Interplay of oxidative stress, cellular communication and signaling pathways in cancer

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 2, 2024

Abstract Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays critical role in development cancer affecting genomic stability signaling pathways cellular microenvironment. Elevated levels ROS disrupt homeostasis contribute to loss normal functions, which are associated initiation progression various types cancer. In this review, we have focused on elucidating downstream that influenced oxidative stress carcinogenesis. These include p53, Keap1-NRF2, RB1, p21, APC, tumor suppressor genes, cell type transitions. Dysregulation these can lead uncontrolled growth, impaired DNA repair mechanisms, evasion death, all hallmark features development. Therapeutic strategies aimed at targeting emerged as area investigation for molecular biologists. The objective is limit response time cancer, including liver, breast, prostate, ovarian, lung cancers. By modulating redox balance restoring homeostasis, it may be possible mitigate damaging effects enhance efficacy treatments. targeted therapies interventions specifically address impact holds great promise improving patient outcomes. approaches antioxidant-based treatments, redox-modulating agents, restore function affected stress. summary, understanding carcinogenesis process through therapeutic utmost importance combating Further research needed unravel complex mechanisms underlying stress-related develop effective translated into clinical applications management treatment

Language: Английский

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Lactic acid bacteria-derived exopolysaccharide: Formation, immunomodulatory ability, health effects, and structure-function relationship

Microbiological Research, Journal Year: 2023, Volume and Issue: 274, P. 127432 - 127432

Published: June 8, 2023

Language: Английский

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Immunological dimensions of neuroinflammation and microglial activation: exploring innovative immunomodulatory approaches to mitigate neuroinflammatory progression

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

The increasing life expectancy has led to a higher incidence of age-related neurodegenerative conditions. Within this framework, neuroinflammation emerges as significant contributing factor. It involves the activation microglia and astrocytes, leading release pro-inflammatory cytokines chemokines infiltration peripheral leukocytes into central nervous system (CNS). These instances result in neuronal damage neurodegeneration through activated nucleotide-binding domain leucine-rich repeat containing (NLR) family pyrin protein 3 (NLRP3) nuclear factor kappa B (NF-kB) pathways decreased erythroid 2-related 2 (Nrf2) activity. Due limited effectiveness regarding inhibition neuroinflammatory targets using conventional drugs, there is challenging growth search for innovative therapies alleviating CNS diseases or even before their onset. Our results indicate that interventions focusing on Interleukin-Driven Immunomodulation, Chemokine (CXC) Receptor Signaling Expression, Cold Exposure, Fibrin-Targeted strategies significantly promise mitigate processes. approaches demonstrate potential anti-neuroinflammatory effects, addressing conditions such Multiple Sclerosis, Experimental autoimmune encephalomyelitis, Parkinson’s Disease, Alzheimer’s Disease. While findings are promising, immunomodulatory often face limitations due Immune-Related Adverse Events. Therefore, conduction randomized clinical trials matter mandatory, will pave way promising future development new medicines with specific therapeutic targets.

Language: Английский

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Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 21, 2024

Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved

Language: Английский

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New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 203 - 203

Published: Feb. 5, 2024

Antioxidant peptides are currently a hotspot in food science, pharmaceuticals, and cosmetics. In different fields, the screening, activity evaluation, mechanisms, applications of antioxidant pivotal areas research. Among these topics, efficient screening stands at forefront cutting-edge To this end, with novel technologies has significantly accelerated research process, gradually replacing traditional approach. After screened identified, time-consuming evaluation is another indispensable procedure, especially vivo models. Cellular rodent models have been widely used for whilst non-rodent provide an solution, even potential high-throughput screening. Meanwhile, further molecular mechanisms can elucidate essence underlying activity, which related to several signaling pathways, including Keap1-Nrf2/ARE, mitochondria-dependent apoptosis, TGF-β/SMAD, AMPK/SIRT1/PGC-1α, PI3K/Akt/mTOR, NF-κB. Last but not least, broad manufacture, therapy, cosmetics industry, requires systematic review. This review introduces peptides, categorized new vision. A wide range assays, encompassing cellular models, as well provided comprehensive manner. addition, recent advances analyzed specific cases. Finally, production, systematically reviewed.

Language: Английский

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Reactive gliosis in traumatic brain injury: a comprehensive review

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 28, 2024

Traumatic brain injury (TBI) is one of the most common pathological conditions impacting central nervous system (CNS). A neurological deficit associated with TBI results from a complex pathogenetic mechanisms including glutamate excitotoxicity, inflammation, demyelination, programmed cell death, or development edema. The critical components contributing to CNS response, damage control, and regeneration after are glial cells–in reaction tissue damage, their activation, hypertrophy, proliferation occur, followed by formation scar. scar creates barrier in damaged helps protect acute phase post-injury. However, this process prevents complete recovery late/chronic producing permanent scarring, which significantly impacts function. Various types participate formation, but mostly attributed reactive astrocytes microglia, play important roles several pathologies. Novel technologies whole-genome transcriptomic epigenomic analyses, unbiased proteomics, show that both microglia represent groups heterogenic subpopulations different genomic functional characteristics, responsible for role neurodegeneration, neuroprotection regeneration. Depending on representation distinct glia subpopulations, as well regenerative processes delayed neurodegeneration may thus differ nearby remote areas structures. This review summarizes process, where resultant effect severity-, region- time-dependent determined model distance explored area lesion site. Here, we also discuss findings concerning intercellular signaling, long-term possibilities novel therapeutical approaches. We believe comprehensive study an emphasis cells, involved post-injury processes, be helpful further research decisive factor when choosing model.

Language: Английский

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Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140221 - 140221

Published: Jan. 22, 2025

Language: Английский

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Novel bioactive peptides alleviate Western diet-induced MAFLD in C57BL/6J mice by inhibiting NLRP3 inflammasome activation and pyroptosis via TLR4/NF-κB and Keap1/Nrf2/HO-1 signaling pathways

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114177 - 114177

Published: Jan. 27, 2025

Metabolic-associated fatty liver disease (MAFLD) has emerged as a leading chronic disease. This condition is characterized by an abnormal accumulation of fat within and can progress from simple steatosis to more severe stages involving inflammation oxidative stress. In this study, we investigated the potential therapeutic effects underlying mechanism novel bioactive peptides (EWYF EWFY) on Western diet-induced MAFLD in C57BL/6J mice. Mice fed normal chow diet (ND group) (WD treatment groups) for 8 weeks. Treatment groups received EWYF EWFY low (10 mg/kg/day) high (50 doses were divided into four groups: EWYF10, EWYF50, EWFY10, EWFY50. body weight gain increased along with visceral adiposity, which markedly reversed dose-dependent manner. Additionally, significantly reduced hepatic steatosis, injury proinflammatory response. glucose tolerance insulin resistance, whereas improved sensitivity. Persistent intake triggered stress, alleviated via inhibiting NOD-like receptor protein 3 (NLRP3) inflammasome activation mitigated pyroptosis modulating TLR4/NF-κB Keap1/Nrf2/HO-1 signaling pathways. Furthermore, molecular docking studies suggest that act fructokinase antagonists TLR4 inhibitors, potentially alleviates MAFLD. Collectively, these findings highlight promising candidates due their potent antioxidant anti-inflammatory properties specific inhibition.

Language: Английский

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Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1098 - 1098

Published: Jan. 27, 2025

This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.

Language: Английский

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Selenium Mitigates Caerulein and LPS-induced Severe Acute Pancreatitis by Inhibiting MAPK, NF-κB, and STAT3 Signaling via the Nrf2/HO-1 Pathway

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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