Phytochemicals Target Multiple Metabolic Pathways in Cancer DOI Creative Commons
Oleg Shuvalov,

Yulia Kirdeeva,

Alexandra Daks

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(11), P. 2012 - 2012

Published: Nov. 17, 2023

Cancer metabolic reprogramming is a complex process that provides malignant cells with selective advantages to grow and propagate in the hostile environment created by immune surveillance of human organism. This underpins cancer proliferation, invasion, antioxidant defense, resistance anticancer immunity therapeutics. Perhaps not surprisingly, rewiring considered be one "Hallmarks cancer". Notably, this often comprises various complementary overlapping pathways. Today, it well known highly inhibition only pathways tumor cell leads limited response and, subsequently, emergence resistance. Therefore, increase overall effectiveness antitumor drugs, advisable use multitarget agents can simultaneously suppress several key processes cell. review focused on group plant-derived natural compounds target different cancer-associated metabolism, including aerobic glycolysis, respiration, glutaminolysis, one-carbon de novo lipogenesis, β-oxidation fatty acids. We discuss those display inhibitory activity against as number important signaling cancer. Information about their pharmacokinetics animals humans also presented. Taken together, may multiple malignancies, something bears great potential for further improvement antineoplastic therapy.

Language: Английский

Dietary Antioxidants and Chronic Diseases DOI Creative Commons
Małgorzata Elżbieta Zujko, Anna Maria Witkowska

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 362 - 362

Published: Feb. 2, 2023

Chronic diseases, most notably diabetes, cancer, cardiovascular neurodegenerative thyroid and allergic diseases are major causes of death, disability, a lower quality life in various populations [...]

Language: Английский

Citations

23
Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy DOI Creative Commons
Douglas Dourado, Júlio Abreu Miranda, Matheus de Oliveira

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 177 - 177

Published: Jan. 26, 2024

Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when physicochemical properties compromise pharmacological potential. As therapeutic strategy against cancer, associated with inorganic nanoparticles. These nanocarriers are capable delivering and offering synergistically enhance anticancer properties. review highlights types curcumin-based nanoparticles discusses their in vivo activity models cancer.

Language: Английский

Citations

9
Re-Sensitization of Resistant Ovarian Cancer SKOV3/CDDP Cells to Cisplatin by Curcumin Pre-Treatment DOI Open Access
Aseel Ali Hasan, Elena Kalinina, Dmitry D. Zhdanov

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 799 - 799

Published: Jan. 18, 2025

A major challenging problem facing effective ovarian cancer therapy is cisplatin resistance. Re-sensitization of cisplatin-resistant cells to (CDDP) has become a critical issue. Curcumin (CUR), the most abundant dietary polyphenolic curcuminoids derived from turmeric (Curcuma longa), achieved previously significant anti-cancer effects against human adenocarcinoma SKOV-3/CDDP by inhibition gene expression antioxidant enzymes (SOD1, SOD2, GPX1, CAT and HO1), transcription factor NFE2L2 signaling pathway (PIK3CA/AKT1/MTOR). However, detailed mechanisms curcumin-mediated re-sensitization in still need further exploration. Here, suggested curcumin pre-treatment therapeutic strategy been evaluated effectively overcome improve our understanding behind The findings present study suggest that significantly exhibited cytotoxic inhibited proliferation cell line compared simultaneous addition drugs. Precisely, apoptosis induced mediated mitochondrial apoptotic (cleaved caspases 9, 3 cleaved PARP) activation as well thioredoxin reductase (TRXR1) mTOR/STAT3 pathway. This current could deepen anticancer mechanism CUR pre-treatment, which not only facilitates but may lead development targeted therapeutics eradicate cells.

Language: Английский

Citations

1
Possible Effects and Mechanisms of Dietary Natural Products and Nutrients on Depression and Anxiety: A Narrative Review DOI Creative Commons
Si-Xia Wu, Jiahui Li, Dan-Dan Zhou

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2132 - 2132

Published: Oct. 28, 2022

Depression and anxiety are severe public health problems have attracted more attention from researchers of food science nutrition. Dietary natural products nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, dietary fiber, could play a vital role in the prevention management these diseases. The potential mechanisms action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating microbiota–gut–brain axis, suppressing hypothalamic–pituitary–adrenal axis hyperactivity, regulating levels monoamine neurotransmitters. In this narrative review, we summarize most recent advancements regarding effects nutrients on depression anxiety, their underlying discussed. We hope that paper can provide better understanding anti-depressive anxiolytic products, it is also helpful for developing functional food, supplements, or auxiliary agents

Language: Английский

Citations

31
Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances DOI
Arif Hussain, Ajay Kumar, Vivek Uttam

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 233, P. 116476 - 116476

Published: June 20, 2023

Language: Английский

Citations

20
Co-encapsulation of hydrophilic and hydrophobic drugs into niosomal nanocarrier for enhanced breast cancer therapy: In silico and in vitro studies DOI Creative Commons
Sahar Amiri, Fatemeh Pashizeh, Kasra Moeinabadi‐Bidgoli

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 239, P. 117292 - 117292

Published: Oct. 6, 2023

Combination therapy has been considered one of the most promising approaches for improving therapeutic effects anticancer drugs. This is first study that uses two different antioxidants in full-characterized niosomal formulation and thoroughly evaluates their synergistic on breast cancer cells. In this study, in-silico studies hydrophilic hydrophobic drugs (ascorbic acid: Asc curcumin: Cur) interactions release were investigated validated by a set vitro experiments to reveal significant improvement using co-delivery approach nanocarrier. The nanoparticles containing surfactants (Span 60 Tween 60) cholesterol at 2:1 M ratio prepared through film hydration method. A systematic evaluation nanoniosomes was carried out. profile demonstrated phases (initial burst followed sustained release) pH-dependent schedule over 72 h. optimized preparation displayed superior storage stability up 2 months 4 °C, exhibiting extremely minor changes pharmaceutical encapsulation efficiency size. Free dual (Asc + dual-drug loaded niosomes (Niosomal Cur)) enhanced apoptotic activity cytotoxicity inhibited cell migration which confirmed effect co-encapsulated Also, up-regulation p53 Bax genes observed cells treated with Cur Niosomal Cur), while anti-apoptotic Bcl-2 gene down-regulated. These results correlation increase enzyme SOD, CAT, caspase, levels malondialdehyde (MDA) reactive oxygen species (ROS) upon treatment mentioned Furthermore, these anti-cancer higher when than Cur. Histopathological examination also revealed had lower mitosis index, invasion, pleomorphism findings indicated would offer delivery system an effective treatment.

Language: Английский

Citations

20
Bioactive phytocompounds for oral cancer prevention and treatment: A comprehensive and critical evaluation DOI
Jack T. Burcher,

Lindsay K. DeLiberto,

Andrea M. Allen

et al.

Medicinal Research Reviews, Journal Year: 2023, Volume and Issue: 43(6), P. 2025 - 2085

Published: May 4, 2023

Abstract The high incidence of oral cancer combined with excessive treatment cost underscores the need for novel preventive and therapeutic options. value natural agents, including plant secondary metabolites (phytochemicals), in preventing carcinogenesis representing expansive source anticancer drugs have been established. While fragmentary research data are available on antioral effects phytochemicals, a comprehensive critical evaluation potential these agents prevention intervention human malignancies has not conducted according to our knowledge. This study presents complete analysis current preclinical clinical results using phytochemicals. Our in‐depth highlights various such as phenolics, terpenoids, alkaloids, sulfur‐containing compounds, against numerous cells and/or vivo models by antiproliferative, proapoptotic, cell cycle‐regulatory, antiinvasive, antiangiogenic, antimetastatic effects. Bioactive phytochemicals exert their antineoplastic modulating signaling pathways, specifically involving epidermal growth factor receptor, cytokine receptors, toll‐like tumor necrosis receptor consequently alter expression downstream genes proteins. Interestingly, demonstrate encouraging trials, reduction lesion size, growth, pain score, development new lesions. most displayed minimal toxicity, concerns bioavailability may limit application. Future directions include more mechanistic studies, administration formulations, investigation phytocompounds adjuvants conventional treatment, randomized trials.

Language: Английский

Citations

17
Contribution of Sub-Saharan African medicinal plants to cancer research: Scientific basis 2013–2023 DOI Creative Commons
Marc Donald Wilfried Adico, Bagora Bayala, Julio Buñay

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107138 - 107138

Published: March 11, 2024

Cancer incidence and mortality rates are increasing worldwide. treatment remains a real challenge for African countries, especially in sub-Saharan Africa where funding resources very limited. High costs, side effects drug resistance associated with cancer have encouraged scientists to invest research into new herbal drugs. In order identify potential anticancer plants development, this review aims collect summarize activities (in vitro/in vivo) molecular mechanisms of medicinal plant extracts against cell lines. Scientific databases such as ScienceDirect, Google Scholar PubMed were used search articles published from January 2013 May 2023 on Africa. The data analyzed highlight the cytotoxicity action these listed plants. A total 85 papers covering 204 species selected review. These come 57 families, most dominant being family Amaryllidaceae (16), Fabaceae (14), Annonaceae (10), Asteraceae (10). Plant exert their activity mainly by inducing apoptosis stopping cycle cells. Several therefore strong original phytochemicals. Chemoproteomics, multi-omics, genetic editing technology (CRISPR/Cas9), combined therapies artificial intelligence tools cutting edge emerging technologies that facilitate discovery structural understanding molecules plants, reveal direct targets, explore therapeutic uses bases.

Language: Английский

Citations

6
Rapid and Facile Electrochemical Synthesis of MIL-101(Fe)-NH2 and Its Curcumin Loading and Release Studies DOI
Larasati Larasati,

Dendy Dendy,

Witri Wahyu Lestari

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(9), P. 4039 - 4049

Published: April 16, 2024

Language: Английский

Citations

6
Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review DOI
Osman Bozkurt, Betül Kocaadam‐Bozkurt, Hilal Yıldıran

et al.

Food & Function, Journal Year: 2022, Volume and Issue: 13(23), P. 11999 - 12010

Published: Jan. 1, 2022

Type 2 diabetes mellitus (T2DM) is a substantial issue in public health. Recently, there has been considerable interest the effectiveness of using herbal supplements for T2DM. Among supplements, turmeric (Curcuma longa L.) attracting an avalanche attention owing to its main component, curcumin. This review examines physiological activities and mechanisms action curcumin associated with T2DM complications. The literature indicates that pro-inflammatory cytokines along oxidative stress play very important role pathogenesis. Since inflammation cause disruption β cell structure, anti-diabetic characteristic mainly attributed anti-inflammatory as well anti-oxidant activities. In addition these activities, developed promising prevention/treatment choice complications by modulating various critical signal steps anti-hyperglycemic anti-hyperlipidemic Studies on diabetic humans animals have revealed may positive effects reduce fasting blood glucose levels, increase insulin sensitivity/secretion regulate lipid profile. Thus, it prevent treat affecting molecular targets.

Language: Английский

Citations

25