Food & Function, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress accelerate ageing.
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1000 - 1000
Published: Feb. 25, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. has potent antioxidant capacity, being able capture reactive oxygen species (ROS), nitrogen (RNS), chlorine (ROC), which act as reducing agents by chelating transition-metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its different pharmacological properties of quercetin have been described, such carcinostatic properties; antiviral, antihypertensive, anti-inflammatory ability protect low-density lipoprotein (LDL) oxidation, inhibit angiogenesis; these developed in this review.
Language: Английский
Citations
59
Published: Feb. 2, 2024
Quercetin is a flavonoid with low molecular weight that belongs to the human diet's phenolic phytochemicals and non-energy constituents. has potent antioxidant capacity, being able capture Reactive Oxygen Species (ROS), reactive nitro-gen species (RNS), Chlorine (ROC), which act as reducing agents by chelating transition metal ions. Its structure five functional hydroxyl groups, work electron donors are responsible for capturing free radicals. In addition its it was described different pharmacological properties of Quercetin, such carcinostatic properties, antiviral, antihypertensive, anti-inflammatory, protection Low-Density Lipoprotein (LDL) oxidation, inhibi-tion angiogenesis developed in this review.
Language: Английский
Citations
22
Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 228, P. 116165 - 116165
Published: March 26, 2024
In this comprehensive review we tried to reassess the role of phytochemicals in cancer chemoprevention. The exploration "synergistic effect" concept, advocating combined chemopreventive agents, faces challenges like low bioavailability. incorporates personal, occasionally controversial, viewpoints on natural compounds' preventive capabilities, delving into mechanisms. Prioritizing significant contributions within vast research domain, aim stimulating discussion provide a insight evolving prevention. While early years downplayed phytochemicals, late nineties witnessed shift, with leaders exploring their potential alongside synthetic compounds. Challenges faced by chemoprevention, such as limited pharmaceutical interest and cost-effectiveness issues, persist despite successful drugs. Recent studies, including EPIC study, nuanced insights, indicating modest risk reduction for increased fruit vegetable intake. Phytochemicals, once attributed antioxidant effects, face scrutiny due bioavailability conflicting evidence. Nrf2-EpRE signaling pathway microbiota-mediated metabolism emerge mechanisms, highlighting complexity understanding phytochemical mechanisms
Language: Английский
Citations
15
Food Research International, Journal Year: 2024, Volume and Issue: 179, P. 114036 - 114036
Published: Jan. 20, 2024
Language: Английский
Citations
11
Metabolites, Journal Year: 2025, Volume and Issue: 15(4), P. 220 - 220
Published: March 24, 2025
The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism plays crucial role in regulating health by producing biologically active molecules can enter systemic circulation. Among them, trimethylamine-N-oxide (TMAO), an organic compound derived from dietary sources and microbial metabolism, has emerged critical biomarker linking diet, gut host metabolism to various pathological conditions. This comprehensive review highlights TMAO’s biosynthesis, physiological functions, clinical significance, focusing on its mechanistic contributions cardiovascular neurodegenerative diseases. Notably, TMAO-mediated pathways include endothelial dysfunction, inflammation via NLRP3 inflammasome activation, cholesterol disruption, which collectively accelerate atherosclerosis disease progression. Nonetheless, this work underscores innovative potential targeting TMAO through dietary, nutraceutical, microbiota-modulating strategies mitigate effects, marking transformative approach prevention management TMAO-related disorders.
Language: Английский
Citations
1
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1201 - 1201
Published: Aug. 23, 2023
The endothelium, as the guardian of vascular homeostasis, is closely related to occurrence and development cardiovascular diseases (CVDs). As an early marker a series diseases, endothelial dysfunction often accompanied by oxidative stress inflammatory response. Natural flavonoids in fruits, vegetables, Chinese herbal medicines have been shown induce regulate cells exert anti-inflammatory, anti-oxidative stress, anti-aging effects large number vitro models vivo experiments so achieve prevention improvement disease. Focusing on mediation, this paper introduces signaling pathways involved common dietary traditional medicine describes them based their metabolism human body relationship with intestinal flora. aim demonstrate broad pharmacological activity target potential food supplements drug components regulating function thus treatment diseases. This also application some new nanoparticle carriers order improve bioavailability play broader role protection.
Language: Английский
Citations
22
Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1035 - 1035
Published: April 30, 2023
Rosehips, particularly dog rose fruits (Rosa canina L.), are a great source of antioxidant compounds, mainly phenolics. However, their health benefits directly depend on the bioaccessibility these compounds affected by gastrointestinal digestion. Thus, purpose this research was to study impact and colonic in vitro digestions concentration total individual bioaccessible phenolic from hydroalcoholic extract rosehips canina) also capacity. A 34 were detected extracts using UPLC-MS/MS. Ellagic acid, taxifolin, catechin most abundant free fraction, while gallic p-coumaric acids main bound fraction. Gastric digestion negatively content activity measured DPPH radical method. there an enhancement properties terms (DPPH (2,2-diphenyl-1-picrylhydrazyl): 18.01 ± 4.22 mmol Trolox Equivalent (TE)/g; FRAP (Ferric Reducing Antioxidant Power): 7.84 1.83 TE/g) after intestinal stage. The flavonols (73.3%) flavan-3-ols (71.4%). 3%, probably indicating that still other components extract. acid is exception since it presented high (93%) as found fraction Total decreased digestion, due chemical transformations gut microbiota. These results demonstrated rosehip have potential be used functional ingredient.
Language: Английский
Citations
18
Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141049 - 141049
Published: Aug. 30, 2024
Language: Английский
Citations
8
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(3)
Published: May 1, 2024
Abstract Natural bioactive compounds from plants exhibit substantial pharmacological potency and therapeutic value. However, the development of most plant is hindered by low solubility instability. Conventional pharmaceutical forms, such as tablets capsules, only partially overcome these limitations, restricting their efficacy. With recent nanotechnology, nanocarriers can enhance bioavailability, stability, precise intracellular transport compounds. Researchers are increasingly integrating nanocarrier‐based drug delivery systems (NDDS) into natural with significant success. Moreover, products benefit nanotechnological enhancement contribute to innovation optimization via self‐assembly, grafting modifications, biomimetic designs. This review aims elucidate collaborative reciprocal advancement achieved botanical products, compounds, polysaccharides, proteins, extracellular vesicles. underscores salient challenges in nanomedicine, encompassing long‐term safety evaluations nanomedicine formulations, targeting mechanisms, biodistribution complexities, hurdles clinical translation. Further, this study provides new perspectives leverage nanotechnology promoting for nanomedical applications guiding progression NDDS toward enhanced efficiency, precision, safety. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Nanotechnology Biology Nanoscale Systems
Language: Английский
Citations
6
Acta Biochimica Polonica, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 18, 2023
Gastric ulcer is the most prevalent disorder affecting a large population. Rosa brunonii Lindl. fruit (RBF) has traditionally been used to treat stomach pains. Therefore, current work aimed isolate, characterize, and investigate gastro-protective effect of chloroform extract (RBFCE) against ethanol-induced gastric ulcers in rats. Quercetin 3-O-glucoside (QUE-G) was isolated characterized by modern spectroscopic techniques. RBFCE orally administered at 250 mg/kg, 500 750 mg/kg doses for ten days. induced single dose absolute ethanol (5 ml/kg) on last day study. Histological changes were calculated, along with inhibition index (UI). juice volume, pH, acidity, mucus content, protein content evaluated understand mechanism underlying its gastroprotective effect. Omeprazole (OMP) as positive control. significantly (p<0.01) reduced UI (3.54) increased protection rate (67.63%) compared negative (ulcer) control group. Treatment dose-dependent manner total while decreasing volume acidity. Histopathological studies showed severe mucosal injury edema animals extract-treated groups. This study demonstrated that oral administration possesses significant due anti-secretory cytoprotective mechanisms. Our findings support traditional use RBF ulcer.
Language: Английский
Citations
11