Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle DOI Creative Commons
Barbara Azzimonti, Chiara Ballacchino, Paola Zanetta

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 546 - 546

Published: Feb. 21, 2023

Mounting evidence indicates that the microbiota, unique combination of micro-organisms residing in a specific environment, plays an essential role development wide range human diseases, including skin cancer. Moreover, persistent imbalance microbial community, named dysbiosis, can also be associated with oxidative stress, well-known emerging force involved pathogenesis several cutaneous malignancies. Although their interplay has been somewhat suggested, connection between and cancer is largely unexplored field. In present review, we discuss current knowledge on these topics, suggesting potential therapeutic strategies.

Language: Английский

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis DOI Creative Commons
Giovanni Tossetta, Sonia Fantone, Lucrezia Togni

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1270 - 1270

Published: Oct. 18, 2024

Periodontitis affects up to 40% of adults over 60 years old and is a consequence gingivitis. characterized by chronic inflammation, periodontal damage, alveolar bone resorption. The nuclear factor erythroid 2-related 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays key role in periodontitis modulating redox balance inflammation the periodontium. However, NRF2 expression decreased gingival tissues patients with while oxidative stress significantly increased this pathology. Oxidative lipopolysaccharide (LPS) produced gram-negative bacteria favor production inflammatory causing favoring bone. In review, we analyzed current literature regarding natural synthetic compounds NRF2/KEAP1 vitro vivo models order evaluate new potential treatments that can improve outcome disease.

Language: Английский

Citations

16
SCDNet: A Deep Learning-Based Framework for the Multiclassification of Skin Cancer Using Dermoscopy Images DOI Creative Commons
Ahmad Naeem, Tayyaba Anees,

Makhmoor Fiza

et al.

Sensors, Journal Year: 2022, Volume and Issue: 22(15), P. 5652 - 5652

Published: July 28, 2022

Skin cancer is a deadly disease, and its early diagnosis enhances the chances of survival. Deep learning algorithms for skin detection have become popular in recent years. A novel framework based on deep proposed this study multiclassification types such as Melanoma, Melanocytic Nevi, Basal Cell Carcinoma Benign Keratosis. The model named SCDNet which combines Vgg16 with convolutional neural networks (CNN) classification different cancer. Moreover, accuracy method also compared four state-of-the-art pre-trained classifiers medical domain Resnet 50, Inception v3, AlexNet Vgg19. performance classifier, well classifiers, evaluated using ISIC 2019 dataset. rate SDCNet 96.91% whereas, rates Alexnet, Vgg19 Inception-v3 are 95.21%, 93.14%, 94.25% 92.54%, respectively. results showed that performed better than competing classifiers.

Language: Английский

Citations

69
Oxidative Stress, Genomic Integrity, and Liver Diseases DOI Creative Commons
Nanthini Sadasivam, Yu‐Ji Kim, Kamalakannan Radhakrishnan

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(10), P. 3159 - 3159

Published: May 15, 2022

Excess reactive oxygen species production and free radical formation can lead to oxidative stress that damage cells, tissues, organs. Cellular is defined as the imbalance between ROS antioxidants. This malfunction or structure modification of major cellular molecules such lipids, proteins, DNAs. During conditions, DNA protein modifications various diseases. Various antioxidant-specific gene expression signal transduction pathways are activated during maintain homeostasis protect organs from injury damage. The liver more vulnerable conditions than other Antioxidants, enzymes, regulation antioxidant responsive element (ARE) genes act against chronic in liver. ARE-mediated target site for averting/preventing diseases caused by stress. Identification these ARE markers will enable early detection help develop new therapeutic interventions. literature review focused on upon stress, factors responsible hepatic response redox signaling, signaling diseases, future aspects.

Language: Английский

Citations

63
Metformin Improves Ovarian Cancer Sensitivity to Paclitaxel and Platinum-Based Drugs: A Review of In Vitro Findings DOI Open Access
Giovanni Tossetta

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 12893 - 12893

Published: Oct. 25, 2022

Ovarian cancer is one of the most dangerous gynecologic cancers worldwide, showing a high fatality rate and recurrence due to diagnosis at an advanced stage disease occurrence chemoresistance, which weakens therapeutic effects chemotherapeutic treatments. In fact, although paclitaxel platinum-based drugs (carboplatin or cisplatin) are widely used alone in combination treat ovarian cancer, chemoresistance significantly reduces these drugs. Metformin hypoglycemic agent that commonly for treatment type 2 diabetes mellitus non-alcoholic fatty liver disease. However, this drug also shows anti-tumor activity, reducing risk chemoresistance. This review analyzes current literature regarding role metformin investigates what currently known about its platinum resistance restore sensitivity

Language: Английский

Citations

51
Carotenoids in Human Skin In Vivo: Antioxidant and Photo-Protectant Role against External and Internal Stressors DOI Creative Commons
Maxim E. Darvin, Jürgen Lademann,

Jörg von Hagen

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1451 - 1451

Published: July 26, 2022

The antioxidant system of the human body plays a crucial role in maintaining redox homeostasis and has an important protective function. Carotenoids have pronounced properties neutralization free radicals. In skin, carotenoids high concentration stratum corneum (SC)-the horny outermost layer epidermis, where they accumulate within lipid lamellae. Resonance Raman spectroscopy diffuse reflectance are optical methods that used to non-invasively determine carotenoid SC vivo. It was shown by electron paramagnetic resonance support entire status vivo neutralizing radicals thus, counteracting development oxidative stress. This review is devoted assembling kinetics using non-invasive spectroscopic methods. Factors contributing changes their influence on summarized. effect chemotherapy cancer patients presented. A potential antioxidant-based pathomechanism chemotherapy-induced hand-foot syndrome method reduce its frequency severity discussed.

Language: Английский

Citations

49
Role of oxidative stress in the relationship between periodontitis and systemic diseases DOI Creative Commons

Jiaxin Shang,

Haifeng Liu, Youli Zheng

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: July 12, 2023

Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver injury. An increasing body evidence show complex interplay between oxidative stress inflammation disease pathogenesis. When periodontitis occurs, increased reactive oxygen species accumulation leads stress. Oxidative contributes major cellular components damage, including DNA, proteins, lipids. In this article, focus will be on periodontal relationship inflammation, impact therapy parameters.

Language: Английский

Citations

41
Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer DOI Creative Commons
Giovanni Tossetta, Sonia Fantone, Daniela Marzioni

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(7)

Published: July 21, 2023

Prostate cancer is the second most common malignancy in men worldwide. can be treated by surgery, radiotherapy and hormone therapy. The latter, form of androgen-deprivation therapy needed to reduce prostate progression at an advanced stage. Several studies demonstrated that oxidative stress involved occurrence, development Nuclear factor erythroid 2-related 2 (NRF2)/Kelch Like ECH Associated Protein 1 (KEAP1) pathway affected reactive oxygen species (ROS). Furthermore, NRF2/KEAP1 signaling has been investigated several related anti-androgen therapy, biochemical recurrence radiotherapy. In this review we analysed current literature regarding indirect modulators regulation their role as possible therapeutic targets cells.

Language: Английский

Citations

38
SBXception: A Shallower and Broader Xception Architecture for Efficient Classification of Skin Lesions DOI Open Access
Abid Mehmood, Yonis Gulzar, Qazi Mudassar Ilyas

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(14), P. 3604 - 3604

Published: July 13, 2023

Skin cancer is a major public health concern around the world. identification critical for effective treatment and improved results. Deep learning models have shown considerable promise in assisting dermatologists skin diagnosis. This study proposes SBXception: shallower broader variant of Xception network. It uses as base model classification increases its performance by reducing depth expanding breadth architecture. We used HAM10000 dataset, which contains 10,015 dermatoscopic images lesions classified into seven categories, training testing proposed model. Using we fine-tuned new reached an accuracy 96.97% on holdout test set. SBXception also achieved significant enhancement with 54.27% fewer parameters reduced time compared to Our findings show that architecture can greatly improve categorization.

Language: Английский

Citations

35
Paraoxonase-2 is upregulated in triple negative breast cancer and contributes to tumor progression and chemoresistance DOI
Roberto Campagna, Valentina Pozzi,

Sara Giorgini

et al.

Human Cell, Journal Year: 2023, Volume and Issue: 36(3), P. 1108 - 1119

Published: March 10, 2023

Language: Английский

Citations

25
pH Switchable Nanozyme Platform for Healing Skin Tumor Wound Infected with Drug‐Resistant Bacteria DOI
Yong Yan, Mengqi Wang, Minyang Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: July 3, 2023

Abstract Nanozymes capable of generating reactive oxygen species have recently emerged as promising treatments for wounds infected with drug‐resistant bacteria, possessing a reduced possibility inducing resistance. However, the therapeutic effect is limited by shortage endogenous oxy‐substrates and undesirable off‐target biotoxicity. Herein, ferrocenyl coordination polymer (FeCP) nanozyme, featuring pH switchable peroxidase (POD)‐ catalase (CAT)‐like activity incorporated indocyanine green (ICG) calcium peroxide (CaO 2 ) to fabricate an H O /O self‐supplying system (FeCP/ICG@CaO precise treatment bacterial infections. At wound site, CaO reacts water generate . Acting POD mimic under acidic microenvironment, FeCP catalyzes into hydroxyl radicals prevent infection. switches CAT‐like in neutral tissue, decomposing oxidative damage facilitate healing. Additionally, FeCP/ICG@CaO shows photothermal therapy capability, ICG can emit heat near‐infrared laser irradiation. This assists fully exerting its enzyme‐like activity. Thus, this achieves antibacterial efficiency 99.8% vitro effectively overcomes main limitations nanozyme‐based assays, resulting satisfactory effects repairing normal special skin tumor bacteria.

Language: Английский

Citations

23