Dietary Antioxidants and Chronic Diseases

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 362 - 362

Published: Feb. 2, 2023

Chronic diseases, most notably diabetes, cancer, cardiovascular neurodegenerative thyroid and allergic diseases are major causes of death, disability, a lower quality life in various populations [...]

Language: Английский

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The Effects of Olive Oil Consumption on Biochemical Parameters and Body Mass Index of People with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 857 - 857

Published: March 15, 2024

Nonalcoholic fatty liver disease (NAFLD), the most common chronic disorder, is closely associated with insulin resistance, obesity, and metabolic syndromes. A body of research has proposed that olive oil, a basic component Mediterranean diet antioxidant anti-inflammatory properties, may alleviate disturbances retard progression NAFLD. We conducted systematic review meta-analysis to assess effectiveness oil intake in people systematically searched major electronic databases (PubMed/MEDLINE, Scopus, Cochrane Central Register Controlled Trials), as well grey literature sources, identify randomized controlled trials (RCTs) investigating effects consumption on biochemical anthropometric parameters individuals The quality studies was evaluated using risk-of-bias tool 2.0 (RoB 2). mean difference (MD) 95% confidence interval (CI) were calculated fixed-effects random-effects models. Seven RCTs involving 515 subjects included analysis. In model, no statistically significant differences identified respect alanine transaminase (MD = −1.83 IU/L, CI: −5.85, 2.19 p 0.37, I2 69%) aspartate −1.65 −4.48, 1.17 0.25, 72%) levels or waist circumference values −0.23 cm, −1.23, 0.76 0.65, 0%). However, effect mass index observed −0.57 kg/m2, −1.08, −0.06 0.03, 51%) for who received compared those an alternative placebo. findings present suggest modestly positive impact weight

Language: Английский

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The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117028 - 117028

Published: July 2, 2024

A wealth of evidence underscores the bioactive properties nutraceuticals and functional foods in addressing oxyinflammatory-based diseases with implications at both peripheral central levels. Opuntia ficus-indica (OFI) is well-documented for its health-promoting attributes, though fruit (OFIF) remains relatively understudied. Not only poses Metabolic Syndrome (MetS) cardiometabolic risks but also contributes significantly to cognitive impairment, especially crucial brain areas such as hippocampus hypothalamus.

Language: Английский

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“Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1121 - 1121

Published: May 18, 2023

Tomato fruits defined as "golden" refer to a food product harvested at an incomplete ripening stage with respect red tomatoes full maturation. The aim of this study is explore the putative influence "golden tomato" (GT) on Metabolic Syndrome (MetS), especially focusing effects redox homeostasis. Firstly, differential chemical properties GT matrix were characterized in terms phytonutrient composition and antioxidant capacities tomato (RT). Later, we assessed biochemical, nutraceutical eventually disease-modifying potential vivo high-fat-diet rat model MetS. Our data revealed that oral supplementation able counterbalance MetS-induced biometric metabolic modifications. Noteworthy nutritional proved reduce plasma oxidant status improve endogenous barriers, by strong systemic biomarkers. Furthermore, consistently reduction hepatic reactive oxygen nitrogen species (RONS) levels, treatment markedly reduced HFD-induced increase lipid peroxidation steatosis. This research elucidates importance prevention management

Language: Английский

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Quercetin and Its Derivative Counteract Palmitate-Dependent Lipotoxicity by Inhibiting Oxidative Stress and Inflammation in Cardiomyocytes

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 3492 - 3492

Published: Feb. 16, 2023

Cardiac lipotoxicity plays an important role in the pathogenesis of obesity-related cardiovascular disease. The flavonoid quercetin (QUE), a nutraceutical compound that is abundant "Mediterranean diet", has been shown to be potential therapeutic agent cardiac and metabolic diseases. Here, we investigated beneficial QUE its derivative Q2, which demonstrates improved bioavailability chemical stability, lipotoxicity. To this end, H9c2 cardiomyocytes were pre-treated with or Q2 then exposed palmitate (PA) recapitulate occurring obesity. Our results showed both significantly attenuated PA-dependent cell death, although was effective at lower concentration (50 nM) when compared (250 nM). decreased release lactate dehydrogenase (LDH), indicator cytotoxicity, accumulation intracellular lipid droplets triggered by PA. On other hand, protected from PA-induced oxidative stress counteracting formation malondialdehyde (MDA) protein carbonyl groups (which are indicators peroxidation oxidation, respectively) ROS generation, improving enzymatic activities catalase superoxide dismutase (SOD). Pre-treatment also inflammatory response induced PA reducing key proinflammatory cytokines (IL-1β TNF-α). Similar QUE, counteracted PA-provoked increase droplets, LDH, MDA, SOD activity decreasing IL-1β TNF-α. These suggest could considered therapeutics for treatment occurs obesity

Language: Английский

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Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 112, P. 105964 - 105964

Published: Dec. 29, 2023

"Golden" tomato (GT) plays a protective role in metabolic dysfunction induced by High-Fat Diet (HFD). Our aim is to characterize the phytonutrient composition of juice and explore influence GT, orally administered for one month, on cognitive impairment associated with Metabolic Syndrome (MetS) male rats. We investigated reactivity, stress response memory, together brain neurotrophic/inflammatory signaling. data showed that HFD-induced functional modifications were ameliorated GT nutritional supplementation. In particular, behavioural reactivity improved HFD/GT rats, also better performance tests measuring anxiety anhedonia. Furthermore, consumption rescued declarative memory impairment. Lastly, supplementation counteracted alterations PI3K\Akt MAPK/ERK signalling pathways. conclusion, this study provides evidence importance food protection from neuroinflammation MetS.

Language: Английский

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The Nutraceutical Properties of Rhus coriaria Linn: Potential Application on Human Health and Aging Biomedicine

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6206 - 6206

Published: March 25, 2023

Rhus coriaria Linn is a little plant growing in the Mediterranean basin, including Sicily, where it known as Sicilian Sumac. Since antiquity, has been used medicinal herb, considering its pharmacological properties and recognized anti-inflammatory, antioxidant, antimicrobial effects. Multiple studies have highlighted that beneficial of Sumac extracts depend on abundance phytochemicals such polyphenols, fatty acids, minerals, fibers. Despite wide use spice, literature effects humans’ health aging still scarce. Considering great nutraceutical potential, could be to treat age-related diseases those which inflammatory process plays crucial role manifestation progression. Thus, an interesting new insight biomedical field, especially biomedicine.

Language: Английский

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Red and golden tomato administration improves fat diet-induced hepatic steatosis in rats by modulating HNF4α, Lepr, and GK expression

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 1, 2023

Nonalcoholic fatty liver disease (NAFLD), characterized by lipid accumulation within hepatocytes exceeding 5% of weight, is strongly related to metabolic disorders, obesity, and diabetes represents a health emergency worldwide. There no standard therapy available for NAFLD. Lifestyle intervention, including phytonutrient intake, key in preventing NAFLD development progression.We used rat model evaluate the effect dietary supplementation with red tomato (RT) golden (GT)-a patented mix fruit varying degrees ripeness particularly rich naringenin chlorogenic acid-after steatosis development. We assessed effects on body profile, hepatic steatosis.We found correlation between amelioration all parameters gene expression. Our results showed that, together reversion steatosis, consumption RT GT can cause significant reduction triglycerides, low-density lipoprotein-cholesterol, fasting glucose, homeostasis assessment index. Meanwhile, we observed an increase high-density lipoprotein-cholesterol according general lipidic profile. Regarding expression, upregulation Gk Hnf4α involved homeostasis, Lepr adipokine signaling, Il6 Tnf inflammatory response. Taken together, our suggest that intake tomatoes, as nutraceutical approach, has potential therapeutics

Language: Английский

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Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117532 - 117532

Published: Oct. 8, 2024

Language: Английский

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Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 114, P. 106034 - 106034

Published: Feb. 12, 2024

Here, we compared the modulatory effects of different dose levels Uxi (Endopleura uchi aqueous bark extract, EUAE) vs simvastatin (SIM) on hyperlipidemia, metabolic stress, and liver dysfunction in HFD-induced obese rats. HFD significantly increased BMI, lee index, body adipose atherogenic indices, cellular toxicity markers, blood glucose level, adipokines, pro-inflammatory mediators, lipid peroxidation promoted accumulation HMGCR ACC. Furthermore, it decreased antioxidants, ghrelin, AG/UAG ratio as well hepatic glycogen content, while these changes were mitigated by either SIM or EUAE treatment. The expression FASN & SREBP1c genes elevated group, with downregulation PPARα expression. These alterations ameliorated beneficial may be attributed to its phenolic compounds their derivatives. This study supports hypothesis that have antihyperlipidemic, antioxidant, hepatoprotective, anti-inflammatory properties rat model obesity.

Language: Английский

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