Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters DOI Open Access
Anna Aiello, Luana Calabrone, Douglas M. Noonan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3068 - 3068

Published: Sept. 11, 2024

Background: Extra virgin olive oil is a fundamental component of the Mediterranean diet. It contains several molecules that sustain human well-being by modulating cellular metabolism and exerting antioxidant, anti-inflammatory, anti-ageing effects to protect normal tissues, it can exert anti-angiogenic pro-apoptotic on cancer cells. Metabolites found in different parts tree, including leaves, also possess properties might help prevention promote wellness aging. Olive mill wastewater (OMWW), liquid residue produced during extraction, represents an environmental issue. However, rich phytochemicals with potential beneficial properties. Dietary supplements based OMWW be for nutritional supplementation advantages ecology. Purpose: This work aims measure hematochemical, anthropometric, metabolomic parameters volunteers taking dietary supplement, Oliphenolia® (OMWW-OL). Methods: The OMWW-OL 25 mL twice daily 30 days was tested pilot cohort characteristics close metabolic syndrome. Hematochemical, serum biomarkers were analyzed before intervention, at days, after stopping consumption. Results: A total 29 enrolled, 23 completed study. participants’ baseline measured, then treatment assumption discontinuation. Although derivative, their weight did not increase. Their body mass index, instead augmenting, slightly decreased, particularly women. Also, hydration increased, especially women, while blood pressure, glycemia, insulin decreased. Cholesterol, high-density lipoproteins, triglycerides stable, LDL levels vitamin D levels, alongside calcium, perceptibly increased. Albumin All values support equilibrium, no damaging effects. By spectrometry analysis, we favorable changes D/histamine homocysteine/methionine ratios, increase new metabolite unknown formula, D/unknown ratio. Conclusions: Supplementation has detrimental imply modulation biological parameters. this small study, limited potency, preliminarily suggests extract use could potentially valuable people risk Some these relevant supporting healthy ageing prevention.

Language: Английский

Health Outcomes Associated with Olive Oil Intake: An Umbrella Review of Meta-Analyses DOI Creative Commons
Manuela Chiavarini, Patrizia Rosignoli, Irene Giacchetta

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2619 - 2619

Published: Aug. 21, 2024

Several studies suggested a negative association between olive oil (OO) consumption and the risk of several chronic diseases. However, an attempt to systematically search, organize, evaluate existing evidence on all health outcomes associated with OO is lacking. The objective this review describe multiple consumption. Medline, Scopus, Web Science databases were searched through 5 April 2024. selected met following criteria: (1) meta-analysis both observational (case–control cohort studies) interventional (trials), (2) evaluation consumption, mortality, and/or incidence non-communicable/chronic degenerative diseases, (3) study population ≥18 years old. Two independent reviewers extracted relevant data assessed bias individual studies. PRISMA statement guidelines for Integration Evidence from Multiple Meta-Analyses followed. literature search identified 723 articles. After selection, 31 articles included in umbrella review. primary benefits observed cardiovascular diseases factors, cancer, diabetes, specific biomarkers related anthropometric status inflammation. As key component Mediterranean diet, can be considered healthy dietary choice improving positive outcomes.

Language: Английский

Citations

5
Oxidative Stress as a Target for Non-Pharmacological Intervention in MAFLD: Could There Be a Role for EVOO? DOI Creative Commons
Aurelio Seidita, Alessandra Cusimano, Alessandra Giuliano

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 731 - 731

Published: June 16, 2024

Oxidative stress plays a central role in most chronic liver diseases and, particular, metabolic dysfunction-associated fatty disease (MAFLD), the new definition of an old condition known as non-alcoholic (NAFLD). The mechanisms leading to hepatocellular fat accumulation genetically predisposed individuals who adopt sedentary lifestyle and consume obesogenic diet progress through mitochondrial endoplasmic reticulum dysfunction, which amplifies reactive oxygen species (ROS) production, lipid peroxidation, malondialdehyde (MDA) formation, influence release inflammation damage biomarkers, such pro-inflammatory cytokines. This close pathogenetic link has been key stimulus search for therapeutic approaches targeting oxidative treat steatosis, number clinical trials have conducted date on subjects with NAFLD using drugs well supplements or nutraceutical products. Vitamin E, D, Silybin are studied substances, but several non-pharmacological also explored, especially modifications. Among dietary approaches, Mediterranean Diet (MD) seems be reliable affecting probably added value presence extra virgin olive oil (EVOO), healthy food high content monounsaturated acids, oleic acid, variable concentrations phenols (oleocanthal) phenolic alcohols, hydroxytyrosol (HT) tyrosol (Tyr). In this review, we focus interventions MAFLD treatment that target EVOO one main antioxidant components MD.

Language: Английский

Citations

4
Systemic Health Effects of Oleuropein and Hydroxytyrosol Supplementation: A Systematic Review of Randomized Controlled Trials DOI Creative Commons
Oleg Frumuzachi, Laura Ioana Gavrilaș, Dan Cristian Vodnar

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1040 - 1040

Published: Aug. 27, 2024

Non-communicable diseases (NCDs) cause 41 million deaths annually, accounting for 74% of global fatalities. The so-called Mediterranean diet, with its especially significant consumption olive oil, has shown promising results in reducing the risk developing NCDs, such as cardiovascular, liver, or bone diseases. In context nutritional health benefits foods, phenolic compounds oil's main components, oleuropein (OLE) and hydroxytyrosol (HT), have been to possess different beneficial effects. However, no systematic review evaluated health-promoting effects OLE HT until now. Consequently, this analyzed 12 human randomized controlled trials (RCTs), involving 683 participants, assess supplements, pure compounds, enriched foods containing regarding systemic outcomes, including CVD factors, liver parameters, bone, joint, cognitive health. found contrasting but encouraging results, some studies reporting modulation body weight, lipid profile, glucose metabolism, improvements functions. described dosages forms supplementation, ranging from 5 mg/d 990 mL/d leaf infusion (320.8 mg 11.9 HT), highlighting need further research determine optimal dosing duration. Despite mixed supplementation show potential improving cardiometabolic outcomes are necessary understand their better address existing limitations.

Language: Английский

Citations

4
Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters DOI Open Access
Anna Aiello, Luana Calabrone, Douglas M. Noonan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3068 - 3068

Published: Sept. 11, 2024

Background: Extra virgin olive oil is a fundamental component of the Mediterranean diet. It contains several molecules that sustain human well-being by modulating cellular metabolism and exerting antioxidant, anti-inflammatory, anti-ageing effects to protect normal tissues, it can exert anti-angiogenic pro-apoptotic on cancer cells. Metabolites found in different parts tree, including leaves, also possess properties might help prevention promote wellness aging. Olive mill wastewater (OMWW), liquid residue produced during extraction, represents an environmental issue. However, rich phytochemicals with potential beneficial properties. Dietary supplements based OMWW be for nutritional supplementation advantages ecology. Purpose: This work aims measure hematochemical, anthropometric, metabolomic parameters volunteers taking dietary supplement, Oliphenolia® (OMWW-OL). Methods: The OMWW-OL 25 mL twice daily 30 days was tested pilot cohort characteristics close metabolic syndrome. Hematochemical, serum biomarkers were analyzed before intervention, at days, after stopping consumption. Results: A total 29 enrolled, 23 completed study. participants’ baseline measured, then treatment assumption discontinuation. Although derivative, their weight did not increase. Their body mass index, instead augmenting, slightly decreased, particularly women. Also, hydration increased, especially women, while blood pressure, glycemia, insulin decreased. Cholesterol, high-density lipoproteins, triglycerides stable, LDL levels vitamin D levels, alongside calcium, perceptibly increased. Albumin All values support equilibrium, no damaging effects. By spectrometry analysis, we favorable changes D/histamine homocysteine/methionine ratios, increase new metabolite unknown formula, D/unknown ratio. Conclusions: Supplementation has detrimental imply modulation biological parameters. this small study, limited potency, preliminarily suggests extract use could potentially valuable people risk Some these relevant supporting healthy ageing prevention.

Language: Английский

Citations

1