Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 633 - 633

Published: March 3, 2023

Various active compounds are easily damaged, so they need protection and must be absorbed targeted. This problem can overcome by encapsulating in the form of solid lipid nanoparticles (SLNs). Initially, SLNs were widely used to encapsulate hydrophobic (non-polar) because their matched affinity interactions. Currently, being for encapsulation hydrophilic (polar) semipolar compounds, but there challenges, including increasing entrapment efficiency. review provides information on current research delivery systems antioxidant which includes various synthesis methods applications fields utilization. developed starting from selection matrices, emulsifiers/surfactants, types or antioxidants, methods, The type determines crystal formation, control compound release, SLN fabrication hydrophilic/hydrophobic have advantages disadvantages. Fabrication design, surfactants, characteristics SLNs. High-shear homogenization combined with ultrasonication is recommended method has been ease preparation good results. Appropriate design produce stable antioxidants that become suitable uses.

Language: Английский

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Biochemical and antioxidant activity of wild edible fruits of the eastern Himalaya, India

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: March 1, 2023

The eastern Himalayas, one of the important hotspots global biodiversity, have a rich diversity wild edible fruit trees. fruits these tree species been consumed by tribal people since time immemorial. However, there is limited information available on biochemical and antioxidant properties fruits. Therefore, present investigation was undertaken to study physico-chemical nine most Among species, Pyrus pashia had maximum weight (37.83 g), while highest juice (43.72%) pulp content (84.67%) were noted in Haematocarpus validus Myrica esculenta, respectively. Maximum total soluble solids (18.27%), sugar (11.27%), moisture (88.39%), ascorbic acid (63.82 mg/100 carotenoids (18.47 monomeric anthocyanin (354.04 g) recorded H. validus. Docynia indica phenolic (19.37 mg GAE/g), flavonoids flavanol content. activities different ranged from 0.17 0.67 IC50 for DPPH activity 3.59-13.82 AAE/g FRAP. These attractive pigmentation both good potential source extraction natural color food industry. also possess high market prices; Prunus nepalensis fetched $ 34.10-$ 141.5 per tree. are sources antioxidants, pigments value livelihood nutritional security.

Language: Английский

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Identification of Oxidative-Stress-Reducing Plant Extracts from a Novel Extract Library—Comparative Analysis of Cell-Free and Cell-Based In Vitro Assays to Quantitate Antioxidant Activity

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 297 - 297

Published: Feb. 28, 2024

Numerous underexplored plant species are believed to possess considerable potential in combating oxidative stress and its associated health impacts, emphasizing the need for a comprehensive methodological screening approach assess their antioxidant capacity. This study investigated 375 extracts, utilizing both cell-free cellular methods evaluate properties. Target-based capacity was evaluated by total phenolic content (TPC) ferric reducing power (FRAP) assays. Cell-based assays employed H2DCF-DA probe measure reactive oxygen (ROS) levels Griess assay quantify nitric oxide (NO) stressed Caco-2 RAW264.7 cells, respectively. The highest TPC FRAP values were found extracts of Origanum vulgare Fragaria × ananassa leaves. Several significantly reduced stress-induced ROS or NO at least 30%. Distinctive selectivity noted certain favoring significant reduction (e.g., Helianthus tuberosus extract), Prunus domestica subsp. Syriaca leaf extract). A strong correlation between moderate correlations results cell-based evident. These findings highlight great diversity underlying mechanisms, importance multifaceted assessment.

Language: Английский

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Effects of Different Solvents on the Extraction of Phenolic and Flavonoid Compounds, and Antioxidant Activities, in Scutellaria baicalensis Hairy Roots

Horticulturae, Journal Year: 2024, Volume and Issue: 10(2), P. 160 - 160

Published: Feb. 9, 2024

The hairy roots (HRs) of Scutellaria baicalensis are widely used and consumed worldwide as a medicine, especially in Asian countries, due to their biological pharmacological activities. HRs this plant rich secondary metabolites. However, the optimal method solvents for extraction metabolites from S. have not been well studied. Therefore, study, were extracted with different solvents, including water (WE), 99.9% pure methanol (PM), 70% aqueous (AM), ethanol (PE), (AE). phenolic flavonoid compounds various antioxidant activities each extract measured. AE (16.85 ± 0.15%) had higher yield, which led highest accumulation total content (TPC) (TFC), activity. TPC TFC (66.03 0.44 mg GAE/g 40.11 1.31 QE/g, respectively), whereas WE, PM, PE showed lower values all assays. In addition, activities, such DPPH, ABTS, SOD-like scavenging reducing power, achieved compared other solvent extracts. Based on these results, highlighting its potential use manufacture useful materials novel applications.

Language: Английский

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Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4113 - 4113

Published: June 26, 2022

The purpose of this study was to find the biological propensities vegetable plant Pleurospermum candollei by investigating its phytochemical profile and activities. Phytochemical analysis done spectroscopic methods investigate amount total polyphenols, evaluation different antioxidant, enzyme inhibitory (tyrosinase, α-amylase, α-glucosidase), thrombolytic, antibacterial highest phenolic flavonoid contents observed in methanolic extract (240.69 ± 2.94 mg GAE/g 167.59 3.47 QE/g); fractions showed comparatively less quantity (57.02 1.31 144.02 2.11 GAE/g, 48.21 0.75 96.58 2.30 QE/g). effect these bioactive also related GCMS led identification compounds with effects from (antioxidant; 55.07%, antimicrobial; 56.41%), while identified n-hexane fraction antioxidant properties constituted 67.86%, those antimicrobial 82.95%; however, synergetic polyphenols may have contributed value activities extract. Molecular docking performed understand relationship secondary metabolites enzyme-inhibitory thrombolytic activity significant (40.18 1.80 57.15 1.10 % clot lysis) comparison streptokinase (78.5 1.53 82.34 1.25% lysis). Methanolic good against Gram-positive strains bacteria, Bacillus subtilis. findings will improve our knowledge phytochemistry, P. candollei, which seems be a ray hope design formulations natural products for improvement health prevention chronic diseases; further research address development novel drugs use pharmaceuticals.

Language: Английский

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Tissue-Specific Transcriptome and Metabolome Analysis Reveals the Response Mechanism of Brassica napus to Waterlogging Stress

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6015 - 6015

Published: March 23, 2023

During the growth period of rapeseed, if there is continuous rainfall, it will easily lead to waterlogging stress, which seriously affect rapeseed. Currently, mechanisms rapeseed resistance stress are largely unknown. In this study, (Brassica napus) inbred lines G230 and G218 were identified as waterlogging-tolerant waterlogging-sensitive respectively, through a potted simulation field experiments. After six days at seedling stage, degree leaf aging root damage lower than those G218. A physiological analysis showed that significantly increased contents malondialdehyde, soluble sugar, hydrogen peroxide in rape leaves roots. The transcriptomic metabolomic differential genes metabolites mainly enriched metabolic pathways, biosynthesis secondary metabolites, flavonoid biosynthesis, vitamin B6 metabolism. Compared G218, expression levels some associated with B metabolism higher G230, such CHI, DRF, LDOX, PDX1.1, PDX2. Furthermore, involved metabolism, naringenin epiafzelechin, up-regulated while pyridoxine phosphate was only down-regulated roots foliar spraying can effectively improve tolerance short term. These results indicate pathways play key role hypoxia Brassica napus provide new insights for improving cultivating varieties.

Language: Английский

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Development of pH-sensitive films based on buckwheat starch, critic acid and rose petal extract for active food packaging

Sustainable Chemistry and Pharmacy, Journal Year: 2023, Volume and Issue: 36, P. 101236 - 101236

Published: Sept. 2, 2023

Language: Английский

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Phytochemical Characterization and Antioxidant Activity Evaluation for Some Plant Extracts in Conjunction with Pharmacological Mechanism Prediction: Insights into Potential Therapeutic Applications in Dyslipidemia and Obesity

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1431 - 1431

Published: June 27, 2024

Lipid metabolism dysregulation can lead to dyslipidemia and obesity, which are major causes of cardiovascular disease associated mortality worldwide. The purpose the study was obtain characterize six plant extracts (ACE-

Language: Английский

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Thymus musilii Velen. Methanolic Extract: In Vitro and In Silico Screening of Its Antimicrobial, Antioxidant, Anti-Quorum Sensing, Antibiofilm, and Anticancer Activities

Life, Journal Year: 2022, Volume and Issue: 13(1), P. 62 - 62

Published: Dec. 25, 2022

Thymus musilii Velen. is a rare plant species cultivated in the Ha’il region (Saudi Arabia) under greenhouse conditions. In this work, we described, for first time, phytochemical composition, antimicrobial, antioxidant, anti-quorum sensing, and anticancer activities of T. methanolic extract using both experimental computational approaches. The obtained results showed identification eight small-like peptides eighteen phyto-compounds by high-resolution liquid chromatography–mass spectrometry (HR-LCMS) dominated mainly compounds belonging to isoprenoid, fatty acyl, flavonoid, alkaloid classes. tested extracts exhibited high antifungal antibacterial activity with mean diameter growth inhibition zones ranging from 12.33 ± 0.57 mm (Pseudomonas aeruginosa ATCC 27853) 29.33 1.15 (Candida albicans 10231). Low minimal inhibitory concentrations were recorded micro-organisms 0.781 mg/mL 12.5 mg/mL. While higher doses necessary completely kill all bacterial fungal strains. Thyme was able scavenge DPPH•, ABTS•+, β-carotene, FRAP free radicals, IC50 values 0.077 0.0015 mg/mL, 0.040 0.011 0.287 0.012 0.106 0.007 respectively. highest percentage swarming swimming at 100 µg/mL 39.73 1.5% 25.18 1%, biofilm 10 S. typhimurium 14028 (53.96 4.21%) L. monocytogenes 7644 (49.54 4.5 mg/mL). silico docking study revealed that observed constituent are thermodynamically feasible, notably, such as those tripeptides (Asn-Met-His, His-Cys-Asn, Phe-His-Gln), isoprenoids (10-Hydroxyloganin), diterpene glycosides (4-Ketoretinoic acid glucuronide).

Language: Английский

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Evaluation of pomegranate (Punica granatum) peel for bioaccessibility of polyphenols and prebiotic potential using in vitro model

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 2, P. 100320 - 100320

Published: May 26, 2023

This research evaluated the bioaccessibility of polyphenols and prebiotic potential pomegranate peel powder (PPP) on an in vitro model static gastrointestinal digestion (IVD) combined with a colonic fermentation assay using L. acidophilus. After IVD, TPC, TFC, FRAP, DPPH-RSA, ABTS-RSA were significantly different (p ≤ 0.05) at each phase. Furthermore, recovery TPC TFC after intestinal was profoundly affected by salivary or gastric phases 52.47 20.34%, correspondingly. The values 34.40 30.35%, respectively. Residual digestibility index (RID) 34.36 14.16%, There strong correlation (between polyphenolic compounds antioxidant capacity PPP is revealed to be excellent source microbial substrates level large intestine; hence, it prebiotic. Moreover, fiber has high functional properties; thus, might utilized food industry as ingredient nutraceutical that promotes health.

Language: Английский

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