Antioxidants, Journal Year: 2022, Volume and Issue: 11(5), P. 996 - 996
Published: May 19, 2022
Extra virgin olive oil (EVOO) is the typical source of fats in Mediterranean diet [...].
Language: Английский
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 284 - 284
Published: Feb. 14, 2025
Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, driven by complex interactions among genetic, environmental, and lifestyle factors, with diet playing a pivotal role. Extra Virgin Olive Oil (EVOO), cornerstone Mediterranean (MedDiet), is plant-based fat that has garnered attention for its robust cardiovascular benefits, which attributed to unique composition monounsaturated fatty acids (MUFAs), particularly oleic acid (OA); bioactive polyphenols, such as Hydroxytyrosol (HT) oleocanthal. These compounds collectively exert antioxidant, anti-inflammatory, vasodilatory, lipid-modulating effects. Numerous clinical preclinical studies have demonstrated EVOO's properties reduce major modifiable risk including hypertension, dyslipidemia, obesity, type 2 diabetes. EVOO also promotes endothelial function increasing nitric oxide (NO) bioavailability, thus favoring vasodilation, lowering blood pressure (BP), supporting vascular integrity. Furthermore, it modulates biomarkers health, C-reactive protein, low-density lipoprotein (LDL) cholesterol, NT-proBNP, aligning improved hemostatic balance reduced arterial vulnerability. Emerging evidence highlights interaction gut microbiota, further augmenting cardioprotective This review synthesizes current evidence, elucidating multifaceted mechanisms action therapeutic potential. Future directions emphasize need advanced extraction techniques, nutraceutical formulations, personalized dietary recommendations maximize health benefits. represents valuable addition strategies aimed at reducing global burden diseases.
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2024, Volume and Issue: 444, P. 138684 - 138684
Published: Feb. 8, 2024
A research platform for food authentication was set up by combining stable isotope ratio analysis, metabolomics gas and liquid mass-spectrometry NMR investigations, chemometric analyses excellences. This multi-analytical approach tested on samples of elephant garlic (Allium ampeloprasum L.), a species belonging to the same genus common sativum mainly produced in southern Tuscany-(TA). The isotopic composition allowed product be geographically characterized. Flavonoids, like (+)-catechin, cinnamic acids, quercetin glycosides were identified. showed also significant amount dipeptides, sulphur-containing metabolites glutathione, latter which could considered molecular marker analyzed garlic. For nutraceutical profiling reach quality labels, extracts investigated specific biological assays, displaying interesting vasorelaxant properties rat aorta perfused heart, mediating nitric oxide release from endothelium.
Language: Английский
Citations
6
Marine Drugs, Journal Year: 2022, Volume and Issue: 20(8), P. 515 - 515
Published: Aug. 13, 2022
Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant vivo hypotensive activities. Given their structural similarity sesquiterpene lactone (+)-sclareolide, this molecule was selected a scaffold to develop novel vasoactive agents. Functional, electrophysiology, molecular dynamics studies were performed. The opening of five-member ring (+)-sclareolide provided series labdane-based small molecules, promoting significant effect. Electrophysiology data identified 7 CaV1.2 channel blocker KCa1.1 stimulator. These activities also confirmed intact vascular tissue. antagonism caused by agonist Bay K 8644 suggested that might interact dihydropyridine binding site. Docking dynamic simulations basis blockade stimulation produced 7. Finally, reduced coronary perfusion pressure heart rate, while prolonging conduction refractoriness atrioventricular node, likely because its Ca2+ antagonism. Taken together, these indicate labdane represents valuable starting point for development new agents negative chronotropic properties targeting key pathways involved pathophysiology hypertension ischemic cardiomyopathy.
Language: Английский
Citations
17
Agriculture, Journal Year: 2023, Volume and Issue: 13(5), P. 993 - 993
Published: April 30, 2023
Antioxidant capacity and sensory analysis of olive oils different quality grades (Extra virgin, Virgin, Ordinary Lampante) were investigated to define their possible differences useful for discrimination. Total phenolic content discriminated the sample Lampante oil (LVOO) with values (0.95 mg GAE/g) significantly lower than other (1.85, 1.80 1.98 A, D E samples, respectively). The principal component (PCA) revealed that attributes (“bitter” “pungent”) antioxidant (expressed by FRAP ABTS•+) are positively correlated Extra-virgin (EVOO) Virgin (VOO) categories, evidencing high values. In conclusion, based on evaluated parameters, between categories found. Still, they did not allow us clearly separate two oils.
Language: Английский
Citations
10
European Journal of Lipid Science and Technology, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
ABSTRACT The sensory characteristics, antioxidant activity, fatty acids, and volatile compounds of extra virgin olive oils (EVOOs) from two different protected designations origin (PDOs) were analyzed to identify any differences that might be useful for characterizing them. profiles the PDO Sabina samples characterized by a medium intensity positive attributes fruity (from 3.0 5.0), bitter 2.8 4.0), pungent 5.0). It is worth underlining our results confirm presence typical tomato note in all EVOOs analyzed. Instead, with intensities ranging 3.5 4.5, artichoke present Tuscia samples. Among compounds, ( E )‐2‐hexenal was most abundant, great variability 5.3% 72.6%) higher percentages 55.0% 80.6%). Practical Applications : very both farmers producers have better knowledge territorial parameters influence qualitative characteristics linked designation origin. This will practical applications, as focusing on high‐quality certified products can winning challenge manufacturers global market.
Language: Английский
Citations
0
Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2606 - 2606
Published: June 1, 2023
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder that includes ulcerative colitis (UC) and Crohn’s (CD), the exact cause of which still unknown. Numerous studies have confirmed diet one major environmental factors associated with IBD, as it can regulate gut microbiota reduce inflammation oxidative stress. Since consumption oil essential in diet, improving IBD through has potential. In this article, we first briefly reviewed current treatment methods for introduce role natural oils diseases. We then focused on recent discovery prevention summarized their main mechanisms action. The results showed anti-inflammatory activity derived from different plants animals been validated various experimental animal models. These are capable homeostasis models multiple mechanisms, including modulation microbiota, protection barrier, reduction colonic inflammation, improvement stress levels intestine, regulation immune homeostasis. Therefore, dietary or topical use may potential therapeutic effects IBD. However, currently, only few clinical trials support aforementioned conclusions. This review emphasized positive encouraged more to provide reliable evidence human by functional substances.
Language: Английский
Citations
7
Antioxidants, Journal Year: 2023, Volume and Issue: 12(12), P. 2025 - 2025
Published: Nov. 21, 2023
In this study, bile acid-based vesicles and nanoparticles (i.e., bilosomes biloparticles) are studied to improve the water solubility of lipophilic drugs. Ursodeoxycholic acid, sodium cholate, taurocholate budesonide were used as acids model drugs, respectively. Bilosomes biloparticles prepared following standard protocols with minor changes, after a preformulation study. The obtained systems showed good encapsulation efficiency dimensional stability. Particularly, for biloparticles, increase in followed order ursodeoxycholic acid < cholate taurocholate. vitro release from both bilosytems was performed by means dialysis using either nylon membrane or portion Wistar rat small intestine two receiving solutions simulated gastric intestinal fluids). Both fluid, released bilosystems more slowly than reference solution, while significant improvement passage into aqueous solution. Immunofluorescence experiments indicated that containing effective reducing inflammatory response induced glucose oxidase stimuli counteract ox-inflammatory damage within cells.
Language: Английский
Citations
4
Cells, Journal Year: 2024, Volume and Issue: 13(7), P. 619 - 619
Published: April 2, 2024
During pregnancy, uterine vasculature undergoes significant circumferential growth to increase blood flow, vital for the growing feto-placental unit. However, this process is often compromised in conditions like maternal high pressure, particularly preeclampsia (PE), leading fetal impairment. Currently, there no cure PE, partly due adverse effects of anti-hypertensive drugs on and health. This study aimed investigate vasodilator effect extra virgin olive oil (EVOO) phenols reproductive vasculature, potentially benefiting both mother fetus. Isolated arteries (UAs) from pregnant rats were tested with EVOO a pressurized myograph. To elucidate underlying mechanisms, additional experiments conducted specific inhibitors: L-NAME/L-NNA (10−4 M) nitric oxide synthases, ODQ (10−5 guanylate cyclase, Verapamil L-type calcium channel, Ryanodine + 2-APB (3 × 10−5 ryanodine inositol triphosphate receptors, respectively, Paxilline large-conductance calcium-activated potassium channel. The results indicated that EVOO-phenols activate Ca2+ signaling pathways, generating oxide, inducing vasodilation via cGMP BKCa2+ signals smooth muscle cells. suggests potential use prevent utero-placental flow restriction, offering promising avenue managing PE.
Language: Английский
Citations
1
PubMed, Journal Year: 2024, Volume and Issue: 49(1), P. 30 - 39
Published: Jan. 1, 2024
Herbal medicines are the preferred anticancer agents due to their lower cytotoxic effects on healthy cells. Plant lignans play an important role in treating various diseases, especially cancer. The present study aimed evaluate effect of podophyllotoxin, pinoresinol, and lariciresinol cellular toxicity inducing apoptosis fibroblasts, HEK-293, SkBr3 cell lines.
Language: Английский
Citations
1
Journal of the Science of Food and Agriculture, Journal Year: 2022, Volume and Issue: 103(1), P. 48 - 56
Published: July 7, 2022
Intensive olive (Olea europaea L.) orchards are fertilized, mostly with the macronutrients nitrogen (N), phosphorus (P) and potassium (K). The effects of different application levels these nutrients on oil composition quality were studied over 6 years in a commercial intensively cultivated 'Barnea' orchard Israel.Oil affected by N, but not P or K availability. Elevated N increased free fatty acid content reduced polyphenol level oil. Peroxide value was levels. relative concentrations palmitoleic, linoleic linolenic acids increasing application, whereas that oleic acid, monounsaturated-to-polyunsaturated ratio oleic-to-linoleic decreased.These results indicate intensive fertilization should be carried out carefully, especially where is concerned, to avoid decrease due over-fertilization. Informed requires leaf fruit analyses establish good agricultural practices, view expansion cultivation new regions soils. © 2022 Authors. Journal Science Food Agriculture published John Wiley & Sons Ltd behalf Society Chemical Industry.
Language: Английский
Citations
6