Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

Antioxidants, Journal Year: 2022, Volume and Issue: 11(9), P. 1663 - 1663

Published: Aug. 26, 2022

Ascorbic acid (AA) is an essential nutrient and has great potential as a cosmeceutical that protects the health beauty of skin. AA expected to attenuate photoaging natural aging skin by reducing oxidative stress caused external internal factors promoting collagen gene expression maturation. In this review, biochemical basis associated with metabolism clinical evidence in increasing dermal inhibiting were discussed. addition, we reviewed emerging strategies have been developed overcome shortcomings achieve maximum efficacy. Because extracellular matrix proteins, such collagen, unique amino compositions, their production cells influenced availability specific acids. For example, glycine residues occupy 1/3 protein, supply can be limiting factor for synthesis. Experiments showed glycinamide was most effective among various acids amidated stimulating human fibroblasts. Thus, it possible synergistically improve synthesis combining analogs act at different stages process. This combination therapy would useful antiaging requires enhanced production.

Language: Английский

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Natural products in cosmetics

Natural Products and Bioprospecting, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 28, 2022

The global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 by 2023, at around a 7% annual growth rate. industry emerging as one of the fastest-growing industries past decade. Data shows that Chinese was US$60 2021. It be world's number consumer 2050, with size approximately US$450 billion. influence social media internet has raised awareness risks associated usage many chemicals health benefits natural products derived from plants other resources. As result, cosmetic now paying more attention products. present review focus on possible applications various biological sources skin care cosmetics, including topical products, fragrances, moisturizers, UV protective, anti-wrinkle In addition, mechanisms targets for evaluation active ingredients these bioactive compounds rejuvenation health, their potential role are also discussed.

Language: Английский

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Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 425 - 425

Published: March 30, 2024

Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. has become key functional ingredient diverse skincare products and cosmetics. This plays pivotal role NAD+ synthesis, notably contributing to redox reactions energy production cutaneous Via diversified biochemical mechanisms, niacinamide also known influence human DNA repair cellular stress responses. Based on decades of safe use cosmetics, recently gained widespread popularity as an active which aligns the “Kligman standards” skincare. From therapeutic standpoint, intrinsic properties may be applied managing acne vulgaris, melasma, psoriasis. cosmeceutical been widely leveraged multipurpose antiaging ingredient. Therein, it was shown significantly reduce oxidative stress, inflammation, pigmentation. Overall, through multimodal considered partially prevent and/or reverse several biophysical changes associated skin aging. The present narrative review provides multifactorial insights into mechanisms niacinamide’s functions. ingredient’s evolving critically appraised, strong focus at play. Finally, novel indications potential applications dermal fillers alternative injectable formulations were prospectively explored.

Language: Английский

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Collagen‐Based Dissolving Microneedles with Flexible Pedestals: A Transdermal Delivery System for Both Anti‐Aging and Skin Diseases

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(21)

Published: April 8, 2023

Biocompatible polymer microneedles (MNs) are emerging as a promising platform for transdermal drug delivery, especially facial treatments. Therefore, an MN patch in this study uses hydrolyzed collagen (HC) contained skin cells the main raw material and adopts two-step cast method to develop rapidly dissolving microneedle (DMN) deliver simple minimally invasive way, allowing release of encapsulated skin. By optimizing formulation proportion HC auxiliary support materials, mechanical strength required pierce is obtained, while soft pedestal allows flexibility application. The DMNs can dissolve completely within 15 min ≈ 8 h, do not cause toxicity or irritation when being applied. In contrast ineffectiveness oral external application, high risk dermal injection, drug-loaded overcome drawbacks traditional methods with direct penetration manner, enabling efficient safe treatment. successful preparation research have innovative practical significance field, it expected become simple, effective, popular delivery cosmetics.

Language: Английский

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Research Progress in Skin Aging, Metabolism, and Related Products

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15930 - 15930

Published: Nov. 3, 2023

In recent years, skin aging has received increasing attention. Many factors affect aging, and research shown that metabolism plays a vital role in but there needs to be more systematic review. This article reviews the interaction between from perspectives of glucose, protein, lipid explores relevant strategies for regulation. We found affects three major substances, which are lipids, substances also process aging. Some drugs or compounds can regulate metabolic disorders mentioned above exert anti-aging effects. Currently, variety products, most them focus on improving collagen levels. Skin is closely related metabolism, they interact with each other. Regulating specific an important strategy. Research development have focused levels, while regulation other glycosylation including key membrane cytoskeleton proteins relatively rare. Further expected.

Language: Английский

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Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 19, 2024

The interplay between the microbes and skin barrier holds pivotal significance in health aging. gut, both of which are critical immune neuroendocrine system, harbor that kept balance. Microbial shifts seen with aging may accelerate age-related changes. This comprehensive review investigates intricate connection microbe dynamics, barrier, process. gut plays essential roles human body, safeguarding host, modulating metabolism, shaping immunity. Aging can perturb microbiome turn accentuates inflammaging by further promoting senescent cell accumulation compromising host’s response. Skin microbiota diligently upholds epidermal adeptly fending off pathogens. encompasses alterations stratum corneum structure lipid content, negatively impact skin’s function decreased moisture retention increased vulnerability to infection. Efficacious restoration dysbiosis strategic integration acidic cleansers, emollients optimal composition, antioxidants, judicious photoprotection be a proactive approach Furthermore, modulation gut-skin axis through probiotics, prebiotics, postbiotics emerges as promising avenue enhance studies have substantiated their efficacy enhancing hydration, reducing wrinkles, fortifying integrity. In summary, is intrinsically woven into tapestry Sound understanding these interactions, coupled interventions aimed at recalibrating equilibrium, potential ameliorate Further in-depth necessary better understand skin-aging develop targeted strategies for successful

Language: Английский

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The state of the art in anti-aging: plant-based phytochemicals for skin care

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Language: Английский

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Mitochondria in cutaneous health, disease, ageing and rejuvenation—the 3PM-guided mitochondria-centric dermatology

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.

Language: Английский

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Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 12

Published: Jan. 18, 2022

Oxidative stress represents an imbalance between the generation of reactive oxygen and nitrogen species ability antioxidant systems to decompose those products. is implicated in pathogenesis hyperpigmentation, hypopigmentation, melanoma, other skin diseases. Regulatory networks involving oxidative related pathways are widely represented hypopigmentation diseases, particularly vitiligo. However, there no complete review into role hyperpigmentation disorders, especially regarding associations cellular signaling pathways. Here, we systems, stress-induced signal transduction mechanisms, effects drugs used preclinical clinical settings disorders.

Language: Английский

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Anti-aging peptides for advanced skincare: Focus on nanodelivery systems

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 89, P. 105087 - 105087

Published: Oct. 19, 2023

Skin plays an essential role in our personal image and aesthetics as it is where the first signs of aging are visible. As a way to prevent mitigate this natural physiological process achieve more youthful appearance, consumers constantly looking for innovative options anti-aging skincare products, including effective safer ingredients. Particularly, peptides cosmetic ingredients present formulations attending their efficacy reducing wrinkles hyperpigmentation, and/or stimulating collagen production. Moreover, less irritating alternatives regarding conventional against skin aging. However, despite these advantages, have considerable difficulty penetrate stratum corneum, which hinders bioactivity. This occurs high molecular weight, hydrophilic character, susceptibility enzymatic degradation, requiring application formulation technologies improve stability release pattern through skin. A detailed exposition focused on smart multifunctional nanodelivery systems that been used encapsulate provided, within scope research development products. Briefly, demonstrated biomolecules reliable outstanding alternative considering retinoids sunscreens

Language: Английский

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