023, Volume and Issue: 8(1), P. 001 - 018

Published: May 5, 2023

Male Infertility has been an issue of significant concern affecting appraised 20-30% couples worldwide. The study aims to access the hormonal and semen profile following metformin ethanolic leave extract Annona muricata (ELAM) on arsenic-induced toxicity in Wistar rats. Thirty-male rats were used study, weighing 150-170 grams, divided into six groups five each. Group A received 50 mg/kg arsenic trioxide (As2O3) only. B feed water ad libitum. Groups C D 50mg/kg As2O3 immediately treated with 30 500 ELAM. E 500mg/kg ELAM As2O3, group F As2O3. Data obtained subjected ANOVA followed by post Hoc LSD using SPSS version 25. Semen quality, Testosterone, FSH, LH levels, gonadal-somatic index analysed. Values presented as Mean±SEM considered at p<0.05. revealed a decrease D, while B, C, E, had no compared A. showed impaired sperm motility, morphology, total count significantly improved count. LH, FSH decline except for LH. increase testosterone FSH. concluded that MET quality profile, which could be reversing prevention male infecundity linked caused oxidative stress.

Language: Английский

Antioxidants and Male Infertility DOI Creative Commons
Ricardo Silva, David F. Carrageta, Marco G. Alves

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1152 - 1152

Published: June 12, 2022

Oxidative stress has been associated with decreased sperm quality and male infertility [...].

Language: Английский

Citations

5
Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance DOI
Jordi Ribas‐Maynou, Marc Llavanera, Yentel Mateo‐Otero

et al.

Theriogenology, Journal Year: 2022, Volume and Issue: 189, P. 290 - 300

Published: July 5, 2022

Language: Английский

Citations

5
Oxidative Stress and Nuclear Reprogramming: A Pilot Study of the Effects of Reactive Oxygen Species on Architectural and Epigenetic Landscapes DOI Open Access
Claudio Casali, Stella Siciliani,

Luca Galgano

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 153 - 153

Published: Dec. 21, 2022

Cell genome integrity is continuously threatened by various sources, both endogenous and exogenous. Oxidative stress causes a multitude of damages, severely affecting cell viability, fidelity genetic information inheritance, determining profound alterations in gene expression. Epigenetics represents major form expression modulation, influencing DNA accessibility to transcription factors the overall nuclear architecture. When assessing stress-induced epigenome reprogramming, widely diffused biochemical molecular approaches commonly fail incorporate analyses such as architectural chromatin target molecules precise spatial localization. Unveiling significance response oxidative stress, well functional effects over organization, may reveal targets strategies for aiming at limiting impact on cellular stability. For these reasons, we utilized potassium bromate treatment, stressor able induce damages without altering microenvironment, hence purely modeling stress. By means high-resolution techniques, described histone epigenetic modifications organization reactive oxygen species.

Language: Английский

Citations

5
Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts DOI Creative Commons
Estefanía Tarazón, Lorena Pérez-Carrillo, Isaac Giménez-Escamilla

et al.

Antioxidants, Journal Year: 2021, Volume and Issue: 10(11), P. 1750 - 1750

Published: Nov. 1, 2021

Although the roles of telomeres and oxidative stress in ischaemic cardiomyopathy (ICM) are known, mechanisms telomere homeostasis their relationship with incompletely understood. We performed two RNA-seq analyses (mRNA n = 23; ncRNA 30) protein validation on left ventricles explanted hearts from ICM control subjects. observed dysregulation shelterin cohesin complexes, which was related to an increase response cellular stress. Moreover, we found alterations at mRNA level telomeric DNA repair. Specifically, increased RAD51D levels were correlated ventricular diameters. unaltered, however, inversely corelated miR-103a-3p upregulation. also overexpression lncRNAs (TERRA GUARDIN) involved protection regulatory molecules. Expression TERRA transcription factor ATF7 superoxide dismutase 1 expression The GUARDIN its FOSL2 those catalase. Therefore, showed specific repair protection, these cardiac dysfunction ICM.

Language: Английский

Citations

7
The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat DOI Creative Commons
Akpoghene Eyeghre Onoriode,

Ezeokafor E.N Dike C.C,

Oparaji K.C

et al.

Magna Scientia Advanced Research and Reviews, Journal Year: 2023, Volume and Issue: 8(1), P. 001 - 018

Published: May 5, 2023

Male Infertility has been an issue of significant concern affecting appraised 20-30% couples worldwide. The study aims to access the hormonal and semen profile following metformin ethanolic leave extract Annona muricata (ELAM) on arsenic-induced toxicity in Wistar rats. Thirty-male rats were used study, weighing 150-170 grams, divided into six groups five each. Group A received 50 mg/kg arsenic trioxide (As2O3) only. B feed water ad libitum. Groups C D 50mg/kg As2O3 immediately treated with 30 500 ELAM. E 500mg/kg ELAM As2O3, group F As2O3. Data obtained subjected ANOVA followed by post Hoc LSD using SPSS version 25. Semen quality, Testosterone, FSH, LH levels, gonadal-somatic index analysed. Values presented as Mean±SEM considered at p<0.05. revealed a decrease D, while B, C, E, had no compared A. showed impaired sperm motility, morphology, total count significantly improved count. LH, FSH decline except for LH. increase testosterone FSH. concluded that MET quality profile, which could be reversing prevention male infecundity linked caused oxidative stress.

Language: Английский

Citations

2