Sustainability,
Journal Year:
2023,
Volume and Issue:
15(4), P. 3268 - 3268
Published: Feb. 10, 2023
This
study
evaluated
the
functional
components
of
hazelnut
waste
products
(cuticles
and
shells)
for
potential
use
in
circular
economy.
HPLC-HRMS
ABTS
assay
were
used
to
determine
molecules
with
properties
antioxidant
capacity,
respectively.
The
capacity
cuticles
shells
was
tested
using
two
different
methods
extraction
(EtOH
50/50
acetone
40/70)
by
radical
cation
decolorization
assay.
growth
inhibition
effect
extracts
against
porcine
O138
E.
coli
F18+
microdilution
bacterial
method
confirmed
determination
minimal
inhibitory
concentration
(MIC).
results
showed
that
produced
a
higher
yield
metabolites
compared
ethanol
extraction,
exhibited
antimicrobial
potential.
acetone/water
led
identification
738
signals
453
detected
after
EtOH/water
extraction.
Through
metabolomic
analysis,
it
found
presented
much
quantitative
qualitative
polyphenolic
profile
than
did
shells.
In
addition,
revealed
had
Thus,
we
believe
hazelnut-derived
show
high
sustainable
Journal of Enzyme Inhibition and Medicinal Chemistry,
Journal Year:
2022,
Volume and Issue:
38(1), P. 176 - 191
Published: Nov. 1, 2022
Herein,
a
set
of
pyridine
and
pyrimidine
derivatives
were
assessed
for
their
impact
on
the
cell
cycle
apoptosis.
Human
breast
cancer
(MCF7),
hepatocellular
carcinoma
(HEPG2),
larynx
(HEP2),
lung
(H460),
colon
cancers
(HCT116
Caco2),
hypopharyngeal
(FADU),
normal
Vero
lines
used.
Compounds
8
14
displayed
outstanding
effects
investigated
further
tested
antioxidant
activity
in
MCF7,
H460,
FADU,
HEP2,
HEPG2,
HCT116,
Caco2,
cells
by
measuring
superoxide
dismutase
(SOD),
malondialdehyde
content
(MDA),
reduced
glutathione
(GSH),
nitric
oxide
(NO)
content.
Besides,
Annexin
V-FITC
apoptosis
detection
DNA
index
using
HEPG-2
line
established
both
compounds
as
well.
Furthermore,
EGFR
kinase
(Wild
T790M)
inhibitory
activities,
revealing
eligible
potential.
Additionally,
molecular
docking,
ADME,
SAR
studies
carried
out
candidates.
Horticulturae,
Journal Year:
2024,
Volume and Issue:
10(5), P. 433 - 433
Published: April 24, 2024
Green
walnuts
have
been
valued
for
their
health
and
medicinal
effects
many
years.
several
bioactive
metabolites,
including
polyphenols,
flavonoids,
tannins,
that
antioxidant,
anti-inflammatory,
antimicrobial,
anticancer
properties.
With
previous
records
of
increased
inclination
towards
natural
or
botanical
sources
therapeutics,
green
regained
the
uniqueness
therapeutic
prominence
globally.
This
comprehensive
review
provides
a
deep
understanding
use
walnut
(Juglans
regia
L.)
around
globe
shows
its
potential
pharmacological
benefits.
It
explores
different
uses
walnuts,
historical
in
traditional
medicine
throughout
continents
regions,
Asia,
Europe,
America,
Africa,
Middle
East.
also
substantial
studies
conducted
on
which
investigate
substances
found
various
parts
tree,
kernel,
shell,
leaves,
shoots,
bark,
roots,
indulging
advantages.
diversifies
antibacterial,
cardiovascular,
antihypertensive
activities
walnut,
clearly
prospective
nutraceutical
applications.
continues
by
emphasizing
necessity
further
research
to
focus
attract
global
researchers
aim
detailed
implications
enhance
modern
medicine.
Biotechnology and Genetic Engineering Reviews,
Journal Year:
2022,
Volume and Issue:
39(2), P. 586 - 621
Published: Dec. 28, 2022
Hazelnut
is
one
of
the
most
widely
consumed
nuts
around
world.
Considering
nutritional
value
hazelnuts,
a
wide
range
hazelnut-based
food
products
are
available
in
market
such
as
oil,
chocolate,
confectionery,
etc.
Nevertheless,
processing
hazelnuts
generates
large
number
by-products
and
waste.
The
valuable
hazelnut
industry
shell,
skin,
meal.
These
rich
bioactive
compounds,
protein,
dietary
fibre,
mono-
polyunsaturated
fatty
acids,
vitamins,
minerals,
phytosterols,
squalene.
current
utilisation
mostly
limited
to
animal
feed
supplementation
meal
skin
use
low-value
heat
source
for
shells.
However,
disposing
these
or
using
them
results
significant
waste
natural
resource
components.
Consequently,
valorising
ingredients
diverse
fields
food,
pharmaceuticals
cosmetics
has
stimulated
interest
among
scientists,
producers,
consumers.
This
review
provides
an
overview
scientific
knowledge
about
main
their
actual
valorisation,
with
focus
on
chemical
composition
inspire
new
applications
resources
fully
exploit
potential.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(13), P. 1977 - 1977
Published: June 21, 2024
Accumulating
evidence
shows
a
strong
correlation
between
type
2
diabetes
mellitus,
mitochondrial
dysfunction,
and
oxidative
stress.
We
evaluated
the
effects
of
dietary
peanut
shell
extract
(PSE)
supplementation
on
function
antioxidative
stress/inflammation
markers
in
diabetic
mice.
Fourteen
db/db
mice
were
randomly
assigned
to
group
(DM
AIN-93G
diet)
PSE
(1%
wt/wt
for
5
weeks.
Six
C57BL/6J
fed
with
an
diet
weeks
(control
group).
Gene
protein
expression
liver,
brain,
white
adipose
tissue
(WAT)
determined
using
qRT-PCR
Immunoblot,
respectively.
Compared
control
group,
DM
had
(i)
increased
gene
levels
DRP1
(fission),
PINK1
(mitophagy),
TNFα
(inflammation)
(ii)
decreased
MFN1,
MFN2,
OPA1
(fusion),
TFAM,
PGC-1α
(biogenesis),
NRF2
(antioxidative
stress)
IBA1
(microglial
activation)
WAT
Supplementation
into
restored
DM-induced
changes
DRP1,
PINK1,
TNFα,
OPA1,
PGC-1α,
NRF2,
This
study
demonstrates
that
improved
mice,
part
due
suppression
stress
inflammation.
RSC Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Donepezil-based
rational
design
of
N
-substituted
quinazoline
tethered
thioacetamide
as
potential
acetylcholine
esterase
inhibitors
for
the
treatment
Alzheimer's
disease.
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(3)
Published: March 1, 2025
Abstract
New
s
‐triazine
hydrazone
hybrids
(
4a
–
4r
)
were
designed
and
synthesized
as
promising
microbial
DNA
gyrase
inhibitors.
This
was
done
by
taking
the
lead
inhibitor
(AstraZeneca
arylaminotriazine)
a
reference.
The
novel
samples
subsequently
tested
antimicrobial
agents
against
certain
pathogenic
bacteria
unicellular
fungi.
antibiofilm
potential
membrane
leakage
test
used
to
determine
mechanism
of
response.
minimum
inhibitory
concentration
(MIC)
values
4g
,
4i
between
62.5
250.0
µg/mL.
MIC
for
candidate
Staphylococcus
aureus,
Candida
albicans,
Enterobacter
agglomerans
Klebsiella
pneumonia
are
62.5,
125.0,
µg/mL,
respectively.
Conversely,
compound
µg/mL
C.
albicans
E.
125.0
S.
aureus
K.
.
Besides,
molecular
docking
study
performed
validate
both
binding
affinity
mode
newly
analogs
candidates
toward
bacterial
receptors.
nanocomposites
had
potentials,
which
encouraging
their
use
in
biomedical
applications.
Consequently,
afforded
compounds
can
be
employed
future
optimization.
