Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 29, 2024

Abstract Background The atherogenic index of plasma (AIP) is closely associated with the onset diabetes, obesity being a significant risk factor for type 2 diabetes mellitus (T2DM). However, association between AIP and T2DM in overweight obese populations has been infrequently studied. Therefore, this study aimed to explore individuals T2DM. Methods This cross-sectional analysis utilized data from 40,633 participants body mass (BMI) ≥ 24 kg/m who were screened January 2018 December 2023 at Henan Provincial People’s Hospital. Participants categorized into groups without according criteria. AIP, our dependent variable, was calculated using formula log10 [(TG mol/L)/HDL-C (mol/L)]. We investigated multivariate logistic regression, subgroup analysis, generalized additive models, smoothed curve fitting, threshold effect analysis. Additionally, mediation evaluated role inflammatory cells AIP-related Results Overweight patients exhibited higher levels than those diabetes. After adjusting confounders, results indicated (odds ratio (OR) = 5.17, 95% confidence interval (CI) 4.69–5.69). Notably, high baseline (Q4 group) had significantly greater Q1 group, an OR 3.18 (95% CI 2.94–3.45). Subgroup revealed that decreased increasing age (interaction P < 0.001). In populations, displayed J-shaped nonlinear pattern, > – 0.07 indicating increase risk. Various cells, including neutrophils, leukocytes, monocytes, mediated 4.66%, 4.16%, 1.93% associations, respectively. Conclusion individuals, independently T2DM, exhibiting association. advancing age. Multiple types mediate

Language: Английский

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Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications

Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 3325 - 3333

Published: Sept. 1, 2024

Insulin resistance (IR) is the major mechanism in pathogenesis of type 2 diabetes mellitus (T2DM). Early identification IR great significance for preventing onset T2DM and delaying progression disease. Previous studies have shown that triglyceride-glucose (TyG) index can be used as an effective surrogate marker IR. There a significant correlation between TyG its common complications. In addition, predictive efficacy better than other indicators. may not only become important to identify people at high risk complications, but also expected strong predictor prognosis these diseases. However, there are still some challenges widespread application clinical practice. future, more high-quality needed clarify assessment methods Further investigations relationship complications will provide new ideas prevention treatment

Language: Английский

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Factors of Obesity and Metabolically Healthy Obesity in Asia

Medicina, Journal Year: 2022, Volume and Issue: 58(9), P. 1271 - 1271

Published: Sept. 13, 2022

The East Asian region (China, Japan, and South Korea) is comprised of almost 1.5 billion people recent industrialization has brought with it a pandemic rising obesity, even in children. As these countries are rapidly aging functioning at sub-replacement birthrates, the burgeoning costs obesity-related care may threaten socialized healthcare systems quality life. However, condition called metabolically healthy obesity (MHO) been found to be without immediate cardiopulmonary or diabetic risk. Thus, maintenance MHO for obese Asia could buffer burden long-term on medical knowledge biochemical, genetic, physiological milieu associated also provide new targets intervention. Diverse physiological, psychological, environmental, social factors play role obesogenesis transition unhealthy obesity. This review will give broad survey various causes MHO, special emphasis population studies from that region.

Language: Английский

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Use of Apolipoprotein B in the Era of Precision Medicine: Time for a Paradigm Change?

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(17), P. 5737 - 5737

Published: Sept. 3, 2023

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and risk a major event is highest among those with established disease. Ongoing management these patients relies on accurate assessment their response to any prescribed therapy, residual risk, in order optimize treatment. Recent international guidelines position statements concur that plasma concentration apolipoprotein B (apoB) most measure lipoprotein associated ASCVD risk. This especially true for growing number individuals diabetes, obesity, or metabolic syndrome, statin therapy. Most guidelines, however, continue promote LDL-C as primary marker due uncertainty whether greater accuracy apoB sufficient warrant paradigm shift. Recommendations regarding measurement vary, information provided how interpret results sometimes insufficient, particularly non-lipid specialists. Misinformation reliability assays also frequently repeated despite its equivalent better standardization than many other diagnostic assays. Thus, demand testing relatively low, which means there little incentive increase availability reduce cost. In this review, we examine recent clinical outcomes studies meta-analyses relative values apoB, LDL-C, non-HDL-C markers Although seemingly minimal difference when only population-based metrics are considered, it evident from our analysis that, personalized precision medicine standpoint, would benefit, at negligible total cost, if were integrated into diagnosis treatment ASCVD.

Language: Английский

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Changes in Cell Biology under the Influence of Low-Level Laser Therapy

Photonics, Journal Year: 2022, Volume and Issue: 9(7), P. 502 - 502

Published: July 20, 2022

Low-level laser therapy (LLLT) has become an important part of the therapeutic process in various diseases. However, despite broad use LLLT everyday clinical practice, full impact on cell life processes not been fully understood. This paper presents current state knowledge concerning mechanisms action cells. A better understanding molecular occurring within after irradiation may result introducing numerous novel applications and potentially increases safety profile this therapy.

Language: Английский

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Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome

Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103311 - 103311

Published: Aug. 14, 2024

Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst identification responsible constituents for beneficial effects is still pending. We sought to assess and compare cardioprotective potential oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury (IRI) CVD risk factors alleviation. The scope study was design a potent safe combinatorial therapy high-cardiovascular-risk patients on bench-to-bedside approach. evaluated IRI-limiting 6-weeks treatment with OL, HT, OC or OA at nutritional doses, healthy metabolic syndrome (MS)-burdened mice. Three regimens were designed mixture preponderant benefits (OL-HT-OC, Combo 2), including infarct sparing antiglycemic potency, compared isolated compounds, further investigated its anti-atherosclerotic effects. In vivo experiments revealed that combination regimen 2 presented most favorable limiting size hyperglycemia, which selected be clinical setting Chronic Coronary Artery Syndrome (CCAS) patients. Cardiac function, inflammation markers oxidative stress assessed baseline after 4 weeks OL-HT-OC supplement study. found significantly reduced Controls. OL exhibited antihyperglycemic properties attenuated hypercholesterolemia. OL-HT-OA, OL-HT-OC-OA cardioprotective, whereas only mitigated hyperglycemia. cardioprotection attributed apoptosis suppression, enhanced antioxidant upregulation enzymes. Additionally, it atherosclerotic plaque extent vivo. ameliorated cardiac, vascular endothelial function small-scale Conclusively, exerts vivo, remarkable clinically translatable high-risk

Language: Английский

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The role of resistin and adiponectin ratios with uric acid in assessing metabolic syndrome in type 2 diabetes

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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Association of the Triglyceride-Glucose Index and Obesity Indicators with Multiple Chronic Diseases: A Longitudinal Cohort Study Based on CHARLS

Journal of Multidisciplinary Healthcare, Journal Year: 2025, Volume and Issue: Volume 18, P. 171 - 182

Published: Jan. 1, 2025

To explore the relationship between triglyceride glucose (TyG) and obesity combined indexes occurrence of multiple chronic diseases (MCD), which will help to provide a basis for prevention treatment this condition. 3037 participants in China Health Retirement Longitudinal Study, was conducted from 2011 2015 were selected study. They divided into four groups (Q1, Q2, Q3, Q4) based on quartiles TyG, TyG-BMI, TyGWC TyGWHtR baseline data. A Cox proportional hazard model used analyze risk MCD associated with TyG its obesity-related indicators. Dose-response relationships analyzed using restricted cubic spline regression, predictive ability detection ROC curve. At end follow-up 2015, 473 new cases observed among study population, an incidence rate 15.6%. After adjusting confounding factors, significantly increased Q4 TyG-WC TyG-WHtR index compared Q1 (p<0.001 all cases). linear dose-response MCD, indicating risks CKD higher indexes. However, exhibited nonlinear (P-nonlinearity <0.0001 cases), MCD. The areas under curves regression models indices 0.610, 0.590, 0.590 0.607, respectively. found be positively correlated developing Measurements regulation these can prevent control

Language: Английский

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Development of ratiometric fluorescent probe based on copper nanoclusters and rhodamine B for the detection of 3-nitrotyrosine

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 336, P. 126035 - 126035

Published: March 12, 2025

Language: Английский

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Tackling Dyslipidemia in Obesity from a Nanotechnology Perspective

Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3774 - 3774

Published: Sept. 13, 2022

Obesity and dyslipidemia are the main features of metabolic syndrome, expressed mainly by adipose tissue dysfunction connected similar pathways pharmacotherapy. Conventional drugs used in these two associated disorders limited due to poor drug efficiency, non-specificity, toxic side effects. Therefore, novel solutions for tackling obesity-associated diseases providing insights into development innovative or improved therapies necessary. Targeted nanotherapy is a revolutionary technology, offering promising solution combatting disadvantages currently available treating obesity its superior features, which include specific cell targeting, protection against physiological degradation, sustained release. This review presents brief assessment dyslipidemia, their impacts on human health, current treatment, limitations, role potential use nanotechnology coupled with targeted delivery nutraceuticals as emerging therapies. To best our knowledge, this paper presents, first time literature, comparison between nano-formulations based and/or natural extracts applied experimental studies.

Language: Английский

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