Current Pharmaceutical Design,
Journal Year:
2023,
Volume and Issue:
29(43), P. 3421 - 3427
Published: Dec. 1, 2023
Abstract:
Polyphenols
and
flavonoids,
naturally
occurring
compounds
found
abundantly
in
plants,
have
gained
considerable
attention
recent
years
due
to
their
potential
health
benefits.
Research
exploring
bioactive
properties
has
revealed
promising
therapeutic
applications
various
diseases.
This
article
aims
provide
a
comprehensive
overview
of
the
intricate
journey
from
academic
laboratory
discoveries
availability
polyphenols
flavonoids
as
drugs
on
pharmacy
shelves.
It
was
shown
that
transformation
these
natural
into
effective
therapies
is
avenue
for
enhancing
human
health.
Yet,
fully
realizing
this
necessitates
sustained
scientific
exploration,
cross-disciplinary
collaboration,
continued
investment
research
development.
underscores
importance
collaboration
key
pillars
progress
towards
innovative
therapies.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(12), P. e32563 - e32563
Published: June 1, 2024
Flavonoids
are
found
in
the
roots,
stems,
leaves,
and
fruits
of
many
plant
taxa.
They
related
to
growth
development,
pigment
formation,
protection
against
environmental
stress.
function
as
antioxidants
exert
anti-inflammatory
effects
cardiovascular
system
by
modulating
classical
inflammatory
response
pathways,
such
TLR4-NF-ĸB,
PI3K-AKT,
Nrf2/HO-1
signalling
pathways.
There
is
increasing
evidence
for
therapeutic
flavonoids
on
hypertension,
atherosclerosis,
other
diseases.
The
potential
clinical
value
diseases
has
been
widely
explored.
For
example,
studies
have
evaluated
roles
regulation
blood
pressure
via
endothelium-dependent
non-endothelium-dependent
pathways
myocardial
systolic
diastolic
functions
influencing
calcium
homeostasis
smooth
muscle-related
protein
expression.
also
hypoglycaemic,
hypolipidemic,
anti-platelet,
autophagy,
antibacterial
effects.
In
this
paper,
role
mechanism
were
reviewed
order
provide
reference
application
future.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(4), P. 2884 - 2925
Published: March 26, 2024
At
present,
the
occurrence
of
a
large
number
infectious
and
non-communicable
diseases
poses
serious
threat
to
human
health
as
well
drug
development
for
treatment
these
diseases.
One
most
significant
challenges
is
finding
new
candidates
that
are
therapeutically
effective
have
few
or
no
side
effects.
In
this
respect,
active
compounds
in
medicinal
plants,
especially
flavonoids,
potentially
useful
with
wide
range
pharmacological
activities.
They
naturally
present
nature
valuable
many
Flavonoids
divided
into
fourteen
categories
mainly
derived
from
plant
extraction,
chemical
synthesis
structural
modification,
biosynthesis.
The
modification
flavonoids
an
important
way
discover
drugs,
but
biosynthesis
currently
considered
promising
research
direction
potential
revolutionize
production
pipeline
flavonoids.
However,
relevant
problems
such
metabolic
pathway
analyses
cell
protocols
need
be
addressed
on
urgent
basis.
review,
techniques
assessing
biological
activities
mechanisms
their
elucidated
modes
interaction
other
drugs
described.
Moreover,
novel
delivery
systems,
nanoparticles,
bioparticles,
colloidals,
etc.,
gradually
becoming
means
addressing
issues
poor
hydrophilicity,
lipophilicity,
stability,
low
bioavailability
review
summarizes
latest
progress
existing
therapeutic
efficacy,
how
can
solved
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 6, 2025
Cardiovascular
disease
(CVD)
remains
the
leading
cause
of
mortality
worldwide,
with
complex
pathophysiological
mechanisms
such
as
oxidative
stress,
inflammation,
apoptosis,
and
endothelial
dysfunction
driving
progression.
MicroRNAs
(miRNAs),
a
class
non-coding
RNAs,
have
emerged
key
regulators
gene
expression
involved
in
these
processes,
positioning
them
potential
biomarkers
therapeutic
targets
CVD
management.
Simultaneously,
flavonoids,
naturally
occurring
polyphenolic
compounds
found
various
plant-based
foods,
gained
attention
for
their
cardioprotective
properties,
including
antioxidant,
anti-inflammatory,
anti-apoptotic
effects.
Recent
studies
suggest
novel
intersection
between
flavonoids
miRNAs,
where
may
modulate
specific
miRNAs
implicated
pathogenesis.
This
review
explores
miRNA
modulators,
focusing
on
ability
to
regulate
associated
cardiac
fibrosis,
hypertrophy,
vascular
inflammation.
By
bridging
targeting,
this
highlights
innovative
pathways
advancing
treatment
strategies.
Additionally,
preclinical
clinical
evidence
supporting
interactions
is
discussed,
alongside
challenges
opportunities
developing
flavonoid-based
therapies.
Unlocking
synergy
could
pave
way
more
effective,
personalized
approaches
management,
addressing
unmet
needs
contemporary
cardiovascular
care.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2962 - 2962
Published: March 4, 2024
The
incidence
and
prevalence
of
cardiovascular
diseases
are
still
rising.
principal
mechanism
that
drives
them
is
atherosclerosis,
an
affection
given
by
dyslipidemia
a
pro-inflammatory
state.
Paraoxonase
enzymes
have
protective
role
due
to
their
ability
contribute
antioxidant
anti-inflammatory
pathways,
especially
paraoxonase
1
(PON1).
PON1
binds
with
HDL
(high-density
lipoprotein),
high
serum
levels
lead
state
against
dyslipidemia,
diseases,
diabetes,
stroke,
nonalcoholic
fatty
liver
disease,
many
others.
Modulating
expression
might
be
treatment
objective
significant
results
in
limiting
the
atherosclerosis.
Lifestyle
including
diet
exercise
can
raise
its
levels,
some
beneficial
plants
been
found
influence
levels;
therefore,
more
studies
on
herbal
components
needed.
Our
purpose
highlight
roles
Praoxonase
1,
implications
other
emphasize
modulate
expression,
targeting
potential
flavonoids
could
introduced
as
supplements
our
validate
hypothesis
any
effects
regarding
function.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5949 - 5949
Published: May 29, 2024
In
recent
years,
research
on
mushrooms
belonging
to
the
Hericium
genus
has
attracted
considerable
attention
due
their
unique
appearance
and
well-known
medicinal
properties.
These
are
abundant
in
bioactive
chemicals
like
polysaccharides,
hericenones,
erinacines,
hericerins,
resorcinols,
steroids,
mono-
diterpenes,
corallocins,
alongside
essential
nutrients.
compounds
demonstrate
beneficial
bioactivities
which
related
various
physiological
systems
of
body,
including
digestive,
immune,
nervous
systems.
Extensive
been
conducted
isolation
identification
numerous
chemicals,
both
vitro
vivo
studies
have
confirmed
antimicrobial,
antioxidant,
immunomodulatory,
antidiabetic,
anticholesterolemic,
anticancer,
neuroprotective
Therefore,
this
review
aims
provide
a
comprehensive
summary
latest
scientific
literature
chemical
composition
secondary
metabolites
profile
spp.
through
an
introduction
characteristics,
speculated
biosynthesis
pathways
for
key
families,
potential
toxicological
aspects,
detailed
description
updates
regarding
bioactivity
these
metabolites.
Current Topics in Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
24(24), P. 2093 - 2116
Published: Aug. 7, 2024
Flavonoids
are
biologically
active
chemicals
in
various
fruits,
plants,
vegetables,
and
leaves,
which
have
promising
uses
medicinal
science.
The
health
properties
of
these
natural
widely
accepted,
efforts
underway
to
extract
the
specific
components
referred
as
flavonoids.
demonstrate
a
diverse
range
bio-activities,
anticancer,
antioxidant
activity,
anti-cholinesterase
antiinflammatory
antimalarial
antidiabetic
neurodegenerative
disease,
cardiovascular
effect,
hepatoprotective
effects,
antiviral
antimicrobial
activity.
This
study
aims
examine
prevailing
trends
flavonoid
investigation
studies,
elucidate
activity
flavonoids,
their
functions
uses,
assess
potential
flavonoids
preventive
medications
for
chronic
diseases,
outline
future
research
opportunities
this
field.
review
explores
preventing
managing
diseases.
Exon.,
Journal Year:
2025,
Volume and Issue:
2(1), P. 25 - 53
Published: Jan. 17, 2025
The
golden
shower
tree,
Cassia
fistula,
is
a
botanical
symbol
of
persistence,
providing
aesthetic
appeal
and
sophisticated
ecological
dynamics.
As
the
climate
change
specter
looms,
this
paper
delves
into
delicate
interplay
between
changing
climatic
circumstances
fistula
phenology
phytochemistry.
tree's
therapeutic
effects
are
linked
to
anthraquinones,
flavonoids,
saponins,
which
have
been
gathered
focused
on
their
significant
antioxidant,
anti-inflammatory,
antibacterial
capabilities.
has
traditionally
utilized
in
various
medical
techniques
treat
illnesses
such
as
digestive
issues
skin
health
management,
demonstrating
its
adaptability
usefulness
herbal
therapy.
review
comprehensively
unravels
climate-induced
changes
attribution,
pharmacological
advantages,
nanotechnology
prospects.
