Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed DOI Creative Commons

Gardika Windar Prahara,

Adhe Humaera,

Lies Mira Yusiati

et al.

Buletin Peternakan, Journal Year: 2023, Volume and Issue: 47(2), P. 82 - 82

Published: May 24, 2023

Aflatoxin B1 is a toxin produced by the fungus Aspergillus flavus which reduces development and function of organs in broilers. The aim this study was to determine effect adding binder from different bentonite feed contaminated with AFB1 on productivity, intestinal morphology, liver toxicity A total 60-day old chick male broilers were placed 12 pens. Each treatment consisted three replicates, each replicate containing five Treatment P0 (control, basal diet, without addition AFB1), P1 (P0 + 100 µg/kg 4 g/kg calcium Type A), P2 B), P3 B kerolite saponite). diets given day 22 35 (finisher phase). results showed that had no consumption, body weight gain conversion (p>0.05). Addition increased relative duodenum (p=0.024), although not significantly different. Treatments villus length, crypt depth, ratio length depth (p>0.05), but decreased width (p=0.013). tended decrease area (p=0.055). SGOT SGPT did show differences between treatments. contamination signs histopathological observations. Based research, it can be concluded reduce negative chemical liver. Toxin has best efficacy for

Language: Английский

Taraxasterol alleviates aflatoxin B1-induced liver damage in broiler chickens via regulation of oxidative stress, apoptosis and autophagy DOI Creative Commons
Rui Sang, Bingjie Ge, Haifeng Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 251, P. 114546 - 114546

Published: Jan. 14, 2023

Aflatoxin B1 (AFB1) is the most dangerous and abundant mycotoxin, which toxic to almost all animals, poultry more sensitive AFB1 toxicity. Ingesting AFB1-contaminated feed can cause significant liver damage brings serious harm poultry, greatly restricts development of industry. The present research was implemented explore intervention effect its mechanism taraxasterol on induced by in broiler chickens. model chickens established feeding 0.5 mg/kg feed, (25, 50 100 BW, respectively) given drinking water for 21 days. growth performance, function, oxidative stress, apoptosis autophagy were evaluated. results showed that increased BW reduced feed-to-gain ratio AFB1. Taraxasterol improved levels serum alanine aminotransferase (ALT), aspartate (AST), γ-glutamyltransferase (GGT), total bilirubin (TBIL) alkaline phosphatase (ALP), attenuated hepatic histopathological changes Meantime, down-regulated cytochrome P450 (CYP450) enzyme system CYP1A1 CYP2A6 mRNA expression, inhibited overproduction reactive oxygen species (ROS) malondialdehyde (MDA), enhanced activities antioxidant enzymes glutathione (GSH) catalase (CAT) content superoxide dismutase (SOD) Furthermore, up-regulated protein expression nuclear factor E2 related 2 (Nrf2), heme oxygenase 1 (HO-1) NAD(P)H: quinone oxidoreductase (NQO1), kelch like ECH associated (Keap1) Keap1/Nrf2 signaling pathway. ultrastructural observation RT-qPCR found hepatocytes, B-cell lymphoma-2 (Bcl-2) Bax caspase3 mRNA. Further, restored hepatocytes phosphatidylinositol 3-kinase K (PI3K), kinase B (AKT) mammalian target rapamycin (mTOR) AFB1-induced above indicate alleviates through regulation pathway exert effect, mitochondrial improve anti-apoptotic ability PI3K/AKT/mTOR restore autophagy.

Language: Английский

Citations

29
Soybean hull polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet-fed zebrafish DOI
Chen Chen, Hong Song, Lina Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141123 - 141123

Published: Feb. 1, 2025

Language: Английский

Citations

0
The molecular mechanisms of alpha-lipoic acid on ameliorating aflatoxin B1-induced liver toxicity and physiological dysfunction in northern snakehead (Channa argus) DOI
Min Li,

Qiongya Fang,

Lei Xiu

et al.

Aquatic Toxicology, Journal Year: 2023, Volume and Issue: 257, P. 106466 - 106466

Published: March 1, 2023

Language: Английский

Citations

9
New perspectives in application of kidney biomarkers in mycotoxin induced nephrotoxicity, with a particular focus on domestic pigs DOI Creative Commons
Zsolt Ráduly, András Szabó, Miklós Mézes

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: April 14, 2023

The gradual spread of Aspergilli worldwide is adding to the global shortage food and affecting its safe consumption. Aspergillus -derived mycotoxins, including aflatoxins ochratoxin A, fumonisins (members fusariotoxin group) can cause pathological damage vital organs, kidney or liver. Although functions as major excretory system in mammals, monitoring screening for mycotoxin induced nephrotoxicity only now a developmental area field livestock feed toxicology. Currently assessment individual exposure mycotoxins man animals usually based on analysis toxin and/or metabolite contamination blood urine. However, this requires selective sensitive analytical methods (e.g., HPLC-MS/MS), which are time consuming expensive. toxicokinetic metabolites becoming better understood. Several biomarkers used successfully drug development, however cost-efficient, reliable urgently needed farm early signs disease. β 2 -microglobulin (β -MG) N -acetyl-β-D-glucosaminidase (NAG) dominant employed routinely environmental toxicology research, while injury molecule 1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) also emerging effective markers identify nephropathy. Pigs exposed due their cereal-based diet particularly susceptible mycotoxins. In addition commonly diagnostic plasma creatinine, NAG, KIM-1 NGAL be pigs. review, currently available techniques summarized, animals. Possible approaches considered, could detect

Language: Английский

Citations

8
Antioxidative and Antimycotoxigenic Efficacies of Thunbergia laurifolia Lindl. for Addressing Aflatoxicosis in Cherry Valley Ducks DOI Creative Commons
Chompunut Lumsangkul,

Phruedrada Kaewtui,

Kiattisak Huanhong

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(8), P. 334 - 334

Published: July 27, 2024

This study aimed to assess the effectiveness of aflatoxin B

Language: Английский

Citations

1
Citrus aurantium ‘Changshan-huyou’ physiological premature fruit drop: A promising prebiotic to tackle obesity DOI
Chao Wang,

Mingfang Peng,

Zhipeng Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156347 - 156347

Published: Dec. 26, 2024

Language: Английский

Citations

1
Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1 DOI Creative Commons
Xi Yu, Jing Chen, Shuangshuang Guo

et al.

Frontiers in Veterinary Science, Journal Year: 2022, Volume and Issue: 9

Published: Oct. 21, 2022

A total of 480 one-day-old AA broiler chicks were randomly allocated to one four treatments in a 2 × factorial investigate the effects tannic acid (TA) on growth performance, relative organ weight, antioxidant capacity, and intestinal health broilers dietary exposed aflatoxin B

Language: Английский

Citations

6
Effect of Phyllosilicates As Toxin Binder On Productivity, Intestinal Morphology, and Liver Toxicity in Broiler Fed Afb1 Contaminated Feed DOI Creative Commons

Gardika Windar Prahara,

Adhe Humaera,

Lies Mira Yusiati

et al.

Buletin Peternakan, Journal Year: 2023, Volume and Issue: 47(2), P. 82 - 82

Published: May 24, 2023

Aflatoxin B1 is a toxin produced by the fungus Aspergillus flavus which reduces development and function of organs in broilers. The aim this study was to determine effect adding binder from different bentonite feed contaminated with AFB1 on productivity, intestinal morphology, liver toxicity A total 60-day old chick male broilers were placed 12 pens. Each treatment consisted three replicates, each replicate containing five Treatment P0 (control, basal diet, without addition AFB1), P1 (P0 + 100 µg/kg 4 g/kg calcium Type A), P2 B), P3 B kerolite saponite). diets given day 22 35 (finisher phase). results showed that had no consumption, body weight gain conversion (p>0.05). Addition increased relative duodenum (p=0.024), although not significantly different. Treatments villus length, crypt depth, ratio length depth (p>0.05), but decreased width (p=0.013). tended decrease area (p=0.055). SGOT SGPT did show differences between treatments. contamination signs histopathological observations. Based research, it can be concluded reduce negative chemical liver. Toxin has best efficacy for

Language: Английский

Citations

1