Medicine,
Journal Year:
2024,
Volume and Issue:
103(28), P. e38689 - e38689
Published: July 12, 2024
Acute
pancreatitis
(AP),
a
severe
inflammatory
condition
affecting
the
pancreas
requires
investigation
into
its
predictors.
Melatonin,
compound
with
anti-inflammatory
and
antioxidant
properties,
has
shown
promise
in
managing
AP.
Additionally,
gut
microbiota,
community
of
microorganisms
residing
intestines
been
linked
to
AP
development.
This
study
aims
explore
correlation
between
melatonin
microbiota
predicting
severity.
involved
199
participants,
99
diagnosed
100
serving
as
healthy
controls.
The
patients
were
categorized
2
groups
based
on
severity
their
condition:
mild
(MAP)
(SAP).
Serum
levels
measured
Days
1,
3,
5
hospitalization,
composition
was
examined
via
16S
rRNA
gene
sequencing.
Other
parameters
evaluated,
such
Physiology
Chronic
Health
Evaluation
(APACHE)
score,
Ranson,
Gastrointestinal
Injury
(AGI)
scores.
Melatonin
significantly
lower
subjects
compared
those
(18.2
ng/mL
vs
32.2
ng/mL,
P
=
.001),
decreased
3
5.
also
revealed
that
individuals
exhibited
altered
control
individuals,
Shannon
index
higher
Simpson
index.
AUCs
for
F/B
ratio
than
other
biomarkers,
indicating
these
markers
may
be
useful
prediction.
proposes
there
is
relationship
dynamics
profiles
relation
As
result,
disease
can
assessed
by
assessing
serum
profiles.
Life,
Journal Year:
2023,
Volume and Issue:
13(2), P. 475 - 475
Published: Feb. 9, 2023
In
recent
years,
we
have
faced
an
increasing
incidence
of
inflammatory
bowel
disease
(IBD),
especially
among
young
people,
affecting
them
during
their
reproductive
years.
The
paucity
data
and
reduced
knowledge
regarding
the
evolution
pregnancy
adverse
effects
therapy
on
mother
infant
increase
voluntary
childlessness
in
this
group
patients.
Depending
type
IBD,
severity
surgical
or
medical
management,
can
negatively
affect
pregnancy.
C-sections
risk
low-birth-weight
babies
are
higher
women
with
independent
active/inactive
disease,
while
preterm
birth,
stillbirth
miscarriage
associated
activity.
last
period,
medicinal
has
evolved,
new
molecules
been
developed
for
better
control
lesions,
but
effect
breastfeeding
is
still
controversial.
We
conducted
review
by
studying
literature
research
order
to
a
image
practical
management
IBD
Cells,
Journal Year:
2023,
Volume and Issue:
12(13), P. 1735 - 1735
Published: June 28, 2023
The
term
‘perinatal
environment’
refers
to
the
period
surrounding
birth,
which
plays
a
crucial
role
in
brain
development.
It
has
been
suggested
that
dynamic
communication
between
neuro–immune
system
and
gut
microbiota
is
essential
maintaining
adequate
function.
This
interaction
depends
on
mother’s
status
during
pregnancy
and/or
newborn
environment.
Here,
we
show
experimental
clinical
evidence
indicates
perinatal
critical
window
stress-induced
immune
activation
altered
compositions
produce
lasting
behavioral
consequences,
although
clear
causative
relationship
not
yet
established.
In
addition,
discuss
potential
early
treatments
for
preventing
deleterious
effect
of
stress
exposure.
this
sense,
environmental
enrichment
exposure
(including
exercise)
melatonin
use
could
be
valuable
improving
negative
consequences
adversities.
presented
review
encourages
realization
studies
investigating
beneficial
administration
mitigating
cognitive
alteration
offspring
under
On
other
hand,
direct
restoration
as
main
mechanism
behind
effects
treatment
fully
demonstrated
should
explored
future
studies.
Current Treatment Options in Gastroenterology,
Journal Year:
2023,
Volume and Issue:
21(4), P. 435 - 446
Published: Oct. 9, 2023
Abstract
Purpose
of
review
This
outlines
the
relationship
between
sleep
and
GI
tract
in
health,
before
appraising
association
disease,
namely
disorders
gut-brain
interaction
(DGBI).
We
aim
to
explore
whether
disturbance
exacerbates
DGBI
symptoms
or
vice
versa,
summarise
evidence
for
pharmacological
psychological
treatment
options.
Recent
findings
Sleep
are
more
common
patients
with
irritable
bowel
syndrome
(IBS)
compared
healthy
subjects,
a
pooled
prevalence
37.6%.
Sufficient
exists
support
use
melatonin
ameliorate
overall
IBS
symptom
severity
improve
quality
life.
Summary
DGBIs
stress-sensitive
simple
lifestyle
advice
is
recognised
as
first-line
management.
Sleep,
cornerstone
management,
appears
be
forgotten
factor.
(both
duration
quality)
has
been
associated
DGBI,
IBS;
however,
further
studies
required
determine
options
targeted
at
can
lead
improvement.
Medicine,
Journal Year:
2024,
Volume and Issue:
103(28), P. e38689 - e38689
Published: July 12, 2024
Acute
pancreatitis
(AP),
a
severe
inflammatory
condition
affecting
the
pancreas
requires
investigation
into
its
predictors.
Melatonin,
compound
with
anti-inflammatory
and
antioxidant
properties,
has
shown
promise
in
managing
AP.
Additionally,
gut
microbiota,
community
of
microorganisms
residing
intestines
been
linked
to
AP
development.
This
study
aims
explore
correlation
between
melatonin
microbiota
predicting
severity.
involved
199
participants,
99
diagnosed
100
serving
as
healthy
controls.
The
patients
were
categorized
2
groups
based
on
severity
their
condition:
mild
(MAP)
(SAP).
Serum
levels
measured
Days
1,
3,
5
hospitalization,
composition
was
examined
via
16S
rRNA
gene
sequencing.
Other
parameters
evaluated,
such
Physiology
Chronic
Health
Evaluation
(APACHE)
score,
Ranson,
Gastrointestinal
Injury
(AGI)
scores.
Melatonin
significantly
lower
subjects
compared
those
(18.2
ng/mL
vs
32.2
ng/mL,
P
=
.001),
decreased
3
5.
also
revealed
that
individuals
exhibited
altered
control
individuals,
Shannon
index
higher
Simpson
index.
AUCs
for
F/B
ratio
than
other
biomarkers,
indicating
these
markers
may
be
useful
prediction.
proposes
there
is
relationship
dynamics
profiles
relation
As
result,
disease
can
assessed
by
assessing
serum
profiles.
